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Review

Chitosan Coatings to Control Release and Target Tissues for Therapeutic Delivery

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Pages 855-871 | Published online: 31 Jul 2015

References

  • Wolinsky JB Colson YL Grinstaff MW . Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers. J. Control. Release159 (1), 14–26 (2012).
  • Manzano M Vallet-Regi M . Revisiting bioceramics: Bone regenerative and local drug delivery systems. Prog. Solid State Chem.40 (3), 17–30 (2012).
  • Heneweer C Gendy SE Penate-Medina O . Liposomes and inorganic nanoparticles for drug delivery and cancer imaging. Ther. Deliv.3 (5), 645–656 (2012).
  • Yeo Y . Battling with environments: drug delivery to target tissues with particles and functional biomaterials. Ther. Deliv.1 (6), 757–761 (2010).
  • Penn-Barwell JG Murray CK Wenke JC . Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model. J. Orthop. Trauma28 (6), 370–375 (2014).
  • Kluin OS Van Der Mei HC Busscher HJ Neut D . Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin. Drug Deliv.10 (3), 341–351 (2013).
  • Cima MJ Lee H Daniel K et al. Single compartment drug delivery. J. Control. Release190, 157–171 (2014).
  • Chen MC Mi FL Liao ZX et al. Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv. Drug Deliv. Rev.65 (6), 865–879 (2013).
  • Felt O Buri P Gurny R . Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm.24 (11), 979–993 (1998).
  • Jayakumar R Menon D Manzoor K Nair SV Tamura H . Biomedical applications of chitin and chitosan based nanomaterials–a short review. Carbohydr. Polym.82 (2), 227–232 (2010).
  • Agnihotri SA Mallikarjuna NN Aminabhavi TM . Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J. Control. Release100 (1), 5–28 (2004).
  • Dash M Chiellini F Ottenbrite RM Chiellini E . Chitosan–a versatile semi-synthetic polymer in biomedical applications. Prog. Polym. Sci.36 (8), 981–1014 (2011).
  • Ganguly K Chaturvedi K More UA Nadagouda MN Aminabhavi TM . Polysaccharide-based micro/nanohydrogels for delivering macromolecular therapeutics. J. Control. Release193, 162–173 (2014).
  • Beenken K Smith J Skinner R et al. Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis. J. Biomater. Appl.29 (4), 514–523 (2014).
  • Karn PR Vanic Z Pepic I Skalko-Basnet N . Mucoadhesive liposomal delivery systems: the choice of coating material. Drug Dev. Ind. Pharm.37 (4), 482–488 (2011).
  • Lai WF Lin MCM . Nucleic acid delivery with chitosan and its derivatives. J. Control. Release134 (3), 158–168 (2009).
  • Mao SR Sun W Kissel T . Chitosan-based formulations for delivery of DNA and siRNA. Adv. Drug Deliv. Rev.62 (1), 12–27 (2010).
  • Kumar MNVR . A review of chitin and chitosan applications. React. Funct. Polym.46 (1), 1–27 (2000).
  • Ii'ina AV Varlamov VP . Chitosan-based polyelectrolyte complexes: a review. Appl. Biochem. Microbiol.41 (1), 5–11 (2005).
  • Shukla SK Mishra AK Arotiba OA Mamba BB . Chitosan-based nanomaterials: a state-of-the-art review. Int. J. Biol. Macromol.59, 46–58 (2013).
  • Chaturvedi K Ganguly K Nadagouda MN Aminabhavi TM . Polymeric hydrogels for oral insulin delivery. J. Control. Release165 (2), 129–138 (2013).
  • Mukhopadhyay P Mishra R Rana D Kundu PP . Strategies for effective oral insulin delivery with modified chitosan nanoparticles: a review. Progr. Polym. Sci.37 (11), 1457–1475 (2012).
  • Varma AJ Deshpande SV Kennedy JF . Metal complexation by chitosan and its derivatives: a review. Carbohydr. Polym.55 (1), 77–93 (2004).
  • Park JH Saravanakumar G Kim K Kwon IC . Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv. Drug Deliv. Rev.62 (1), 28–41 (2010).
  • Prabaharan M . Chitosan derivatives as promising materials for controlled drug delivery. J. Biomater. Appl.23 (1), 5–36 (2008).
  • Haggard WO Bumgardner JD Noel S Richelsoph K Yuan Y . Chitosan-coated calcium sulfate based medicament delivery system. (2008). US Patent Application # PCT/US2007/080324, filed Oct. 3, 2007.
  • Yao QQ Nooeaid P Roether JA Dong YN Zhang QQ Boccaccini AR . Bioglass (R)-based scaffolds incorporating polycaprolactone and chitosan coatings for controlled vancomycin delivery. Ceram. Int.39 (7), 7517–7522 (2013).
  • Kundu B Lemos A Soundrapandian C et al. Development of porous HAp and beta-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system. J. Mater. Sci. Mater. Med.21 (11), 2955–2969 (2010).
  • Chen H Cui X Yu XZ et al. Effects of chitosan-coated pressed calcium sulfate pellets combined with recombinant human bone morphogenetic protein 2 on bone formation in femoral condyle-contained bone defects. J. Craniofac. Surg.21 (1), 188–197 (2010).
  • Pastor E Matveeva E Valle-Gallego A Goycoolea FM Garcia-Fuentes M . Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles. Colloids Surf. B Biointerfaces88 (2), 601–609 (2011).
  • Mattioli-Belmonte M Cometa S Ferretti C et al. Characterization and cytocompatibility of an antibiotic/chitosan/cyclodextrins nanocoating on titanium implants. Carbohydr. Polym.110, 173–182 (2014).
  • De Giglio E Trapani A Cafagna D et al. Ciprofloxacin-loaded chitosan nanoparticles as titanium coatings: a valuable strategy to prevent implant-associated infections. Nano Biomed. Eng.4, 157–163 (2012).
  • Cheng S Wei DQ Zhou Y . Mechanical and corrosion resistance of hydrophilic sphene/titania composite coatings on titanium and deposition and release of cefazolin sodium/chitosan films. Appl. Surf. Sci.257 (7), 2657–2664 (2011).
  • Gulati K Ramakrishnan S Aw MS Atkins GJ Findlay DM Losic D . Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion. Acta Biomater.8 (1), 449–456 (2012).
  • Hossfeld S Nolte A Hartmann H et al. Bioactive coronary stent coating based on layer-by-layer technology for siRNA release. Acta Biomater.9 (5), 6741–6752 (2013).
  • Zhu DW Jin X Leng XG et al. Local gene delivery via endovascular stents coated with dodecylated chitosan-plasmid DNA nanoparticles. Int. J. Nanomedicine5, 1095–1102 (2010).
  • Shi W Gu C Jiang H Zhang M Lang M . Effects of amphiphilic chitosan-g-poly (ε-caprolactone) polymer additives on paclitaxel release from drug eluting implants. Mater. Sci. Eng. C Mater. Biol. Appl.45, 502–509 (2014).
  • Omwancha W Kouba C Yelamanchili S Neau SH . Colon-specific drug delivery using ethylcellulose and chitosan in the coat of compression-coated tablets. Drug Dev. Ind. Pharm.37 (8), 945–953 (2011).
  • Yamamoto H Kuno Y Sugimoto S Takeuchi H Kawashima Y . Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. J. Control. Release102 (2), 373–381 (2005).
  • Lee C Choi JS Kim I et al. Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating Type 2 diabetes. Int. J. Nanomedicine8, 2975–2983 (2013).
  • Mazzarino L Travelet C Ortega-Murillo S et al. Elaboration of chitosan-coated nanoparticles loaded with curcumin for mucoadhesive applications. J. Colloid Interface Sci.370 (1), 58–66 (2012).
  • Mazzarino L Coche-Guerente L Labbe P Lemos-Senna E Borsali R . On the mucoadhesive properties of chitosan-coated polycaprolactone nanoparticles loaded with curcumin using quartz crystal microbalance with dissipation monitoring. J. Biomed. Nanotechnol.10 (5), 787–794 (2014).
  • Huang D Zuo Y Zou Q et al. Antibacterial chitosan coating on nano-hydroxyapatite/polyamide66 porous bone scaffold for drug delivery. J. Biomater. Sci. Polym. Ed.22 (7), 931–944 (2011).
  • Nagarwal RC Singh P Kant S Maiti P Pandit J . Chitosan coated PLA nanoparticles for ophthalmic delivery: characterization, in-vitro and in-vivo study in rabbit eye. J. Biomed. Nanotechnol.6 (6), 648–657 (2010).
  • Nagarwal RC Kumar R Pandit J . Chitosan coated sodium alginate–chitosan nanoparticles loaded with 5-FU for ocular delivery: In vitro characterization and in vivo study in rabbit eye. Eur. J. Pharm. Sci.47 (4), 678–685 (2012).
  • Angadi SC Manjeshwar LS Aminabhavi TM . Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin. Int. J. Biol. Macromol.51 (1–2), 45–55 (2012).
  • Calderini A Pessine FB Franchi GC Nowill AE . Preparation and characterisation of 5–fluorouracil containing PLGA nanospheres coated with chitosan, for drug delivery. Int. J. Nanotechnol.9 (10), 851–861 (2012).
  • Barea MJ Jenkins MJ Lee YS Johnson P Bridson RH . Encapsulation of Liposomes within pH Responsive Microspheres for Oral Colonic Drug Delivery. Int. J. Biomater.2012, 458712 (2012).
  • Abdelbary G . Ocular ciprofloxacin hydrochloride mucoadhesive chitosan-coated liposomes. Pharm. Dev. Technol.16 (1), 44–56 (2011).
  • Kim DH Kim KN Kim KM Lee YK . Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia. J. Biomed. Mater. Res. A88 (1), 1–11 (2009).
  • Kim DH Nikles DE Brazel CS . Synthesis and characterization of multifunctional chitosan- MnFe2O4 nanoparticles for magnetic hyperthermia and drug delivery. Materials3 (7), 4051–4065 (2010).
  • Li N Zhuang C Wang M Sun X Nie S Pan W . Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int. J. Pharm.379 (1), 131–138 (2009).
  • Tang H Guo J Sun Y Chang B Ren Q Yang W . Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery. Int. J. Pharm.421 (2), 388–396 (2011).
  • Popat A Liu J Lu GQM Qiao SZ . A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. J. Mater. Chem.22 (22), 11173–11178 (2012).
  • Agnihotri SA Aminabhavi TM . Formulation and evaluation of novel tableted chitosan microparticles for the controlled release of clozapine. J. Microencapsul.21 (7), 709–718 (2004).
  • Wang M Feng Q Niu X Tan R She Z . A spheres-in-sphere structure for improving protein-loading poly (lactide-co-glycolide) microspheres. Polym. Degrad. Stab.95 (1), 6–13 (2010).
  • Zhao J Shen G Liu CS et al. Enhanced healing of rat calvarial defects with sulfated chitosan-coated calcium-deficient hydroxyapatite/bone morphogenetic protein 2 scaffolds. Tissue Eng. A18 (1–2), 185–197 (2012).
  • Swanson TE Cheng X Friedrich C . Development of chitosan-vancomycin antimicrobial coatings on titanium implants. J. Biomed. Mater. Res. A97 (2), 167–176 (2011).
  • Norowski PA Courtney HS Babu J Haggard WO Bumgardner JD . Chitosan coatings deliver antimicrobials from titanium implants: a preliminary study. Implant Dent.20 (1), 56–67 (2011).
  • Lv H Chen Z Yang X Cen L Zhang X Gao P . Layer-by-layer self-assembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation. J. Dent.42 (11), 1464–1472 (2014).
  • Leedy MR Jennings JA Haggard WO Bumgardner JD . Effects of VEGF-loaded chitosan coatings. J. Biomed. Mater. Res. A102 (3), 752–759 (2014).
  • Fang K Song W Wang L et al. Immobilization of chitosan film containing semaphorin 3A onto a microarc oxidized titanium implant surface via silane reaction to improve MG63 osteogenic differentiation. Int. J. Nanomedicine9, 4649–4657 (2014).
  • Shi ZL Neoh KG Kang ET Poh CK Wang W . Surface Functionalization of Titanium with Carboxymethyl Chitosan and Immobilized Bone Morphogenetic Protein-2 for Enhanced Osseointegration. Biomacromolecules10 (6), 1603–1611 (2009).
  • Chen H Wu J Sun M et al. N-trimethyl chitosan chloride-coated liposomes for the oral delivery of curcumin. J. Liposome Res.22 (2), 100–109 (2012).
  • Kowapradit J Apirakaramwong A Ngawhirunpat T Rojanarata T Sajomsang W Opanasopit P . Methylated N-(4-N,N-dimethylaminobenzyl) chitosan coated liposomes for oral protein drug delivery. Eur. J. Pharm. Sci.47 (2), 359–366 (2012).
  • Yang KK Kong M Wei YN et al. Folate-modified-chitosan-coated liposomes for tumor-targeted drug delivery. J. Mater. Sci.48 (4), 1717–1728 (2013).
  • Amoozgar Z Park JY Lin QN Yeo Y . Low molecular-weight chitosan as a pH-sensitive stealth coating for tumor-specific drug delivery. Mol. Pharm.9 (5), 1262–1270 (2012).
  • Chen JP Yang PC Ma YH Wu T . Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator. Carbohydr. Polym.84 (1), 364–372 (2011).
  • Zhou JB Cai XW Cheng K et al. Release behaviors of drug loaded chitosan/calcium phosphate coatings on titanium. Thin Solid Films519 (15), 4658–4662 (2011).
  • Patel KD Singh RK Lee EJ et al. Tailoring solubility and drug release from electrophoretic deposited chitosan-gelatin films on titanium. Surf. Coat. Technol.242, 232–236 (2014).
  • Patel KD El-Fiqi A Lee HY et al. Chitosan-nanobioactive glass electrophoretic coatings with bone regenerative and drug delivering potential. J. Mater. Chem.22 (47), 24945–24956 (2012).
  • Ordikhani F Tamjid E Simchi A . Characterization and antibacterial performance of electrodeposited chitosan-vancomycin composite coatings for prevention of implant-associated infections. Mater. Sci. Eng. C Mater. Biol. Appl.41, 240–248 (2014).
  • Ordikhani F Simchi A . Long-term antibiotic delivery by chitosan-based composite coatings with bone regenerative potential. Appl. Surf. Sci.317, 56–66 (2014).
  • Pishbin F Simchi A Ryan MP Boccaccini AR . Electrophoretic deposition of chitosan/45S5 Bioglass? composite coatings for orthopaedic applications. Surf. Coat. Technol.205 (23–24), 5260–5268 (2011).
  • Pishbin F Mourino V Gilchrist JB et al. Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system. Acta Biomater.9 (7), 7469–7479 (2013).
  • Zhao P Liu H Deng H et al. A study of chitosan hydrogel with embedded mesoporous silica nanoparticles loaded by Ibuprofen as a dual stimuli-responsive drug release system for surface coating of Titanium implants. Colloids Surf. B Biointerfaces123, 657–663 (2014).
  • Yang CC Lin CC Liao JW Yen SK . Vancomycin-chitosan composite deposited on post porous hydroxyapatite coated Ti6Al4V implant for drug controlled release. Mater. Sci. Eng. C Mater. Biol. Appl.33 (4), 2203–2212 (2013).
  • Tahara K Sakai T Yamamoto H Takeuchi H Kawashima Y . Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery. Int. J. Pharm.354 (1–2), 210–216 (2008).
  • Yuan XD Shah BA Kotadia NK Li JA Gu H Wu ZQ . The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery. Pharm. Res.27 (7), 1285–1295 (2010).
  • Nafee N Taetz S Schneider M Schaefer UF Lehr C-M . Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine3 (3), 173–183 (2007).
  • Taetz S Nafee N Beisner J et al. The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2′-O-methyl-RNA directed against telomerase in lung cancer cells. Eur. J. Pharm. Biopharm.72 (2), 358–369 (2009).
  • Goncalves MCF Mertins O Pohlmann AR Silveira NP Guterres SS . Chitosan Coated Liposomes as an Innovative Nanocarrier for Drugs. J. Biomed. Nanotechnol.8 (2), 240–250 (2012).
  • Kesavan K Kant S Singh PN Pandit JK . Mucoadhesive chitosan-coated cationic microemulsion of dexamethasone for ocular delivery: in vitro and in vivo evaluation. Curr. Eye Res.38 (3), 342–352 (2013).
  • Jain S Jain NK Gupta Y Jain A Jain D Chaurasia M . Mucoadhesive chitosan microspheres for non-invasive and improved nasal delivery of insulin. Indian J. Pharm. Sci.69 (4), 498 (2007).
  • Sarmento B Mazzaglia D Bonferoni MC Neto AP Monteiro MD Seabra V . Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system. Carbohydr. Polym.84 (3), 919–925 (2011).
  • Fonte P Andrade F Araujo F Andrade C Das Neves J Sarmento B . Chitosan-coated solid lipid nanoparticles for insulin delivery. Nanomedicine508, 295–314 (2012).
  • Fonte P Nogueira T Gehm C Ferreira D Sarmento B . Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Deliv. Transl. Res.1 (4), 299–308 (2011).
  • Qu JB Shao HH Jing GL Huang F . PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studies. Colloids Surf. B Biointerfaces102, 37–44 (2013).
  • Wang L Rao RR Stegemann JP . Delivery of mesenchymal stem cells in chitosan/collagen microbeads for orthopedic tissue repair. Cells Tissues Organs197 (5), 333–343 (2013).
  • Shu XZ Zhu KJ . A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery. Int. J. Pharm.201 (1), 51–58 (2000).
  • Channarong S Chaicumpa W Sinchaipanid N Mitrevej A . Development and evaluation of chitosan-coated liposomes for oral DNA vaccine: the improvement of Peyer's patch targeting using a polyplex-loaded liposomes. AAPS PharmSciTech12 (1), 192–200 (2011).
  • Li L Zhang Y Han S et al. Penetration enhancement of lidocaine hydrochlorid by a novel chitosan coated elastic liposome for transdermal drug delivery. J. Biomed. Nanotechnol.7 (5), 704–713 (2011).
  • Khor E . Chitin: Fulfilling A Biomaterials Promise. Elsevier Health Sciences (2001).
  • Muzzarelli R Muzzarelli C . Chitosan chemistry: relevance to the biomedical sciences. In : Polysaccharides I. HeinzeT ( Ed.). Springer, 151–209 (2005).
  • Hamilton V Yuan Y Rigney DA et al. Bone cell attachment and growth on well‐characterized chitosan films. Polym. Int.56 (5), 641–647 (2007).
  • Yuan Y Chesnutt BM Wright L Haggard WO Bumgardner JD . Mechanical property, degradation rate, and bone cell growth of chitosan coated titanium influenced by degree of deacetylation of chitosan. J. Biomed. Mater. Res. B.86 (1), 245–252 (2008).
  • Kumar MR Muzzarelli RA Muzzarelli C Sashiwa H Domb A . Chitosan chemistry and pharmaceutical perspectives. Chem. Rev.104 (12), 6017–6084 (2004).
  • Paul W Sharma CP . Ceramic drug delivery: a perspective. J. Biomater. Appl.17 (4), 253–264 (2003).
  • Thomas MV Puleo DA . Calcium sulfate: properties and clinical applications. J. Biomed. Mater. Res. B Appl. Biomater.88 (2), 597–610 (2009).
  • Habraken WJ Wolke JG Jansen JA . Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv. Drug Deliv. Rev.59 (4–5), 234–248 (2007).
  • Turner TM Urban RM Gitelis S Haggard WO Richelsoph K . Resorption evaluation of a large bolus of calcium sulfate in a canine medullary defect. Orthopedics26 (5 Suppl.), s577–s579 (2003).
  • Orellana BR Hilt JZ Puleo DA . Drug release from calcium sulfate-based composites. J. Biomed. Mater. Res. B Appl. Biomater.103 (1), 135–1342 (2014).
  • Soundrapandian C Datta S Kundu B Basu D Sa B . Porous bioactive glass scaffolds for local drug delivery in osteomyelitis: development and in vitro characterization. AAPS PharmSciTech11 (4), 1675–1683 (2010).
  • Li RH Bouxsein ML Blake CA et al. rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model. J. Orthop. Res.21 (6), 997–1004 (2003).
  • Cheng S Wei DQ Zhou Y . Structure of microarc oxidized coatings containing Si, Ca and Na on titanium and deposition of cefazolin sodium/chitosan composite film. Surf. Coat. Technol.205 (13–14), 3798–3804 (2011).
  • Mundargi RC Babu VR Rangaswamy V Patel P Aminabhavi TM . Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J. Control. Release125 (3), 193–209 (2008).
  • Van Der Lubben IM Verhoef JC Borchard G Junginger HE . Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur. J. Pharm. Sci.14 (3), 201–207 (2001).
  • Kumari A Yadav SK Yadav SC . Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf. B Biointerfaces75 (1), 1–18 (2010).
  • Kawashima Y Yamamoto H Takeuchi H Fujioka S Hino T . Pulmonary delivery of insulin with nebulized dl-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J. Control. Release62 (1–2), 279–287 (1999).
  • Mora-Huertas C Fessi H Elaissari A . Polymer-based nanocapsules for drug delivery. Int. J. Pharm.385 (1), 113–142 (2010).
  • Mazzarino L Borsali R Lemos-Senna E . Mucoadhesive films containing chitosan-coated nanoparticles: a new strategy for buccal curcumin release. J. Pharm. Sci.103 (11), 3764–3771 (2014).
  • Rudzinski WE Aminabhavi TM . Chitosan as a carrier for targeted delivery of small interfering RNA. Int. J. Pharm.399 (1–2), 1–11 (2010).
  • Gomes CP Lopes CDF Moreno PMD Varela-Moreira A Alonso MJ Pego AP . Translating chitosan to clinical delivery of nucleic acid-based drugs. MRS Bull.39 (1), 60–70 (2014).
  • Li N Zhuang CY Wang M Sun XY Nie SF Pan WS . Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int. J. Pharm.379 (1), 131–138 (2009).
  • Li N Zhuang CY Wang M Sui CG Pan WS . Low molecular weight chitosan-coated liposomes for ocular drug delivery: In vitro and in vivo studies. Drug Deliv.19 (1), 28–35 (2012).
  • Arami H Stephen Z Veiseh O Zhang MQ . Chitosan-coated iron oxide nanoparticles for molecular imaging and drug delivery. In : Chitosan for Biomaterials I. Advances in Polymer Science. JayakumarRPrabaharanMMuzzarelliRA ( Eds). Springer, Berlin, Germany, 243, 163–184 (2011).
  • Chomoucka J Drbohlavova J Huska D Adam V Kizek R Hubalek J . Magnetic nanoparticles and targeted drug delivering. Pharmacol. Res.62 (2), 144–149 (2010).

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