Therapeutic value of brown adipose tissue

References

• Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation 2012; 125:e2 - 220; http://dx.doi.org/10.1161/CIR.0b013e31823ac046; PMID: 22179539
   PubMed Web of Science ®Google Scholar
• Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol 2012; 59:635 - 43; http://dx.doi.org/10.1016/j.jacc.2011.08.080; PMID: 22322078
   PubMed Web of Science ®Google Scholar
• Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008; 28:629 - 36; http://dx.doi.org/10.1161/ATVBAHA.107.151092; PMID: 18174459
   PubMed Web of Science ®Google Scholar
• Gauthier MS, Ruderman NB. Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem J 2010; 430:e1 - 4; http://dx.doi.org/10.1042/BJ20101062; PMID: 20704568
   PubMedGoogle Scholar
• Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012; 53:792 - 801; http://dx.doi.org/10.1194/jlr.P022905; PMID: 22323564
   PubMed Web of Science ®Google Scholar
• Wronska A, Kmiec Z. Structural and biochemical characteristics of various white adipose tissue depots. [Epub ahead of print] Acta Physiol (Oxf) 2012; 205:194 - 208; http://dx.doi.org/10.1111/j.1748-1716.2012.02409.x; PMID: 22226221
   PubMed Web of Science ®Google Scholar
• Bjørndal B, Burri L, Staalesen V, Skorve J, Berge RK. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes 2011; 2011:490650; http://dx.doi.org/10.1155/2011/490650; PMID: 21403826
   PubMedGoogle Scholar
• Harwood HJ Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 2011; 63:57 - 75; http://dx.doi.org/10.1016/j.neuropharm.2011.12.010; PMID: 22200617
   PubMed Web of Science ®Google Scholar
• Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11:85 - 97; http://dx.doi.org/10.1038/nri2921; PMID: 21252989
   PubMed Web of Science ®Google Scholar
• Wozniak SE, Gee LL, Wachtel MS, Frezza EE. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 2009; 54:1847 - 56; http://dx.doi.org/10.1007/s10620-008-0585-3; PMID: 19052866
   PubMed Web of Science ®Google Scholar
• Wolfson N, Gavish D, Matas Z, Boaz M, Shargorodsky M. Relation of adiponectin to glucose tolerance status, adiposity, and cardiovascular risk factor load. Exp Diabetes Res 2012; 2012:250621; http://dx.doi.org/10.1155/2012/250621; PMID: 22253614
   PubMed Web of Science ®Google Scholar
• Pereira RI, Snell-Bergeon JK, Erickson C, Schauer IE, Bergman BC, Rewers M, et al. Adiponectin dysregulation and insulin resistance in type 1 diabetes. J Clin Endocrinol Metab 2012; 97:E642 - 7; http://dx.doi.org/10.1210/jc.2011-2542; PMID: 22278421
   PubMedGoogle Scholar
• Tishinsky JM, Robinson LE, Dyck DJ. Insulin-sensitizing properties of adiponectin. Biochimie 2012; http://dx.doi.org/10.1016/j.biochi.2012.01.017; PMID: 22314192
   PubMed Web of Science ®Google Scholar
• Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, et al. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest 2011; 121:2518 - 28; http://dx.doi.org/10.1172/JCI45942; PMID: 21606593
   PubMed Web of Science ®Google Scholar
• Gardener H, Sjoberg C, Crisby M, Goldberg R, Mendez A, Wright CB, et al. Adiponectin and carotid intima-media thickness in the northern Manhattan study. Stroke 2012; 43:1123 - 5; http://dx.doi.org/10.1161/STROKEAHA.111.641761; PMID: 22198981
   PubMed Web of Science ®Google Scholar
• Tian L, Luo N, Zhu X, Chung BH, Garvey WT, Fu Y. Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses. Atherosclerosis 2012; 221:66 - 75; http://dx.doi.org/10.1016/j.atherosclerosis.2011.12.014; PMID: 22227293
   PubMed Web of Science ®Google Scholar
• Carlton ED, Demas GE, French SS. Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors. Horm Behav 2012; In press http://dx.doi.org/10.1016/j.yhbeh.2012.04.010; PMID: 22561456
   PubMed Web of Science ®Google Scholar
• Bremer AA, Devaraj S, Afify A, Jialal I. Adipose tissue dysregulation in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96:E1782 - 8; http://dx.doi.org/10.1210/jc.2011-1577; PMID: 21865369
   PubMed Web of Science ®Google Scholar
• Ramachandran R, Gravenstein KS, Metter EJ, Egan JM, Ferrucci L, Chia CW. Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults. [Epub ahead of print] J Am Geriatr Soc 2012; 60:707 - 12; http://dx.doi.org/10.1111/j.1532-5415.2011.03865.x; PMID: 22417789
   PubMed Web of Science ®Google Scholar
• Satoor SN, Puranik AS, Kumar S, Williams MD, Ghale M, Rahalkar A, et al. Location, location, location: Beneficial effects of autologous fat transplantation. Sci Rep 2011; 1:81; http://dx.doi.org/10.1038/srep00081; PMID: 22355600
   PubMed Web of Science ®Google Scholar
• Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci U S A 2010; 107:240 - 5; http://dx.doi.org/10.1073/pnas.0905310107; PMID: 20007767
   PubMed Web of Science ®Google Scholar
• Snell-Bergeon JK, West NA, Mayer-Davis EJ, Liese AD, Marcovina SM, D’Agostino RB Jr., et al. Inflammatory markers are increased in youth with type 1 diabetes: the SEARCH Case-Control study. J Clin Endocrinol Metab 2010; 95:2868 - 76; http://dx.doi.org/10.1210/jc.2009-1993; PMID: 20371668
   PubMed Web of Science ®Google Scholar
• Verrijn Stuart AA, Schipper HS, Tasdelen I, Egan DA, Prakken BJ, Kalkhoven E, et al. Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type 1 diabetes. J Clin Endocrinol Metab 2012; 97:463 - 72; http://dx.doi.org/10.1210/jc.2011-1858; PMID: 22112811
   PubMed Web of Science ®Google Scholar
• Gervois P, Fruchart JC, Staels B. Inflammation, dyslipidaemia, diabetes and PPars: pharmacological interest of dual PPARalpha and PPARgamma agonists. Int J Clin Pract Suppl 2004; 22 - 9; http://dx.doi.org/10.1111/j.1368-504X.2004.00376.x; PMID: 16035393
   PubMedGoogle Scholar
• Hammarstedt A, Andersson CX, Rotter Sopasakis V, Smith U. The effect of PPARgamma ligands on the adipose tissue in insulin resistance. Prostaglandins Leukot Essent Fatty Acids 2005; 73:65 - 75; http://dx.doi.org/10.1016/j.plefa.2005.04.008; PMID: 15936183
   PubMed Web of Science ®Google Scholar
• Schwanstecher C, Schwanstecher M. Targeting type 2 diabetes. Handb Exp Pharmacol 2011; 203:1 - 33; http://dx.doi.org/10.1007/978-3-642-17214-4_1; PMID: 21484565
   PubMedGoogle Scholar
• Akash MS, Shen Q, Rehman K, Chen S. Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus. J Pharm Sci 2012; 101:1647 - 58; http://dx.doi.org/10.1002/jps.23057; PMID: 22271340
   PubMed Web of Science ®Google Scholar
• Gunawardana SC, Piston DW. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 2012; 61:674 - 82; http://dx.doi.org/10.2337/db11-0510; PMID: 22315305
   PubMed Web of Science ®Google Scholar
• Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84:277 - 359; http://dx.doi.org/10.1152/physrev.00015.2003; PMID: 14715917
   PubMed Web of Science ®Google Scholar
• Hansen JB, Kristiansen K. Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J 2006; 398:153 - 68; http://dx.doi.org/10.1042/BJ20060402; PMID: 16898874
   PubMed Web of Science ®Google Scholar
• Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab 2010; 11:257 - 62; http://dx.doi.org/10.1016/j.cmet.2010.03.005; PMID: 20374957
   PubMed Web of Science ®Google Scholar
• Billon N, Dani C. Developmental origins of the adipocyte lineage: new insights from genetics and genomics studies. Stem Cell Rev 2012; 8:55 - 66; http://dx.doi.org/10.1007/s12015-011-9242-x; PMID: 21365256
   PubMed Web of Science ®Google Scholar
• Hu X, She M, Hou H, Li Q, Shen Q, Luo Y, et al. Adiponectin decreases plasma glucose and improves insulin sensitivity in diabetic Swine. Acta Biochim Biophys Sin (Shanghai) 2007; 39:131 - 6; http://dx.doi.org/10.1111/j.1745-7270.2007.00255.x; PMID: 17277888
   PubMed Web of Science ®Google Scholar
• Fukushima M, Hattori Y, Tsukada H, Koga K, Kajiwara E, Kawano K, et al. Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection. J Gene Med 2007; 9:976 - 85; http://dx.doi.org/10.1002/jgm.1104; PMID: 17868184
   PubMed Web of Science ®Google Scholar
• Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A 2008; 105:14070 - 5; http://dx.doi.org/10.1073/pnas.0806993105; PMID: 18779578
   PubMed Web of Science ®Google Scholar
• Wang MY, Chen L, Clark GO, Lee Y, Stevens RD, Ilkayeva OR, et al. Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A 2010; 107:4813 - 9; http://dx.doi.org/10.1073/pnas.0909422107; PMID: 20194735
   PubMed Web of Science ®Google Scholar
• Kraus D, Herman MA, Kahn BB. Leveraging leptin for type I diabetes?. Proc Natl Acad Sci U S A 2010; 107:4793 - 4; http://dx.doi.org/10.1073/pnas.1000736107; PMID: 20212134
   PubMed Web of Science ®Google Scholar
• Gunawardana SC, Benninger RKP, Piston DW. Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes. Am J Physiol Endocrinol Metab 2009; 296:E323 - 32; http://dx.doi.org/10.1152/ajpendo.90544.2008; PMID: 19066321
   PubMedGoogle Scholar
• Gunawardana SC, Benninger RKP, Piston DW. Blood glucose regulation through adipose tissue hormones following subcutaneous transplantation of pancreas. Keystone Symposia, Banff, Alberta, January 2009.
   Google Scholar
• Miranda S, González-Rodríguez A, Revuelta-Cervantes J, Rondinone CM, Valverde AM. Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli. Cell Signal 2010; 22:645 - 59; http://dx.doi.org/10.1016/j.cellsig.2009.11.019; PMID: 20026400
   PubMed Web of Science ®Google Scholar
• Lowell BB, Flier JS. Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med 1997; 48:307 - 16; http://dx.doi.org/10.1146/annurev.med.48.1.307; PMID: 9046964
   PubMed Web of Science ®Google Scholar
• Gómez-Herńndez A, Otero YF, de las Heras N, Escribano O, Cachofeiro V, Lahera V, et al. Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction. Endocrinology 2012; 153:1242 - 55; http://dx.doi.org/10.1210/en.2011-1765; PMID: 22253415
   PubMed Web of Science ®Google Scholar
• Skarulis MC, Celi FS, Mueller E, Zemskova M, Malek R, Hugendubler L, et al. Thyroid hormone induced brown adipose tissue and amelioration of diabetes in a patient with extreme insulin resistance. J Clin Endocrinol Metab 2010; 95:256 - 62; http://dx.doi.org/10.1210/jc.2009-0543; PMID: 19897683
   PubMed Web of Science ®Google Scholar
• Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360:1509 - 17; http://dx.doi.org/10.1056/NEJMoa0810780; PMID: 19357406
   PubMed Web of Science ®Google Scholar
• Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58:1526 - 31; http://dx.doi.org/10.2337/db09-0530; PMID: 19401428
   PubMed Web of Science ®Google Scholar
• Cypess AM, Kahn CR. Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 2010; 17:143 - 9; http://dx.doi.org/10.1097/MED.0b013e328337a81f; PMID: 20160646
   PubMed Web of Science ®Google Scholar
• Ginter E, Simko V. Brown fat tissue—a potential target to combat obesity. Bratisl Lek Listy 2012; 113:52 - 6; PMID: 22380505
   PubMed Web of Science ®Google Scholar
• Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 2010; 6:195 - 213; http://dx.doi.org/10.1038/nrendo.2010.20; PMID: 20195269
   PubMed Web of Science ®Google Scholar
• Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011; 121:96 - 105; http://dx.doi.org/10.1172/JCI44271; PMID: 21123942
   PubMed Web of Science ®Google Scholar
• Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 2012; 15:395 - 404; http://dx.doi.org/10.1016/j.cmet.2012.01.019; PMID: 22405074
   PubMed Web of Science ®Google Scholar
• Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481:463 - 8; http://dx.doi.org/10.1038/nature10777; PMID: 22237023
   PubMed Web of Science ®Google Scholar
• Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 2010; 328:1158 - 61; http://dx.doi.org/10.1126/science.1186034; PMID: 20448152
   PubMed Web of Science ®Google Scholar
• Bordicchia M, Liu D, Amri EZ, Ailhaud G, Dessì-Fulgheri P, Zhang C, et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest 2012; 122:1022 - 36; http://dx.doi.org/10.1172/JCI59701; PMID: 22307324
   PubMed Web of Science ®Google Scholar
• Hansen BF, Glendorf T, Hegelund AC, Lundby A, Lützen A, Slaaby R, et al. Molecular Characterisation of Long-Acting Insulin Analogues in Comparison with Human Insulin, IGF-1 and Insulin X10. PLoS One 2012; 7:e34274; http://dx.doi.org/10.1371/journal.pone.0034274; PMID: 22590494
   PubMedGoogle Scholar
• Holly J, Sabin M, Perks C, Shield J. Adipogenesis and IGF-1. Metab Syndr Relat Disord 2006; 4:43 - 50; http://dx.doi.org/10.1089/met.2006.4.43; PMID: 18370770
   PubMedGoogle Scholar
• Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, et al. IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One 2011; 6:e28663; http://dx.doi.org/10.1371/journal.pone.0028663; PMID: 22194879
   PubMed Web of Science ®Google Scholar
• Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab 2009; 297:E1105 - 14; http://dx.doi.org/10.1152/ajpendo.00348.2009; PMID: 19706786
   PubMed Web of Science ®Google Scholar
• Ge X, Chen C, Hui X, Wang Y, Lam KS, Xu A. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J Biol Chem 2011; 286:34533 - 41; http://dx.doi.org/10.1074/jbc.M111.248591; PMID: 21846717
   PubMed Web of Science ®Google Scholar
• Domouzoglou EM, Maratos-Flier E. Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr 2011; 93:901S - 5; http://dx.doi.org/10.3945/ajcn.110.001941; PMID: 21346090
   PubMed Web of Science ®Google Scholar
• Phillips LK, Prins JB. Update on incretin hormones. Ann N Y Acad Sci 2011; 1243:E55 - 74; http://dx.doi.org/10.1111/j.1749-6632.2012.06491.x; PMID: 22545749
   PubMed Web of Science ®Google Scholar
• Challa TD, Beaton N, Arnold M, Rudofsky G, Langhans W, Wolfrum C. Regulation of adipocyte formation by GLP-1/GLP-1R signaling. J Biol Chem 2012; 287:6421 - 30; http://dx.doi.org/10.1074/jbc.M111.310342; PMID: 22207759
   PubMed Web of Science ®Google Scholar
• Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000; 105:271 - 8; http://dx.doi.org/10.1172/JCI7901; PMID: 10675352
   PubMed Web of Science ®Google Scholar
• Klebanov S, Astle CM, DeSimone O, Ablamunits V, Harrison DE. Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility. J Endocrinol 2005; 186:203 - 11; http://dx.doi.org/10.1677/joe.1.06150; PMID: 16002549
   PubMed Web of Science ®Google Scholar
• Ablamunits V, Klebanov S, Giese SY, Herold KC. Functional human to mouse adipose tissue xenotransplantation. J Endocrinol 2012; 212:41 - 7; http://dx.doi.org/10.1530/JOE-11-0201; PMID: 22007021
   PubMed Web of Science ®Google Scholar