ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels

References

• Sullivan KD, Gallant-Behm CL, Henry RE, Fraikin JL, Espinosa JM. The p53 circuit board. Biochim Biophys Acta 2012; 1825:229-44; PMID:22333261
   PubMed Web of Science ®Google Scholar
• Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009; 137:413-31; PMID:19410540; http://dx.doi.org/10.1016/j.cell.2009.04.037
   PubMed Web of Science ®Google Scholar
• Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer 2014; 14:359-70; PMID:24739573; http://dx.doi.org/10.1038/nrc3711
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10; PMID:11099028; http://dx.doi.org/10.1038/35042675
   PubMed Web of Science ®Google Scholar
• Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303:844-8; PMID:14704432; http://dx.doi.org/10.1126/science.1092472
   PubMed Web of Science ®Google Scholar
• Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A 2006; 103:1888-93; PMID:16443686; http://dx.doi.org/10.1073/pnas.0507493103
   PubMed Web of Science ®Google Scholar
• Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol 2012; 8:646-54; PMID:22660439; http://dx.doi.org/10.1038/nchembio.965
   PubMed Web of Science ®Google Scholar
• Brummelkamp TR, Fabius AWM, Mullenders J, Madiredjo M, Velds A, Kerkhoven RM, Bernards R, Beijersbergen RL. An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat Chem Biol 2006; 2:202-6; PMID:16474381; http://dx.doi.org/10.1038/nchembio774
   PubMed Web of Science ®Google Scholar
• Henry RE, Andrysik Z, París R, Galbraith MD, Espinosa JM. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. EMBO J 2012; 31:1266-78; PMID:22246181; http://dx.doi.org/10.1038/emboj.2011.498
   PubMed Web of Science ®Google Scholar
• Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-Mediated IKK activation in response to genotoxic stress. Mol Cell 2010; 40:75-86; PMID:20932476; http://dx.doi.org/10.1016/j.molcel.2010.09.010
   PubMed Web of Science ®Google Scholar
• Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT. ATM activation by oxidative stress. Science 2010; 330:517-21; PMID:20966255; http://dx.doi.org/10.1126/science.1192912
   PubMed Web of Science ®Google Scholar
• Lee S-Y, Shin SJ, Kim H-S. ERK12 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53. Int J Oncol 2013; 42:1027-35; PMID:23314357
   PubMed Web of Science ®Google Scholar
• Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedström E, Issaeva N, Kel A, et al. ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell Death Differ 2014; 21:612-23; PMID:24413150; http://dx.doi.org/10.1038/cdd.2013.186
   PubMed Web of Science ®Google Scholar
• Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, Kastan MB. Mitochondrial dysfunction in ataxia-telangiectasia. Blood 2012; 119:1490-500; PMID:22144182; http://dx.doi.org/10.1182/blood-2011-08-373639
   PubMed Web of Science ®Google Scholar
• N’guessan P, Pouyet L, Gosset G, Hamlaoui S, Seillier M, Cano CE, Seux M, Stocker P, Culcasi M, Iovanna JL, et al. Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis. Antioxid Redox Signal 2011; 15:1639-53; PMID:21235351; http://dx.doi.org/10.1089/ars.2010.3553
   PubMed Web of Science ®Google Scholar
• Budanov A V, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 2002; 21:6017-31; PMID:12203114; http://dx.doi.org/10.1038/sj.onc.1205877
   PubMed Web of Science ®Google Scholar
• Budanov A V, Sablina AA, Feinstein E, Koonin EV, Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 2004; 304:596-600; PMID:15105503; http://dx.doi.org/10.1126/science.1095569
   PubMed Web of Science ®Google Scholar
• Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Oncogene 1999; 18:127-37; PMID:9926927; http://dx.doi.org/10.1038/sj.onc.1202274
   PubMed Web of Science ®Google Scholar
• Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160:1-40; PMID:16430879; http://dx.doi.org/10.1016/j.cbi.2005.12.009
   PubMed Web of Science ®Google Scholar
• Pietrocola F, Izzo V, Niso-Santano M, Vacchelli E, Galluzzi L, Maiuri MC, Kroemer G. Regulation of autophagy by stress-responsive transcription factors. Semin Cancer Biol 2013; 23:310-22; PMID:23726895; http://dx.doi.org/10.1016/j.semcancer.2013.05.008
   PubMed Web of Science ®Google Scholar
• Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 2013; 14:197-210; http://dx.doi.org/10.1038/nrm3546
   Web of Science ®Google Scholar
• Crighton D, Wilkinson S, O’Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. DRAM, a p53-induced modulator of autophagy, Is critical for apoptosis. Cell 2006; 126:121-34; PMID:16839881; http://dx.doi.org/10.1016/j.cell.2006.05.034
   PubMed Web of Science ®Google Scholar
• Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 2008; 10:676-87; PMID:18454141; http://dx.doi.org/10.1038/ncb1730
   PubMed Web of Science ®Google Scholar
• Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A 2010; 107:9660-4; PMID:20457898; http://dx.doi.org/10.1073/pnas.1002298107
   PubMed Web of Science ®Google Scholar
• Leontieva O V, Gudkov A V, Blagosklonny M V. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-7; PMID:21051933; http://dx.doi.org/10.4161/cc.9.21.13584
   PubMed Web of Science ®Google Scholar
• McCubrey JA, Demidenko ZN. Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany. NY) 2012; 4:887-93; PMID:23425920
   PubMedGoogle Scholar
• Papandreou I, Lim AL, Laderoute K, Denko NC. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ 2008; 15:1572-81; PMID:18551130; http://dx.doi.org/10.1038/cdd.2008.84
   PubMed Web of Science ®Google Scholar
• Alexander A, Cai S-L, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 2010; 107:4153-8; PMID:20160076; http://dx.doi.org/10.1073/pnas.0913860107
   PubMed Web of Science ®Google Scholar
• Lin C-S, Wang Y-C, Huang J-L, Hung CC, Chen JY. Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells. Oral Oncol 2012; 48:1152-8; PMID:22763242; http://dx.doi.org/10.1016/j.oraloncology.2012.05.020
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http://dx.doi.org/10.4161/auto.19496
   PubMed Web of Science ®Google Scholar
• Ichimura Y, Kominami E, Tanaka K, Komatsu M. Selective turnover of p62A170SQSTM1 by autophagy. Autophagy 2008; 4:1063-6; PMID:18776737; http://dx.doi.org/10.4161/auto.6826
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 3:542-5; PMID:17611390; http://dx.doi.org/10.4161/auto.4600
   PubMed Web of Science ®Google Scholar
• Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson ÅB. Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ 2011; 18:721-31; PMID:21278801; http://dx.doi.org/10.1038/cdd.2010.146
   PubMed Web of Science ®Google Scholar
• Thomas RL, Kubli DA, Gustafsson AB. Bnip3-mediated defects in oxidative phosphorylation promote mitophagy. Autophagy 2011; 7:775-7; PMID:21460627; http://dx.doi.org/10.4161/auto.7.7.15536]Z
   PubMed Web of Science ®Google Scholar
• Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson ÅB. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 2012; 287:19094-104; PMID:22505714; http://dx.doi.org/10.1074/jbc.M111.322933
   PubMed Web of Science ®Google Scholar
• Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev 2006; 20:601-12; PMID:16510875; http://dx.doi.org/10.1101/gad.1398206
   PubMed Web of Science ®Google Scholar