8,369
Views
0
CrossRef citations to date
0
Altmetric
Review

Recent Developments in Silicones for Topical and Transdermal Drug Delivery

&
Pages 827-839 | Published online: 31 Jul 2015

References

  • Park K Mrsny RJ . Controlled drug delivery: present and future. ACS Symp. Ser.752, 2–12 (2000).
  • Suksaeree J Pichayakorn W Monton C Sakunpak A Chusut T Saingam W . Rubber polymers for transdermal drug delivery systems. Ind. Eng. Chem. Res.53, 507–513 (2014).
  • Gupta J Gill HS Andrews SN Prausnitz MR . Kinetics of skin resealing after insertion of microneedles in human subjects. J. Control. Release154, 148–155 (2011).
  • Prausnitz MR Langer R . Transdermal drug delivery. Nat. Biotechnol.26, 1261–1268 (2008).
  • Wagner H Kostka K-H Adelhardt W Schaefer UF . Effects of various vehicles on the penetration of flufenamic acid into human skin. Eur. J. Pharm. Biopharm.58, 121–129 (2004).
  • Kydonieus A Wille JJ . Transdermal delivery device development: a patent review. In : Skin Delivery Systems: Transdermals, Dermatologicals, and Cosmetic Actives. WilleJJ ( Ed.). Blackwell Publishing Professional, IA, USA, 259–275 (2006).
  • Walters KA Brain KR . Topical and transdermal delivery. Drugs Pharm. Sci.199, 475–525 (2009).
  • Fu XC Wang GP Liang WQ Chow MSS . Prediction of drug release from HPMC matrices: effect of physicochemical properties of drug and polymer concentration. J. Control. Release95, 209–216 (2004).
  • Liu T-Y Chen S-Y Li J-H Liu D-M . Study on drug release behaviour of CDHA/chitosan nanocomposites–effect of CDHA nanoparticles. J. Control. Release112, 88–95 (2006).
  • Sawant PD Luu D Ye R Buchta R . Drug release from hydroethanolic gels. Effect of drug's lipophilicity (log P), polymer-drug interactions and solvent lipophilicity. Int. J. Pharm.396, 45–52 (2010).
  • Miyajima M Koshika A Okada JI Ikeda M . Mechanism of drug release from poly(L-lactic acid) matrix containing acidic or neutral drugs. J. Control. Release60, 199–209 (1999).
  • Miyajima M Koshika A Okada JI Ikeda M Nishimura K . Effect of polymer crystallinity on papaverine release from poly (L-lactic acid) matrix. J. Control. Release49, 207–215 (1997).
  • Padula C Nicoli S Colombo P Santi P . Single-layer transdermal film containing lidocaine: modulation of drug release. Eur. J. Pharm. Biopharm.66, 422–428 (2007).
  • Tomlinson R Davey G : WO9823291A1 (1998).
  • Valenta C Auner BG . The use of polymers for dermal and transdermal delivery. Eur. J. Pharm. Biopharm.58, 279–289 (2004).
  • Miller KJ . Transdermal product formulation development. In : Transdermal And Topical Drug Delivery: Principles And Practice. BensonHWatkinsonAC ( Eds). John Wiley & Sons, Inc., NJ, USA, 287–308 (2012).
  • Owen MJ Dvornic PR . General introduction to silicone surfaces. Adv. Silicon Sci.4, 1–21 (2012).
  • Noll W . Chemistry And Technology Of Silicones.Academic Press, Inc., NY, USA, 1–2 (1968).
  • Smith AL . The Analytical Chemistry of Silicones. Wiley, NJ, USA (1991).
  • Brook MA . Silicon in Organic Organometallic, and Polymer Chemistry. Wiley-VCH Verlag, NJ, USA (2000).
  • Sene C . Silicone excipients for aesthetically superior and substantive topical pharmaceutical formulations. PharmaChem2, 17–20 (2003).
  • Colas A Rafidison P . Silicones in new pharmaceutical developments, from formulations to manufacturing processes. PharmaChem4, 46–49 (2005).
  • US National Library of Medicine DailyMed (2015). http://dailymed.nlm.nih.gov/dailymed/index.cfm.
  • Subedi RK Oh SY Chun M-K Choi H-K . Recent advances in transdermal drug delivery. Arch. Pharm. Res.33 (3), 339–351 (2010).
  • Bhowmik D Chiranjib Chandira M Jayakar B Sampath KP . Recent advances in transdermal drug delivery system. Int. J. PharmTech Res.2 (1), 68–77 (2010).
  • Paolino D Vono M Cilurzo F . Polymers-based devices for dermal and transdermal delivery. In : Polymeric Biomaterials. Taylor & Francis Group, FL, USA (2013).
  • Mashak A Rahimi A . Silicone polymers in controlled drug delivery systems: a review. Iran. Polym. J.18 (4), 279–295 (2009).
  • US FDA . Skin protectant drug products for over-the-counter human use; reduced labeling; technical amendment. Fed. Regist.73, 6014–6017 (2008).
  • Brand HM Brand-Garnys EE . Practical application of quantitative emolliency. Cosmetics Toiletries107, 93–99 (1992).
  • Owen MJ . Why silicones behave funny. Chim. Nouv.22 (85), 27–33 (2004).
  • Schalau G Ulman K . Silicone excipients in drug development. www.contractpharma.com/issues/2009-06/view_features/silicone-excipients-in-drug-development/.
  • Aust DT Jones DP Shah BP : US20050287081A1 (2005).
  • Draelos ZD . Sensitive skin: perceptions, evaluation, and treatment. Am. J. Contact Dermat.8 (2), 67–78 (1997).
  • Nair B . Final report on the safety assessment of stearoxy dimethicone, dimethicone, methicone, amino bispropyl dimethicone, aminopropyl dimethicone, amodimethicone, amodimethicone hydroxystearate, behenoxy dimethicone, C24–28 alkyl methicone, C30–45 alkyl methicone, C30–45 alkyl dimethicone, cetearyl methicone, cetyl dimethicone, dimethoxysilyl ethylenediaminopropyl dimethicone, hexyl methicone, hydroxypropyldimethicone, stearamidopropyl dimethicone, stearyl dimethicone, stearyl methicone, and vinyldimethicone. Int. J. Toxicol.22 (Suppl. 2), 11–35 (2003).
  • Van DKPC De HD De KJ Cobelens SA Kuipers MV . Patient compliance and disease management in the treatment of psoriasis in the Netherlands. Dermatology200, 292–298 (2000).
  • Carroll CL Feldman SR Camacho FT Balkrishnan R . Better medication adherence results in greater improvement in severity of psoriasis. Br. J. Dermatol.151, 895–897 (2004).
  • Brown KK Rehmus WE Kimball AB . Determining the relative importance of patient motivations for nonadherence to topical corticosteroid therapy in psoriasis. J. Am. Acad. Dermatol.55, 607–613 (2006).
  • Stedman T . Stedman's Medical Dictionary. Lippincott Williams and Wilkins, PA, USA (2005).
  • Aguadisch LMJ : EP-966972-A1 (1999).
  • Sene CN Neun D Tan-Sien-Hee L Ulman K . Silicones as excipients for topical formulations (2002). https://www.dowcorning.com/content/publishedlit/52-1034-01.pdf.
  • De Paepe K Sieg A Le Meur M Rogiers V . Silicones as nonocclusive topical agents. Skin Pharmacol. Physiol.27, 164–171 (2014).
  • Lin SB Stark-Kasley LA : WO2009042535A2 (2009).
  • Kennan JJ Messner KE : WO2009006091A2 (2009).
  • Forbes CJ Lowry D Geer L et al. Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc. J. Control. Release156, 161–169 (2011).
  • Forbes CJ Mccoy CF Murphy DJ et al. Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides. J. Pharm. Sci.103, 1422–1432 (2014).
  • Aliyar H Huber R Loubert G Schalau G . Efficient ibuprofen delivery from anhydrous semisolid formulation based on a novel cross-linked silicone polymer Network: an in vitro and in vivo study. J. Pharm. Sci.103, 2005–2011 (2014).
  • Arvidsson P-O Farkas E Saeed CS et al. : WO2014090857A1 (2014).
  • Harrison JJ Harrison N : US20140018328A1 (2014).
  • Manfredini S Vertuani S : WO2011092581A2 (2011).
  • Archer M Butterworth A : EP-2201926-A1 (2010).
  • Klykken PC Nartker LS Raul VA Caprasse V : WO2006138035A1 (2006).
  • Blizzard JD : WO2012158448A2 (2012).
  • McGraw TL McGraw DM McGraw KC McGraw DV : US20100080768A1 (2010).
  • Lee WA . WO2014011456A1 (2014).
  • Bott RR Brandstadt KF Kollar C et al. : US20060083776A1 (2006).
  • Bott RR Gebert MS Klykken PC Mazeaud I Thomas XJ-P : US20040105874A1 (2004).
  • Huber RO Messner KE Nartker LS Raul VA Schalau GK : WO2012009048A1 (2012).
  • Pedlar B . Covalon announces FDA clearance for SurgiClear™ antimicrobial silicone wound dressing (2012). www.covalon.com/press-release/30/covalon-announces-fda-clearance-for-surgiclear-antimicrobial-silicone-wound-dressing.
  • Smith JM Thomas X Gantner DC Lin Z . Loosely cross-linked silicone elastomer blends and topical delivery. ACS Symp. Ser.846, 113–127 (2003).
  • Anon . Soft silicone elastomer emulsion as topical drug delivery system. IP.com J.14, 1–8 (2014).
  • Cauvin S Le Meur M Liles D Thomas X Vincent AM : WO2014019841A1 (2014).
  • Plochocka K Chuang J-C Shih JS . Poly(N-vinyl-pyrrolidone)/silicone oil/water emulsion compositions for topical controlled-release drug delivery. Polym. Mater. Sci. Eng.84, 578–579 (2001).
  • Hasenoehrl EJ Ponte JM Sabatelli AD : US6093408A (2000).
  • Duffy JA Ptchelintsev DS . WO2001062247A1 (2001).
  • Creevy KS . WO2010019155A1 (2010).
  • Patel A . WO2009114419A1 (2009).
  • Aliyar H Huber RO Liles DT Loubert GL Schalau GK Toth S : WO2013119633A1 (2013).
  • Liles DT Mitchell TP : WO2013119561A1 (2013).
  • Thomas X Mitchell TP : WO2012095752A2 (2012).
  • Joffre EJ Mcauliffe JC Kollar C : WO2006071772A2 (2006).
  • Kollar C Thomas X Caprasse V : WO2007139812A2 (2007).
  • Colas A Horstman JB Swier S : WO2013148979A1 (2013).
  • Kulesza JE : WO2014066225A1 (2014).
  • Kulesza JE : US20110142769A1 (2011).
  • Cohen DM Cooper ER : WO2010008600A1 (2010).
  • Cohen DM Cooper ER : WO2010008601A1 (2010).
  • Tamarkin D Eini M Friedman D et al. : US8486374B2 (2013).
  • De Oliveira MaM Giorgi P Clark KL Reynolds JS : US20070071705A1 (2007).
  • Vishnupad M : US20050255131A1 (2005).
  • Vishnupad M : US20050255130A1 (2005).
  • Pitre F Fredon L Mallard C : WO2005053666A1 (2005).
  • US-FDA . National Drug Code Directory. www.fda.gov/Drugs/InformationOnDrugs/ucm142438.htm.
  • Yeoh T . Current landscape and trends in transdermal drug delivery systems. Ther. Delive.3, 295–297 (2012).
  • Lin SB Durfee LD Knott AA Schalau GK . Silicone pressure-sensitive adhesives. In : Technology of Pressure-Sensitive Adhesives and Products. BenedekIFeldsteinMM ( Eds). CRC Press, FL, USA (2009).
  • Yeoh T . Profiles of recently approved transdermal drug delivery systems. Transdermal (2011).
  • US-FDA . National Drug Code Directory NDC Search. www.accessdata.fda.gov/scripts/cder/ndc/default.cfm.
  • Kokubo T Sugibayashi K Morimoto Y . Interaction between drugs and pressure-sensitive adhesives in transdermal therapeutic systems. Pharm. Res.11, 104–107 (1994).
  • Ahn TS Lee J-P Kim J Oh SY Chun M-K Choi H-K . Effect of pressure sensitive adhesive and vehicles on permeation of terbinafine across porcine hoof membrane. Arch. Pharmacol. Res.36 (11), 1403–1409 (2013).
  • Naruse M Ogawara K-I Kimura T Konishi R Higaki K . Development of transdermal therapeutic formulation of CNS5161, a novel N-methyl-D-aspartate receptor antagonist, by utilizing pressure-sensitive adhesives I. Biol. Pharm. Bull.35, 321–328 (2012).
  • Jackson K Miller KJ : US20050202073A1 (2005).
  • Kanios D : WO2001052823A2 (2001).
  • Kanios D : US20060078601A1 (2006).
  • Lauterbach T Schollmayer E : WO2003092677A1 (2003).
  • Mantelle J . WO2010006143A2 (2010).
  • Stinchcomb AL Li G Banks SL Howard JL Golinski MJ : WO2011123866A1 (2011).
  • Mori K Liu P : WO2014106009A1.
  • Lee E-Y Chun M-K Chang J-S Choi H-K . Development of matrix based transdermal delivery system for ketotifen. J. Pharm. Invest.44, 291–296 (2014).
  • Hille T Wauer G : WO2013088254A1 (2013).
  • Algieri C Drioli E Donato L . Development of mixed matrix membranes for controlled release of ibuprofen. J. Appl. Polym. Sci.128, 754–760 (2013).
  • Panchaxari DM Pampana S Pal T Devabhaktuni B Aravapalli AK . Design and characterization of diclofenac diethylamine transdermal patch using silicone and acrylic adhesives combination. Daru21, 6 (2013).
  • Inoue K Ogawa K Okada JI Sugibayashi K . Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug. J. Control. Release108, 306–318 (2005).
  • Mantelle JA : US20110129535A1 (2011).
  • Kanios D : US20060078602A1 (2006).
  • Chun M-K Choi H-K . Transdermal delivery of estradiol and norethindrone acetate: effect of vehicles and pressure sensitive adhesive matrix. Yakche Hakhoechi35, 173–177 (2005).
  • Raul VA Nartker LS Huber RO : WO2009009134A1 (2009).
  • Choi YK : WO2004028515A1 (2004).
  • Loubert GL Menjoulet TA Mitchell TP Thomas XJ-P : US20120114737A1 (2012).
  • Liu Y Ouyang J Paul CW Foreman P Sridhar LM Shah S : WO2010124187A2 (2010).
  • US-FDA . Residual drug in transdermal and related drug delivery systems. www.fda.gov/downloads/Drugs/Guidances/UCM220796.pdf.
  • Ternes TA Joss A Siegrist H . Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ. Sci. Technol.38, 392A–399A (2004).
  • Phillips PJ Smith SG Kolpin DW et al. Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents. Environ. Sci. Technol.44, 4910–4916 (2010).
  • Ruiz AM Maerz JC Davis AK et al. Patterns of development and abnormalities among tadpoles in a constructed wetland receiving treated wastewater. Environ. Sci. Technol.44, 4862–4868 (2010).
  • Ternes TA Meisenheimer M Mcdowell D et al. Removal of pharmaceuticals during drinking water treatment. Environ. Sci. Technol.36, 3855–3863 (2002).
  • Vieno NM Tuhkanen T Kronberg L . Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environ. Sci. Technol.39, 8220–8226 (2005).
  • Santos P Watkinson AC Hadgraft J Lane ME . Formulation issues associated with transdermal fentanyl delivery. Int. J. Pharm.416, 155–159 (2011).
  • Ratilal VP Vardhan GGH : IN2009MU01595A (2011).
  • Hair PI Keating GM Mckeage K . Transdermal matrix fentanyl membrane patch (matrifen): in severe cancer-related chronic pain. Drugs68, 2001–2009 (2008).
  • Marier J-F Lor M Potvin D Dimarco M Morelli G Saedder EA . Pharmacokinetics, tolerability, and performance of a novel matrix transdermal delivery system of fentanyl relative to the commercially available reservoir formulation in healthy subjects. J. Clin. Pharmacol.46, 642–653 (2006).
  • Sharma S Good W : US20040202704A1 (2004).
  • Miller KJ Govil SK Bhatia KS : US20040086551A1 (2004).
  • Mueller W : WO2003018071A1 (2003).
  • Brown TA Osborne J Rudella M Hunt B Malik V : WO2003015678A1 (2003).
  • Stojanovic A Olveira S Fischer M Seeger S . Polysiloxane Nanotubes. Chem. Mater.25, 2787–2792 (2013).
  • Teixeira RFA Van Den Berg O Nguyen L-TT Feher K Du Prez FE . Microencapsulation of active ingredients using PDMS as shell material. Macromolecules47, 8231–8237 (2014).
  • Mokkaphan J Banlunara W Palaga T Sombuntham P Wanichwecharungruang S . Silicone surface with drug nanodepots for medical devices. ACS Appl. Mater. Interfaces6, 20188–20196 (2014).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.