Polymer-based Vehicles for Therapeutic Peptide Delivery

References

• Uhlig T Kyprianou T Martinelli FG et al. The emergence of peptides in the pharmaceutical business: from exploration to exploitation. EuPA Open Proteom.4, 58–69 (2014).
   Google Scholar
• Hummel G Reineke U Reimer U . Translating peptides into small molecules. Mol. Biosyst.2 (10), 499–508 (2006).
   PubMedGoogle Scholar
• Loffet A . Peptides as drugs: is there a market?J. Pept. Sci.8, 1–7 (2002).
   PubMed Web of Science ®Google Scholar
• Mcgregor DP . Discovering and improving novel peptide therapeutics. Curr. Opin. Pharmacol.8 (5), 616–619 (2008).
   PubMed Web of Science ®Google Scholar
• Pichereau C Allary C . Therapeutic peptides under the spotlight. Eur. Biopharm. Rev.5, 88–91 (2005).
   Google Scholar
• Kaspar AA Reichert JM . Future directions for peptide therapeutics development. Drug Discov. Today18 (17), 807–817 (2013).
   PubMed Web of Science ®Google Scholar
• Fosgerau K Hoffmann T . Peptide therapeutics: current status and future directions. Drug Discov. Today20 (1), 122–128 (2015).
   PubMed Web of Science ®Google Scholar
• Koffeman EC Genovese M Amox D et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot Phase II trial. Arthritis Rheum.60 (11), 3207–3216 (2009).
   PubMed Web of Science ®Google Scholar
• Aviles-Olmos I Dickson J Kefalopoulou Z et al. Exenatide and the treatment of patients with Parkinson's disease. J. Clin. Invest.123 (6), 2730 (2013).
   PubMed Web of Science ®Google Scholar
• Colao A Petersenn S Newell-Price J et al. A 12-month Phase 3 study of pasireotide in Cushing's disease. N. Engl. J. Med.366 (10), 914–924 (2012).
   PubMed Web of Science ®Google Scholar
• Lewis AL Richard J . Challenges in the delivery of peptide drugs: an industry perspective. Ther. Deliv.6 (2), 149–163 (2015).
   PubMedGoogle Scholar
• Niu CH Chiu YY . FDA perspective on peptide formulation and stability issues. J. Pharm. Sci.87 (11), 1331–1334 (1998).
   PubMed Web of Science ®Google Scholar
• Bernard N Siegel R . Protein and peptide chemical and physical stability. In : Peptide and Protein Drug Analysis. ReidR ( Ed.). Marcel Dekker, NY, USA257–284 (2000).
   Google Scholar
• Hamman JH Enslin GM Kotzé AF . Oral delivery of peptide drugs. Biodrugs19 (3), 165–177 (2005).
   PubMed Web of Science ®Google Scholar
• Langguth P Bohner V Heizmann J et al. The challenge of proteolytic enzymes in intestinal peptide delivery. J. Control. Release46 (1), 39–57 (1997).
   Web of Science ®Google Scholar
• Langer R Folkman J . Polymers for the sustained release of proteins and other macromolecules. Nature263 (5580), 797–800 (1976).
   PubMed Web of Science ®Google Scholar
• Benincasa M Zahariev S Pelillo C Milan A Gennaro R Scocchi M . PEGylation of the peptide Bac7(1–35) reduces renal clearance while retaining antibacterial activity and bacterial cell penetration capacity. Eur. J. Med. Chem.95, 210–219 (2015).
   PubMed Web of Science ®Google Scholar
• Prego C Torres D Fernandez-Megia E Novoa-Carballal R Quiñoá E Alonso M . Chitosan-PEG nanocapsules as new carriers for oral peptide delivery: effect of chitosan pegylation degree. J. Control. Release111 (3), 299–308 (2006).
   PubMed Web of Science ®Google Scholar
• Tan ML Choong PF Dass CR . Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery. Peptides31 (1), 184–193 (2010).
   PubMed Web of Science ®Google Scholar
• Patel A Cholkar K Mitra AK . Recent developments in protein and peptide parenteral delivery approaches. Ther. Deliv.5 (3), 337–365 (2014).
   PubMedGoogle Scholar
• Fonte P Araújo F Silva C et al. Polymer-based nanoparticles for oral insulin delivery: revisited approaches. Biotechnol. Adv.33 (6), 1342–1354 (2015).
   PubMed Web of Science ®Google Scholar
• Sonia T Sharma CP . An overview of natural polymers for oral insulin delivery. Drug Discov. Today17 (13), 784–792 (2012).
   PubMed Web of Science ®Google Scholar
• Herrero EP Alonso MJ Csaba N . Polymer-based oral peptide nanomedicines. Ther. Deliv.3 (5), 657–668 (2012).
   PubMedGoogle Scholar
• Fu K Klibanov A Langer R . Protein stability in controlled-release systems. Nat. Biotechnol.18 (1), 24–25 (2000).
   PubMed Web of Science ®Google Scholar
• Pisal DS Kosloski MP Balu-Iyer SV . Delivery of therapeutic proteins. J. Pharm. Sci.99 (6), 2557–2575 (2010).
   PubMed Web of Science ®Google Scholar
• Mishra N Goyal AK Khatri K et al. Biodegradable polymer based particulate carrier (s) for the delivery of proteins and peptides. Antiinflamm. Antiallergy Agents Med. Chem.7 (4), 240–251 (2008).
   Google Scholar
• Torchilin V . Intracellular delivery of protein and peptide therapeutics. Drug Discov. Today Technol.5 (2), 95–103 (2008).
   Google Scholar
• Shi Y Li L . Current advances in sustained-release systems for parenteral drug delivery. Expert Opin. Drug Deliv.2 (6), 1039–1058 (2005).
   PubMedGoogle Scholar
• Takeuchi H Yamamoto H Kawashima Y . Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv. Drug Deliv. Rev.47 (1), 39–54 (2001).
   PubMed Web of Science ®Google Scholar
• Satheesh Kumar P Ramakrishna S Ram Saini T Diwan P . Influence of microencapsulation method and peptide loading on formulation of poly (lactide-co-glycolide) insulin nanoparticles. Pharmazie61 (7), 613–617 (2006).
   PubMed Web of Science ®Google Scholar
• Mundargi RC Babu VR Rangaswamy V Patel P Aminabhavi TM . Nano/micro technologies for delivering macromolecular therapeutics using poly (d, l-lactide-co-glycolide) and its derivatives. J. Control. Release125 (3), 193–209 (2008).
   PubMed Web of Science ®Google Scholar
• Giteau A Venier-Julienne M-C Aubert-Pouëssel A Benoit J-P . How to achieve sustained and complete protein release from PLGA-based microparticles?Int. J. Pharm.350 (1), 14–26 (2008).
   PubMedGoogle Scholar
• Van De Weert M Hennink WE Jiskoot W . Protein instability in poly (lactic-co-glycolic acid) microparticles. Pharm. Res.17 (10), 1159–1167 (2000).
   PubMed Web of Science ®Google Scholar
• Tracy M Ward K Firouzabadian L et al. Factors affecting the degradation rate of poly (lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials20 (11), 1057–1062 (1999).
   PubMed Web of Science ®Google Scholar
• Makadia HK Siegel SJ . Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers3 (3), 1377–1397 (2011).
   PubMed Web of Science ®Google Scholar
• Silva A Rosalia R Sazak A et al. Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: low-burst release is crucial for efficient CD8+ T cell activation. Eur. J. Pharm. Biopharm.83 (3), 338–345 (2013).
   PubMed Web of Science ®Google Scholar
• Schwendeman SP Shah RB Bailey BA Schwendeman AS . Injectable controlled release depots for large molecules. J. Control. Release190, 240–253 (2014).
   PubMed Web of Science ®Google Scholar
• Zhu G Mallery SR Schwendeman SP . Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide). Nat. Biotechnol.18 (1), 52–57 (2000).
   PubMed Web of Science ®Google Scholar
• Kumari A Yadav SK Yadav SC . Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf. B Biointerfaces75 (1), 1–18 (2010).
   PubMed Web of Science ®Google Scholar
• Cruz LJ Tacken PJ Fokkink R et al. Targeted PLGA nano-but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro. J. Control. Release144 (2), 118–126 (2010).
   PubMed Web of Science ®Google Scholar
• Hu K Shi Y Jiang W Han J Huang S Jiang X . Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: preparation, characterization and efficacy in Parkinson's disease. Int. J. Pharm.415 (1), 273–283 (2011).
   PubMedGoogle Scholar
• Freitas S Merkle HP Gander B . Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J. Control. Release102 (2), 313–332 (2005).
   PubMed Web of Science ®Google Scholar
• Dai C Wang B Zhao H . Microencapsulation peptide and protein drugs delivery system. Colloids Surf. B Biointerfaces41 (2), 117–120 (2005).
   PubMed Web of Science ®Google Scholar
• Sah H Chien YW . Drug Delivery And Targeting: For Pharmacists And Pharmaceutical Scientists. CRC Press, FL, USA (2002).
   Google Scholar
• Banga AK . Therapeutic Peptides And Proteins: Formulation, Processing, And Delivery Systems. CRC press, FL, USA (2005).
   Google Scholar
• Panyam J Labhasetwar V . Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev.55 (3), 329–347 (2003).
   PubMed Web of Science ®Google Scholar
• Danhier F Ansorena E Silva JM Coco R Le Breton A Préat V . PLGA-based nanoparticles: an overview of biomedical applications. J. Control. Release161 (2), 505–522 (2012).
   PubMed Web of Science ®Google Scholar
• Chong CS Cao M Wong WW et al. Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery. J. Control. Release102 (1), 85–99 (2005).
   PubMed Web of Science ®Google Scholar
• Hamdy S Haddadi A Hung RW Lavasanifar A . Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations. Adv. Drug Deliv. Rev.63 (10), 943–955 (2011).
   PubMed Web of Science ®Google Scholar
• Zhang Z Tongchusak S Mizukami Y et al. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Biomaterials32 (14), 3666–3678 (2011).
   PubMed Web of Science ®Google Scholar
• Cui F Tao A Cun D Zhang L Shi K . Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J. Pharm. Sci.96 (2), 421–427 (2007).
   PubMed Web of Science ®Google Scholar
• Zhang X Sun M Zheng A Cao D Bi Y Sun J . Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration. Eur. J. Pharm. Sci.45 (5), 632–638 (2012).
   PubMed Web of Science ®Google Scholar
• Chen M-C Sonaje K Chen K-J Sung H-W . A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials32 (36), 9826–9838 (2011).
   PubMed Web of Science ®Google Scholar
• Kawashima Y Yamamoto H Takeuchi H Fujioka S Hino T . Pulmonary delivery of insulin with nebulized DL-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect. J. Control. Release62 (1), 279–287 (1999).
   PubMed Web of Science ®Google Scholar
• Cui F Shi K Zhang L Tao A Kawashima Y . Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation. J. Control. Release114 (2), 242–250 (2006).
   PubMed Web of Science ®Google Scholar
• Shi K Cui F Yamamoto H Kawashima Y . Optimized preparation of insulin-lauryl sulfate complex loaded poly (lactide-co-glycolide) nanoparticles using response surface methodology. Pharmazie63 (10), 721–725 (2008).
   PubMed Web of Science ®Google Scholar
• Sun S Liang N Piao H Yamamoto H Kawashima Y Cui F . Insulin-SO (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation. J. Microencapsul.27 (6), 471–478 (2010).
   PubMed Web of Science ®Google Scholar
• Davaran S Omidi Y Rashidi MR et al. Preparation and in vitro evaluation of linear and star-branched PLGA nanoparticles for insulin delivery. J. Bioact. Compat. Polym.23 (2), 115–131 (2008).
   Web of Science ®Google Scholar
• Cui J Van Koeverden MP Müllner M Kempe K Caruso F . Emerging methods for the fabrication of polymer capsules. Adv. Colloid Interface Sci.207, 14–31 (2014).
   PubMed Web of Science ®Google Scholar
• Sukhorukov GB Rogach AL Zebli B et al. Nanoengineered polymer capsules: tools for detection, controlled delivery, and site-specific manipulation. Small1 (2), 194–200 (2005).
   PubMed Web of Science ®Google Scholar
• Chong S-F Sexton A De Rose R Kent SJ Zelikin AN Caruso F . A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules. Biomaterials30 (28), 5178–5186 (2009).
   PubMed Web of Science ®Google Scholar
• Allémann E Leroux J-C Gurny R . Polymeric nano-and microparticles for the oral delivery of peptides and peptidomimetics. Adv. Drug Deliv. Rev.34 (2), 171–189 (1998).
   PubMed Web of Science ®Google Scholar
• Damgé C Vonderscher J Marbach P Pinget M . Poly (alkyl cyanoacrylate) nanocapsules as a delivery system in the rat for octreotide, a long-acting somatostatin analogue. J. Pharm. Pharmacol.49 (10), 949–954 (1997).
   PubMed Web of Science ®Google Scholar
• Graf A Mcdowell A Rades T . Poly (alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics-is there real potential?Expert Opin. Drug Deliv.6 (4), 371–387 (2009).
   PubMed Web of Science ®Google Scholar
• Damge C Michel C Aprahamian M Couvreur P Devissaguet J . Nanocapsules as carriers for oral peptide delivery. J. Control. Release13 (2), 233–239 (1990).
   Web of Science ®Google Scholar
• Garcia-Fuentes M Prego C Torres D Alonso M . A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci.25 (1), 133–143 (2005).
   PubMed Web of Science ®Google Scholar
• Prego C Torres D Alonso M . Chitosan nanocapsules: a new carrier for nasal peptide delivery. J. Drug Deliv. Sci. Technol.16 (5), 331–337 (2006).
   Web of Science ®Google Scholar
• Garcia-Fuentes M Alonso MJ . Chitosan-based drug nanocarriers: where do we stand?J. Control. Release161 (2), 496–504 (2012).
   PubMed Web of Science ®Google Scholar
• Jhaveri AM Torchilin VP . Multifunctional polymeric micelles for delivery of drugs and siRNA. Front. Pharmacol.5, 77 (2014).
   PubMed Web of Science ®Google Scholar
• Torchilin VP . Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res.24 (1), 1–16 (2007).
   PubMed Web of Science ®Google Scholar
• Torchilin VP . Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release73 (2), 137–172 (2001).
   PubMed Web of Science ®Google Scholar
• Allen C Maysinger D Eisenberg A . Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf. B. Biointerfaces16 (1), 3–27 (1999).
   Web of Science ®Google Scholar
• O'reilly RK Hawker CJ Wooley KL . Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility. Chem. Soc. Rev.35 (11), 1068–1083 (2006).
   PubMed Web of Science ®Google Scholar
• Lim SB Rubinstein I Sadikot RT Artwohl JE Önyüksel H . A novel peptide nanomedicine against acute lung injury: GLP–1 in phospholipid micelles. Pharm. Res.28 (3), 662–672 (2011).
   PubMed Web of Science ®Google Scholar
• Kuzmis A Lim SB Desai E et al. Micellar nanomedicine of human neuropeptide Y. Nanomedicine7 (4), 464–471 (2011).
   PubMed Web of Science ®Google Scholar
• Önyüksel H Séjourné F Suzuki H Rubinstein I . Human VIP-α: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension. Peptides27 (9), 2271–2275 (2006).
   PubMed Web of Science ®Google Scholar
• Sethi V Rubinstein I Kuzmis A Kastrissios H Artwohl J Onyuksel H . Novel biocompatible, and disease modifying VIP nanomedicine for rheumatoid arthritis. Mol. Pharm.10 (2), 728–738 (2013).
   PubMedGoogle Scholar
• Banerjee A Onyuksel H . Peptide delivery using phospholipid micelles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.4 (5), 562–574 (2012).
   PubMed Web of Science ®Google Scholar
• Önyüksel H Ikezaki H Patel M Gao X-P Rubinstein I . A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharm. Res.16 (1), 155–160 (1999).
   PubMed Web of Science ®Google Scholar
• Zeng Q Jiang H Wang T Zhang Z Gong T Sun X . Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. J. Control. Release200, 1–12 (2015).
   PubMed Web of Science ®Google Scholar
• Aliabadi HM Mahmud A Sharifabadi AD Lavasanifar A . Micelles of methoxy poly (ethylene oxide)-b-poly (∊-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A. J. Control. Release104 (2), 301–311 (2005).
   PubMed Web of Science ®Google Scholar
• Mondon K Zeisser-Labouèbe M Gurny R Möller M . Novel cyclosporin A formulations using MPEG-hexyl-substituted polylactide micelles: a suitability study. Eur. J. Pharm. Biopharm.77 (1), 56–65 (2011).
   PubMed Web of Science ®Google Scholar
• Francis MF Lavoie L Winnik FM Leroux J-C . Solubilization of cyclosporin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles. Eur. J. Pharm. Biopharm.56 (3), 337–346 (2003).
   PubMed Web of Science ®Google Scholar
• Aliabadi HM Brocks DR Lavasanifar A . Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution. Biomaterials26 (35), 7251–7259 (2005).
   PubMed Web of Science ®Google Scholar
• Xiong XY Li YP Li ZL et al. Vesicles from pluronic/poly (lactic acid) block copolymers as new carriers for oral insulin delivery. J. Control. Release120 (1), 11–17 (2007).
   PubMed Web of Science ®Google Scholar
• Cooper C Dubin P Kayitmazer A Turksen S . Polyelectrolyte-protein complexes. Curr. Opin. Colloid & Interface Sci.10 (1), 52–78 (2005).
   Web of Science ®Google Scholar
• Hartig SM Greene RR Dikov MM Prokop A Davidson JM . Multifunctional nanoparticulate polyelectrolyte complexes. Pharm. Res.24 (12), 2353–2369 (2007).
   PubMed Web of Science ®Google Scholar
• Goycoolea FM Lollo G Remunan-Lopez C Quaglia F Alonso MJ . Chitosan-alginate blended nanoparticles as carriers for the transmucosal delivery of macromolecules. Biomacromolecules10 (7), 1736–1743 (2009).
   PubMed Web of Science ®Google Scholar
• Huang M Vitharana SN Peek LJ Coop T Berkland C . Polyelectrolyte complexes stabilize and controllably release vascular endothelial growth factor. Biomacromolecules8 (5), 1607–1614 (2007).
   PubMed Web of Science ®Google Scholar
• Griffiths PC Mauro N Murphy DM et al. Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromol. Biosci.13 (5), 641–649 (2013).
   PubMed Web of Science ®Google Scholar
• Mao S Bakowsky U Jintapattanakit A Kissel T . Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J. Pharm. Sci.95 (5), 1035–1048 (2006).
   PubMed Web of Science ®Google Scholar
• Sarmento B Ribeiro A Veiga F Sampaio P Neufeld R Ferreira D . Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm. Res.24 (12), 2198–2206 (2007).
   PubMed Web of Science ®Google Scholar
• Makhlof A Tozuka Y Takeuchi H . Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Eur. J. Pharm. Sci.42 (5), 445–451 (2011).
   PubMed Web of Science ®Google Scholar
• Zhang N Li J Jiang W et al. Effective protection and controlled release of insulin by cationic β-cyclodextrin polymers from alginate/chitosan nanoparticles. Int. J. Pharm.393 (1), 213–219 (2010).
   Google Scholar
• Jintapattanakit A Junyaprasert VB Mao S Sitterberg J Bakowsky U Kissel T . Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int. J. Pharm.342 (1), 240–249 (2007).
   PubMedGoogle Scholar
• Harada A Kataoka K . Chain length recognition: core-shell supramolecular assembly from oppositely charged block copolymers. Science283 (5398), 65–67 (1999).
   PubMed Web of Science ®Google Scholar
• Kabanov AV Vinogradov SV Suzdaltseva YG Alakhov VY . Water-soluble block polycations as carriers for oligonucleotide delivery. Bioconjug. Chem.6 (6), 639–643 (1995).
   PubMed Web of Science ®Google Scholar
• Kakizawa Y Kataoka K . Block copolymer micelles for delivery of gene and related compounds. Adv. Drug Deliv. Rev.54 (2), 203–222 (2002).
   PubMed Web of Science ®Google Scholar
• Batrakova EV Li S Reynolds AD et al. A macrophage-nanozyme delivery system for Parkinson's disease. Bioconjug. Chem.18 (5), 1498–1506 (2007).
   PubMed Web of Science ®Google Scholar
• Kabanov AV Kabanov VA . Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects. Adv. Drug Deliv. Rev.30 (1), 49–60 (1998).
   PubMed Web of Science ®Google Scholar
• Manickam DS Brynskikh AM Kopanic JL et al. Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury. J. Control. Release162 (3), 636–645 (2012).
   PubMed Web of Science ®Google Scholar
• Yi X Manickam DS Brynskikh A Kabanov AV . Agile delivery of protein therapeutics to CNS. J. Control. Release190, 637–663 (2014).
   PubMed Web of Science ®Google Scholar
• Zhang J Mulvenon A Makarov E et al. Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection. Biomaterials34 (15), 3846–3857 (2013).
   PubMed Web of Science ®Google Scholar
• Gombotz WR Pettit DK . Biodegradable polymers for protein and peptide drug delivery. Bioconjug. Chem.6 (4), 332–351 (1995).
   PubMed Web of Science ®Google Scholar
• Bysell H Månsson R Hansson P Malmsten M . Microgels and microcapsules in peptide and protein drug delivery. Adv. Drug Deliv. Rev.63 (13), 1172–1185 (2011).
   PubMed Web of Science ®Google Scholar
• Ahmed EM . Hydrogel: preparation characterization, and applications: a review. J. Adv. Res.6 (2), 105–121 (2015).
   PubMed Web of Science ®Google Scholar
• Kabanov AV Vinogradov SV . Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew. Chem. Int. Ed. Engl.48 (30), 5418–5429 (2009).
   PubMed Web of Science ®Google Scholar
• Nukolova NV Oberoi HS Cohen SM Kabanov AV Bronich TK . Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials32 (23), 5417–5426 (2011).
   PubMed Web of Science ®Google Scholar
• Nukolova NV Oberoi HS Zhao Y Chekhonin VP Kabanov AV Bronich TK . LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer. Mol. Pharm.10 (10), 3913–3921 (2013).
   PubMedGoogle Scholar
• Haynes CA Norde W . Globular proteins at solid/liquid interfaces. Colloids Surf. B. Biointerfaces2 (6), 517–566 (1994).
   Web of Science ®Google Scholar
• Arnfast L Madsen CG Jorgensen L Baldursdottir S . Design and processing of nanogels as delivery systems for peptides and proteins. Ther. Deliv.5 (6), 691–708 (2014).
   PubMedGoogle Scholar
• Oh JK Drumright R Siegwart DJ Matyjaszewski K . The development of microgels/nanogels for drug delivery applications. Prog. Polym. Sci.33 (4), 448–477 (2008).
   Web of Science ®Google Scholar
• Fiorica C Pitarresi G Palumbo FS Di Stefano M Calascibetta F Giammona G . A new hyaluronic acid pH sensitive derivative obtained by ATRP for potential oral administration of proteins. Int. J. Pharm.457 (1), 150–157 (2013).
   PubMedGoogle Scholar
• Dionísio M Cordeiro C Remuñán-López C Seijo B Da Costa AMR Grenha A . Pullulan-based nanoparticles as carriers for transmucosal protein delivery. Eur. J. Pharm. Sci.50 (1), 102–113 (2013).
   PubMed Web of Science ®Google Scholar
• Akiyoshi K Deguchi S Moriguchi N Yamaguchi S Sunamoto J . Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles. Macromolecules26 (12), 3062–3068 (1993).
   Web of Science ®Google Scholar
• Akiyoshi K Kobayashi S Shichibe S et al. Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J. Control. Release54 (3), 313–320 (1998).
   PubMed Web of Science ®Google Scholar
• Bronich TK Keifer PA Shlyakhtenko LS Kabanov AV . Polymer micelle with cross-linked ionic core. J. Am. Chem. Soc.127 (23), 8236–8237 (2005).
   PubMed Web of Science ®Google Scholar
• Lee WC Li YC Chu I . Amphiphilic poly(d, l-lactic acid)/poly (ethylene glycol)/poly(dl-lactic acid) nanogels for controlled release of hydrophobic drugs. Macromol. Biosci.6 (10), 846–854 (2006).
   PubMed Web of Science ®Google Scholar
• Bütün V Lowe A Billingham N Armes S . Synthesis of zwitterionic shell cross-linked micelles. J. Am. Chem. Soc.121 (17), 4288–4289 (1999).
   Web of Science ®Google Scholar
• Chen W Zheng M Meng F et al. In situ forming reduction-sensitive degradable nanogels for facile loading and triggered intracellular release of proteins. Biomacromolecules14 (4), 1214–1222 (2013).
   PubMed Web of Science ®Google Scholar
• Zhang J Zhou Y Zhu Z Ge Z Liu S . Polyion complex micelles possessing thermoresponsive coronas and their covalent core stabilization via “click” chemistry. Macromolecules41 (4), 1444–1454 (2008).
   Web of Science ®Google Scholar
• Muraoka D Harada N Hayashi T et al. ACS Nano 8 (9), 9209–9218 (2014).
   PubMed Web of Science ®Google Scholar
• Lee J Lee C Kim TH et al. Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system. J. Control. Release161 (3), 728–734 (2012).
   PubMed Web of Science ®Google Scholar
• Ozawa Y Sawada SI Morimoto N Akiyoshi K . Self-assembled nanogel of hydrophobized dendritic dextrin for protein delivery. Macromol. Biosci.9 (7), 694–701 (2009).
   PubMed Web of Science ®Google Scholar
• Du AW Stenzel MH . Drug carriers for the delivery of therapeutic peptides. Biomacromolecules15 (4), 1097–1114 (2014).
   PubMed Web of Science ®Google Scholar
• Gupta P Vermani K Garg S . Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discov. Today7 (10), 569–579 (2002).
   PubMed Web of Science ®Google Scholar
• Foss AC Goto T Morishita M Peppas NA . Development of acrylic-based copolymers for oral insulin delivery. Eur. J. Pharm. Biopharm.57 (2), 163–169 (2004).
   PubMed Web of Science ®Google Scholar
• Sonaje K Lin KJ Wang JJ et al. Self-assembled pH-sensitive nanoparticles: a platform for oral delivery of protein drugs. Adv. Funct. Mater.20 (21), 3695–3700 (2010).
   Web of Science ®Google Scholar
• Pan Y Li Y-J Zhao H-Y et al. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm.249 (1), 139–147 (2002).
   PubMedGoogle Scholar
• Akiyoshi K Sunamoto J . Supramolecular assembly of hydrophobized polysaccharides. Supramol. Sci.3 (1), 157–163 (1996).
   Google Scholar
• Akiyoshi K Sasaki Y Sunamoto J . Molecular chaperone-like activity of hydrogel nanoparticles of hydrophobized pullulan: thermal stabilization with refolding of carbonic anhydrase B. Bioconjug. Chem.10 (3), 321–324 (1999).
   PubMed Web of Science ®Google Scholar
• Nishikawa T Akiyoshi K Sunamoto J . Macromolecular complexation between bovine serum albumin and the self-assembled hydrogel nanoparticle of hydrophobized polysaccharides. J. Am. Chem. Soc.118 (26), 6110–6115 (1996).
   Web of Science ®Google Scholar
• Shimizu T Kishida T Hasegawa U et al. Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy. Biochem. Biophys. Res. Commun.367 (2), 330–335 (2008).
   PubMed Web of Science ®Google Scholar
• Morimoto N Endo T Iwasaki Y Akiyoshi K . Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: interaction with proteins and chaperone-like activity. Biomacromolecules6 (4), 1829–1834 (2005).
   PubMed Web of Science ®Google Scholar
• Hirakura T Yasugi K Nemoto T et al. Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function. J. Control. Release142 (3), 483–489 (2010).
   PubMed Web of Science ®Google Scholar
• Licciardi M Pitarresi G Cavallaro G Giammona G . Nanoaggregates based on new poly-hydroxyethyl-aspartamide copolymers for oral insulin absorption. Mol. Pharm.10 (5), 1644–1654 (2013).
   PubMedGoogle Scholar
• Sonaje K Lin Y-H Juang J-H Wey S-P Chen C-T Sung H-W . In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials30 (12), 2329–2339 (2009).
   PubMed Web of Science ®Google Scholar
• Packhaeuser C Schnieders J Oster C Kissel T . In situ forming parenteral drug delivery systems: an overview. Eur. J. Pharm. Biopharm.58 (2), 445–455 (2004).
   PubMed Web of Science ®Google Scholar
• Agarwal P Rupenthal ID . Injectable implants for the sustained release of protein and peptide drugs. Drug Discov. Today18 (7), 337–349 (2013).
   PubMed Web of Science ®Google Scholar
• Kempe S Mäder K . In situ forming implants–an attractive formulation principle for parenteral depot formulations. J. Control. Release161 (2), 668–679 (2012).
   PubMed Web of Science ®Google Scholar
• Dunn RL English JP Cowsar DR Vanderbilt DP : US 5990194 A (1990).
   Google Scholar
• Bhardwaj V Kumar MR . Drug delivery systems to fight cancer. In : Fundamentals and Applications of Controlled Release Drug Delivery. SiepmannJSRRathboneMJ ( Eds). Springer, London, UK493–516 (2012).
   Google Scholar
• Rathi RC Zentner GM : US 6117949 A (1999).
   Google Scholar
• Kim YJ Choi S Koh JJ Lee M Ko KS Kim SW . Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm. Res.18 (4), 548–550 (2001).
   PubMed Web of Science ®Google Scholar
• Choi S Baudys M Kim SW . Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in Type 2 diabetic rats. Pharm. Res.21 (5), 827–831 (2004).
   PubMed Web of Science ®Google Scholar
• Zentner GM Rathi R Shih C et al. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J. Control. Release72 (1), 203–215 (2001).
   PubMed Web of Science ®Google Scholar
• Pasut G Veronese FM . PEGylation for improving the effectiveness of therapeutic biomolecules. Drugs Today (Barc.)45 (9), 687–695 (2009).
   PubMed Web of Science ®Google Scholar
• Gaertner HF Offord RE . Site-specific attachment of functionalized poly (ethylene glycol) to the amino terminus of proteins. Bioconjug. Chem.7 (1), 38–44 (1996).
   PubMed Web of Science ®Google Scholar
• Veronese FM . Peptide and protein PEGylation: a review of problems and solutions. Biomaterials22 (5), 405–417 (2001).
   PubMed Web of Science ®Google Scholar
• Roberts M Bentley M Harris J . Chemistry for peptide and protein PEGylation. Adv. Drug Deliv. Rev.64, 116–127 (2012).
   Web of Science ®Google Scholar
• Canalle LA Löwik DW Van Hest JC . Polypeptide-polymer bioconjugates. Chem. Soc. Rev.39 (1), 329–353 (2010).
   PubMed Web of Science ®Google Scholar
• Gauthier MA Klok H-A . Peptide/protein-polymer conjugates: synthetic strategies and design concepts. Chem. Commun. (Camb.) (23), 2591–2611 (2008).
   PubMed Web of Science ®Google Scholar
• Gaberc-Porekar V Zore I Podobnik B Menart V . Obstacles and pitfalls in the PEGylation of therapeutic proteins. Curr. Opin. Drug Discov. Dev.11 (2), 242–250 (2008).
   PubMedGoogle Scholar
• Zalipsky S . Chemistry of polyethylene glycol conjugates with biologically active molecules. Adv. Drug Deliv. Rev.16 (2), 157–182 (1995).
   Web of Science ®Google Scholar
• Harris JM . Laboratory synthesis of polyethylene glycol derivatives. J. Macromol. Sci. Rev. Macromol. Chem. Phys.25 (3), 325–373 (1985).
   Web of Science ®Google Scholar
• Schumacher FF Nobles M Ryan CP et al. In situ maleimide bridging of disulfides and a new approach to protein PEGylation. Bioconjug. Chem.22 (2), 132–136 (2011).
   PubMed Web of Science ®Google Scholar
• Cox GN Rosendahl MS Chlipala EA Smith DJ Carlson SJ Doherty DH . A long-acting, mono-PEGylated human growth hormone analog is a potent stimulator of weight gain and bone growth in hypophysectomized rats. Endocrinology148 (4), 1590–1597 (2007).
   PubMed Web of Science ®Google Scholar
• Rosendahl MS Doherty DH Smith DJ Carlson SJ Chlipala EA Cox GN . A long-acting, highly potent interferon α-2 conjugate created using site-specific PEGylation. Bioconjug. Chem.16 (1), 200–207 (2005).
   PubMed Web of Science ®Google Scholar
• Guiotto A Pozzobon M Sanavio C Schiavon O Orsolini P Veronese FM . An improved procedure for the synthesis of branched polyethylene glycols (PEGs) with the reporter dipeptide met-βala for protein conjugation. Bioorg. Med. Chem. Lett.12 (2), 177–180 (2002).
   PubMed Web of Science ®Google Scholar
• Veronese FM Pasut G . PEGylation, successful approach to drug delivery. Drug Discov. Today10 (21), 1451–1458 (2005).
   PubMed Web of Science ®Google Scholar
• Harris JM Chess RB . Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov.2 (3), 214–221 (2003).
   PubMed Web of Science ®Google Scholar
• US FDA . News release: FDA approves Omontys to treat anemia in adult patients on dialysis (2012). www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm297464.htm.
   Google Scholar
• R⊘der ME . PEGylated insulin Lispro (LY2605541): clinical overview of a new long-acting basal insulin analog in the treatment of Type 2 diabetes mellitus. Expert Rev. Endocrinol. Metab.10 (4), 365–374 (2015).
   PubMedGoogle Scholar
• Ferruti P Mauro N Manfredi A Ranucci E . Hetero-difunctional dimers as building blocks for the synthesis of poly (amidoamine) s with hetero-difunctional chain terminals and their derivatives. J. Polym. Sci. A Polym. Chem.50 (23), 4947–4957 (2012).
   Web of Science ®Google Scholar
• Gaowa A Horibe T Kohno M et al. Enhancement of anti-tumor activity of hybrid peptide in conjugation with carboxymethyl dextran via disulfide linkers. Eur. J. Pharm. Biopharm.92 (0), 228–236 (2015).
   PubMedGoogle Scholar
• Yamamoto Y Tsutsumi Y Mayumi T . Molecular design of bioconjugated cell adhesion peptide with a water-soluble polymeric modifier for enhancement of antimetastatic effect. Curr. Drug Targets3 (2), 123–130 (2002).
   PubMed Web of Science ®Google Scholar
• Mu Y Kamada H Kaneda Y et al. Bioconjugation of laminin peptide YIGSR with poly (styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16–BL6 melanoma cells. Biochem. Biophys. Res. Commun.255 (1), 75–79 (1999).
   PubMed Web of Science ®Google Scholar