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Mutant IDH1: An immunotherapeutic target in tumors

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Article: e974392 | Received 22 Sep 2014, Accepted 03 Oct 2014, Published online: 07 Jan 2015

References

  • Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 2014; 512(7514):324-7; PMID:25043048; http://dx.doi.org/10.1038/nature13387
  • Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361(11):1058-66; PMID:19657110; http://dx.doi.org/10.1056/NEJMoa0903840
  • Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321(5897):1807-12; PMID:18772396; http://dx.doi.org/10.1126/science.1164382
  • Cairns RA and Mak TW. Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov 2013; 3(7):730-41; PMID:23796461; http://dx.doi.org/10.1158/2159-8290.CD-13-0083
  • Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS, Gilbert MR, Herndon JE 2nd, McLendon RE, Mitchell DA, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 2010; 28(31):4722-9; PMID:20921459; http://dx.doi.org/10.1200/JCO.2010.28.6963
  • Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, et al. Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts. J Exp Med 2010; 207(3):637-50; PMID:20156971; http://dx.doi.org/10.1084/jem.20091918
  • Muranski P and Restifo NP. Adoptive immunotherapy of cancer using CD4(+) T cells. Curr Opin Immunol 2009; 21(2):200-8; PMID:19285848; http://dx.doi.org/10.1016/j.coi.2009.02.004
  • Platten M, Ochs K, Lemke D, Opitz C, Wick W. Microenvironmental clues for glioma immunotherapy. Curr Neurol Neurosci Rep 2014; 14(4):440; PMID:24604058; http://dx.doi.org/10.1007/s11910-014-0440-1
  • Platten M, Wick W, Van den Eynde BJ. Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res 2012; 72(21):5435-40; PMID:23090118; http://dx.doi.org/10.1158/0008-5472.CAN-12-0569

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