ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells

References

• Liu J, Tran V, Leung AS, Alexander DC, Zhu B. BCG vaccines: their mechanisms of attenuation and impact on safety and protective efficacy. Hum Vaccin 2009; 5:70 - 8; http://dx.doi.org/10.4161/hv.5.2.7210; PMID: 19164935
   PubMed Web of Science ®Google Scholar
• Aagaard C, Dietrich J, Doherty M, Andersen P. TB vaccines: current status and future perspectives. Immunol Cell Biol 2009; 87:279 - 86; http://dx.doi.org/10.1038/icb.2009.14; PMID: 19350048
   PubMed Web of Science ®Google Scholar
• Brosch R, Gordon SV, Garnier T, Eiglmeier K, Frigui W, Valenti P, et al. Genome plasticity of BCG and impact on vaccine efficacy. Proc Natl Acad Sci U S A 2007; 104:5596 - 601; http://dx.doi.org/10.1073/pnas.0700869104; PMID: 17372194
   PubMed Web of Science ®Google Scholar
• Simeone R, Bottai D, Brosch R. ESX/type VII secretion systems and their role in host-pathogen interaction. Curr Opin Microbiol 2009; 12:4 - 10; http://dx.doi.org/10.1016/j.mib.2008.11.003; PMID: 19155186
   PubMed Web of Science ®Google Scholar
• Kumar D, Rao KV. Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances. Microbes Infect 2011; 13:121 - 33; http://dx.doi.org/10.1016/j.micinf.2010.10.009; PMID: 20971210
   PubMed Web of Science ®Google Scholar
• Deretic V, Delgado M, Vergne I, Master S, De Haro S, Ponpuak M, et al. Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol 2009; 335:169 - 88; http://dx.doi.org/10.1007/978-3-642-00302-8_8; PMID: 19802565
   PubMed Web of Science ®Google Scholar
• Vergne I, Chua J, Deretic V. Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking. Traffic 2003; 4:600 - 6; http://dx.doi.org/10.1034/j.1600-0854.2003.00120.x; PMID: 12911814
   PubMed Web of Science ®Google Scholar
• Rohde K, Yates RM, Purdy GE, Russell DG. Mycobacterium tuberculosis and the environment within the phagosome. Immunol Rev 2007; 219:37 - 54; http://dx.doi.org/10.1111/j.1600-065X.2007.00547.x; PMID: 17850480
   PubMed Web of Science ®Google Scholar
• Alonso S, Pethe K, Russell DG, Purdy GE. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc Natl Acad Sci U S A 2007; 104:6031 - 6; http://dx.doi.org/10.1073/pnas.0700036104; PMID: 17389386
   PubMed Web of Science ®Google Scholar
• Biswas D, Qureshi OS, Lee WY, Croudace JE, Mura M, Lammas DA. ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages. BMC Immunol 2008; 9:35; http://dx.doi.org/10.1186/1471-2172-9-35; PMID: 18627610
   PubMed Web of Science ®Google Scholar
• Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313:1438 - 41; http://dx.doi.org/10.1126/science.1129577; PMID: 16888103
   PubMed Web of Science ®Google Scholar
• Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753 - 66; http://dx.doi.org/10.1016/j.cell.2004.11.038; PMID: 15607973
   PubMed Web of Science ®Google Scholar
• Jagannath C, Lindsey DR, Dhandayuthapani S, Xu Y, Hunter RL Jr., Eissa NT. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med 2009; 15:267 - 76; http://dx.doi.org/10.1038/nm.1928; PMID: 19252503
   PubMed Web of Science ®Google Scholar
• Kumar D, Nath L, Kamal MA, Varshney A, Jain A, Singh S, et al. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 2010; 140:731 - 43; http://dx.doi.org/10.1016/j.cell.2010.02.012; PMID: 20211141
   PubMed Web of Science ®Google Scholar
• Schmid D, Münz C. Innate and adaptive immunity through autophagy. Immunity 2007; 27:11 - 21; http://dx.doi.org/10.1016/j.immuni.2007.07.004; PMID: 17663981
   PubMed Web of Science ®Google Scholar
• Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009; 5:527 - 49; http://dx.doi.org/10.1016/j.chom.2009.05.016; PMID: 19527881
   PubMed Web of Science ®Google Scholar
• Virgin HW, Levine B. Autophagy genes in immunity. Nat Immunol 2009; 10:461 - 70; http://dx.doi.org/10.1038/ni.1726; PMID: 19381141
   PubMed Web of Science ®Google Scholar
• Levine B, Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 2007; 7:767 - 77; http://dx.doi.org/10.1038/nri2161; PMID: 17767194
   PubMed Web of Science ®Google Scholar
• Van Limbergen J, Stevens C, Nimmo ER, Wilson DC, Satsangi J. Autophagy: from basic science to clinical application. Mucosal Immunol 2009; 2:315 - 30; http://dx.doi.org/10.1038/mi.2009.20; PMID: 19421182
   PubMed Web of Science ®Google Scholar
• Münz C. Enhancing immunity through autophagy. Annu Rev Immunol 2009; 27:423 - 49; http://dx.doi.org/10.1146/annurev.immunol.021908.132537; PMID: 19105657
   PubMed Web of Science ®Google Scholar
• Schmid D, Pypaert M, Münz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007; 26:79 - 92; http://dx.doi.org/10.1016/j.immuni.2006.10.018; PMID: 17182262
   PubMed Web of Science ®Google Scholar
• Giacomini E, Iona E, Ferroni L, Miettinen M, Fattorini L, Orefici G, et al. Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J Immunol 2001; 166:7033 - 41; PMID: 11390447
   PubMed Web of Science ®Google Scholar
• Lande R, Giacomini E, Grassi T, Remoli ME, Iona E, Miettinen M, et al. IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: selective recruitment of NK and activated T cells. J Immunol 2003; 170:1174 - 82; PMID: 12538673
   PubMed Web of Science ®Google Scholar
• Remoli ME, Giacomini E, Lutfalla G, Dondi E, Orefici G, Battistini A, et al. Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis. J Immunol 2002; 169:366 - 74; PMID: 12077266
   PubMed Web of Science ®Google Scholar
• Harris J, De Haro SA, Master SS, Keane J, Roberts EA, Delgado M, et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007; 27:505 - 17; http://dx.doi.org/10.1016/j.immuni.2007.07.022; PMID: 17892853
   PubMed Web of Science ®Google Scholar
• Haidinger M, Poglitsch M, Geyeregger R, Kasturi S, Zeyda M, Zlabinger GJ, et al. A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J Immunol 2010; 185:3919 - 31; http://dx.doi.org/10.4049/jimmunol.1000296; PMID: 20805416
   PubMed Web of Science ®Google Scholar
• Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, et al. The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A 2003; 100:12420 - 5; http://dx.doi.org/10.1073/pnas.1635213100; PMID: 14557547
   PubMed Web of Science ®Google Scholar
• Brodin P, de Jonge MI, Majlessi L, Leclerc C, Nilges M, Cole ST, et al. Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity. J Biol Chem 2005; 280:33953 - 9; http://dx.doi.org/10.1074/jbc.M503515200; PMID: 16048998
   PubMed Web of Science ®Google Scholar
• Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun 2006; 74:88 - 98; http://dx.doi.org/10.1128/IAI.74.1.88-98.2006; PMID: 16368961
   PubMed Web of Science ®Google Scholar
• Pym AS, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat Med 2003; 9:533 - 9; http://dx.doi.org/10.1038/nm859; PMID: 12692540
   PubMed Web of Science ®Google Scholar
• Frigui W, Bottai D, Majlessi L, Monot M, Josselin E, Brodin P, et al. Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog 2008; 4:e33; http://dx.doi.org/10.1371/journal.ppat.0040033; PMID: 18282096
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323 - 35; http://dx.doi.org/10.1038/nature09782; PMID: 21248839
   PubMed Web of Science ®Google Scholar
• Remoli ME, Gafa V, Giacomini E, Severa M, Lande R, Coccia EM. IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur J Immunol 2007; 37:3499 - 508; http://dx.doi.org/10.1002/eji.200737566; PMID: 17985330
   PubMed Web of Science ®Google Scholar
• Ní Cheallaigh C, Keane J, Lavelle EC, Hope JC, Harris J. Autophagy in the immune response to tuberculosis: clinical perspectives. Clin Exp Immunol 2011; 164:291 - 300; http://dx.doi.org/10.1111/j.1365-2249.2011.04381.x; PMID: 21438870
   PubMed Web of Science ®Google Scholar
• Renshaw PS, Veverka V, Kelly G, Frenkiel TA, Williamson RA, Gordon SV, et al. Sequence-specific assignment and secondary structure determination of the 195-residue complex formed by the Mycobacterium tuberculosis proteins CFP-10 and ESAT-6. J Biomol NMR 2004; 30:225 - 6; http://dx.doi.org/10.1023/B:JNMR.0000048852.40853.5c; PMID: 15557808
   PubMed Web of Science ®Google Scholar
• de Jonge MI, Pehau-Arnaudet G, Fretz MM, Romain F, Bottai D, Brodin P, et al. ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. J Bacteriol 2007; 189:6028 - 34; http://dx.doi.org/10.1128/JB.00469-07; PMID: 17557817
   PubMed Web of Science ®Google Scholar
• Vergne I, Chua J, Lee HH, Lucas M, Belisle J, Deretic V. Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 2005; 102:4033 - 8; http://dx.doi.org/10.1073/pnas.0409716102; PMID: 15753315
   PubMed Web of Science ®Google Scholar
• Shin DM, Jeon BY, Lee HM, Jin HS, Yuk JM, Song CH, et al. Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathog 2010; 6:e1001230; http://dx.doi.org/10.1371/journal.ppat.1001230; PMID: 21187903
   PubMed Web of Science ®Google Scholar
• Samuel LP, Song CH, Wei J, Roberts EA, Dahl JL, Barry CE 3rd, et al. Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion. Microbiology 2007; 153:529 - 40; http://dx.doi.org/10.1099/mic.0.2006/002642-0; PMID: 17259625
   PubMed Web of Science ®Google Scholar
• Lerena MC, Colombo MI. Mycobacterium marinum induces a marked LC3 recruitment to its containing phagosome that depends on a functional ESX-1 secretion system. Cell Microbiol 2011; 13:814 - 35; http://dx.doi.org/10.1111/j.1462-5822.2011.01581.x; PMID: 21447143
   PubMed Web of Science ®Google Scholar
• Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol 2004; 53:1677 - 93; http://dx.doi.org/10.1111/j.1365-2958.2004.04261.x; PMID: 15341647
   PubMed Web of Science ®Google Scholar
• Collins CA, De Mazière A, van Dijk S, Carlsson F, Klumperman J, Brown EJ. Atg5-independent sequestration of ubiquitinated mycobacteria. PLoS Pathog 2009; 5:e1000430; http://dx.doi.org/10.1371/journal.ppat.1000430; PMID: 19436699
   PubMed Web of Science ®Google Scholar
• Smith J, Manoranjan J, Pan M, Bohsali A, Xu J, Liu J, et al. Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole. Infect Immun 2008; 76:5478 - 87; http://dx.doi.org/10.1128/IAI.00614-08; PMID: 18852239
   PubMed Web of Science ®Google Scholar
• van der Wel N, Hava D, Houben D, Fluitsma D, van Zon M, Pierson J, et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 2007; 129:1287 - 98; http://dx.doi.org/10.1016/j.cell.2007.05.059; PMID: 17604718
   PubMed Web of Science ®Google Scholar
• Petruccioli E, Romagnoli A, Corazzari M, Coccia EM, Butera O, Delogu G, et al. Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. J Infect Dis 2012; 205:1425 - 35; http://dx.doi.org/10.1093/infdis/jis226; PMID: 22457295
   PubMed Web of Science ®Google Scholar
• Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 2010; 189:925 - 35; http://dx.doi.org/10.1083/jcb.201002021; PMID: 20548099
   PubMed Web of Science ®Google Scholar
• Harris J, Hartman M, Roche C, Zeng SG, O’Shea A, Sharp FA, et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011; 286:9587 - 97; http://dx.doi.org/10.1074/jbc.M110.202911; PMID: 21228274
   PubMed Web of Science ®Google Scholar
• Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007; 315:1398 - 401; http://dx.doi.org/10.1126/science.1136880; PMID: 17272685
   PubMed Web of Science ®Google Scholar
• Giacomini E, Remoli ME, Gafa V, Pardini M, Fattorini L, Coccia EM. IFN-beta improves BCG immunogenicity by acting on DC maturation. J Leukoc Biol 2009; 85:462 - 8; http://dx.doi.org/10.1189/jlb.0908583; PMID: 19056860
   PubMed Web of Science ®Google Scholar
• Bardarov S, Kriakov J, Carriere C, Yu S, Vaamonde C, McAdam RA, et al. Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 1997; 94:10961 - 6; http://dx.doi.org/10.1073/pnas.94.20.10961; PMID: 9380742
   PubMed Web of Science ®Google Scholar
• Delogu G, Pusceddu C, Bua A, Fadda G, Brennan MJ, Zanetti S. Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Mol Microbiol 2004; 52:725 - 33; http://dx.doi.org/10.1111/j.1365-2958.2004.04007.x; PMID: 15101979
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, Cuervo AM, Ravikumar B, Sarkar S, Korolchuk V, Kaushik S, et al. In search of an “autophagomometer”. Autophagy 2009; 5:585 - 9; http://dx.doi.org/10.4161/auto.5.5.8823; PMID: 19411822
   PubMed Web of Science ®Google Scholar