Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

References

• Wu SK, Gomez GA, Michael M, Verma S, Cox HL, Lefevre JG, Parton RG, Hamilton NA, Neufeld Z, Yap AS. Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia. Nat Cell Biol 2014; 16:167-78; PMID:4413434
   PubMed Web of Science ®Google Scholar
• Wu SK, Yap AS. Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions. Cell Commun Adhes 2013; 20:201-12; PMID:24205985; http://dx.doi.org/10.3109/15419061.2013.856889
   PubMed Web of Science ®Google Scholar
• Engl W, Arasi B, Yap LL, Thiery JP, Viasnoff V. Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions. Nat Cell Biol 2014; 16:587-94; PMID:24859003; http://dx.doi.org/10.1038/ncb2973
   PubMed Web of Science ®Google Scholar
• Roh-Johnson M, Shemer G, Higgins CD, McClellan JH, Werts AD, Tulu US, Gao L, Betzig E, Kiehart DP, Goldstein B. Triggering a cell shape change by exploiting preexisting actomyosin contractions. Science 2012; 335:1232-5; PMID:22323741; http://dx.doi.org/10.1126/science.1217869
   PubMed Web of Science ®Google Scholar
• Fernandez-Gonzalez R, Simoes Sde M, Roper JC, Eaton S, Zallen JA. Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell 2009; 17:736-43; PMID:19879198; http://dx.doi.org/10.1016/j.devcel.2009.09.003
   PubMed Web of Science ®Google Scholar
• Martin AC, Gelbart M, Fernandez-Gonzalez R, Kaschube M, Wieschaus EF. Integration of contractile forces during tissue invagination. J Cell Biol 2010; 188:735-49; PMID:20194639; http://dx.doi.org/10.1083/jcb.200910099
   PubMed Web of Science ®Google Scholar
• Maitre JL, Berthoumieux H, Krens SF, Salbreux G, Julicher F, Paluch E, Heisenberg CP. Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science 2012; 338:253-6; PMID:22923438; http://dx.doi.org/10.1126/science.1225399
   PubMed Web of Science ®Google Scholar
• de Rooij J. Cadherin adhesion controlled by cortical actin dynamics. Nat Cell Biol 2014; 16:508-10; PMID:24875740
   PubMed Web of Science ®Google Scholar
• Rauzi M, Verant P, Lecuit T, Lenne PF. Nature and anisotropy of cortical forces orienting drosophila tissue morphogenesis. Nat Cell Biol 2008; PMID:18978783; http://dx.doi.org/10.1038/ncb1798
   PubMed Web of Science ®Google Scholar
• Smutny M, Wu SK, Gomez GA, Mangold S, Yap AS, Hamilton NA. Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens. PloS one 2011; 6:e22458; PMID:21799860; http://dx.doi.org/10.1371/journal.pone.0022458
   PubMed Web of Science ®Google Scholar
• Lugo-Martinez VH, Petit CS, Fouquet S, Le Beyec J, Chambaz J, Pincon-Raymond M, Cardot P, Thenet S. Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions. Am J Physiol Gastrointest Liver Physiol 2009; 296:G235-44; PMID:19056766; http://dx.doi.org/10.1152/ajpgi.90313.2008
   PubMed Web of Science ®Google Scholar
• Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell 2008; 135:948-59; PMID:19041755; http://dx.doi.org/10.1016/j.cell.2008.09.040
   PubMed Web of Science ®Google Scholar
• Priya R, Yap AS, Gomez GA. E-cadherin supports steady-state rho signaling at the epithelial zonula adherens. Differentiation 2013; 86:117-8; PMID:23643492; http://dx.doi.org/10.1016/j.diff.2013.01.002
   PubMed Web of Science ®Google Scholar
• Truong Quang BA, Mani M, Markova O, Lecuit T, Lenne PF. Principles of E-Cadherin supramolecular organization in vivo. Curr Biol 2013; 23:2197-207; PMID:24184100; http://dx.doi.org/10.1016/j.cub.2013.09.015
   PubMed Web of Science ®Google Scholar
• Vaezi A, Bauer C, Vasioukhin V, Fuchs E. Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Developmental cell 2002; 3:367-81; PMID:12361600
   PubMed Web of Science ®Google Scholar
• Wu SK, Budnar S, Yap AS, Gomez GA. Pulsatile contractility of actomyosin networks organizes the cellular cortex at lateral cadherin junctions. Eur J Cell Biol 2014; 93:396-404; PMID:25269995; http://dx.doi.org/10.1016/j.ejcb.2014.09.001
   PubMed Web of Science ®Google Scholar
• Mangold S, Wu SK, Norwood SJ, Collins BM, Hamilton NA, Thorn P, Yap AS. Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens. Curr Biol 2011; 21:503-7; PMID:21396819; http://dx.doi.org/10.1016/j.cub.2011.02.018
   PubMed Web of Science ®Google Scholar
• Otani T, Ichii T, Aono S, Takeichi M. Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells. J Cell Biol 2006; 175:135-46; PMID:17015620
   PubMed Web of Science ®Google Scholar
• Tang VW, Brieher WM. Alpha-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol 2012; 196:115-30; PMID:2232703
   PubMed Web of Science ®Google Scholar
• Kovacs EM, Goodwin M, Ali RG, Paterson AD, Yap AS. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr Biol 2002; 12:379-82; PMID:11882288
   PubMed Web of Science ®Google Scholar
• Leerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS. Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. Curr biol 2014; 24:1689-99; PMID:25065757; http://dx.doi.org/10.1016/j.cub.2014.06.028
   PubMed Web of Science ®Google Scholar
• Shewan AM, Maddugoda M, Kraemer A, Stehbens SJ, Verma S, Kovacs EM, Yap AS. Myosin 2 is a key rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Mol Biol Cell 2005; 16:4531-42; PMID:16030252
   PubMed Web of Science ®Google Scholar
• Yonemura S, Hirao-Minakuchi K, Nishimura Y. Rho localization in cells and tissues. Exp Cell Res 2004; 295:300-14; PMID:15093731
   PubMed Web of Science ®Google Scholar
• Smutny M, Cox HL, Leerberg JM, Kovacs EM, Conti MA, Ferguson C, Hamilton NA, Parton RG, Adelstein RS, Yap AS. Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol 2010; 12:696-702; PMID:20543839; http://dx.doi.org/10.1038/ncb2072
   PubMed Web of Science ®Google Scholar
• Ratheesh A, Gomez GA, Priya R, Verma S, Kovacs EM, Jiang K, Brown NH, Akhmanova A, Stehbens SJ, Yap AS. Centralspindlin and α-catenin regulate rho signalling at the epithelial zonula adherens. Nat Cell Biol 2012; 14:818-28; PMID:22750944; http://dx.doi.org/10.1038/ncb2532
   PubMed Web of Science ®Google Scholar
• (a) Verma S, Han SP, Michael M, Gomez GA, Yang Z, Teasdale RD, Ratheesh A, Kovacs EM, Ali RG, Yap AS. A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens. Mol Biol Cell 2012; 23:4601-10; PMID:23051739; http://dx.doi.org/10.1091/mbc.E12-08-0574; (b) Moore T, Wu SK, Michael M, Yap AS, Gomez GA, Neufeld Z. Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions. Biophysical journal 2014; 107:2652-61.
   PubMed Web of Science ®Google Scholar
• Padrick SB, Rosen MK. Physical mechanisms of signal integration by WASP family proteins. Ann Rev Biochem 2010; 79:707-35; PMID:20533885; http://dx.doi.org/10.1146/annurev.biochem.77.060407
   PubMed Web of Science ®Google Scholar
• Kovacs EM, Verma S, Ali RG, Ratheesh A, Hamilton NA, Akhmanova A, Yap AS. N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. Nat Cell Biol 2011; 13:934-43; PMID:21785420; http://dx.doi.org/10.1038/ncb2290
   PubMed Web of Science ®Google Scholar
• Han SP, Gambin Y, Gomez GA, Verma S, Giles N, Michael M, Wu SK, Guo Z, Johnston W, Sierecki E, et al. Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. J Biol Chem 2014; 289:7764-75; PMID:24469447; http://dx.doi.org/10.1074/jbc.M113.544478
   PubMed Web of Science ®Google Scholar
• Rosenblatt J, Raff MC, Cramer LP. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol 2001; 11:1847-57; PMID:11728307
   PubMed Web of Science ®Google Scholar
• Knodler LA, Vallance BA, Celli J, Winfree S, Hansen B, Montero M, Steele-Mortimer O. Dissemination of invasive salmonella via bacterial-induced extrusion of mucosal epithelia. Proc Nat Acad Sci U S A 2010:17733-8; PMID:20876119; http://dx.doi.org/10.1073/pnas.1006098107
   PubMed Web of Science ®Google Scholar
• Marinari E, Mehonic A, Curran S, Gale J, Duke T, Baum B. Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding. Nature 2012; 484:542-5; PMID:22504180; http://dx.doi.org/10.1038/nature10984
   PubMed Web of Science ®Google Scholar
• Leung CT, Brugge JS. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature 2012; 482:410-3; PMID:22318515; http://dx.doi.org/10.1038/nature10826
   PubMed Web of Science ®Google Scholar
• Slattum G, McGee KM, Rosenblatt J. P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. J Cell Biol 2009; 186:693-702; PMID:19720875; http://dx.doi.org/10.1083/jcb.200903079
   PubMed Web of Science ®Google Scholar
• Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, et al. Filamin acts as a key regulator in epithelial defence against transformed cells. Nat Commun 2014; 5:4428; PMID:25079702; http://dx.doi.org/10.1038/ncomms5428
   PubMed Web of Science ®Google Scholar
• Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, Charras G, Tada M, Fujita Y. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 2010; 123:171-80; PMID:20026643; http://dx.doi.org/10.1242/jcs.057976
   PubMed Web of Science ®Google Scholar
• Hogan C, Dupre-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-Lopez LA, Vincent JP, Itoh Y, et al. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 2009; 11:460-7; PMID:19287376; http://dx.doi.org/10.1038/ncb1853
   PubMed Web of Science ®Google Scholar
• Liotta LA, Kohn E. Anoikis: cancer and the homeless cell. Nature 2004; 430:973-4; PMID:15329701
   PubMed Web of Science ®Google Scholar
• Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182:311-22; PMID:10653597
   PubMed Web of Science ®Google Scholar
• McFall A, Ulku A, Lambert QT, Kusa A, Rogers-Graham K, Der CJ. Oncogenic ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol 2001; 21:5488-99; PMID:11463831
   PubMed Web of Science ®Google Scholar
• Thullberg M, Gad A, Le Guyader S, Stromblad S. Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts. Proc Nat Acad Sci U S A 2007; http://dx.doi.org/104:20338-43; PMID:18077377
   PubMed Web of Science ®Google Scholar
• Grieve AG, Rabouille C. Extracellular cleavage of E-cadherin promotes epithelial cell extrusion. J Cell Sci 2014; 127:3331-46; PMID:24895403; http://dx.doi.org/10.1242/jcs.147926
   PubMed Web of Science ®Google Scholar
• Kuipers D, Mehonic A, Kajita M, Peter L, Fujita Y, Duke T, Charras G, Gale JE. Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours. J Cell Sci 2014; 127:1229-41; PMID:24463819; http://dx.doi.org/10.1242/jcs.138289
   PubMed Web of Science ®Google Scholar
• Saravanan S, Meghana C, Narasimha M. Local, cell-nonautonomous feedback regulation of myosin dynamics patterns transitions in cell behavior: a role for tension and geometry? Mol Biol Cell 2013; 24:2350-61; PMID:23741052; http://dx.doi.org/10.1091/mbc.E12-12-0868
   PubMed Web of Science ®Google Scholar
• Hogan C, Kajita M, Lawrenson K, Fujita Y. Interactions between normal and transformed epithelial cells: their contributions to tumourigenesis. Int J Biochem Cell Biol 2011; 43:496-503; PMID:21187160; http://dx.doi.org/10.1016/j.biocel.2010.12.019
   PubMed Web of Science ®Google Scholar
• Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ. Programmed cell-to-cell variability in ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep 2012; 2:1461-70; PMID:23041312; http://dx.doi.org/10.1016/j.celrep.2012.08.037
   PubMed Web of Science ®Google Scholar
• Marshall TW, Lloyd IE, Delalande JM, Nathke I, Rosenblatt J. The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. Mol Biol Cell 2011; 22:3962-70; PMID:21900494; http://dx.doi.org/10.1091/mbc.E11-05-0469
   PubMed Web of Science ®Google Scholar
• Nowell PC. The clonal evolution of tumor cell populations. Science 1976; 194:23-8; PMID:959840
   PubMed Web of Science ®Google Scholar
• Fialkow PJ. Clonal origin of human tumors. Biochim Biophysica Acta 1976; 458:283-321; PMID:1067873
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230
   PubMed Web of Science ®Google Scholar
• Slattum G, Gu Y, Sabbadini R, Rosenblatt J. Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Curr Biol 2014; 24:19-28; PMID:24361067; http://dx.doi.org/10.1016/j.cub.2013.11.029
   PubMed Web of Science ®Google Scholar
• Burstein HJ, Polyak K, Wong JS, Lester SC, Kaelin CM. Ductal carcinoma in situ of the breast. N Eng J med 2004; 350:1430-41; PMID:15070793
   PubMed Web of Science ®Google Scholar
• Fodde R. The APC gene in colorectal cancer. Eur J Cancer 2002; 38:867-71; PMID:11978510
   PubMed Web of Science ®Google Scholar
• Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futo K, Timpson P, et al. N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol 2012; 199:527-44; PMID:23091069; http://dx.doi.org/10.1083/jcb.201203025
   PubMed Web of Science ®Google Scholar
• Gligorijevic B, Wyckoff J, Yamaguchi H, Wang Y, Roussos ET, Condeelis J. N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci 2012; 125:724-34; PMID:22389406; http://dx.doi.org/10.1242/jcs.092726
   PubMed Web of Science ®Google Scholar