Autophagy is a protective response to ethanol neurotoxicity

References

• Riley EP, McGee CL. Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior. Exp Biol Med (Maywood) 2005; 230:357 - 65; PMID: 15956765
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Zeh HJ 3rd, Lotze MT. High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal 2011; 14:1315 - 35; http://dx.doi.org/10.1089/ars.2010.3356; PMID: 20969478
   PubMed Web of Science ®Google Scholar
• Yang C, Han LO. Knockdown of Beclin 1 inhibits vitamin K3‑induced autophagy, but promotes apoptosis of human hepatoma SMMC-7721 cells. Mol Med Report 2010; 3:801 - 7; PMID: 21472317
   PubMed Web of Science ®Google Scholar
• Larsen KB, Lamark T, Øvervatn A, Harneshaug I, Johansen T, Bjørkøy G. A reporter cell system to monitor autophagy based on p62/SQSTM1. Autophagy 2010; 6:784 - 93; http://dx.doi.org/10.4161/auto.6.6.12510; PMID: 20574168
   PubMed Web of Science ®Google Scholar
• Chen Y, Gibson SB. Is mitochondrial generation of reactive oxygen species a trigger for autophagy?. Autophagy 2008; 4:246 - 8; PMID: 18094624
   PubMed Web of Science ®Google Scholar
• Kimura S, Fujita N, Noda T, Yoshimori T. Monitoring autophagy in mammalian cultured cells through the dynamics of LC3.. Methods Enzymol 2009; 452:1 - 12; http://dx.doi.org/10.1016/S0076-6879(08)03601-X; PMID: 19200872
   PubMed Web of Science ®Google Scholar
• Ichimura Y, Komatsu M. Selective degradation of p62 by autophagy. Semin Immunopathol 2010; 32:431 - 6; http://dx.doi.org/10.1007/s00281-010-0220-1; PMID: 20814791
   PubMed Web of Science ®Google Scholar
• Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, et al. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ 2007; 14:1948 - 57; http://dx.doi.org/10.1038/sj.cdd.4402207; PMID: 17690712
   PubMed Web of Science ®Google Scholar
• Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 2010; 285:10850 - 61; http://dx.doi.org/10.1074/jbc.M109.080796; PMID: 20123989
   PubMed Web of Science ®Google Scholar
• Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11:777 - 90; http://dx.doi.org/10.1089/ars.2008.2270; PMID: 18828708
   PubMed Web of Science ®Google Scholar
• Henderson GI, Chen JJ, Schenker S. Ethanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci 1999; 4:D541 - 50; http://dx.doi.org/10.2741/Henderson; PMID: 10369807
   PubMedGoogle Scholar
• Zhang Z, Wang X, Cheng S, Sun L, Son YO, Yao H, et al. Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/β-catenin pathway in human colorectal adenocarcinoma DLD1 cells. Toxicol Appl Pharmacol 2011; 256:114 - 21; http://dx.doi.org/10.1016/j.taap.2011.07.016; PMID: 21854796
   PubMed Web of Science ®Google Scholar
• Pan J, Chang Q, Wang X, Son Y, Zhang Z, Chen G, et al. Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol 2010; 23:568 - 77; http://dx.doi.org/10.1021/tx9003193; PMID: 20112989
   PubMed Web of Science ®Google Scholar
• Liu Y, Chen G, Ma C, Bower KA, Xu M, Fan Z, et al. Overexpression of glycogen synthase kinase 3beta sensitizes neuronal cells to ethanol toxicity. J Neurosci Res 2009; 87:2793 - 802; http://dx.doi.org/10.1002/jnr.22098; PMID: 19382207
   PubMed Web of Science ®Google Scholar
• Nowoslawski L, Klocke BJ, Roth KA. Molecular regulation of acute ethanol-induced neuron apoptosis. J Neuropathol Exp Neurol 2005; 64:490 - 7; PMID: 15977640
   PubMed Web of Science ®Google Scholar
• Giansanti V, Torriglia A, Scovassi AI. Conversation between apoptosis and autophagy: “Is it your turn or mine?”. Apoptosis 2011; 16:321 - 33; http://dx.doi.org/10.1007/s10495-011-0589-x; PMID: 21404107
   PubMed Web of Science ®Google Scholar
• Krebiehl G, Ruckerbauer S, Burbulla LF, Kieper N, Maurer B, Waak J, et al. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson’s disease-associated protein DJ-1. PLoS One 2010; 5:e9367; http://dx.doi.org/10.1371/journal.pone.0009367; PMID: 20186336
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22:124 - 31; http://dx.doi.org/10.1016/j.ceb.2009.11.014; PMID: 20034776
   PubMed Web of Science ®Google Scholar
• Osna NA, Thomes PG, Jr TM. Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol 2011; 17:2507 - 14; http://dx.doi.org/10.3748/wjg.v17.i20.2507; PMID: 21633655
   PubMed Web of Science ®Google Scholar
• Ge W, Ren J. mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J Cell Mol Med 2012; 16:616 - 26; http://dx.doi.org/10.1111/j.1582-4934.2011.01347.x; PMID: 21609394
   PubMed Web of Science ®Google Scholar
• Zhang Y, Ren J. ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. Pharmacol Ther 2011; 132:86 - 95; http://dx.doi.org/10.1016/j.pharmthera.2011.05.008; PMID: 21664374
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981 - 91; http://dx.doi.org/10.1091/mbc.E08-12-1248; PMID: 19211835
   PubMed Web of Science ®Google Scholar
• Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280 - 93; http://dx.doi.org/10.1016/j.molcel.2010.09.023; PMID: 20965422
   PubMed Web of Science ®Google Scholar
• Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323 - 35; http://dx.doi.org/10.1038/nature09782; PMID: 21248839
   PubMed Web of Science ®Google Scholar
• Chen G, Luo J. Anthocyanins: Are They Beneficial in Treating Ethanol Neurotoxicity?. Neurotox Res 2010; 17:91 - 101; http://dx.doi.org/10.1007/s12640-009-9083-4; PMID: 19590929
   PubMed Web of Science ®Google Scholar
• Chen G, Ma C, Bower KA, Shi X, Ke Z, Luo J. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. J Neurosci Res 2008; 86:937 - 46; http://dx.doi.org/10.1002/jnr.21540; PMID: 17941056
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vicencio JM, Kepp O, Tasdemir E, Maiuri MC, Kroemer G. To die or not to die: that is the autophagic question. Curr Mol Med 2008; 8:78 - 91; http://dx.doi.org/10.2174/156652408783769616; PMID: 18336289
   PubMed Web of Science ®Google Scholar
• Shen HM, Codogno P. Autophagic cell death: Loch Ness monster or endangered species?. Autophagy 2011; 7:457 - 65; http://dx.doi.org/10.4161/auto.7.5.14226; PMID: 21150268
   PubMed Web of Science ®Google Scholar
• Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221:3 - 12; http://dx.doi.org/10.1002/path.2697; PMID: 20225336
   PubMed Web of Science ®Google Scholar
• Huett A, Goel G, Xavier RJ. A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 2010; 26:302 - 9; http://dx.doi.org/10.1097/MOG.0b013e32833ae2ed; PMID: 20571384
   PubMed Web of Science ®Google Scholar
• Liang C. Negative regulation of autophagy. Cell Death Differ 2010; 17:1807 - 15; http://dx.doi.org/10.1038/cdd.2010.115; PMID: 20865012
   PubMed Web of Science ®Google Scholar
• Olney JW, Tenkova T, Dikranian K, Qin YQ, Labruyere J, Ikonomidou C. Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Brain Res Dev Brain Res 2002; 133:115 - 26; http://dx.doi.org/10.1016/S0165-3806(02)00279-1; PMID: 11882342
   PubMedGoogle Scholar
• Luo J, Lindström CL, Donahue A, Miller MW. Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons. J Neurochem 2001; 76:1354 - 63; http://dx.doi.org/10.1046/j.1471-4159.2001.00129.x; PMID: 11238720
   PubMed Web of Science ®Google Scholar
• Chen G, Bower KA, Ma C, Fang S, Thiele CJ, Luo J. Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. FASEB J 2004; 18:1162 - 4; PMID: 15132987
   PubMed Web of Science ®Google Scholar
• Ke ZJ, Calingasan NY, Karuppagounder SS, DeGiorgio LA, Volpe BT, Gibson GE. CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. J Neuroimmunol 2005; 164:85 - 92; http://dx.doi.org/10.1016/j.jneuroim.2005.04.002; PMID: 15904977
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098 - 101; http://dx.doi.org/10.1126/science.1106148; PMID: 15718470
   PubMed Web of Science ®Google Scholar
• Airoldi I, Di Carlo E, Cocco C, Taverniti G, D’Antuono T, Ognio E, et al. Endogenous IL-12 triggers an antiangiogenic program in melanoma cells. Proc Natl Acad Sci U S A 2007; 104:3996 - 4001; http://dx.doi.org/10.1073/pnas.0609028104; PMID: 17360466
   PubMed Web of Science ®Google Scholar