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SPECIAL FOCUS: EPHRIN SIGNALING: REVIEWS

Beyond boundaries—Eph:ephrin signaling in neurogenesis

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Pages 349-359 | Received 20 May 2014, Accepted 30 Jun 2014, Published online: 20 Dec 2014

References

  • Nievergall E, Lackmann M, Janes PW. Eph-dependent cell-cell adhesion and segregation in development and cancer. Cell Mol Life Sci 2011; 69:1813-42; PMID:22204021; http://dx.doi.org/10.1007/s00018-011-0900-6
  • Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010; 10:165-80; PMID:20179713; http://dx.doi.org/10.1038/nrc2806
  • Arvanitis DN, Davy A. Regulation and mis-regulation of Eph/ephrin expression. Cell Adh Migr 2012; 6:epub; http://dx.doi.org/10.4161/cam.19690
  • Lisabeth EM, Falivelli G, Pasquale EB. Eph Receptor Signaling and Ephrins. Cold Spring Harb Perspect Biol 2013; 5:a009159; PMID:24003208; http://dx.doi.org/10.1101/cshperspect.a009159
  • Noberini R, Rubio de la Torre E, Pasquale EB. Profiling Eph receptor expression in cells and tissues: A targeted mass spectrometry approach. Cell Adh Migr 2012; 6:[ Epub ahead of print]; PMID:22568954; http://dx.doi.org/10.4161/cam.19620
  • Klein R, Kania A. Ephrin signalling in the developing nervous system. Curr Opin Neurobiol 2014; 27C:16-24; http://dx.doi.org/10.1016/j.conb.2014.02.006
  • North HA, Clifford MA, Donoghue MJ. 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation. Cereb Cortex 2013 23:1765-73; PMID:22744705; http://dx.doi.org/10.1093/cercor/bhs183
  • Hansen DV, Lui JH, Parker PR, Kriegstein AR. Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 2010; 464:554-61; PMID:20154730; http://dx.doi.org/10.1038/nature08845
  • Fietz SA, Kelava I, Vogt J, Wilsch-Bräuninger M, Stenzel D, Fish JL, Corbeil D, Riehn A, Distler W, Nitsch R, et al. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat Neurosci 2010; 13:690-9; PMID:20436478; http://dx.doi.org/10.1038/nn.2553
  • Shitamukai S, Konno D, Matsuzaki F. Oblique Radial Glial Divisions in the Developing Mouse Neocortex Induce Self-Renewing Progenitors outside the Germinal Zone That Resemble Primate Outer Subventricular Zone Progenitors. J Neurosci 2011; 31:3683-95; PMID:21389223; http://dx.doi.org/10.1523/JNEUROSCI.4773-10.2011
  • Fietz SA, Huttner WB. Cortical progenitor expansion, self-renewal and neurogenesis-a polarized perspective. Curr Opin Neurobiol 2011 21:23-35; PMID:21036598; http://dx.doi.org/10.1016/j.conb.2010.10.002
  • Ming GL, Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011 70:687-702; PMID:21609825; http://dx.doi.org/10.1016/j.neuron.2011.05.001
  • Rolando C, Taylor V. Neural stem cell of the hippocampus: development, physiology regulation, and dysfunction in disease. Curr Top Dev Biol 2014; 107:183-206; PMID:24439807; http://dx.doi.org/10.1016/B978-0-12-416022-4.00007-X
  • Miller FD, Gauthier-Fisher A. Home at last: neural stem cell niches defined. Cell Stem Cell 2009; 4:507-10; PMID:19497279; http://dx.doi.org/10.1016/j.stem.2009.05.008
  • Goldman SA, Chen Z. Perivascular instruction of cell genesis and fate in the adult brain. Nat Neurosci 2013; 14:1382-9; http://dx.doi.org/10.1038/nn.2963
  • Conover JC, Doetsch F, Garcia-Verdugo JM, Gale NW, Yancopoulos GD, Alvarez-Buylla A. Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone. Nat Neurosci 2000; 3:1091-7; PMID:11036265; http://dx.doi.org/10.1038/80606
  • Katakowski M, Zhang Z, deCarvalho AC, Chopp M. EphB2 induces proliferation and promotes a neuronal fate in adult subventricular neural precursor cells. Neurosci Lett 2005; 385:204-9; PMID:15970380; http://dx.doi.org/10.1016/j.neulet.2005.05.060
  • Ricard J, Salinas J, Garcia L, Liebl DJ. EphrinB3 regulates cell proliferation and survival in adult neurogenesis. Mol Cell Neurosci 2006; 31:713-22; PMID:16483793; http://dx.doi.org/10.1016/j.mcn.2006.01.002
  • del Valle K, Theus MH, Bethea JR, Liebl DJ, Ricard J. Neural progenitors proliferation is inhibited by EphB3 in the developing subventricular zone. Int J Devl Neurosci 2011; 29:9-14; http://dx.doi.org/10.1016/j.ijdevneu.2010.10.005
  • Chumley MJ, Catchpole T, Silvany RE, Kernie SG, Henkemeyer M. EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis. J Neurosci 2007; 27:13481-90; PMID:18057206; http://dx.doi.org/10.1523/JNEUROSCI.4158-07.2007
  • Catchpole T, Henkemeyer M. EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche. J Neurosci 2011; 31:11472-83; PMID:21832177; http://dx.doi.org/10.1523/JNEUROSCI.6349-10.2011
  • Ashton RS, Conway A, Chinmay P, Bergen J, Kwang-Il L, Shah P, Bissell M, Schaffer DV. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nat Neurosci 2012; 15:1399-407; PMID:22983209; http://dx.doi.org/10.1038/nn.3212
  • Holmberg J, Armulik A, Senti KA, Edoff K, Spalding K, Momma S, Cassidy R, Flanagan JG, Frisen J. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev 2005; 19:462-71; PMID:15713841; http://dx.doi.org/10.1101/gad.326905
  • Jiao JW, Feldheim DA, Chen DF. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. Proc Natl Acad Sci U S A 2008; 105:8778-83; PMID:18562299; http://dx.doi.org/10.1073/pnas.0708861105
  • Khodosevich K, Watanabe Y, Monyer H. EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo. J Cell Sci 2011; 124:1268-79; PMID:21444754; http://dx.doi.org/10.1242/jcs.076059
  • Hara Y, Nomura T, Yoshisaki K, Frisen J, Osumi N. Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice. Stem Cells 2010; 28:974-83; PMID:20474079
  • Fang Y, Cho KS, Tchedre K, Guo C, Kinouchi H, Fried S, Chen DF. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency. Stem Cells 2013; 31:349-59; PMID:23165658; http://dx.doi.org/10.1002/stem.1283
  • Stuckmann I, Weigmann A, Shevchenko A, Mann M, Huttner WB. Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis. J Neurosci 2001; 21:2726-37; PMID:11306625
  • Qiu R, Wang X, Davy A, Wu C, Murai KHZ, Flanagan JG, Soriano P, Lu Q. Regulation of neural progenitor cell state by ephrin-B. J Cell Biol 2008; 181:973-83; PMID:18541704; http://dx.doi.org/10.1083/jcb.200708091
  • North HA, Zhao X, Kolk SM, Clifford MA, Ziskind DM, Donoghue MJ. Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development 2009; 136:2467-76; PMID:19542359; http://dx.doi.org/10.1242/dev.034405
  • Aoki M, Yamashita T, Tohyama M. EphA Receptors Direct the Differentiation of Mammalian Neural Precursor Cells through a Mitogen-activated Protein Kinase-dependent Pathway. J Biol Chem 2004; 279:32643-50; PMID:15145949; http://dx.doi.org/10.1074/jbc.M313247200
  • Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 2005; 435:1244-50; PMID:15902206; http://dx.doi.org/10.1038/nature03651
  • Torii M, Hashimoto-Torii K, Levitt P, Rakic P. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature 2009; 461:524-8; PMID:19759535; http://dx.doi.org/10.1038/nature08362
  • Park E, Kim Y, Noh H, Lee H, Yoo S, Park S. EphA/ephrin-A signaling is critically involved in region-specific apoptosis during early brain development. Cell Death Diff 2013; 20:169-80; http://dx.doi.org/10.1038/cdd.2012.121
  • Kim Y, Park E, Noh H, Park S. Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development. Dev Neurobiol 2013 73:702-12; PMID:23696555; http://dx.doi.org/10.1002/dneu.22092
  • Willars GB. Mammalian RGS proteins: multifunctional regulators of cellular signalling. Semin Cell Dev Biol 2006; 17:363-76; PMID:16687250; http://dx.doi.org/10.1016/j.semcdb.2006.03.005
  • Murai K, Qiu R, Zhang H, Wang J, Wu C, Neubig RR, Lu Q. Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells. Stem Cells 2010 9:1581-9; http://dx.doi.org/10.1002/stem.474
  • Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J 2006; 25:1242-52; PMID:16511561; http://dx.doi.org/10.1038/sj.emboj.7601031
  • Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Presenilin-dependent intramembrane cleavage of ephrin-B1. Mol Neurodegener 2006; 1:2; PMID:16930449; http://dx.doi.org/10.1186/1750-1326-1-2
  • Wu C, Qiu R, Wang J, Zhang H, Murai K, Lu Q. ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci 2009; 29:7404-12; PMID:19515908; http://dx.doi.org/10.1523/JNEUROSCI.5841-08.2009
  • Arvanitis DN, Jungas T, Behar A, Davy A. Ephrin-B1 reverse signaling controls a post-transcriptional feedback mechanism in neural progenitors. Mol Cell Biol 2010; 30:2508-17; PMID:20308325; http://dx.doi.org/10.1128/MCB.01620-09
  • Yoshimatsu T, Kawaguchi D, Oishi K, Takeda K, Akira S, Masuyama N, Gotoh Y. Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 2006; 133:2553-63; PMID:16728475; http://dx.doi.org/10.1242/dev.02419
  • Bong YS, Lee HS, Carim-Todd L, Mood K, Nishanian TG, Tessarollo L, Daar IO. EphrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci U S A 2007; 104:17305-10; PMID:17954917; http://dx.doi.org/10.1073/pnas.0702337104
  • Arvanitis DN, Behar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A. Ephrin-B1 maintains apical adhesion of neural progenitors. Development 2013; 140:2082-92; PMID:23578932; http://dx.doi.org/10.1242/dev.088203
  • Xing S, He Y, Ling L, Hou Q, Yu J, Zeng J, Pei Z. Blockade of EphB2 enhances neurogenesis in the subventricular zone and improves neurological function after cerebral cortical infarction in hypertensive rats. Brain Res 2008; 230:237-46; http://dx.doi.org/10.1016/j.brainres.2008.06.097
  • Doeppner TN, Bretschneider E, Doehring M, Segura I, Sentu¨rk A, Acker-Palmer A, Hasan MR, ElAli A, Hermann DM, Ba¨hr M. Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia. Acta Neuropathol 2011; 122:429-42; PMID:21779764; http://dx.doi.org/10.1007/s00401-011-0856-5
  • Jing X, Miwa H, Sawada T, Nakanishi I, Kondo T, Miyajima M, Sakaguchi K. Ephrin-A1-Mediated Dopaminergic Neurogenesis and Angiogenesis in a Rat Model of Parkinson's Disease. PLoS ONE 2012; 7:e32019; PMID:22363788; http://dx.doi.org/10.1371/journal.pone.0032019
  • Theus MH, Ricard J, Bethea JR, Liebl DJ. Ephb3 Inhibits the Expansion of Neural Progenitor Cells in the SVZ by Regulating p53 During Homeostasis and Following Traumatic Brain Injury. Stem Cells 2010: Epub; PMID:20496368
  • Conway A, Schaffer DV. Biomaterial microenvironments to support the generation of new neurons in the adult brain. Stem Cells 2014; 32:1220-9; PMID:24449485; http://dx.doi.org/10.1002/stem.1650
  • Till J, McCulloch E, Siminovitch L. A Stochastic Model of Stem Cell Proliferation, Based on the Growth of Spleen Colony-Forming Cells. Proc Natl Acad Sci U S A 1964; 51:29-36; PMID:14104600; http://dx.doi.org/10.1073/pnas.51.1.29
  • Loeffler M, Roeder I. Conceptual models to understand tissue stem cell organization. Curr Opin Hematol 2004; 11:81-7; PMID:15257023; http://dx.doi.org/10.1097/01.moh.0000133648.83991.af
  • Takahashi T, Nowakowski RS, Caviness VS. Mode of cell proliferation in the developing mouse neocortex. Proc Natl Acad Sci U S A 1994; 91:375-9; PMID:8278397; http://dx.doi.org/10.1073/pnas.91.1.375
  • Caviness V, Takahashi T, Nowakowski R. Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model. Trends Neurosci 1995; 18:379-83; PMID:7482802; http://dx.doi.org/10.1016/0166-2236(95)93933-O
  • Takahashi T, Nowakowski RS, Caviness VS. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J Neurosci 1996; 16:6183-96; PMID:8815900
  • Nowakowski RS, Caviness VS, Takahashi T, Hayes NL. Population dynamics during cell proliferation and neuronogenesis in the developing murine neocortex. Res Probl Cell Differ 2002; 39:1-25; http://dx.doi.org/10.1007/978-3-540-46006-0_1.
  • Caviness VS, Goto T, Tarui T, Takahashi T, Bhide PG, Nowakowski RS. Cell output, cell cycle duration and neuronal specification: a model of integrated mechanisms of the neocortical proliferative process. Cereb Cortex 2003; 13:592-8; PMID:12764033; http://dx.doi.org/10.1093/cercor/13.6.592
  • Calegari F, Huttner WB. An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J Cell Sci 2003; 116:4947-55; PMID:14625388; http://dx.doi.org/10.1242/jcs.00825
  • McConnell MJ, MacMillan HR, Chun J. Mathematical modeling supports substantial mouse neural progenitor cell death. Neural Dev 2009; 4:28; PMID:19602274; http://dx.doi.org/10.1186/1749-8104-4-28
  • McConnell SK. Constructing the cerebral cortex: neurogenesis and fate determination. Neuron 1995; 15:761-8; PMID:7576626; http://dx.doi.org/10.1016/0896-6273(95)90168-X
  • MacMillan HR, McConnell MJ. Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development. Theory in biosciences = Theorie in den Biowissenschaften 2011; 130:31-43; PMID:20824512; http://dx.doi.org/10.1007/s12064-010-0107-7
  • Sun Z, Komarova NL. Stochastic modeling of stem-cell dynamics with control. Math Biosci 2012; 240:231-40; PMID:22960597; http://dx.doi.org/10.1016/j.mbs.2012.08.004
  • Lander AD, Gokoffski KK, Wan FYM, Nie Q, Calof AL. Cell lineages and the logic of proliferative control. PLoS biology 2009; 7:e15; PMID:19166268; http://dx.doi.org/10.1371/journal.pbio.1000015
  • Agur Z, Daniel Y, Ginosar Y. The universal properties of stem cells as pinpointed by a simple discrete model. J Math Biol 2002; 44:79-86; PMID:11942526; http://dx.doi.org/10.1007/s002850100115
  • Wu J, Rostami M, Tzanakakis E. Stem cell modeling: From gene networks to cell populations. Curr Opin Chem 2013; 2:17-25; http://dx.doi.org/10.1016/j.coche.2013.01.001
  • Zubler F, Hauri A, Pfister S, Bauer R, Anderson JC, Whatley AM, Douglas RJ. Simulating cortical development as a self constructing process: a novel multi-scale approach combining molecular and physical aspects. PLoS Comput Biol 2013; 9:e1003173; PMID:23966845; http://dx.doi.org/10.1371/journal.pcbi.1003173