1,040
Views
8
CrossRef citations to date
0
Altmetric
REPORTS

Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication

, , , &
Pages 333-341 | Received 22 Aug 2014, Accepted 21 Oct 2014, Published online: 06 Feb 2015

References

  • Capco DG, Wan KM, Penman S. The nuclear matrix: three-dimensional architecture and protein composition. Cell 1982; 29:847-58; PMID:7151171; http://dx.doi.org/10.1016/0092-8674(82)90446-9
  • Cook PR. The nucleoskeleton and the topology of replication. Cell 1991; 66:627-35; PMID:1652367; http://dx.doi.org/10.1016/0092-8674(91)90109-C
  • Wilson RH, Coverley D. Relationship between DNA replication and the nuclear matrix. Genes Cells 2013; 18:17-31; PMID:23134523; http://dx.doi.org/10.1111/gtc.12010
  • Chong JPJ, Mahbubani HM, Khoo C-Y, Blow JJ. Purification of an MCM-containing complex as a component of the replication licensing system. Nature 1995; 375:418-21; PMID:7760937; http://dx.doi.org/10.1038/375418a0
  • Coster G, Frigola J, Beuron F, Morris Edward P, Diffley John FX. Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase. Mol Cell 2014; 55:666-77; PMID:25087873; http://dx.doi.org/10.1016/j.molcel.2014.06.034
  • Moyer SE, Lewis PW, Botchan MR. Isolation of the Cdc45Mcm2-7GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc Nat Acad Sci U S A 2006; 103:10236-41; PMID:16798881; http://dx.doi.org/10.1073/pnas.0602400103
  • Labib K. How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev 2010; 24:1208-19; PMID:20551170; http://dx.doi.org/10.1101/gad.1933010
  • Gros J, Devbhandari S, Remus D. Origin plasticity during budding yeast DNA replication in vitro. EMBO J 2014; 33:621-36; PMID:24566988; http://dx.doi.org/10.1002/embj.201387278
  • On KF, Beuron F, Frith D, Snijders AP, Morris EP, Diffley JFX. Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication. EMBO J 2014; 33:605-21; PMID:24566989; http://dx.doi.org/10.1002/embj.201387369
  • Lyubimov AY, Costa A, Bleichert F, Botchan MR, Berger JM. ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proc Nat Acad Sci U S A 2012; 109:11999-2004; PMID:22778422; http://dx.doi.org/10.1073/pnas.1209406109
  • Samel SA, Fernandez-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C. A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev 2014; 28:1653-66; PMID:25085418; http://dx.doi.org/10.1101/gad.242404.114
  • Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T. Nuclear organization of DNA replication initiation proteins in mammalian cells. J Biol Chem 2002; 277:10354-61; PMID:11779870; http://dx.doi.org/10.1074/jbc.M111398200
  • Burkhart R, Schulte D, Hu B, Musahl C, Gohring F, Knippers R. Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. Eur J Biochem 1995; 228:431-8; PMID:7705359; http://dx.doi.org/10.1111/j.1432-1033.1995.tb20281.x
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M. In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. J Biol Chem 1997; 272:10928-35; PMID:9099751; http://dx.doi.org/10.1074/jbc.272.16.10928
  • Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH. Cdc6 protein causes premature entry into S phase in a mammalian cell-free system. Embo J 1998; 17:7219-29; PMID:9857179; http://dx.doi.org/10.1093/emboj/17.24.7219
  • Cook JG, Chasse DA, Nevins JR. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J Biol Chem 2004; 279:9625-33; PMID:14672932; http://dx.doi.org/10.1074/jbc.M311933200
  • Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000; 20:8602-12; PMID:11046155; http://dx.doi.org/10.1128/MCB.20.22.8602-8612.2000
  • Cook JG, Park C-H, Burke T, Leone G, DeGregori J, Engel A, Nevins J. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A 2002; 99:1347-52; PMID:11805305; http://dx.doi.org/10.1073/pnas.032677499
  • Coverley D, Laman H, Laskey RA. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 2002; 4:523-8; PMID:12080347; http://dx.doi.org/10.1038/ncb813
  • Munkley J, Copeland NA, Moignard V, Knight JR, Greaves E, Ramsbottom SA, Pownall ME, Southgate J, Ainscough JF, Coverley D. Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Res 2011; 39:2671-7; PMID:21109536; http://dx.doi.org/10.1093/nar/gkq1190
  • Baumert HG, Fasold H. Cross-linking techniques. Methods Enzymol 1989; 172:584-609; PMID:2546017; http://dx.doi.org/10.1016/S0076-6879(89)72035-8
  • Masai H, Matsumoto S, You Z, Yoshizawa-Sugata N, Oda M. Eukaryotic Chromosome DNA Replication: Where, When and How? In: Kornberg RD, Raetz CRH, Rothman JE, Thorner JW, eds. Annual Review of Biochemistry, Vol 79, 2010:89-130; PMID:20373915; http://dx.doi.org/10.1146/annurev.biochem.052308.103205
  • Blow JJ, Gillespie PJ. Replication licensing and cancer - a fatal entanglement? Nat Rev Cancer 2008; 8:799-806; PMID:18756287; http://dx.doi.org/10.1038/nrc2500
  • Gonzalez MA, Tachibana KK, Laskey RA, Coleman N. Innovation - Control of DNA replication and its potential clinical exploitation. Nat Rev Cancer 2005; 5:135-41; PMID:15660109; http://dx.doi.org/10.1038/nrc1548
  • Hook SS, Lin JJ, Dutta A. Mechanisms to control rereplication and implications for cancer. Curr Opin Cell Biol 2007; 19:663-71; PMID:18053699; http://dx.doi.org/10.1016/j.ceb.2007.10.007
  • Williams GH, Stoeber K. Cell cycle markers in clinical oncology. Curr Opin Cell Biol 2007; 19:672-9; PMID:18032010; http://dx.doi.org/10.1016/j.ceb.2007.10.005
  • Xouri G, Lygerou Z, Nishitani H, Pachnis V, Nurse P, Taraviras S. Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur J Biochem 2004; 271:3368-78; PMID:15291814; http://dx.doi.org/10.1111/j.1432-1033.2004.04271.x
  • Lau E, Tsuji T, Guo L, Lu S-H, Jiang W. The role of pre-replicative complex (pre-RC) components in oncogenesis. Faseb Journal 2007; 21:3786-94; PMID:17690155; http://dx.doi.org/10.1096/fj.07-8900rev
  • Dudderidge TJ, Kelly JD, Wollenschlaeger A, Okoturo O, Prevost T, Robson W, Leung HY, Williams GH, Stoeber K. Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments. Brit J Cancer 2010; 103:701-7; PMID:20648010; http://dx.doi.org/10.1038/sj.bjc.6605785
  • Lau KM, Chan QKY, Pang JCS, Li KKW, Yeung WW, Chung NYF, Lui PC, Tam YS, Li HM, Zhou L, et al. Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion. Oncogene 2010; 29:5475-89; PMID:20661220; http://dx.doi.org/10.1038/onc.2010.287
  • Neskoromna-Jedrzejczak A, Tyndorf M, Arkuszewski P, Kobos J. Potential prognostic value of MCM2 expression evaluation in oral cavity squamous cell carcinoma. Wspolczesna Onkologia-Contemp Oncol 2010; 14:196-9
  • Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, et al. Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22. Plos One 2012; 7:e40305; PMID:22792272; http://dx.doi.org/10.1371/journal.pone.0040305
  • Williams GH, Stoeber K. The cell cycle and cancer. J Pathol 2012; 226:352-64; PMID:21990031; http://dx.doi.org/10.1002/path.3022
  • Coleman N, Laskey RA. Minichromosome maintenance proteins in cancer screening. Eur J Cancer (Oxford, England: 1990) 2009; 45 Suppl 1:416-7; PMID:19775653; http://dx.doi.org/10.1016/S0959-8049(09)70071-1
  • Donovan S, Harwood J, Drury LS, Diffley JF. Cdc6-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 1997; 94:5611-6; PMID:9159120; http://dx.doi.org/10.1073/pnas.94.11.5611
  • Symeonidou I-E, Kotsantis P, Roukos V, Rapsomaniki M-A, Grecco HE, Bastiaens P, Taraviras S, Lygerou Z. Multi-step loading of human minichromosome maintenance proteins in live human cells. J Biol Chem 2013; 288:35852-67; PMID:24158436; http://dx.doi.org/10.1074/jbc.M113.474825
  • Aparicio T, Megias D, Mendez J. Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis. Chromosoma 2012; 121:499-507; PMID:22911457; http://dx.doi.org/10.1007/s00412-012-0381-x
  • Kuipers MA, Stasevich TJ, Sasaki T, Wilson KA, Hazelwood KL, McNally JG, Davidson MW, Gilbert DM. Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload. J Cell Biol 2011; 192:29-41; PMID:21220507; http://dx.doi.org/10.1083/jcb.201007111
  • Krude T, Musahl C, Laskey RA, Knippers R. Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication. J Cell Sci 1996; 109:309-18; PMID:8838654
  • Dimitrova DS, Todorov IT, Melendy T, Gilbert DM. Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex. J Cell Biol 1999; 146:709-22; PMID:10459007; http://dx.doi.org/10.1083/jcb.146.4.709
  • Lei M, Kawasaki Y, Tye BK. Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae. Mol Cell Biol 1996; 16:5081-90; PMID:8756666
  • Ge XQ, Jackson DA, Blow JJ. Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress. Genes Dev 2007; 21:3331-41; PMID:18079179; http://dx.doi.org/10.1101/gad.457807
  • Ibarra A, Schwob E, Mendez J. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Nat Acad Sci U S A 2008; 105:8956-61; PMID:18579778; http://dx.doi.org/10.1073/pnas.0803978105
  • Liang DT, Hodson JA, Forsburg SL. Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay. J Cell Sci 1999; 112:559-67; PMID:9914167
  • Mechali M. Eukaryotic DNA replication origins: many choices for appropriate answers. Nat Rev Mol Cell Biol 2010; 11:728-38; PMID:20861881; http://dx.doi.org/10.1038/nrm2976
  • Eide T, Tasken KA, Carlson C, Williams G, Jahnsen T, Tasken K, Collas P. Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. J Biol Chem 2003; 278:26750-6; PMID:12740381; http://dx.doi.org/10.1074/jbc.M300765200
  • Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C. A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication. Proc Nat Acad Sci U S A 2009; 106:20240-5; PMID:19910535; http://dx.doi.org/10.1073/pnas.0911500106
  • Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JFX. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell 2009; 139:719-30; PMID:19896182; http://dx.doi.org/10.1016/j.cell.2009.10.015
  • Fu YV, Yardimci H, Long DT, The Vinh H, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Schaerer OD, Walter JC. Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase. Cell 2011; 146:930-40; PMID:21925316; http://dx.doi.org/10.1016/j.cell.2011.07.045
  • Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM. DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife 2014; 3:e03273; PMID:25117490; http://dx.doi.org/10.7554/eLife.03273
  • Ainscough JF, Rahman FA, Sercombe H, Sedo A, Gerlach B, Coverley D. C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix. J Cell Sci 2007; 120:115-24; PMID:17182902; http://dx.doi.org/10.1242/jcs.03327
  • Wilson RHC, Hesketh EL, Coverley D. Preparation of the nuclear matrix for parallel microscopy and biochemical analyses. Cold Spring Harb Protoc 2014; http://dx.doi.org/10.1101/pdb.prot083758

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.