Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex

References

• Dhavan R, Tsai LH. A decade of CDK5. Nat Rev Mol Cell Biol 2001; 2:749-59; PMID:11584302; http://dx.doi.org/10.1038/35096019
   PubMed Web of Science ®Google Scholar
• Arif A. Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5. Biochem Pharmacol 2012; 84:985-93; PMID:22795893; http://dx.doi.org/10.1016/j.bcp.2012.06.027
   PubMed Web of Science ®Google Scholar
• Jessberger S, Gage FH, Eisch AJ, Lagace DC. Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci 2009; 32:575-82; PMID:19782409; http://dx.doi.org/10.1016/j.tins.2009.07.002
   PubMed Web of Science ®Google Scholar
• Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med 2010; 207:2507-19; PMID:20937706; http://dx.doi.org/10.1084/jem.20100876
   PubMed Web of Science ®Google Scholar
• Nohara A, Okada S, Ohshima K, Pessin JE, Mori M. Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-alpha-induced insulin resistance. J Biol Chem 2011; 286:33457-65; PMID:21813649; http://dx.doi.org/10.1074/jbc.M111.231431
   PubMed Web of Science ®Google Scholar
• Strock CJ, Park JI, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD. Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res 2006; 66:7509-15; PMID:16885348; http://dx.doi.org/10.1158/0008-5472.CAN-05-3048
   PubMed Web of Science ®Google Scholar
• Cheung ZH, Ip NY. Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol 2012; 22:169-75; PMID:22189166; http://dx.doi.org/10.1016/j.tcb.2011.11.003
   PubMed Web of Science ®Google Scholar
• Lin H, Chen MC, Chiu CY, Song YM, Lin SY. Cdk5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells. J Biol Chem 2007; 282:2776-84; PMID:17145757; http://dx.doi.org/10.1074/jbc.M607234200
   PubMed Web of Science ®Google Scholar
• Brinkkoetter PT, Wu JS, Ohse T, Krofft RD, Schermer B, Benzing T, Pippin JW, Shankland SJ. p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo. Kidney Int 2010; 77:690-9; PMID:20130526; http://dx.doi.org/10.1038/ki.2009.548
   PubMed Web of Science ®Google Scholar
• Yang HS, Alexander K, Santiago P, Hinds PW. ERM proteins and Cdk5 in cellular senescence. Cell Cycle 2003; 2:517-20; PMID:14504464; http://dx.doi.org/10.4161/cc.2.6.582
   PubMed Web of Science ®Google Scholar
• Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G. Coronin 1A is an essential regulator of the TGFbeta receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun 2011; 37:198-208; PMID:21700422; http://dx.doi.org/10.1016/j.jaut.2011.05.018
   PubMed Web of Science ®Google Scholar
• Popmihajlov Z, Xu D, Morgan H, Milligan Z, Smith KA. Conditional IL-2 gene deletion: consequences for T cell proliferation. Front Immunol 2012; 3:102; PMID:22590468; http://dx.doi.org/10.3389/fimmu.2012.00102
   PubMed Web of Science ®Google Scholar
• Castro I, Yu A, Dee MJ, Malek TR. The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. J Immunol 2011; 187:5170-82; PMID:21984699; http://dx.doi.org/10.4049/jimmunol.1003961
   PubMed Web of Science ®Google Scholar
• Liao W, Lin JX, Leonard WJ. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol 2011; 23:598-604; PMID:21889323; http://dx.doi.org/10.1016/j.coi.2011.08.003
   PubMed Web of Science ®Google Scholar
• Koyama Y, Adachi M, Sekiya M, Takekawa M, Imai K. Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis. Blood 2000; 96:1490-5; PMID:10942396
   PubMed Web of Science ®Google Scholar
• Ikiz B, Przedborski S. A sequel to the tale of p25/Cdk5 in neurodegeneration. Neuron 2008; 60:731-2; PMID:19081365; http://dx.doi.org/10.1016/j.neuron.2008.11.020
   PubMed Web of Science ®Google Scholar
• Kametani Y, Wang L, Koduka K, Sato T, Katano I, Habu S. Rapid histone deacetylation and transient HDAC association in the IL-2 promoter region of TSST-1-stimulated T cells. Immunol Lett 2008; 119:97-102; PMID:18606456; http://dx.doi.org/10.1016/j.imlet.2008.05.006
   PubMed Web of Science ®Google Scholar
• Fu AK, Hung KW, Wong HH, Fu WY, Ip NY. Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Neurosignals 2013; 21(1-2):55-60; PMID:22398430; http://dx.doi.org/10.1159/000335158
   PubMedGoogle Scholar
• Li Z, David G, Hung KW, DePinho RA, Fu AK, Ip NY. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J Biol Chem 2004; 279:54438-44; PMID:15489224; http://dx.doi.org/10.1074/jbc.M411002200
   PubMed Web of Science ®Google Scholar
• Nicolas E, Yamada T, Cam HP, Fitzgerald PC, Kobayashi R, Grewal SI. Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection. Nat Struct Mol Biol 2007; 14:372-80; PMID:17450151; http://dx.doi.org/10.1038/nsmb1239
   PubMed Web of Science ®Google Scholar
• Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10:32-42; PMID:19065135; http://dx.doi.org/10.1038/nrg2485
   PubMed Web of Science ®Google Scholar
• Grzenda A, Lomberk G, Zhang JS, Urrutia R. Sin3: master scaffold and transcriptional corepressor. Biochim Biophys Acta 2009; 1789:443-50; PMID:19505602; http://dx.doi.org/10.1016/j.bbagrm.2009.05.007
   PubMed Web of Science ®Google Scholar
• Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, et al. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron 2008; 60:803-17; PMID:19081376; http://dx.doi.org/10.1016/j.neuron.2008.10.015
   PubMed Web of Science ®Google Scholar
• Segre CV, Chiocca S. Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol 2011; 2011:690848; PMID:21197454; http://dx.doi.org/10.1155/2011/690848
   PubMedGoogle Scholar
• Pflum MK, Tong JK, Lane WS, Schreiber SL. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem 2001; 276:47733-41; PMID:11602581; http://dx.doi.org/10.1074/jbc.M105590200
   PubMed Web of Science ®Google Scholar
• Wang J, Lee S, Teh CE, Bunting K, Ma L, Shannon MF. The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells. Int Immunol 2009; 21:227-35; PMID:19181930; http://dx.doi.org/10.1093/intimm/dxn143
   PubMed Web of Science ®Google Scholar
• Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 1997; 89:373-80; PMID:9150137; http://dx.doi.org/10.1016/S0092-8674(00)80218-4
   PubMed Web of Science ®Google Scholar
• Spain MM, Caruso JA, Swaminathan A, Pile LA. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem 2010; 285:27457-67; PMID:20566628; http://dx.doi.org/10.1074/jbc.M110.130245
   PubMed Web of Science ®Google Scholar
• Cowley SM, Iritani BM, Mendrysa SM, Xu T, Cheng PF, Yada J, Liggitt HD, Eisenman RN. The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol 2005; 25:6990-7004; PMID:16055712; http://dx.doi.org/10.1128/MCB.25.16.6990-7004.2005
   PubMed Web of Science ®Google Scholar
• Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J 1999; 18:3090-100; PMID:10357820; http://dx.doi.org/10.1093/emboj/18.11.3090
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay S, Dure M, Paroder M, Soto-Nieves N, Puga I, Macian F. Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood 2007; 109:2878-86; PMID:17148585
   PubMed Web of Science ®Google Scholar
• Zhang J, Li H, Herrup K. Cdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation. J Biol Chem 2010; 285:14052-61; PMID:20189989; http://dx.doi.org/10.1074/jbc.M109.068262
   PubMed Web of Science ®Google Scholar
• Ajay AK, Upadhyay AK, Singh S, Vijayakumar MV, Kumari R, Pandey V, Boppana R, Bhat MK. Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Mol Cancer 2010; 9:204; PMID:20673369; http://dx.doi.org/10.1186/1476-4598-9-204
   PubMed Web of Science ®Google Scholar
• Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ. The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. J Biol Chem 2002; 277:7324-32; PMID:11741927; http://dx.doi.org/10.1074/jbc.M107270200
   PubMed Web of Science ®Google Scholar
• Fu X, Choi YK, Qu D, Yu Y, Cheung NS, Qi RZ. Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem 2006; 281:39014-21; PMID:17060323; http://dx.doi.org/10.1074/jbc.M512663200
   PubMed Web of Science ®Google Scholar
• Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, Blair LA, Marshall J, Mao Z. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 2003; 38:33-46; PMID:12691662; http://dx.doi.org/10.1016/S0896-6273(03)00191-0
   PubMed Web of Science ®Google Scholar
• Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, et al. Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011; 147:815-26; PMID:22078880; http://dx.doi.org/10.1016/j.cell.2011.09.050
   PubMed Web of Science ®Google Scholar
• Shen L, Ciesielski M, Ramakrishnan S, Miles KM, Ellis L, Sotomayor P, Shrikant P, Fenstermaker R, Pili R. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PLoS One 2012; 7:e30815; PMID:22303460; http://dx.doi.org/10.1371/journal.pone.0030815
   PubMed Web of Science ®Google Scholar
• Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007; 13:1299-307; PMID:17922010; http://dx.doi.org/10.1038/nm1652
   PubMed Web of Science ®Google Scholar
• Shakespear MR, Halili MA, Irvine KM, Fairlie DP, Sweet MJ. Histone deacetylases as regulators of inflammation and immunity. Trends Immunol 2011; 32:335-43; PMID:21570914; http://dx.doi.org/10.1016/j.it.2011.04.001
   PubMed Web of Science ®Google Scholar