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Commentary

Stay lean without dieting

Lose Sam68

&
Pages 246-249 | Published online: 01 Oct 2012

References

  • Lukong KE, Richard S. Sam68, the KH domain-containing superSTAR. Biochim Biophys Acta 2003; 1653:73 - 86; PMID: 14643926
  • Huot ME, Brown CM, Lamarche-Vane N, Richard S. An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization. Mol Cell Biol 2009; 29:1933 - 43; http://dx.doi.org/10.1128/MCB.01707-08; PMID: 19139276
  • Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, et al. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol Cell Biol 1995; 15:186 - 97; PMID: 7799925
  • Chen T, Damaj BB, Herrera C, Lasko P, Richard S. Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol 1997; 17:5707 - 18; PMID: 9315629
  • Huot ME, Vogel G, Zabarauskas A, Ngo CT, Coulombe-Huntington J, Majewski J, et al. The Sam68 STAR RNA-Binding Protein Regulates mTOR Alternative Splicing during Adipogenesis. Mol Cell 2012; 46:187 - 99; http://dx.doi.org/10.1016/j.molcel.2012.02.007; PMID: 22424772
  • Lin Q, Taylor SJ, Shalloway D. Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains. J Biol Chem 1997; 272:27274 - 80; http://dx.doi.org/10.1074/jbc.272.43.27274; PMID: 9341174
  • Matter N, Herrlich P, König H. Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature 2002; 420:691 - 5; http://dx.doi.org/10.1038/nature01153; PMID: 12478298
  • Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003; 4:33 - 45; http://dx.doi.org/10.1038/nrm1004; PMID: 12511867
  • Batsché E, Yaniv M, Muchardt C. The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol 2006; 13:22 - 9; http://dx.doi.org/10.1038/nsmb1030; PMID: 16341228
  • Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, et al. SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1. Cell 2011; 147:1601 - 14; http://dx.doi.org/10.1016/j.cell.2011.11.028; PMID: 22196734
  • Paronetto MP, Achsel T, Massiello A, Chalfant CE, Sette C. The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol 2007; 176:929 - 39; http://dx.doi.org/10.1083/jcb.200701005; PMID: 17371836
  • Paronetto MP, Cappellari M, Busà R, Pedrotti S, Vitali R, Comstock C, et al. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res 2010; 70:229 - 39; http://dx.doi.org/10.1158/0008-5472.CAN-09-2788; PMID: 20028857
  • Valacca C, Bonomi S, Buratti E, Pedrotti S, Baralle FE, Sette C, et al. Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol 2010; 191:87 - 99; http://dx.doi.org/10.1083/jcb.201001073; PMID: 20876280
  • Chawla G, Lin CH, Han A, Shiue L, Ares M Jr., Black DL. Sam68 regulates a set of alternatively spliced exons during neurogenesis. Mol Cell Biol 2009; 29:201 - 13; http://dx.doi.org/10.1128/MCB.01349-08; PMID: 18936165
  • Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, et al. Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis. J Cell Biol 2009; 185:235 - 49; http://dx.doi.org/10.1083/jcb.200811138; PMID: 19380878
  • Richard S, Torabi N, Franco GV, Tremblay GA, Chen T, Vogel G, et al. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet 2005; 1:e74; http://dx.doi.org/10.1371/journal.pgen.0010074; PMID: 16362077
  • Bianchi E, Barbagallo F, Valeri C, Geremia R, Salustri A, De Felici M, et al. Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development. Hum Mol Genet 2010; 19:4886 - 94; http://dx.doi.org/10.1093/hmg/ddq422; PMID: 20881015
  • Richard S, Vogel G, Huot ME, Guo T, Muller WJ, Lukong KE. Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis. Oncogene 2008; 27:548 - 56; http://dx.doi.org/10.1038/sj.onc.1210652; PMID: 17621265
  • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926 - 45; http://dx.doi.org/10.1101/gad.1212704; PMID: 15314020
  • Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, et al. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 2004; 24:6710 - 8; http://dx.doi.org/10.1128/MCB.24.15.6710-6718.2004; PMID: 15254238
  • Yeh WC, Bierer BE, McKnight SL. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci U S A 1995; 92:11086 - 90; http://dx.doi.org/10.1073/pnas.92.24.11086; PMID: 7479942
  • Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One 2009; 4:e6189; http://dx.doi.org/10.1371/journal.pone.0006189; PMID: 19593385
  • Houde VP, Brûlé S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, et al. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 2010; 59:1338 - 48; http://dx.doi.org/10.2337/db09-1324; PMID: 20299475
  • Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, Chao TH, et al. Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci 2009; 109:496 - 503; http://dx.doi.org/10.1254/jphs.08215FP; PMID: 19372632
  • Carnevalli LS, Masuda K, Frigerio F, Le Bacquer O, Um SH, Gandin V, et al. S6K1 plays a critical role in early adipocyte differentiation. Dev Cell 2010; 18:763 - 74; http://dx.doi.org/10.1016/j.devcel.2010.02.018; PMID: 20493810
  • Polak P, Cybulski N, Feige JN, Auwerx J, Rüegg MA, Hall MN. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab 2008; 8:399 - 410; http://dx.doi.org/10.1016/j.cmet.2008.09.003; PMID: 19046571
  • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200 - 5; http://dx.doi.org/10.1038/nature02866; PMID: 15306821
  • Andrade MA, Petosa C, O’Donoghue SI, Müller CW, Bork P. Comparison of ARM and HEAT protein repeats. J Mol Biol 2001; 309:1 - 18; http://dx.doi.org/10.1006/jmbi.2001.4624; PMID: 11491282