Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer

References

• Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg 2005; 241:27 - 39; PMID: 15621988
   PubMed Web of Science ®Google Scholar
• Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345:725 - 30; http://dx.doi.org/10.1056/NEJMoa010187; PMID: 11547741
   PubMed Web of Science ®Google Scholar
• Zheng L, Wang L, Ajani J, Xie K. Molecular basis of gastric cancer development and progression. Gastric Cancer 2004; 7:61 - 77; http://dx.doi.org/10.1007/s10120-004-0277-4; PMID: 15224192
   PubMedGoogle Scholar
• Zhang XW, Sheng YP, Li Q, Qin W, Lu YW, Cheng YF, et al. BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. Mol Cancer 2010; 9:40; http://dx.doi.org/10.1186/1476-4598-9-40; PMID: 20170541
   PubMed Web of Science ®Google Scholar
• de Maat MF, van de Velde CJ, Umetani N, de Heer P, Putter H, van Hoesel AQ, et al. Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer. J Clin Oncol 2007; 25:4887 - 94; http://dx.doi.org/10.1200/JCO.2006.09.8921; PMID: 17971584
   PubMed Web of Science ®Google Scholar
• Hayashi M, Inokuchi M, Takagi Y, Yamada H, Kojima K, Kumagai J, et al. High expression of HER3 is associated with a decreased survival in gastric cancer. Clin Cancer Res 2008; 14:7843 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-08-1064; PMID: 19047113
   PubMed Web of Science ®Google Scholar
• Chatterjee D, Sabo E, Tavares R, Resnick MB. Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome. Clin Cancer Res 2008; 14:2994 - 3001; http://dx.doi.org/10.1158/1078-0432.CCR-07-4496; PMID: 18483365
   PubMed Web of Science ®Google Scholar
• Zhao ZS, Wang YY, Chu YQ, Ye ZY, Tao HQ. SPARC is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res 2010; 16:260 - 8; http://dx.doi.org/10.1158/1078-0432.CCR-09-1247; PMID: 20028745
   PubMed Web of Science ®Google Scholar
• De Vita F, Giuliani F, Silvestris N, Catalano G, Ciardiello F, Orditura M. Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target. Cancer Treat Rev 2010; 36:Suppl 3 S11 - 5; http://dx.doi.org/10.1016/S0305-7372(10)70014-1; PMID: 21129604
   PubMed Web of Science ®Google Scholar
• Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376:687 - 97; http://dx.doi.org/10.1016/S0140-6736(10)61121-X; PMID: 20728210
   PubMed Web of Science ®Google Scholar
• Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nature reviews 2005; 5:886-97.
   Google Scholar
• Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science (New York, NY 2000; 290:1717-21.
   Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069 - 75; http://dx.doi.org/10.1038/nature06639; PMID: 18305538
   PubMed Web of Science ®Google Scholar
• Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP. Autophagy regulates programmed cell death during the plant innate immune response. Cell 2005; 121:567 - 77; http://dx.doi.org/10.1016/j.cell.2005.03.007; PMID: 15907470
   PubMed Web of Science ®Google Scholar
• Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120:237 - 48; http://dx.doi.org/10.1016/j.cell.2004.11.046; PMID: 15680329
   PubMed Web of Science ®Google Scholar
• Colell A, Ricci JE, Tait S, Milasta S, Maurer U, Bouchier-Hayes L, et al. GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 2007; 129:983 - 97; http://dx.doi.org/10.1016/j.cell.2007.03.045; PMID: 17540177
   PubMed Web of Science ®Google Scholar
• Zeng X, Overmeyer JH, Maltese WA. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 2006; 119:259 - 70; http://dx.doi.org/10.1242/jcs.02735; PMID: 16390869
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672 - 6; http://dx.doi.org/10.1038/45257; PMID: 10604474
   PubMed Web of Science ®Google Scholar
• Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59:59 - 65; http://dx.doi.org/10.1006/geno.1999.5851; PMID: 10395800
   PubMed Web of Science ®Google Scholar
• Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809 - 20; PMID: 14638851
   PubMed Web of Science ®Google Scholar
• Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077 - 82; http://dx.doi.org/10.1073/pnas.2436255100; PMID: 14657337
   PubMed Web of Science ®Google Scholar
• Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927 - 39; http://dx.doi.org/10.1016/j.cell.2005.07.002; PMID: 16179260
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26:2527 - 39; http://dx.doi.org/10.1038/sj.emboj.7601689; PMID: 17446862
   PubMed Web of Science ®Google Scholar
• Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282:13123 - 32; http://dx.doi.org/10.1074/jbc.M700492200; PMID: 17337444
   PubMed Web of Science ®Google Scholar
• Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621 - 35; http://dx.doi.org/10.1101/gad.1565707; PMID: 17606641
   PubMed Web of Science ®Google Scholar
• Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21:1367 - 81; http://dx.doi.org/10.1101/gad.1545107; PMID: 17510285
   PubMed Web of Science ®Google Scholar
• Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, Dai Z, et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008; 68:9167 - 75; http://dx.doi.org/10.1158/0008-5472.CAN-08-1573; PMID: 19010888
   PubMed Web of Science ®Google Scholar
• Yokozaki H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int 2000; 50:767 - 77; http://dx.doi.org/10.1046/j.1440-1827.2000.01117.x; PMID: 11107048
   PubMed Web of Science ®Google Scholar
• Zou XM, Li YL, Wang H, Cui W, Li XL, Fu SB, et al. Gastric cancer cell lines induced by trichostatin A. World J Gastroenterol 2008; 14:4810 - 5; http://dx.doi.org/10.3748/wjg.14.4810; PMID: 18720545
   PubMed Web of Science ®Google Scholar
• Wang J. Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 2008; 4:947 - 8; PMID: 18769161
   PubMed Web of Science ®Google Scholar
• Shen Y, Li DD, Wang LL, Deng R, Zhu XF. Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 2008; 4:1067 - 8; PMID: 18776739
   PubMed Web of Science ®Google Scholar
• Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, Monciatti I, et al. Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 2007; 30:429 - 36; PMID: 17203225
   PubMed Web of Science ®Google Scholar
• Shi YH, Ding ZB, Zhou J, Qiu SJ, Fan J. Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 2009; 5:380 - 2; http://dx.doi.org/10.4161/auto.5.3.7658; PMID: 19145109
   PubMed Web of Science ®Google Scholar
• Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009; 5:303 - 6; http://dx.doi.org/10.4161/auto.5.3.7491; PMID: 19066461
   PubMed Web of Science ®Google Scholar
• Wan XB, Fan XJ, Chen MY, Xiang J, Huang PY, Guo L, et al. Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 2010; 6:395 - 404; http://dx.doi.org/10.4161/auto.6.3.11303; PMID: 20150769
   PubMed Web of Science ®Google Scholar
• Wang J, Lian H, Zhao Y, Kauss MA, Spindel S. Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem 2008; 283:25596 - 605; http://dx.doi.org/10.1074/jbc.M801716200; PMID: 18628207
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3:374 - 6; PMID: 17438366
   PubMed Web of Science ®Google Scholar
• Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, et al. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ 2011; 18:60 - 71; http://dx.doi.org/10.1038/cdd.2010.74; PMID: 20577262
   PubMed Web of Science ®Google Scholar
• Tian S, Lin J, Jun Zhou J, Wang X, Li Y, Ren X, et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 2010; 6:1032 - 41; http://dx.doi.org/10.4161/auto.6.8.13336; PMID: 20818185
   PubMed Web of Science ®Google Scholar
• Chen C, Ma Q, Ma X, Liu Z, Liu X. Association of Elevated HIF-2alpha Levels with Low Beclin 1 Expression and Poor Prognosis in Patients with Chondrosarcoma. Ann Surg Oncol 2011; 18:2364 - 72; http://dx.doi.org/10.1245/s10434-011-1587-5; PMID: 21327823
   PubMed Web of Science ®Google Scholar
• Xie D, Sham JS, Zeng WF, Lin HL, Che LH, Wu HX, et al. Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. Int J Cancer 2003; 107:896 - 902; http://dx.doi.org/10.1002/ijc.11514; PMID: 14601048
   PubMed Web of Science ®Google Scholar
• Zlobec I, Steele R, Terracciano L, Jass JR, Lugli A. Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer. J Clin Pathol 2007; 60:1112 - 6; http://dx.doi.org/10.1136/jcp.2006.044537; PMID: 17182662
   PubMed Web of Science ®Google Scholar