Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis

References

• Arrasate M., Finkbeiner S. Protein aggregates in Huntington's disease. Exp Neurol 2012; 238:1-11; PMID:22200539; http://dx.doi.org/10.1016/j.expneurol.2011.12.013
   PubMed Web of Science ®Google Scholar
• Lanska DJ, Lavine L, Lanska MJ, Schoenberg BS. Huntington's disease mortality in the United States. Neurology 1988; 38:769-72; PMID:2966305; http://dx.doi.org/10.1212/WNL.38.5.769
   PubMed Web of Science ®Google Scholar
• Bradford JW, Li S, Li XJ. Polyglutamine toxicity in non-neuronal cells. Cell Res 2010; 20:400-07; PMID:20231860; http://dx.doi.org/10.1038/cr.2010.32
   PubMed Web of Science ®Google Scholar
• Chiu E, Alexander L. Causes of death in Huntington's disease. Med J Aust 1982; 1:153; PMID:6210834
   PubMed Web of Science ®Google Scholar
• Heemskerk AW, Roos RA. Aspiration pneumonia and death in Huntington's disease. PLoS Curr 2012; 4:RRN1293; PMID:22307361; http://dx.doi.org/10.1371/currents.RRN1293
   PubMedGoogle Scholar
• Sorensen SA, Fenger K. Causes of death in patients with Huntington's disease and in unaffected first degree relatives. J Med Genet 1992; 29:911-4; PMID:1479606; http://dx.doi.org/10.1136/jmg.29.12.911
   PubMed Web of Science ®Google Scholar
• Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. PLoS Genet 2013; 9:e1004024; PMID:24367279; http://dx.doi.org/10.1371/journal.pgen.1004024
   PubMed Web of Science ®Google Scholar
• Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene 2004; 342:1-11; PMID: 15527959; http://dx.doi.org/10.1016/j.gene.2004.07.018
   PubMed Web of Science ®Google Scholar
• Ocorr K, Akasaka T, Bodmer R. Age-related cardiac disease model of Drosophila. Mech Ageing Dev 2007; 128: 112-6; PMID:17125816; http://dx.doi.org/10.1016/j.mad.2006.11.023
   PubMed Web of Science ®Google Scholar
• Wolf MJ, Amrein H, Izatt JA, Choma MA, Reedy MC, Rockman HA. Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A 2006; 103:1394-9; PMID: 16432241; http://dx.doi.org/10.1073/pnas.0507359103
   PubMed Web of Science ®Google Scholar
• Li SH, Schilling G, Young WS 3rd, Li XJ, Margolis RL, Stine OC, Wagster MV, Abbott MH, Franz ML, Ranen NG, et al. Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron 1993; 11:985-93; PMID:8240819; http://dx.doi.org/10.1016/0896-6273(93)90127-D
   PubMed Web of Science ®Google Scholar
• Waters CW, Varuzhanyan G, Talmadge RJ, Voss AA. Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction. Proc Natl Acad Sci U S A 2013; 110:9160-5; PMID: 23671115; http://dx.doi.org/10.1073/pnas.1220068110
   PubMed Web of Science ®Google Scholar
• Strand AD, Aragaki AK, Shaw D, Bird T, Holton J, Turner C, Tapscott SJ, Tabrizi SJ, Schapira AH, Kooperberg C, et al. Gene expression in Huntington's disease skeletal muscle: a potential biomarker. Hum Mol Genet 2005; 14:1863-76; PMID:15888475; http://dx.doi.org/10.1093/hmg/ddi192
   PubMed Web of Science ®Google Scholar
• Han Z, Yi P, Li X, Olson EN. Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. Development 2006; 133:1175-82; PMID:16467358; http://dx.doi.org/10.1242/dev.02285
   PubMed Web of Science ®Google Scholar
• Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A 2004; 101:10132-6; PMID:15220483; http://dx.doi.org/10.1073/pnas.0401900101
   PubMed Web of Science ®Google Scholar
• Mihm MJ, Amann DM, Schanbacher BL, Altschuld RA, Bauer JA, Hoyt KR. Cardiac dysfunction in the R6/2 mouse model of Huntington's disease. Neurobiol Dis 2007; 25:297-308; PMID:17126554; http://dx.doi.org/10.1016/j.nbd.2006.09.016
   PubMed Web of Science ®Google Scholar
• Tashiro E, Zako T, Muto H, Itoo Y, Sörgjerd K, Terada N, Abe A, Miyazawa M, Kitamura A, Kitaura H, et al. Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation. J Biol Chem 2013; 288:19958-72; PMID:23720755; http://dx.doi.org/10.1074/jbc.M113.477984
   PubMed Web of Science ®Google Scholar
• Albers DS, Beal MF. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm Suppl 2000; 59:133-54; PMID: 10961426
   PubMedGoogle Scholar
• Cheng B, Gong H, Xiao H, Petersen RB, Zheng L, Huang K. Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases. Biochim Biophys Acta 2013; 1830:4860-71; PMID:23820032
   PubMed Web of Science ®Google Scholar
• Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med 2010; 2:490-503; PMID:21069748; http://dx.doi.org/10.1002/emmm.201000102
   PubMed Web of Science ®Google Scholar
• Pattison JS, Sanbe A, Maloyan A, Osinska H, Klevitsky R, Robbins J. Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation 2008; 117:2743-51; PMID:18490523; http://dx.doi.org/10.1161/CIRCULATIONAHA.107.750232
   PubMed Web of Science ®Google Scholar
• Kobayashi, Y, Kume A, Li M, Doyu M, Hata M, Ohtsuka K, Sobue G. Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 2000; 275:8772-8; PMID:10722721; http://dx.doi.org/10.1074/jbc.275.12.8772
   PubMed Web of Science ®Google Scholar
• Kuo Y, Ren S, Lao U, Edgar BA, Wang T. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis 2013; 4:e833; PMID:24091676; http://dx.doi.org/10.1038/cddis.2013.351
   PubMed Web of Science ®Google Scholar
• Kiriazis H, Jennings NL, Davern P, Lambert G, Su Y, Pang T, Du X, La Greca L, Head GA, Hannan AJ, et al. Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease. J Physiol 2012; 590:5845-60; PMID:22890713; http://dx.doi.org/10.1113/jphysiol.2012.238113
   PubMed Web of Science ®Google Scholar
• Groenendyk J, Sreenivasaiah PK, Kim do H, Agellon LB, Michalak M. Biology of endoplasmic reticulum stress in the heart. Circ Res 2010; 107:1185-97; PMID:21071716; http://dx.doi.org/10.1161/CIRCRESAHA.110.227033
   PubMed Web of Science ®Google Scholar
• Wang X, Osinska H, Klevitsky R, Gerdes AM, Nieman M, Lorenz J, Hewett T, Robbins J. Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res 2001; 89:84-91; PMID:11440982; http://dx.doi.org/10.1161/hh1301.092688
   PubMed Web of Science ®Google Scholar
• Rodolfo C, Ciccosanti F, Giacomo GD, Piacentini M, Fimia GM. Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases. Expert Rev Proteomics 2010; 7:519-42; PMID:20653508; http://dx.doi.org/10.1586/epr.10.43
   PubMed Web of Science ®Google Scholar
• Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH. Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage. Hum Mol Genet 2011; 20:1438-55; PMID:21257639; http://dx.doi.org/10.1093/hmg/ddr024
   PubMed Web of Science ®Google Scholar
• Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003; 552:335-44; PMID:14561818; http://dx.doi.org/10.1113/jphysiol.2003.049478
   PubMed Web of Science ®Google Scholar
• Barth E, Stammler G, Speiser B, Schaper J. Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. J Mol Cell Cardiol 1992; 24:669-81; PMID:1404407; http://dx.doi.org/10.1016/0022-2828(92)93381-S
   PubMed Web of Science ®Google Scholar
• Zang Q, Maass DL, White J, Horton JW. Cardiac mitochondrial damage and loss of ROS defense after burn injury: the beneficial effects of antioxidant therapy. J Appl Physiol 1985; 102:103-12 (2007); PMID:16931562; http://dx.doi.org/10.1152/japplphysiol.00359.2006
   PubMed Web of Science ®Google Scholar
• Maloyan A, Sanbe A, Osinska H, Westfall M, Robinson D, Imahashi K, Murphy E, Robbins J. Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation 2005; 112:3451-61; PMID: 16316967; http://dx.doi.org/10.1161/CIRCULATIONAHA.105.572552
   PubMed Web of Science ®Google Scholar
• Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD, Wallace DC. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet 1998; 18:159-63; PMID:9462746; http://dx.doi.org/10.1038/ng0298-159
   PubMed Web of Science ®Google Scholar
• Maloyan A, Osinska H, Lammerding J, Lee RT, Cingolani OH, Kass DA, Lorenz JN, Robbins J, et al. Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy. Circ Res 2009; 104:1021-8; PMID:19299643; http://dx.doi.org/10.1161/CIRCRESAHA.108.193516
   PubMed Web of Science ®Google Scholar
• Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochem Biophys Res Commun 2006; 342:184-90; PMID:16472774; http://dx.doi.org/10.1016/j.bbrc.2006.01.136
   PubMed Web of Science ®Google Scholar
• Taverne YJ, Bogers AJ, Duncker DJ, Merkus D. Reactive oxygen species and the cardiovascular system. Oxid Med Cell Longev 2013; 2013:862423; PMID:23738043; http://dx.doi.org/10.1155/2013/862423
   PubMed Web of Science ®Google Scholar
• Wohlgemuth SL, Crawford BD, Pilgrim DB. The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. Dev Biol 2007; 303:483-92; PMID:17189627; http://dx.doi.org/10.1016/j.ydbio.2006.11.027
   PubMed Web of Science ®Google Scholar
• Lee CF, Melkani GC, Yu Q, Suggs JA, Kronert WA, Suzuki Y, Hipolito L, Price MG, Epstein HF, Bernstein SI. Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. J Cell Sci 2011; 124:699-705; PMID:21285246; http://dx.doi.org/10.1242/jcs.078964
   PubMed Web of Science ®Google Scholar
• Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 2013; 152:183-95; PMID:23332754; http://dx.doi.org/10.1016/j.cell.2012.12.025
   PubMed Web of Science ®Google Scholar
• Melkani GC, Bodmer R, Ocorr K, Bernstein SI. The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. PLoS One 2011; 6:e22579; PMID:21799905; http://dx.doi.org/10.1371/journal.pone.0022579
   PubMed Web of Science ®Google Scholar
• Srikakulam R, Liu L, Winkelmann DA. Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS One 2008; 3:e2137; PMID:18478096; http://dx.doi.org/10.1371/journal.pone.0002137
   PubMed Web of Science ®Google Scholar
• Barral JM, Hutagalung AH, Brinker A, Hartl FU, Epstein HF. Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science 2002; 295:669-71; PMID:11809970; http://dx.doi.org/10.1126/science.1066648
   PubMed Web of Science ®Google Scholar
• Pattison JS, Robbins J. Protein misfolding and cardiac disease: establishing cause and effect. Autophagy 2008; 4:821-3; PMID:18612262; http://dx.doi.org/10.4161/auto.6502
   PubMed Web of Science ®Google Scholar
• Kim H-D, Kim CH, Rah B-J, Chung H-I, Shim T-S. Quantitative study on the relation between structural and functional properties of the hearts from three different mammals. The Anatomical Record 1994; 238:199-206; PMID:8154606; http://dx.doi.org/10.1002/ar.1092380206
   PubMedGoogle Scholar