GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation

References

• Do K, Doroshow JH, Kummar S. Wee1 kinase as a target for cancer therapy. Cell Cycle 2013; 12:3159-64; PMID: 24013427; http://dx.doi.org/10.4161/cc.26062
   PubMed Web of Science ®Google Scholar
• Vriend LE, De Witt Hamer PC, Van Noorden CJ, Wurdinger T. WEE1 inhibition and genomic instability in cancer. Biochimica Biophys Acta 2013; 1836:227-35; PMID:23727417
   PubMed Web of Science ®Google Scholar
• Stathis A, Oza A. Targeting Wee1-like protein kinase to treat cancer. Drug News Perspect 2010; 23:425-9; PMID:20862394
   PubMed Web of Science ®Google Scholar
• Leijen S, Beijnen JH, Schellens JH. Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents. Current Clin Pharmacol 2010; 5:186-91; PMID:20406171; http://dx.doi.org/10.2174/157488410791498824
   PubMedGoogle Scholar
• Murrow LM, Garimella SV, Jones TL, Caplen NJ, Lipkowitz S. Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome. Breast Cancer Res Treat 2010; 122:347-57; PMID:19821025; http://dx.doi.org/10.1007/s10549-009-0571-2
   PubMed Web of Science ®Google Scholar
• Mir SE, De Witt Hamer PC, Krawczyk PM, Balaj L, Claes A, Niers JM, Van Tilborg AA, Zwinderman AH, Geerts D, Kaspers GJ, et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell 2010; 18:244-57; PMID:20832752; http://dx.doi.org/10.1016/j.ccr.2010.08.011
   PubMed Web of Science ®Google Scholar
• Mahajan K, Mahajan NP. WEE1 tyrosine kinase, a novel epigenetic modifier. Trends Genet 2013; 29:394-402; PMID:23537585; http://dx.doi.org/10.1016/j.tig.2013.02.003
   PubMed Web of Science ®Google Scholar
• Mahajan K, Fang B, Koomen JM, Mahajan NP. H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes. Nat Struct Mol Biol 2012; 19:930-7; PMID:22885324; http://dx.doi.org/10.1038/nsmb.2356
   PubMed Web of Science ®Google Scholar
• Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors. J Biomol Screen 2010; 15:907-17; PMID:20660794; http://dx.doi.org/10.1177/1087057110375848
   PubMed Web of Science ®Google Scholar
• Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1999; 22:103-14; PMID:10027293; http://dx.doi.org/10.1016/S0896-6273(00)80682-0
   PubMed Web of Science ®Google Scholar
• Roussel MF, Hatten ME. Cerebellum development and medulloblastoma. Curr Top Dev Biol 2011; 94:235-82; PMID:21295689; http://dx.doi.org/10.1016/B978-0-12-380916-2.00008-5
   PubMed Web of Science ®Google Scholar
• Simanski S, Madoux F, Rahaim RJ, Chase P, Schurer S, Cameron M, Mercer BA, Hodder P, Roush WR, Ayad NG. Identification of small molecule inhibitors of Wee1 degradation and mitotic entry. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) 2010; PMID:23762957
   PubMedGoogle Scholar
• Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, et al. Casein kinase 1delta-dependent Wee1 protein degradation. J Biolog Chem 2014; 289:18893-903; PMID:24817118; http://dx.doi.org/10.1074/jbc.M114.547661
   PubMed Web of Science ®Google Scholar
• Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schurer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, et al. Development of highly selective casein kinase 1delta/1epsilon (CK1delta/epsilon) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett 2013; 23:4374-80; PMID:23787102; http://dx.doi.org/10.1016/j.bmcl.2013.05.075
   PubMed Web of Science ®Google Scholar
• Reed SI. Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nat Rev Mol Cell Biol 2003; 4:855-64; PMID:14625536; http://dx.doi.org/10.1038/nrm1246
   PubMed Web of Science ®Google Scholar
• Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J 1995; 14:1878-91; PMID:7743995
   PubMed Web of Science ®Google Scholar
• Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T, Osada H. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A 2005; 102:11663-8; PMID:16085715; http://dx.doi.org/10.1073/pnas.0500410102
   PubMed Web of Science ®Google Scholar
• Owens L, Simanski S, Squire C, Smith A, Cartzendafner J, Cavett V, Caldwell Busby J, Sato T, Ayad NG. Activation domain-dependent degradation of somatic Wee1 kinase. J Biol Chem 2010; 285:6761-9; PMID:20038582; http://dx.doi.org/10.1074/jbc.M109.093237
   PubMed Web of Science ®Google Scholar
• Enders GH. Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry. Cell Div 2010; 5:12; PMID:20465818; http://dx.doi.org/10.1186/1747-1028-5-12
   PubMed Web of Science ®Google Scholar
• Tighe A, Ray-Sinha A, Staples OD, Taylor SS. GSK-3 inhibitors induce chromosome instability. BMC Cell Biol 2007; 8:34; PMID:17697341; http://dx.doi.org/10.1186/1471-2121-8-34
   PubMed Web of Science ®Google Scholar
• Korur S, Huber RM, Sivasankaran B, Petrich M, Morin P, Jr., Hemmings BA, Merlo A, Lino MM. GSK3beta regulates differentiation and growth arrest in glioblastoma. PloS One 2009; 4:e7443; PMID:19823589; http://dx.doi.org/10.1371/journal.pone.0007443
   PubMed Web of Science ®Google Scholar
• Pizarro JG, Folch J, Esparza JL, Jordan J, Pallas M, Camins A. A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. J Cell Mol Med 2009; 13:3906-17; PMID:18624766; http://dx.doi.org/10.1111/j.1582-4934.2008.00389.x
   PubMed Web of Science ®Google Scholar
• Lee YC, Liao PC, Liou YC, Hsiao M, Huang CY, Lu PJ. Glycogen synthase kinase 3 beta activity is required for hBora/Aurora A-mediated mitotic entry. Cell Cycle 2013; 12:953-60; PMID:23442801; http://dx.doi.org/10.4161/cc.23945
   PubMed Web of Science ®Google Scholar
• Smith A, Simanski S, Fallahi M, Ayad NG. Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry. Cell Cycle 2007; 6:2795-9; PMID:18032919; http://dx.doi.org/10.4161/cc.6.22.4919
   PubMed Web of Science ®Google Scholar
• Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Nat Acad Sci U S A 2004; 101:4419-24; PMID:15070733; http://dx.doi.org/10.1073/pnas.0307700101
   PubMed Web of Science ®Google Scholar
• Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jorgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, et al. Systematic discovery of in vivo phosphorylation networks. Cell 2007; 129:1415-26; PMID:17570479; http://dx.doi.org/10.1016/j.cell.2007.05.052
   PubMed Web of Science ®Google Scholar
• Frame S, Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem J 2001; 359:1-16; PMID:11563964; http://dx.doi.org/10.1042/0264-6021:3590001
   PubMed Web of Science ®Google Scholar
• Takahashi-Yanaga F. Activator or inhibitor? GSK-3 as a new drug target. Biochem Pharmacol 2013; 86:191-9; PMID:23643839; http://dx.doi.org/10.1016/j.bcp.2013.04.022
   PubMed Web of Science ®Google Scholar
• Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469-80; PMID:17081971; http://dx.doi.org/10.1016/j.cell.2006.10.018
   PubMed Web of Science ®Google Scholar
• MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17:9-26; PMID:19619488; http://dx.doi.org/10.1016/j.devcel.2009.06.016
   PubMed Web of Science ®Google Scholar
• Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, et al. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell 2007; 11:321-33; PMID:17418409; http://dx.doi.org/10.1016/j.ccr.2007.02.016
   PubMed Web of Science ®Google Scholar
• Adachi K, Mirzadeh Z, Sakaguchi M, Yamashita T, Nikolcheva T, Gotoh Y, Peltz G, Gong L, Kawase T, Alvarez-Buylla A, et al. Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells 2007; 25:2827-36; PMID:17673525; http://dx.doi.org/10.1634/stemcells.2007-0177
   PubMed Web of Science ®Google Scholar
• Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 2009; 136:1017-31; PMID:19303846; http://dx.doi.org/10.1016/j.cell.2008.12.044
   PubMed Web of Science ®Google Scholar
• Wrobel CN, Mutch CA, Swaminathan S, Taketo MM, Chenn A. Persistent expression of stabilized -catenin delays maturation of radial glial cells into intermediate progenitors. Dev Biol 2007; 309:285-97; PMID:17706960; http://dx.doi.org/10.1016/j.ydbio.2007.07.013
   PubMed Web of Science ®Google Scholar
• Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schuller U. Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors. Mol Cell Biol 2011; 31:3326-38; PMID:21690300; http://dx.doi.org/10.1128/MCB.05718-11
   PubMed Web of Science ®Google Scholar
• Poschl J, Grammel D, Dorostkar MM, Kretzschmar HA, Schuller U. Constitutive activation of beta-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system. Dev Biol 2013; 374:319-32; PMID:23237957; http://dx.doi.org/10.1016/j.ydbio.2012.12.001
   PubMed Web of Science ®Google Scholar
• Wen J, Yang HB, Zhou B, Lou HF, Duan S. beta-Catenin is critical for cerebellar foliation and lamination. PloS One 2013; 8:e64451; PMID:23691221; http://dx.doi.org/10.1371/journal.pone.0064451
   PubMed Web of Science ®Google Scholar
• Hydbring P, Larsson LG. Cdk2: a key regulator of the senescence control function of Myc. Aging 2010; 2:244-50; PMID:20445224
   PubMedGoogle Scholar
• Knoepfler PS, Kenney AM. Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes. Cell Cycle 2006; 5:47-52; PMID:16322694; http://dx.doi.org/10.4161/cc.5.1.2292
   PubMed Web of Science ®Google Scholar
• Ling H, Samarasinghe S, Kulasiri D. Computational experiments reveal the efficacy of targeting CDK2 and CKIs for significantly lowering cellular senescence bar for potential cancer treatment. Biosystems 2013; 111:71-82; PMID:23254306; http://dx.doi.org/10.1016/j.biosystems.2012.12.001
   PubMed Web of Science ®Google Scholar
• Atkins RJ, Stylli SS, Luwor RB, Kaye AH, Hovens CM. Glycogen synthase kinase-3beta (GSK-3beta) and its dysregulation in glioblastoma multiforme. J Clin Neurosci 2013; 20:1185-92; PMID:23768967; http://dx.doi.org/10.1016/j.jocn.2013.02.003
   PubMed Web of Science ®Google Scholar
• Qu Z, Sun D, Young W. Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3beta-NF-AT signaling. Cell Biosc 2011; 1:18; PMID:21711903; http://dx.doi.org/10.1186/2045-3701-1-18
   PubMed Web of Science ®Google Scholar
• Vidal F, de Araujo WM, Cruz AL, Tanaka MN, Viola JP, Morgado-Diaz JA. Lithium reduces tumorigenic potential in response to EGF signaling in human colorectal cancer cells. Int J Oncol 2011; 38:1365-73; PMID:21369697
   PubMed Web of Science ®Google Scholar
• Sun A, Shanmugam I, Song J, Terranova PF, Thrasher JB, Li B. Lithium suppresses cell proliferation by interrupting E2F-DNA interaction and subsequently reducing S-phase gene expression in prostate cancer. Prostate 2007; 67:976-88; PMID:17440966; http://dx.doi.org/10.1002/pros.20586
   PubMed Web of Science ®Google Scholar
• Nowicki MO, Dmitrieva N, Stein AM, Cutter JL, Godlewski J, Saeki Y, Nita M, Berens ME, Sander LM, Newton HB, et al. Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro-Oncol 2008; 10:690-9; PMID:18715951; http://dx.doi.org/10.1215/15228517-2008-041
   PubMed Web of Science ®Google Scholar
• Madoux F, Mishra J, Mercer BA, Ayad N, Roush W, Hodder P, Rosen HR. Small molecule inhibitors of Wee1 degradation and mitotic entry. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD), 2010; PMID:21735595
   PubMedGoogle Scholar