1,029
Views
32
CrossRef citations to date
0
Altmetric
Basic Research Paper

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction

, , &
Pages 1553-1565 | Received 30 Nov 2012, Accepted 22 Jul 2013, Published online: 07 Aug 2013

References

  • Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83:993 - 1000; http://dx.doi.org/10.1016/0092-8674(95)90214-7; PMID: 8521522
  • Sherr CJ, Bertwistle D, DEN Besten W, Kuo ML, Sugimoto M, Tago K, Williams RT, Zindy F, Roussel MF. p53-Dependent and -independent functions of the Arf tumor suppressor. Cold Spring Harb Symp Quant Biol 2005; 70:129 - 37; http://dx.doi.org/10.1101/sqb.2005.70.004; PMID: 16869746
  • Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22:463 - 75; http://dx.doi.org/10.1016/j.molcel.2006.04.014; PMID: 16713577
  • Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998; 17:5001 - 14; http://dx.doi.org/10.1093/emboj/17.17.5001; PMID: 9724636
  • Reef S, Kimchi A. Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy. Autophagy 2008; 4:866 - 9; PMID: 18719357
  • Abida WM, Gu W. p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res 2008; 68:352 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-07-2069; PMID: 18199527
  • Irvine M, Philipsz S, Frausto M, Mijatov B, Gallagher SJ, Fung C, Becker TM, Kefford RF, Rizos H. Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria. Cell Cycle 2010; 9:829 - 39; http://dx.doi.org/10.4161/cc.9.4.10785; PMID: 20107316
  • Pimkina J, Humbey O, Zilfou JT, Jarnik M, Murphy ME. ARF induces autophagy by virtue of interaction with Bcl-xl. J Biol Chem 2009; 284:2803 - 10; http://dx.doi.org/10.1074/jbc.M804705200; PMID: 19049976
  • Pietsch EC, Leu JI, Frank A, Dumont P, George DL, Murphy ME. The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biol Ther 2007; 6:1576 - 83; http://dx.doi.org/10.4161/cbt.6.10.4719; PMID: 17895645
  • Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151 - 75; PMID: 18188003
  • Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010; 6:1090 - 106; http://dx.doi.org/10.4161/auto.6.8.13426; PMID: 20890124
  • Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem 2010; 285:27879 - 90; http://dx.doi.org/10.1074/jbc.M110.119537; PMID: 20573959
  • Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell 2008; 13:542 - 53; http://dx.doi.org/10.1016/j.ccr.2008.04.002; PMID: 18538737
  • Jin S, White E. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 2008; 4:563 - 6; PMID: 18326941
  • Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 1995; 375:506 - 10; http://dx.doi.org/10.1038/375506a0; PMID: 7777061
  • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 2005; 102:8204 - 9; http://dx.doi.org/10.1073/pnas.0502857102; PMID: 15928081
  • Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D’Amelio M, Criollo A, Morselli E, Zhu C, Harper F, et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 2008; 10:676 - 87; http://dx.doi.org/10.1038/ncb1730; PMID: 18454141
  • Tasdemir E, Maiuri MC, Orhon I, Kepp O, Morselli E, Criollo A, Kroemer G. p53 represses autophagy in a cell cycle-dependent fashion. Cell Cycle 2008; 7:3006 - 11; http://dx.doi.org/10.4161/cc.7.19.6702; PMID: 18838865
  • Tasdemir E, Chiara Maiuri M, Morselli E, Criollo A, D’Amelio M, Djavaheri-Mergny M, Cecconi F, Tavernarakis N, Kroemer G. A dual role of p53 in the control of autophagy. Autophagy 2008; 4:810 - 4; PMID: 18604159
  • Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 1998; 18:6457 - 73; PMID: 9774662
  • Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A 1998; 95:8292 - 7; http://dx.doi.org/10.1073/pnas.95.14.8292; PMID: 9653180
  • Saporita AJ, Maggi LB Jr., Apicelli AJ, Weber JD. Therapeutic targets in the ARF tumor suppressor pathway. Curr Med Chem 2007; 14:1815 - 27; http://dx.doi.org/10.2174/092986707781058869; PMID: 17627519
  • Matsuoka M, Kurita M, Sudo H, Mizumoto K, Nishimoto I, Ogata E. Multiple domains of the mouse p19ARF tumor suppressor are involved in p53-independent apoptosis. Biochem Biophys Res Commun 2003; 301:1000 - 10; http://dx.doi.org/10.1016/S0006-291X(03)00080-9; PMID: 12589812
  • Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR. Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Mol Cell Biol 2006; 26:2360 - 72; http://dx.doi.org/10.1128/MCB.26.6.2360-2372.2006; PMID: 16508011
  • Kelly-Spratt KS, Gurley KE, Yasui Y, Kemp CJ. p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol 2004; 2:E242; http://dx.doi.org/10.1371/journal.pbio.0020242; PMID: 15314658
  • Weber JD, Jeffers JR, Rehg JE, Randle DH, Lozano G, Roussel MF, Sherr CJ, Zambetti GP. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev 2000; 14:2358 - 65; http://dx.doi.org/10.1101/gad.827300; PMID: 10995391
  • Bertwistle D, Sugimoto M, Sherr CJ. Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23. Mol Cell Biol 2004; 24:985 - 96; http://dx.doi.org/10.1128/MCB.24.3.985-996.2004; PMID: 14729947
  • Zerrouqi A, Pyrzynska B, Febbraio M, Brat DJ, Van Meir EG. P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3. J Clin Invest 2012; 122:1283 - 95; http://dx.doi.org/10.1172/JCI38596; PMID: 22378045
  • di Tommaso A, Hagen J, Tompkins V, Muniz V, Dudakovic A, Kitzis A, Ladeveze V, Quelle DE. Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities. Exp Cell Res 2009; 315:1326 - 35; http://dx.doi.org/10.1016/j.yexcr.2009.01.010; PMID: 19331830
  • Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE. A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem 2007; 282:1322 - 33; http://dx.doi.org/10.1074/jbc.M609612200; PMID: 17110379
  • Datta A, Nag A, Pan W, Hay N, Gartel AL, Colamonici O, Mori Y, Raychaudhuri P. Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc. J Biol Chem 2004; 279:36698 - 707; http://dx.doi.org/10.1074/jbc.M312305200; PMID: 15199070
  • Humbey O, Pimkina J, Zilfou JT, Jarnik M, Dominguez-Brauer C, Burgess DJ, Eischen CM, Murphy ME. The ARF tumor suppressor can promote the progression of some tumors. Cancer Res 2008; 68:9608 - 13; http://dx.doi.org/10.1158/0008-5472.CAN-08-2263; PMID: 19047137
  • Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445 - 544; http://dx.doi.org/10.4161/auto.19496; PMID: 22966490
  • Miceli AP, Saporita AJ, Weber JD. Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint. Mol Cell Biol 2012; 32:348 - 64; http://dx.doi.org/10.1128/MCB.06030-11; PMID: 22064482
  • Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet 2003; 33:396 - 400; http://dx.doi.org/10.1038/ng1091; PMID: 12567186
  • Tokuyasu KT. Immunochemistry on ultrathin frozen sections. Histochem J 1980; 12:381 - 403; http://dx.doi.org/10.1007/BF01011956; PMID: 7440248

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.