1,089
Views
15
CrossRef citations to date
0
Altmetric
REPORTS

KSHV latent protein LANA2 inhibits sumo2 modification of p53

, , , , , , , , & show all
Pages 277-282 | Received 22 Aug 2014, Accepted 21 Oct 2014, Published online: 21 Jan 2015

References

  • Collot-Teixeira S, Bass J, Denis F, Ranger-Rogez S. Human tumor suppressor p53 and DNA viruses. Rev Med Virol 2004; 14:301-19; PMID:15334538; http://dx.doi.org/10.1002/rmv.431
  • Jayaraman L, Prives C. Covalent and noncovalent modifiers of the p53 protein. Cell Mol Life Sci 1999; 55:76-87; PMID:10065153; http://dx.doi.org/10.1007/s000180050271
  • Baresova P, Musilova J, Pitha PM, Lubyova B. p53 Tumor Suppressor Protein Stability and Transcriptional Activity Are Targeted by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factor 3. Mol Cell Biol 2014; 34:386-99; PMID:24248600; http://dx.doi.org/10.1128/MCB.01011-13
  • Chudasama P, Konrad A, Jochmann R, Lausen B, Holz P, Naschberger E, et al. Structural proteins of Kaposi's sarcoma-associated herpesvirus antagonize p53-mediated apoptosis. Oncogene 2014; PMID:24469037
  • Friborg J, Jr., Kong W, Hottiger MO, Nabel GJ. p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 1999; 402:889-94; PMID:10622254
  • Gwack Y, Hwang S, Byun H, Lim C, Kim JW, Choi EJ, et al. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol 2001; 75:6245-8; PMID:11390631; http://dx.doi.org/10.1128/JVI.75.13.6245-6248.2001
  • Lee HR, Toth Z, Shin YC, Lee JS, Chang H, Gu W, et al. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol 2009; 83:6739-47; PMID:19369353; http://dx.doi.org/10.1128/JVI.02353-08
  • Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol 2001; 75:429-38; PMID:11119611; http://dx.doi.org/10.1128/JVI.75.1.429-438.2001
  • Marcos-Villar L, Gallego P, Munoz-Fontela C, de la Cruz-Herrera CF, Campagna M, Gonzalez D, Lopitz-Otsoa F, Rodríguez MS, Rivas C. Kaposi's sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation. Oncogene 2014; 33:495-503; PMID:23318443; http://dx.doi.org/10.1038/onc.2012.603
  • Marcos-Villar L, Lopitz-Otsoa F, Gallego P, Munoz-Fontela C, Gonzalez-Santamaria J, Campagna M, Shou-Jiang G, Rodriguez MS, Rivas C. Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene. J Virol 2009; 83:8849-58; PMID:19553342; http://dx.doi.org/10.1128/JVI.00339-09
  • Marcos-Villar L, Campagna M, Lopitz-Otsoa F, Gallego P, Gonzalez-Santamaria J, Gonzalez D, Rodriguez MS, Rivas C. Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2. J Gen Virol 2011; 92:188-94; PMID:20881090; http://dx.doi.org/10.1099/vir.0.024984-0
  • Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB. Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem 2006; 281:36221-7; PMID:17012228; http://dx.doi.org/10.1074/jbc.M608236200
  • Marcos-Villar L, Perez-Giron JV, Vilas JM, Soto A, de la Cruz-Hererra CF, Lang V, Collado M, Vidal A, Rodríguez MS, Muñoz-Fontela C, et al. SUMOylation of p53 mediates interferon activities. Cell Cycle 2013; 12:2809-16; PMID:23966171; http://dx.doi.org/10.4161/cc.25868
  • Gostissa M, Hengstermann A, Fogal V, Sandy P, Schwarz SE, Scheffner M, Del Sal G. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. Embo J 1999; 18:6462-71; PMID:10562558; http://dx.doi.org/10.1093/emboj/18.22.6462
  • Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A. c-Jun and p53 activity is modulated by SUMO-1 modification. J Biol Chem 2000; 275:13321-9; PMID:10788439; http://dx.doi.org/10.1074/jbc.275.18.13321
  • Bischof O, Schwamborn K, Martin N, Werner A, Sustmann C, Grosschedl R, Dejean A. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell 2006; 22:783-94; PMID:16793547; http://dx.doi.org/10.1016/j.molcel.2006.05.016
  • Yates KE, Korbel GA, Shtutman M, Roninson IB, DiMaio D. Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell 2008; 7:609-21; PMID:18616636; http://dx.doi.org/10.1111/j.1474-9726.2008.00411.x
  • Wies E, Mori Y, Hahn A, Kremmer E, Sturzl M, Fleckenstein B, Neipel F. The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells. Blood 2008; 111:320-7; PMID:17890449; http://dx.doi.org/10.1182/blood-2007-05-092288
  • Desterro JM, Rodriguez MS, Hay RT. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell 1998; 2:233-9; PMID:9734360; http://dx.doi.org/10.1016/S1097-2765(00)80133-1
  • Vertegaal AC, Andersen JS, Ogg SC, Hay RT, Mann M, Lamond AI. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics 2006; 5:2298-310; PMID:17000644; http://dx.doi.org/10.1074/mcp.M600212-MCP200
  • Campagna M, Herranz D, Garcia MA, Marcos-Villar L, Gonzalez-Santamaria J, Gallego P, Gutierrez S, Collado M, Serrano M, Esteban M, Rivas C. SIRT1 stabilizes PML promoting its sumoylation. Cell Death Differ 2011; 18:72-9; PMID:20577263; http://dx.doi.org/10.1038/cdd.2010.77
  • Chang PC, Li M. Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. J Virol 2008; 82:278-90; PMID:17942552; http://dx.doi.org/10.1128/JVI.01552-07
  • Curreli F, Friedman-Kien AE, Flore O. Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J Clin Invest 2005; 115:642-52; PMID:15765147; http://dx.doi.org/10.1172/JCI200523334
  • Cai QL, Knight JS, Verma SC, Zald P, Robertson ES. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog 2006; 2:e116.
  • Nakamura H, Li M, Zarycki J, Jung JU. Inhibition of p53 tumor suppressor by viral interferon regulatory factor. J Virol 2001; 75:7572-82; PMID:11462029; http://dx.doi.org/10.1128/JVI.75.16.7572-7582.2001
  • Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. J Virol 2006; 80:2257-66; PMID:16474133; http://dx.doi.org/10.1128/JVI.80.5.2257-2266.2006
  • Feng P, Scott CW, Cho NH, Nakamura H, Chung YH, Monteiro MJ, Jung JU. Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation. Mol Cell Biol 2004; 24:3938-48; PMID:15082787; http://dx.doi.org/10.1128/MCB.24.9.3938-3948.2004
  • Chang PC, Izumiya Y, Wu CY, Fitzgerald LD, Campbell M, Ellison TJ, Lam KS, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific. J Biol Chem 2010; 285:5266-73; PMID:20034935; http://dx.doi.org/10.1074/jbc.M109.088088

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.