IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function

References

• Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR, et al. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007; 6:975 - 90; http://dx.doi.org/10.1038/nrd2422; PMID: 18049472
   PubMed Web of Science ®Google Scholar
• Caraglia M, Marra M, Tagliaferri P, Lamberts SW, Zappavigna S, Misso G, et al. Emerging strategies to strengthen the anti-tumour activity of type I interferons: overcoming survival pathways. Curr Cancer Drug Targets 2009; 9:690 - 704; http://dx.doi.org/10.2174/156800909789056980; PMID: 19508175
   PubMed Web of Science ®Google Scholar
• Chawla-Sarkar M, Lindner DJ, Liu YF, Williams BR, Sen GC, Silverman RH, et al. Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 2003; 8:237 - 49; http://dx.doi.org/10.1023/A:1023668705040; PMID: 12766484
   PubMed Web of Science ®Google Scholar
• Sangfelt O, Erickson S, Grander D. Mechanisms of interferon-induced cell cycle arrest. Front Biosci 2000; 5:D479 - 87; http://dx.doi.org/10.2741/Sangfelt; PMID: 10762599
   PubMed Web of Science ®Google Scholar
• Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 2005; 5:375 - 86; http://dx.doi.org/10.1038/nri1604; PMID: 15864272
   PubMed Web of Science ®Google Scholar
• Darnell JE Jr., Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264:1415 - 21; http://dx.doi.org/10.1126/science.8197455; PMID: 8197455
   PubMed Web of Science ®Google Scholar
• Codarri L, Fontana A, Becher B. Cytokine networks in multiple sclerosis: lost in translation. Curr Opin Neurol 2010; 23:205 - 11; http://dx.doi.org/10.1097/WCO.0b013e3283391feb; PMID: 20442570
   PubMed Web of Science ®Google Scholar
• Kieseier BC. The mechanism of action of interferon-β in relapsing multiple sclerosis. CNS Drugs 2011; 25:491 - 502; http://dx.doi.org/10.2165/11591110-000000000-00000; PMID: 21649449
   PubMed Web of Science ®Google Scholar
• Rosenblum MG, Yung WK, Kelleher PJ, Ruzicka F, Steck PA, Borden EC. Growth inhibitory effects of interferon-beta but not interferon-alpha on human glioma cells: correlation of receptor binding, 2′,5′-oligoadenylate synthetase and protein kinase activity. J Interferon Res 1990; 10:141 - 51; http://dx.doi.org/10.1089/jir.1990.10.141; PMID: 2140395
   PubMedGoogle Scholar
• Damdinsuren B, Nagano H, Sakon M, Kondo M, Yamamoto T, Umeshita K, et al. Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs. Ann Surg Oncol 2003; 10:1184 - 90; http://dx.doi.org/10.1245/ASO.2003.03.010; PMID: 14654475
   PubMed Web of Science ®Google Scholar
• Vitale G, de Herder WW, van Koetsveld PM, Waaijers M, Schoordijk W, Croze E, et al. IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro. Cancer Res 2006; 66:554 - 62; http://dx.doi.org/10.1158/0008-5472.CAN-05-3043; PMID: 16397272
   PubMed Web of Science ®Google Scholar
• Vitale G, van Eijck CH, van Koetsveld Ing PM, Erdmann JI, Speel EJ, van der Wansem Ing K, et al. Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors. Ann Surg 2007; 246:259 - 68; http://dx.doi.org/10.1097/01.sla.0000261460.07110.f2; PMID: 17667505
   PubMed Web of Science ®Google Scholar
• Coradini D, Biffi A, Pirronello E, Di Fronzo G. The effect of alpha-, beta- and gamma-interferon on the growth of breast cancer cell lines. Anticancer Res 1994; 14:5A 1779 - 84; PMID: 7531412
   PubMedGoogle Scholar
• Horikoshi T, Fukuzawa K, Hanada N, Ezoe K, Eguchi H, Hamaoka S, et al. In vitro comparative study of the antitumor effects of human interferon-alpha, beta and gamma on the growth and invasive potential of human melanoma cells. J Dermatol 1995; 22:631 - 6; PMID: 8537547
   PubMedGoogle Scholar
• Zaidi MR, Merlino G. The two faces of interferon-γ in cancer. Clin Cancer Res 2011; 17:6118 - 24; http://dx.doi.org/10.1158/1078-0432.CCR-11-0482; PMID: 21705455
   PubMed Web of Science ®Google Scholar
• Carpi A, Nicolini A, Antonelli A, Ferrari P, Rossi G. Cytokines in the management of high risk or advanced breast cancer: an update and expectation. Curr Cancer Drug Targets 2009; 9:888 - 903; http://dx.doi.org/10.2174/156800909790192392; PMID: 20025599
   PubMed Web of Science ®Google Scholar
• Schmidberger H, Rave-Fränk M, Lehmann J, Schweinfurth S, Rehring E, Henckel K, et al. The combined effect of interferon beta and radiation on five human tumor cell lines and embryonal lung fibroblasts. Int J Radiat Oncol Biol Phys 1999; 43:405 - 12; http://dx.doi.org/10.1016/S0360-3016(98)00411-8; PMID: 10030269
   PubMed Web of Science ®Google Scholar
• Kang JX, Liu J, Wang J, He C, Li FP. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis 2005; 26:1934 - 9; http://dx.doi.org/10.1093/carcin/bgi154; PMID: 15958519
   PubMed Web of Science ®Google Scholar
• Lindner DJ, Borden EC. Synergistic antitumor effects of a combination of interferon and tamoxifen on estrogen receptor-positive and receptor-negative human tumor cell lines in vivo and in vitro. J Interferon Cytokine Res 1997; 17:681 - 93; PMID: 9402106
   PubMed Web of Science ®Google Scholar
• Lindner DJ, Kolla V, Kalvakolanu DV, Borden EC. Tamoxifen enhances interferon-regulated gene expression in breast cancer cells. Mol Cell Biochem 1997; 167:169 - 77; http://dx.doi.org/10.1023/A:1006854110122; PMID: 9059994
   PubMed Web of Science ®Google Scholar
• Kalie E, Jaitin DA, Abramovich R, Schreiber G. An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities. J Biol Chem 2007; 282:11602 - 11; http://dx.doi.org/10.1074/jbc.M610115200; PMID: 17310065
   PubMed Web of Science ®Google Scholar
• Lindner DJ, Borden EC. Effects of tamoxifen and interferon-beta or the combination on tumor-induced angiogenesis. Int J Cancer 1997; 71:456 - 61; http://dx.doi.org/10.1002/(SICI)1097-0215(19970502)71:3<456::AID-IJC25>3.0.CO;2-C; PMID: 9139884
   PubMed Web of Science ®Google Scholar
• Cheriyath V, Kuhns MA, Jacobs BS, Evangelista P, Elson P, Downs-Kelly E, et al. G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer. Oncogene 2012; 31:2222 - 36; http://dx.doi.org/10.1038/onc.2011.393; PMID: 21996729
   PubMed Web of Science ®Google Scholar
• He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67 - 93; http://dx.doi.org/10.1146/annurev-genet-102808-114910; PMID: 19653858
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27 - 42; http://dx.doi.org/10.1016/j.cell.2007.12.018; PMID: 18191218
   PubMed Web of Science ®Google Scholar
• Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280 - 93; http://dx.doi.org/10.1016/j.molcel.2010.09.023; PMID: 20965422
   PubMed Web of Science ®Google Scholar
• Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 2011; 25:1999 - 2010; http://dx.doi.org/10.1101/gad.17558811; PMID: 21979913
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90:1383 - 435; http://dx.doi.org/10.1152/physrev.00030.2009; PMID: 20959619
   PubMed Web of Science ®Google Scholar
• Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007; 21:1367 - 81; http://dx.doi.org/10.1101/gad.1545107; PMID: 17510285
   PubMed Web of Science ®Google Scholar
• Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621 - 35; http://dx.doi.org/10.1101/gad.1565707; PMID: 17606641
   PubMed Web of Science ®Google Scholar
• Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10:51 - 64; http://dx.doi.org/10.1016/j.ccr.2006.06.001; PMID: 16843265
   PubMed Web of Science ®Google Scholar
• Dikic I, Johansen T, Kirkin V. Selective autophagy in cancer development and therapy. Cancer Res 2010; 70:3431 - 4; http://dx.doi.org/10.1158/0008-5472.CAN-09-4027; PMID: 20424122
   PubMed Web of Science ®Google Scholar
• Denton D, Nicolson S, Kumar S. Cell death by autophagy: facts and apparent artefacts. Cell Death Differ 2012; 19:87 - 95; http://dx.doi.org/10.1038/cdd.2011.146; PMID: 22052193
   PubMed Web of Science ®Google Scholar
• Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell 2011; 22:165 - 78; http://dx.doi.org/10.1091/mbc.E10-06-0500; PMID: 21119005
   PubMed Web of Science ®Google Scholar
• Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011; 25:1510 - 27; http://dx.doi.org/10.1101/gad.2051011; PMID: 21764854
   PubMed Web of Science ®Google Scholar
• Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25:717 - 29; http://dx.doi.org/10.1101/gad.2016111; PMID: 21406549
   PubMed Web of Science ®Google Scholar
• Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 2011; 10:1533 - 41; http://dx.doi.org/10.1158/1535-7163.MCT-11-0047; PMID: 21878654
   PubMed Web of Science ®Google Scholar
• Cook KL, Shajahan AN, Clarke R. Autophagy and endocrine resistance in breast cancer. Expert Rev Anticancer Ther 2011; 11:1283 - 94; http://dx.doi.org/10.1586/era.11.111; PMID: 21916582
   PubMed Web of Science ®Google Scholar
• Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753 - 66; http://dx.doi.org/10.1016/j.cell.2004.11.038; PMID: 15607973
   PubMed Web of Science ®Google Scholar
• Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol 2002; 157:455 - 68; http://dx.doi.org/10.1083/jcb.200109094; PMID: 11980920
   PubMed Web of Science ®Google Scholar
• Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313:1438 - 41; http://dx.doi.org/10.1126/science.1129577; PMID: 16888103
   PubMed Web of Science ®Google Scholar
• Tu SP, Quante M, Bhagat G, Takaishi S, Cui G, Yang XD, et al. IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis. Cancer Res 2011; 71:4247 - 59; http://dx.doi.org/10.1158/0008-5472.CAN-10-4009; PMID: 21512143
   PubMed Web of Science ®Google Scholar
• Li P, Du Q, Cao Z, Guo Z, Evankovich J, Yan W, et al. Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett 2012; 314:213 - 22; http://dx.doi.org/10.1016/j.canlet.2011.09.031; PMID: 22056812
   PubMed Web of Science ®Google Scholar
• Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 2007; 25:193 - 205; http://dx.doi.org/10.1016/j.molcel.2006.12.009; PMID: 17244528
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720 - 8; http://dx.doi.org/10.1093/emboj/19.21.5720; PMID: 11060023
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004; 117:2805 - 12; http://dx.doi.org/10.1242/jcs.01131; PMID: 15169837
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542 - 5; PMID: 17611390
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151 - 75; PMID: 18188003
   PubMed Web of Science ®Google Scholar
• Farkas T, Høyer-Hansen M, Jäättelä M. Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux. Autophagy 2009; 5:1018 - 25; http://dx.doi.org/10.4161/auto.5.7.9443; PMID: 19652534
   PubMed Web of Science ®Google Scholar
• Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131 - 45; http://dx.doi.org/10.1074/jbc.M702824200; PMID: 17580304
   PubMed Web of Science ®Google Scholar
• Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603 - 14; http://dx.doi.org/10.1083/jcb.200507002; PMID: 16286508
   PubMed Web of Science ®Google Scholar
• Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 2009; 452:181 - 97; http://dx.doi.org/10.1016/S0076-6879(08)03612-4; PMID: 19200883
   PubMed Web of Science ®Google Scholar
• Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515 - 27; http://dx.doi.org/10.1016/j.ccr.2006.10.008; PMID: 17157791
   PubMed Web of Science ®Google Scholar
• Samejima K, Earnshaw WC. Trashing the genome: the role of nucleases during apoptosis. Nat Rev Mol Cell Biol 2005; 6:677 - 88; http://dx.doi.org/10.1038/nrm1715; PMID: 16103871
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19:107 - 20; http://dx.doi.org/10.1038/cdd.2011.96; PMID: 21760595
   PubMed Web of Science ®Google Scholar
• Gao G, Dou QP. N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death. J Cell Biochem 2000; 80:53 - 72; http://dx.doi.org/10.1002/1097-4644(20010101)80:1<53::AID-JCB60>3.0.CO;2-E; PMID: 11029754
   PubMed Web of Science ®Google Scholar
• Yanase N, Ohshima K, Ikegami H, Mizuguchi J. Cytochrome c release, mitochondrial membrane depolarization, caspase-3 activation, and Bax-alpha cleavage during IFN-alpha-induced apoptosis in Daudi B lymphoma cells. J Interferon Cytokine Res 2000; 20:1121 - 9; http://dx.doi.org/10.1089/107999000750053799; PMID: 11152579
   PubMed Web of Science ®Google Scholar
• Wood DE, Newcomb EW. Caspase-dependent activation of calpain during drug-induced apoptosis. J Biol Chem 1999; 274:8309 - 15; http://dx.doi.org/10.1074/jbc.274.12.8309; PMID: 10075737
   PubMed Web of Science ®Google Scholar
• Wood DE, Thomas A, Devi LA, Berman Y, Beavis RC, Reed JC, et al. Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene 1998; 17:1069 - 78; http://dx.doi.org/10.1038/sj.onc.1202034; PMID: 9764817
   PubMed Web of Science ®Google Scholar
• Chaitanya GV, Steven AJ, Babu PP. PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal 2010; 8:31; http://dx.doi.org/10.1186/1478-811X-8-31; PMID: 21176168
   PubMed Web of Science ®Google Scholar
• Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425 - 34; http://dx.doi.org/10.1083/jcb.200412022; PMID: 15866887
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657 - 68; http://dx.doi.org/10.1083/jcb.152.4.657; PMID: 11266458
   PubMed Web of Science ®Google Scholar
• Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809 - 20; PMID: 14638851
   PubMed Web of Science ®Google Scholar
• Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282:25464 - 74; http://dx.doi.org/10.1074/jbc.M703663200; PMID: 17595159
   PubMed Web of Science ®Google Scholar
• Høyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jäättelä M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005; 12:1297 - 309; http://dx.doi.org/10.1038/sj.cdd.4401651; PMID: 15905882
   PubMed Web of Science ®Google Scholar
• Pestka S. The interferons: 50 years after their discovery, there is much more to learn. J Biol Chem 2007; 282:20047 - 51; http://dx.doi.org/10.1074/jbc.R700004200; PMID: 17502369
   PubMed Web of Science ®Google Scholar
• Vitale G, Zappavigna S, Marra M, Dicitore A, Meschini S, Condello M, et al. The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells. Biotechnol Adv 2012; 30:169 - 84; http://dx.doi.org/10.1016/j.biotechadv.2011.08.001; PMID: 21871555
   PubMed Web of Science ®Google Scholar
• Caraglia M, Tagliaferri P, Marra M, Giuberti G, Budillon A, Gennaro ED, et al. EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-alpha-mediated apoptosis in epidermoid cancer cells. Cell Death Differ 2003; 10:218 - 29; http://dx.doi.org/10.1038/sj.cdd.4401131; PMID: 12700650
   PubMed Web of Science ®Google Scholar
• Cheriyath V, Glaser KB, Waring JF, Baz R, Hussein MA, Borden EC. G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells. J Clin Invest 2007; 117:3107 - 17; http://dx.doi.org/10.1172/JCI31122; PMID: 17823654
   PubMed Web of Science ®Google Scholar
• Sun WL, Chen J, Wang YP, Zheng H. Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development. Autophagy 2011; 7:1035 - 44; http://dx.doi.org/10.4161/auto.7.9.16521; PMID: 21646864
   PubMed Web of Science ®Google Scholar
• Samaddar JS, Gaddy VT, Duplantier J, Thandavan SP, Shah M, Smith MJ, et al. A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Mol Cancer Ther 2008; 7:2977 - 87; http://dx.doi.org/10.1158/1535-7163.MCT-08-0447; PMID: 18790778
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009; 4:e6251; http://dx.doi.org/10.1371/journal.pone.0006251; PMID: 19606230
   PubMed Web of Science ®Google Scholar
• Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 2007; 14:500 - 10; http://dx.doi.org/10.1038/sj.cdd.4402039; PMID: 16990848
   PubMed Web of Science ®Google Scholar
• Orvedahl A, Sumpter R Jr., Xiao G, Ng A, Zou Z, Tang Y, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011; 480:113 - 7; http://dx.doi.org/10.1038/nature10546; PMID: 22020285
   PubMed Web of Science ®Google Scholar
• Yellen P, Saqcena M, Salloum D, Feng J, Preda A, Xu L, et al. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle 2011; 10:3948 - 56; http://dx.doi.org/10.4161/cc.10.22.18124; PMID: 22071574
   PubMed Web of Science ®Google Scholar
• Sarkar S, Krishna G, Imarisio S, Saiki S, O’Kane CJ, Rubinsztein DC. A rational mechanism for combination treatment of Huntington’s disease using lithium and rapamycin. Hum Mol Genet 2008; 17:170 - 8; http://dx.doi.org/10.1093/hmg/ddm294; PMID: 17921520
   PubMed Web of Science ®Google Scholar
• Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ 2009; 16:46 - 56; http://dx.doi.org/10.1038/cdd.2008.110; PMID: 18636076
   PubMed Web of Science ®Google Scholar
• Wang RC, Levine B. Autophagy in cellular growth control. FEBS Lett 2010; 584:1417 - 26; http://dx.doi.org/10.1016/j.febslet.2010.01.009; PMID: 20096689
   PubMed Web of Science ®Google Scholar
• Chen Q, Gong B, Mahmoud-Ahmed AS, Zhou A, Hsi ED, Hussein M, et al. Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood 2001; 98:2183 - 92; http://dx.doi.org/10.1182/blood.V98.7.2183; PMID: 11568006
   PubMed Web of Science ®Google Scholar
• Panaretakis T, Pokrovskaja K, Shoshan MC, Grandér D. Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax. Oncogene 2003; 22:4543 - 56; http://dx.doi.org/10.1038/sj.onc.1206503; PMID: 12881711
   PubMed Web of Science ®Google Scholar
• Jänicke RU. MCF-7 breast carcinoma cells do not express caspase-3. Breast Cancer Res Treat 2009; 117:219 - 21; http://dx.doi.org/10.1007/s10549-008-0217-9; PMID: 18853248
   PubMed Web of Science ®Google Scholar
• Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, et al. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One 2011; 6:e24705; http://dx.doi.org/10.1371/journal.pone.0024705; PMID: 21931823
   PubMed Web of Science ®Google Scholar
• Ning Y, Riggins RB, Mulla JE, Chung H, Zwart A, Clarke R. IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Mol Cancer Ther 2010; 9:1274 - 85; http://dx.doi.org/10.1158/1535-7163.MCT-09-1169; PMID: 20457620
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402 - 8; http://dx.doi.org/10.1006/meth.2001.1262; PMID: 11846609
   PubMed Web of Science ®Google Scholar
• Frankel LB, Wen J, Lees M, Høyer-Hansen M, Farkas T, Krogh A, et al. microRNA-101 is a potent inhibitor of autophagy. EMBO J 2011; 30:4628 - 41; http://dx.doi.org/10.1038/emboj.2011.331; PMID: 21915098
   PubMed Web of Science ®Google Scholar