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The alternative translated MDMXp60 isoform regulates MDM2 activity

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Pages 449-458 | Received 04 Jul 2014, Accepted 12 Oct 2014, Published online: 06 Feb 2015

References

  • Blandino G, Dobbelstein M. p73 and p63: why do we still need them? Cell Cycle 2004; 3:886-94; PMID:15254416; http://dx.doi.org/10.4161/cc.3.7.996
  • Levrero M, De Laurenzi V, Costanzo A, Gong J, Wang JY, Melino G. The p53/p63/p73 family of transcription factors: overlapping and distinct functions. J Cell Sci 2000; 113 (Pt 10):1661-70; PMID:10769197
  • Dotsch V, Bernassola F, Coutandin D, Candi E, Melino G. p63 and p73, the ancestors of p53. Cold Spring Harbor Perspec Biol 2010; 2:a004887; PMID:20484388; http://dx.doi.org/10.1101/cshperspect.a004887
  • Truong AB, Khavari PA. Control of keratinocyte proliferation and differentiation by p63. Cell Cycle 2007; 6:295-9; PMID:17264679; http://dx.doi.org/10.4161/cc.6.3.3753
  • Murray-Zmijewski F, Lane DP, Bourdon JC. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 2006; 13:962-72; PMID:16601753; http://dx.doi.org/10.1038/sj.cdd.4401914
  • Moll UM, Slade N. p63 and p73: roles in development and tumor formation. Mol Cancer Res 2004; 2:371-86; PMID:15280445
  • Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S, Fahraeus R. Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell 2010; 38:78-88; PMID:20385091; http://dx.doi.org/10.1016/j.molcel.2010.01.041
  • Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, et al. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol 2009; 11:1135-42; PMID:19701195; http://dx.doi.org/10.1038/ncb1928
  • Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N, Bourougaa K, Calvo F, Fahraeus R. P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol 2008; 10:1098-105; PMID:19160491; http://dx.doi.org/10.1038/ncb1770
  • Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387:299-303; PMID:9153396; http://dx.doi.org/10.1038/387299a0
  • Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ 2006; 13:927-34; PMID:16543935; http://dx.doi.org/10.1038/sj.cdd.4401912
  • Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420:25-7; PMID:9450543; http://dx.doi.org/10.1016/S0014-5793(97)01480-4
  • Maslon MM, Hupp TR. Drug discovery and mutant p53. Trends Cell Biol 2010; 20:542-55; PMID:20656489; http://dx.doi.org/10.1016/j.tcb.2010.06.005
  • Ganguli G, Wasylyk B. p53-independent functions of MDM2. Mol Cancer Res : MCR 2003; 1:1027-35; PMID:14707286
  • Manfredi JJ. The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev 2010; 24:1580-9; PMID:20679392; http://dx.doi.org/10.1101/gad.1941710
  • Fåhraeus R, Olivares-Illana V. MDM2s social network. Oncogene 2014; 33, 4365-4376; http://dx.doi.org/10.1038/onc.2013.410
  • Giglio S, Mancini F, Pellegrino M, Di Conza G, Puxeddu E, Sacchi A, Pontecorvi A, Moretti F. Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity. Oncogene 2010; 29:5935-45; PMID:20697359; http://dx.doi.org/10.1038/onc.2010.324
  • Bartel F, Taubert H, Harris LC. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002; 2:9-15; PMID:12150820; http://dx.doi.org/10.1016/S1535-6108(02)00091-0
  • Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res 2006; 66:9502-8; PMID:17018606; http://dx.doi.org/10.1158/0008-5472.CAN-05-4271
  • Saucedo LJ, Myers CD, Perry ME. Multiple murine double minute gene 2 (MDM2) proteins are induced by ultraviolet light. J Biol Chem 1999; 274:8161-8; PMID:10075719; http://dx.doi.org/10.1074/jbc.274.12.8161
  • Candeias MM, Malbert-Colas L, Powell DJ, Daskalogianni C, Maslon MM, Naski N, Bourougaa K, Calvo F, Fahraeus R. p53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol 2008; 10(9):1098–105; PMID:19160491; http://dx.doi.org/10.1038/ncb1770
  • Marine JC, Jochemsen AG. Mdmx and Mdm2: brothers in arms? Cell Cycle 2004; 3:900-4; PMID:15254433; http://dx.doi.org/10.4161/cc.3.7.998
  • Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, et al. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 2004; 24:5835-43; PMID:15199139; http://dx.doi.org/10.1128/MCB.24.13.5835-5843.2004
  • Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med 2012; 18:1239-47; PMID:22820643; http://dx.doi.org/10.1038/nm.2863
  • Pei D, Zhang Y, Zheng J. Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget 2012; 3:228-35; PMID:22410433
  • Wang X. p53 regulation: teamwork between RING domains of Mdm2 and MdmX. Cell Cycle 2011; 10:4225-9; PMID:22134240; http://dx.doi.org/10.4161/cc.10.24.18662
  • Rallapalli R, Strachan G, Cho B, Mercer WE, Hall DJ. A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity. J Biol Chem 1999; 274:8299-308; PMID:10075736; http://dx.doi.org/10.1074/jbc.274.12.8299
  • Gentiletti F, Mancini F, D’Angelo M, Sacchi A, Pontecorvi A, Jochemsen AG, Moretti F. MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Oncogene 2002; 21:867-77; PMID:11840332; http://dx.doi.org/10.1038/sj.onc.1205137
  • Mathews M, Sonenberg N, Hershey J. Translational Control in Biology and Medicine, Mathews M. B., Sonenberg N., Hershey J. W. B., eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2007.
  • Metzger MB, Pruneda JN, Klevit RE, Weissman AM. RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochimica et Biophy Acta 2014; 1843:47-60; PMID:23747565; http://dx.doi.org/10.1016/j.bbamcr.2013.05.026
  • Rocco JW, Ellisen LW. p63 and p73: life and death in squamous cell carcinoma. Cell Cycle 2006; 5:936-40; PMID:16687923; http://dx.doi.org/10.4161/cc.5.9.2716
  • Sharp DA, Kratowicz SA, Sank MJ, George DL. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 1999; 274:38189-96; PMID:10608892; http://dx.doi.org/10.1074/jbc.274.53.38189
  • Stad R, Ramos YF, Little N, Grivell S, Attema J, van Der Eb AJ, Jochemsen AG. Hdmx stabilizes Mdm2 and p53. J Biol Chem 2000; 275:28039-44; PMID:10827196
  • Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A 2003; 100:12009-14; PMID:14507994; http://dx.doi.org/10.1073/pnas.2030930100
  • Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL. Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Mol Cell 2006; 23:251-63; PMID:16857591; http://dx.doi.org/10.1016/j.molcel.2006.05.029
  • Kulikov R, Letienne J, Kaur M, Grossman SR, Arts J, Blattner C. Mdm2 facilitates the association of p53 with the proteasome. Proc Natl Acad Sci U S A 2010; 107:10038-43; PMID:20479273; http://dx.doi.org/10.1073/pnas.0911716107