The mitochondria-targeted antioxidant SkQ1 restores αB-crystallin expression and protects against AMD-like retinopathy in OXYS rats

References

• Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J Alzheimers Dis 2011; 24(4):615-31; PMID:21297256; http://dx.doi.org/10.3233/JAD-2011-101908
   PubMed Web of Science ®Google Scholar
• Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta 2013; 1833(12):3460-70; PMID:23850759; http://dx.doi.org/10.1016/j.bbamcr.2013.06.028
   PubMed Web of Science ®Google Scholar
• Landis G, Shen J, Tower J. Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY) 2012; 4(11):768-89; PMID:23211361
   PubMedGoogle Scholar
• Fort PE, Lampi KJ. New focus on alpha-crystallins in retinal neurodegenerative diseases. Exp Eye Res 2011; 92(2):98-103; PMID:21115004; http://dx.doi.org/10.1016/j.exer.2010.11.008
   PubMed Web of Science ®Google Scholar
• Bloemendal H. Lens proteins. CRC Critical Reviews in Biochem 1982; 12:1-38; http://dx.doi.org/10.3109/10409238209105849
   Web of Science ®Google Scholar
• Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR. Alpha-crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis 2007; 13:566e577
   Google Scholar
• Kannan R, Sreekumar PG, Hinton DR. Novel roles for α-crystallins in retinal function and disease. Prog Retin Eye Res 2012; 31(6):576-604; PMID:22721717; http://dx.doi.org/10.1016/j.preteyeres.2012.06.001
   PubMed Web of Science ®Google Scholar
• Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR. Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med 2012; 1;53(5):1111-22; PMID:22781655; http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.042
   PubMed Web of Science ®Google Scholar
• Neroev VV, Archipova MM, Bakeeva LE, Fursova AZh, Grigorian EN, Grishanova AY, Iomdina EN, Ivashchenko ZhN, Katargina LA, Khoroshilova-Maslova IP, et al. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals. Biochem (Mosc) 2008; 73(12):1317-28; PMID:19120017; http://dx.doi.org/10.1134/S0006297908120043
   PubMed Web of Science ®Google Scholar
• Saprunova VB, Pilipenko DI, Alexeevsky AV, Fursova AZh, Kolosova NG, Bakeeva LE. Lipofuscin granule dynamics during development of age-related macular degeneration. Biochem (Mosc) 2010; 75(2):130-8; PMID:20367599; http://dx.doi.org/10.1134/S0006297910020021
   PubMed Web of Science ®Google Scholar
• Saprunova VB, Lelekova MA, Kolosova NG, Bakeeva LE. SkQ1 slows development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats. Biochem (Mosc) 2012; 77(6):648-58; PMID:22817465; http://dx.doi.org/10.1134/S0006297912060120
   PubMed Web of Science ®Google Scholar
• Markovets AM, Saprunova VB, Zhdankina AA, Fursova AZh, Bakeeva LE, Kolosova NG. Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats. Aging (Albany NY) 2011; 3:44-54; PMID:21191149
   PubMedGoogle Scholar
• Skulachev VP, Anisimov VN, Antonenko YN, Bakeeva LE, Chernyak BV, Erichev VP, Filenko OF, Kalinina NI, Kapelko VI, Kolosova NG, et al. An attempt to prevent senescence: a mitochondrial approach. Biochim Biophys Acta 2009; 1787(5):437-61; PMID:19159610; http://dx.doi.org/10.1016/j.bbabio.2008.12.008
   PubMed Web of Science ®Google Scholar
• Kolosova NG, Stefanova NA, Muraleva NA, Skulachev VP. The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats. Aging (Albany NY) 2012; 4(10):686-94; PMID:23104863
   PubMedGoogle Scholar
• Vays VB, Eldarov CM, Vangely IM, Kolosova NG, Bakeeva LE, Skulachev VP. Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure. Aging (Albany NY) 2014; 6(2):140-8; PMID:24519884
   PubMedGoogle Scholar
• Kolosova NG, Vitovtov AO, Muraleva NA, Akulov AE, Stefanova NA, Blagosklonny MV. Rapamycin suppresses brain aging in senescence-accelerated OXYS rats. Aging (Albany NY) 2013; 5(6):474-84; PMID:23817674
   PubMedGoogle Scholar
• Obukhova LA, Skulachev VP, Kolosova NG. Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats. Aging (Albany NY) 2009; 1(4):389-401; PMID:20195490
   PubMedGoogle Scholar
• Skulachev VP. SkQ1 treatment and food restriction–two ways to retard an aging program of organisms. Aging (Albany NY) 2011; 3(11):1045-50; PMID:22170754
   PubMedGoogle Scholar
• Anisimov VN, Egorov MV, Krasilshchikova MS, Lyamzaev KG, Manskikh VN, Moshkin MP, Novikov EA, Popovich IG, Rogovin KA, Shabalina IG, et al. Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents. Aging (Albany NY) 2011; 3(11):1110-9; PMID:22166671
   PubMedGoogle Scholar
• Zhdankina AA, Fursova AZh, Logvinov SV, Kolosova NG. Clinical and Morphological Characteristics of Chorioretinal Degeneration in Early Aging OXYS Rats. Bull Exp Biol Med 2008; 146(4):455-8; PMID:19489319; http://dx.doi.org/10.1007/s10517-009-0298-4
   PubMed Web of Science ®Google Scholar
• Markovets AM, Fursova AZ, Kolosova NG. Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression. PLoS One 2011; 6:e21682; PMID:21750722; http://dx.doi.org/10.1371/journal.pone.0021682
   PubMed Web of Science ®Google Scholar
• Kozhevnikova OS, Korbolina EE, Stefanova NA, Muraleva NA, Orlov YL, Kolosova NG. Association of AMD-like retinopathy development with an Alzheimer's disease metabolic pathway in OXYS rats. Biogerontology 2013; 14(6):753-62; PMID:23959258; http://dx.doi.org/10.1007/s10522-013-9439-2
   PubMed Web of Science ®Google Scholar
• Kozhevnikova OS, Korbolina EE, Ershov NI, Kolosova NG. Rat retinal transcriptome: effects of aging and AMD-like retinopathy. Cell Cycle 2013; 12(11):1745-61; PMID:23656783; http://dx.doi.org/10.4161/cc.24825
   PubMed Web of Science ®Google Scholar
• Korbolina EE, Kozhevnikova OS, Stefanova NA, Kolosova NG. Quantitative trait loci on chromosome 1 for cataract and AMD-like retinopathy in senescence-accelerated OXYS rats. Aging (Albany NY) 2012; 4(1):49-59; PMID:22300709
   PubMedGoogle Scholar
• De S, Rabin DM, Salero E, Lederman PL, Temple S, Stern JH. Human retinal pigment epithelium cell changes and expression of alphaB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular degeneration. Arch Ophthalmol 2007; 125(5):641-5; PMID:17502503; http://dx.doi.org/10.1001/archopht.125.5.641
   PubMedGoogle Scholar
• Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR. AlphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood 2010; 22; 115(16):3398-406; PMID:20023214; http://dx.doi.org/10.1182/blood-2009-01-197095
   PubMed Web of Science ®Google Scholar
• Beatty S, Koh H, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45(2):115-34; PMID:11033038; http://dx.doi.org/10.1016/S0039-6257(00)00140-5
   PubMed Web of Science ®Google Scholar
• Yaung J, Kannan R, Wawrousek EF, Spee C, Sreekumar PG, Hinton DR. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res 2008; 86:355e365; http://dx.doi.org/10.1016/j.exer.2007.11.007
   Web of Science ®Google Scholar
• He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR. Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol 2008; 246(5):677-83; PMID:18278507; http://dx.doi.org/10.1007/s00417-008-0770-2
   PubMed Web of Science ®Google Scholar
• Rabin DM, Rabin RL, Blenkinsop TA, Temple S, Stern JH. Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: a novel culture model for dry AMD. Aging (Albany NY) 2013; 5(1):51-66; PMID:23257616
   PubMedGoogle Scholar
• Kourtis N, Nikoletopoulou V, Tavernarakis N. Heat shock response and ionstasis: axis against neurodegeneration. Aging (Albany NY) 2012; 4(12):856-8; PMID:23257629
   PubMedGoogle Scholar
• Bhat SP, Gangalum RK. Secretion of αB-Crystallin via exosomes: new clues to the function of human retinal pigment epithelium. Commun Integr Biol 2011; 1;4(6):739-41; PMID:22446542; http://dx.doi.org/10.4161/cib.17610
   PubMedGoogle Scholar
• Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C, Tong P, Lutty GA. Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp Eye Res 2006; 82(1):99-110; PMID:16019000; http://dx.doi.org/10.1016/j.exer.2005.05.007
   PubMed Web of Science ®Google Scholar
• Binz N, Ali Rahman IS, Chinnery HR, McKeone R, Simpson KM, Speed TP, Lai CM, Rakoczy PE. Effect of vascular endothelial growth factor upregulation on retinal gene expression in the Kimba mouse. Clin Experiment Ophthalmol 2013; 41(3):251-62; PMID:22788671; http://dx.doi.org/10.1111/j.1442-9071.2012.02845.x
   PubMed Web of Science ®Google Scholar
• Barot M, Gokulgandhi MR, Mitra AK. Mitochondrial dysfunction in retinal diseases. Curr Eye Res 2011; 36(12):1069-77; PMID:21978133; http://dx.doi.org/10.3109/02713683.2011.607536
   PubMed Web of Science ®Google Scholar
• Kolosova NG, Aidagulova SV, Nepomnyashchikh GI, Shabalina IG, Shalbueva NI. Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats. Bull Exp Biol Med 2001; 132(2):814-9; PMID:11713575; http://dx.doi.org/10.1023/A:1013014919721
   PubMed Web of Science ®Google Scholar
• Stefanova NA, Zhdankina AA, Fursova AZh, Kolosova NG. Potential of melatonin for prevention of age-related macular degeneration: experimental study. Adv Gerontol 2013; 26(1):122-9; PMID:24003738
   PubMedGoogle Scholar
• Kolosova NG, Shcheglova TV, Sergeeva SV, Loskutova LV. Long-term antioxidant supplementation attenuates oxidative stress markers and cognitive deficits in senescent-accelerated OXYS rats. Neurobiol Aging 2006; 27(9):1289-97; PMID:16246464; http://dx.doi.org/10.1016/j.neurobiolaging.2005.07.022
   PubMed Web of Science ®Google Scholar
• Dehle FC, Ecroyd H, Musgrave IF, Carver JA. aB-Crystallin inhibits the cell toxicity associated with amyloid fibril formation by k-casein and the amyloidb peptide. Cell Stress Chaperones 2010; 15:1013e1026; http://dx.doi.org/10.1007/s12192-010-0212-z
   Web of Science ®Google Scholar
• Stefanova NA, Kozhevnikova OS, Vitovtov AO, Maksimova KY, Logvinov SV, Rudnitskaya EA, Korbolina EE, Muraleva NA, Kolosova NG. Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell Cycle 2014; 13(6):898-909; PMID:24552807; http://dx.doi.org/10.4161/cc.28255
   PubMed Web of Science ®Google Scholar