1,007
Views
9
CrossRef citations to date
0
Altmetric
Commentaries

Insights into an adipocyte whitening program

Pages 75-80 | Received 11 Aug 2014, Accepted 27 Aug 2014, Published online: 28 Jan 2015

References

  • Williams G, Frühbeck G. Obesity: Science to Practice. Hoboken, NJ: Wiley; 2009.
  • Ahima RS. Digging deeper into obesity. J Clin Invest 2011; 121:2076-9; PMID:21633174; http://dx.doi.org/10.1172/JCI58719
  • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief 2012; 82:1-8.
  • Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, et al. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab 2014; 307:E262-77; PMID:24918202; http://dx.doi.org/10.1152/ajpendo.00271.2013
  • Collins S, Martin TL, Surwit RS, Robidoux J. Genetic vulnerability to diet-induced obesity in the C57BL6J mouse: physiological and molecular characteristics. Physiol Behav 2004; 81:243-8; PMID:15159170; http://dx.doi.org/10.1016/j.physbeh.2004.02.006
  • Petro AE, Cotter J, Cooper DA, Peters JC, Surwit SJ, Surwit RS. Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL6J mouse. Metabolism 2004; 53:454-7; PMID:15045691; http://dx.doi.org/10.1016/j.metabol.2003.11.018
  • Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL6J mice. Diabetes 1988; 37:1163-7; PMID:3044882; http://dx.doi.org/10.2337/diab.37.9.1163
  • West DB, Boozer CN, Moody DL, Atkinson RL. Dietary obesity in nine inbred mouse strains. Am J Physiol 1992; 262:R1025-32; PMID:1621856
  • Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, et al. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circulat Res 2012; 111:1176-89; PMID:22896587; http://dx.doi.org/10.1161/CIRCRESAHA.112.266395
  • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-808; PMID:14679176; http://dx.doi.org/10.1172/JCI200319246
  • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117:175-84; PMID:17200717; http://dx.doi.org/10.1172/JCI29881
  • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007; 56:16-23; PMID:17192460; http://dx.doi.org/10.2337/db06-1076
  • Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab 2013; 17:851-9.
  • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15:914-20; PMID:19633658; http://dx.doi.org/10.1038/nm.1964
  • Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B. Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol 2011; 187:1942-9; http://dx.doi.org/10.4049/jimmunol.1100196
  • Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW, 2nd, DeFuria J, Jick Z, Greenberg AS, Obin MS. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 2007; 56:2910-8; PMID:17848624; http://dx.doi.org/10.2337/db07-0767
  • Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Disc 2010; 9:465-82; PMID:20514071; http://dx.doi.org/10.1038/nrd3138
  • Owen OE, Kalhan SC, Hanson RW. The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 2002; 277:30409-12; PMID:12087111; http://dx.doi.org/10.1074/jbc.R200006200
  • Regard JB, Sato IT, Coughlin SR. Anatomical profiling of G protein-coupled receptor expression. Cell 2008; 135:561-71; PMID:18984166; http://dx.doi.org/10.1016/j.cell.2008.08.040
  • Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009; 7:99-109; PMID:19148178; http://dx.doi.org/10.1038/nrmicro2070
  • Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140:821-32; PMID:20303873; http://dx.doi.org/10.1016/j.cell.2010.01.040
  • Giordano A, Murano I, Mondini E, Perugini J, Smorlesi A, Severi I, Barazzoni R, Scherer PE, Cinti S. Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J Lipid Res 2013; 54:2423-36; PMID:23836106; http://dx.doi.org/10.1194/jlr.M038638
  • Yu BL, Zhao SP, Hu JR. Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity. Obes Rev 2010; 11:560-7; PMID:20025694; http://dx.doi.org/10.1111/j.1467-789X.2009.00699.x
  • Wernstedt Asterholm I, Tao C, Morley TS, Wang QA, Delgado-Lopez F, Wang ZV, Scherer PE. Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. Cell Metab 2014; 20:103-18; PMID:24930973; http://dx.doi.org/10.1016/j.cmet.2014.05.005
  • Karbowski M, Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ 2003; 10:870-80; PMID:12867994; http://dx.doi.org/10.1038/sj.cdd.4401260
  • Cheung EC, McBride HM, Slack RS. Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis: An Int J Programmed Cell Death 2007; 12:979-92; PMID:17453163; http://dx.doi.org/10.1007/s10495-007-0745-5
  • Galloway CA, Yoon Y. Mitochondrial morphology in metabolic diseases. Antioxidants Redox Signaling 2013; 19:415-30; PMID:22793999; http://dx.doi.org/10.1089/ars.2012.4779
  • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A 2009; 106:19860-5.
  • Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest 2011; 121:2094-101; PMID:21633177; http://dx.doi.org/10.1172/JCI45887
  • Wang QA, Tao C, Gupta RK, Scherer PE. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med 2013; 19:1338-44; PMID:23995282; http://dx.doi.org/10.1038/nm.3324
  • Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007; 117:2621-37.
  • Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, et al. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med 2012; 18:1539-49.
  • Trayhurn P. Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity. Ann Rev Nutr 2014; 34:207-36; PMID:24819450; http://dx.doi.org/10.1146/annurev-nutr-071812-161156
  • Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-30; PMID:14679177; http://dx.doi.org/10.1172/JCI200319451
  • Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. British J Nutr 2004; 92:347-55; PMID:15469638; http://dx.doi.org/10.1079/BJN20041213
  • Goossens GH, Bizzarri A, Venteclef N, Essers Y, Cleutjens JP, Konings E, Jocken JW, Cajlakovic M, Ribitsch V, Clement K, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011; 124:67-76; PMID:21670228; http://dx.doi.org/10.1161/CIRCULATIONAHA.111.027813
  • Hodson L, Humphreys SM, Karpe F, Frayn KN. Metabolic signatures of human adipose tissue hypoxia in obesity. Diabetes 2013; 62:1417-25; PMID:23274888; http://dx.doi.org/10.2337/db12-1032
  • Hodson L. Adipose tissue oxygenation: effects on metabolic function. Adipocyte 2014; 3:75-80; PMID:24575375; http://dx.doi.org/10.4161/adip.27114
  • Yin X, Lanza IR, Swain JM, Sarr MG, Nair KS, Jensen MD. Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size. J Clin Endocrinol Metab 2014; 99:E209-16; PMID:24276464; http://dx.doi.org/10.1210/jc.2013-3042
  • Lee YS, Kim JW, Osborne O, Oh da Y, Sasik R, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, et al. Increased adipocyte O2 consumption triggers HIF-1alpha, causing inflammation and insulin resistance in obesity. Cell 2014; 157:1339-52.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.