Advanced search
Publication Cover
Molecular & Cellular Oncology Volume 1, 2014 - Issue 4
Submit an article Journal homepage
683
Views
0
CrossRef citations to date
0
Altmetric
AUTHOR'S VIEW

Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Katharina SchulenburgCell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School; Frankfurt, Germany
,
Gabor GlatzDepartment of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences; Budapest, Hungary
,
Attila RemenyiDepartment of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences; Budapest, Hungary
&
Krishnaraj RajalingamCell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School; Frankfurt, Germany;FZI; Molecular Signaling Unit; Institute for immunology; University Medical Center of the Johannes Gutenberg-University Mainz; Mainz, GermanyCorrespondence[email protected]
Article: e969170 | Received 22 Aug 2014, Accepted 26 Aug 2014, Published online: 31 Dec 2014

References

  • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007; 26:3100-12; PMID:17496909; http://dx.doi.org/10.1038/sj.onc.1210392
  • Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K. Ubiquitin-dependent regulation of MEKK23-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J 2014; 33:1784-801; PMID:24975362; http://dx.doi.org/10.15252/embj.201487808
  • Nithianandarajah-Jones GN, Wilm B, Goldring CE, Muller J, Cross MJ. ERK5: structure, regulation and function. Cell Signalling 2012; 24:2187-196; PMID:22800864; http://dx.doi.org/10.1016/j.cellsig.2012.07.007
  • Kenneth NS, Duckett CS. IAP proteins: regulators of cell migration and development. Curr Opin Cell Biol 2012; 24:871-5; PMID:23219152; http://dx.doi.org/10.1016/j.ceb.2012.11.004
  • Vucic D, Dixit VM, Wertz IE. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat Rev Mol Cell Biol 2011; 12:439-52; PMID:21697901; http://dx.doi.org/10.1038/nrm3143
  • Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer Zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Koster RW, Rajalingam K. IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. EMBO J 2011; 31:14-28; PMID:22117219; http://dx.doi.org/10.1038/emboj.2011.423
  • Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. Nat Cell Biol 2008; 10:1447-55; PMID:19011619; http://dx.doi.org/10.1038/ncb1804
  • Glatz G, Gogl G, Alexa A, Remenyi A. Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. J Biol Chem 2013; 288:8596-609; PMID:23382384; http://dx.doi.org/10.1074/jbc.M113.452235
  • Fulda S, Rajalingam K, Dikic I. Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications. EMBO Mol Med 2012; 4:545-56; PMID:22730341; http://dx.doi.org/10.1002/emmm.201100707

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.