SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

References

• Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153:1194-217; PMID:23746838; http://dx.doi.org/10.1016/j.cell.2013.05.039
   PubMed Web of Science ®Google Scholar
• Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stuhler K, et al. The hallmarks of fibroblast ageing. Mech Ageing Dev 2014; 138:26-44; PMID:24686308; http://dx.doi.org/10.1016/j.mad.2014.03.004
   PubMed Web of Science ®Google Scholar
• Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993; 362:709-15; PMID:8469282; http://dx.doi.org/10.1038/362709a0
   PubMed Web of Science ®Google Scholar
• Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC, Bohr VA. Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 2009; 30:2-10; PMID:18978338; http://dx.doi.org/10.1093/carcin/bgn250
   PubMed Web of Science ®Google Scholar
• Wilson DM 3rd, Bohr VA. The mechanics of base excision repair, and its relationship to aging and disease. DNA Rep 2007; 6:544-59; PMID:17112792; http://dx.doi.org/10.1016/j.dnarep.2006.10.017
   PubMed Web of Science ®Google Scholar
• Caldecott KW. Mammalian single-strand break repair: mechanisms and links with chromatin. DNA Rep 2007; 6:443-53; PMID:17118715; http://dx.doi.org/10.1016/j.dnarep.2006.10.006
   PubMed Web of Science ®Google Scholar
• Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR. Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res 2002; 500:135-45; PMID:11890943; http://dx.doi.org/10.1016/S0027-5107(02)00003-9
   PubMed Web of Science ®Google Scholar
• Intano GW, Cho EJ, McMahan CA, Walter CA. Age-related base excision repair activity in mouse brain and liver nuclear extracts. J Gerontol A Biol Sci Med Sci 2003; 58:205-11; PMID:12634285; http://dx.doi.org/10.1093/gerona/58.3.B205
   PubMed Web of Science ®Google Scholar
• Krishna TH, Mahipal S, Sudhakar A, Sugimoto H, Kalluri R, Rao KS. Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase. J Neurochem 2005; 92:818-23; PMID:15686483; http://dx.doi.org/10.1111/j.1471-4159.2004.02923.x
   PubMed Web of Science ®Google Scholar
• Atamna H, Cheung I, Ames BN. A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci U S A 2000; 97:686-91; PMID:10639140; http://dx.doi.org/10.1073/pnas.97.2.686
   PubMed Web of Science ®Google Scholar
• Szczesny B, Bhakat KK, Mitra S, Boldogh I. Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech Ageing Dev 2004; 125:755-65; PMID:15541770; http://dx.doi.org/10.1016/j.mad.2004.07.005
   PubMed Web of Science ®Google Scholar
• Szczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I. Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc Natl Acad Sci U S A 2003; 100:10670-5; PMID:12960370; http://dx.doi.org/10.1073/pnas.1932854100
   PubMed Web of Science ®Google Scholar
• Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000; 289:2126-8; PMID:11000115; http://dx.doi.org/10.1126/science.289.5487.2126
   PubMed Web of Science ®Google Scholar
• Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012; 483:218-21; PMID:22367546; http://dx.doi.org/10.1038/nature10815
   PubMed Web of Science ®Google Scholar
• Kaidi A, Weinert BT, Choudhary C, Jackson SP. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010; 329:1348-53; PMID:20829486; http://dx.doi.org/10.1126/science.1192049
   PubMed Web of Science ®Google Scholar
• Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011; 332:1443-6; PMID:21680843; http://dx.doi.org/10.1126/science.1202723
   PubMed Web of Science ®Google Scholar
• Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci U S A 2012; 109:11800-5; PMID:22753495; http://dx.doi.org/10.1073/pnas.1200583109
   PubMed Web of Science ®Google Scholar
• McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, et al. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging 2009; 1:109-21; PMID:20157594
   PubMedGoogle Scholar
• Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, et al. SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell 2013; 51:454-68; PMID:23911928; http://dx.doi.org/10.1016/j.molcel.2013.06.018
   PubMed Web of Science ®Google Scholar
• Lombard DB. Sirtuins at the breaking point: SIRT6 in DNA repair. Aging 2009; 1:12-6; PMID:20157593
   PubMedGoogle Scholar
• Van Meter M, Mao Z, Gorbunova V, Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging 2011; 3:829-35; PMID:21946623
   PubMedGoogle Scholar
• Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124:315-29; PMID:16439206; http://dx.doi.org/10.1016/j.cell.2005.11.044
   PubMed Web of Science ®Google Scholar
• Floyd RA, West MS, Eneff KL, Schneider JE. Methylene blue plus light mediates 8-hydroxyguanine formation in DNA. Arch Biochem Biophys 1989; 273:106-11; PMID:2502945; http://dx.doi.org/10.1016/0003-9861(89)90167-7
   PubMed Web of Science ®Google Scholar
• Epe B, Pflaum M, Boiteux S. DNA damage induced by photosensitizers in cellular and cell-free systems. Mutati Res 1993; 299:135-45; PMID:7683082; http://dx.doi.org/10.1016/0165-1218(93)90091-Q
   PubMed Web of Science ®Google Scholar
• Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, Patel R, Wu H, Huber-Keener K, Yang JW, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis 2013; 4:e731; PMID:23868064; http://dx.doi.org/10.1038/cddis.2013.254
   PubMed Web of Science ®Google Scholar
• Chen D, Cao G, Hastings T, Feng Y, Pei W, O'Horo C, Chen J. Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria. J Neurochem 2002; 81:1273-84; PMID:12068075; http://dx.doi.org/10.1046/j.1471-4159.2002.00916.x
   PubMed Web of Science ®Google Scholar
• Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC, Bohr VA. Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging 2006; 27:1129-36; PMID:16005114; http://dx.doi.org/10.1016/j.neurobiolaging.2005.06.002
   PubMed Web of Science ®Google Scholar
• Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic Acids Res 2007; 35:7466-74; PMID:17913742; http://dx.doi.org/10.1093/nar/gkm756
   PubMed Web of Science ®Google Scholar
• Pegoraro G, Misteli T. The central role of chromatin maintenance in aging. Aging 2009; 1:1017-22; PMID:20157584
   PubMedGoogle Scholar
• Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Schor N, Cohen HY. SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell 2010; 9:162-73; PMID:20047575; http://dx.doi.org/10.1111/j.1474-9726.2009.00544.x
   PubMed Web of Science ®Google Scholar
• Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151:1185-99; PMID:23217706; http://dx.doi.org/10.1016/j.cell.2012.10.047
   PubMed Web of Science ®Google Scholar
• Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 2011; 10:3153-8; PMID:21900744; http://dx.doi.org/10.4161/cc.10.18.17435
   PubMed Web of Science ®Google Scholar
• Seluanov A, Hine C, Bozzella M, Hall A, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 2008; 7:813-23; PMID:18778411; http://dx.doi.org/10.1111/j.1474-9726.2008.00431.x
   PubMed Web of Science ®Google Scholar