Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells

Reference

• Mizumura K, Cloonan SM, Haspel JA, Choi AM. The emerging importance of autophagy in pulmonary diseases. Chest 2012; 142:1289 - 99; http://dx.doi.org/10.1378/chest.12-0809; PMID: 23131937
   PubMed Web of Science ®Google Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926 - 45; http://dx.doi.org/10.1101/gad.1212704; PMID: 15314020
   PubMed Web of Science ®Google Scholar
• Tsang CK, Qi H, Liu LF, Zheng XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007; 12:112 - 24; http://dx.doi.org/10.1016/j.drudis.2006.12.008; PMID: 17275731
   PubMed Web of Science ®Google Scholar
• Zaytseva YY, Valentino JD, Gulhati P, Evers BM. mTOR inhibitors in cancer therapy. Cancer Lett 2012; 319:1 - 7; http://dx.doi.org/10.1016/j.canlet.2012.01.005; PMID: 22261336
   PubMed Web of Science ®Google Scholar
• Weichhart T. Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life. Methods Mol Biol 2012; 821:1 - 14; http://dx.doi.org/10.1007/978-1-61779-430-8_1; PMID: 22125056
   PubMedGoogle Scholar
• Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013; 493:338 - 45; http://dx.doi.org/10.1038/nature11861; PMID: 23325216
   PubMed Web of Science ®Google Scholar
• Alayev A, Holz MK. mTOR signaling for biological control and cancer. J Cell Physiol 2013; 228:1658 - 64; http://dx.doi.org/10.1002/jcp.24351; PMID: 23460185
   PubMed Web of Science ®Google Scholar
• Lei FR, Li XQ, Liu H, Zhu RD, Meng QY, Rong JJ. Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells. Chin Med J (Engl) 2012; 125:4076 - 82; PMID: 23158146
   PubMed Web of Science ®Google Scholar
• Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, Klumperman J, Thorens B, Thomas G. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 2000; 408:994 - 7; http://dx.doi.org/10.1038/35050135; PMID: 11140689
   PubMed Web of Science ®Google Scholar
• Hamada S, Hara K, Hamada T, Yasuda H, Moriyama H, Nakayama R, Nagata M, Yokono K. Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 2009; 58:1321 - 32; http://dx.doi.org/10.2337/db08-0519; PMID: 19258434
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149:274 - 93; http://dx.doi.org/10.1016/j.cell.2012.03.017; PMID: 22500797
   PubMed Web of Science ®Google Scholar
• Huang B, Meng N, Zhao B, Zhao J, Zhang Y, Zhang S, Miao J. Protective effects of a synthesized butyrolactone derivative against chloroquine-induced autophagic vesicle accumulation and the disturbance of mitochondrial membrane potential and Na+,K+-ATPase activity in vascular endothelial cells. Chem Res Toxicol 2009; 22:471 - 5; http://dx.doi.org/10.1021/tx8002824; PMID: 19199859
   PubMed Web of Science ®Google Scholar
• Meng N, Zhao J, Su L, Zhao B, Zhang Y, Zhang S, Miao J. A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells. Int J Biochem Cell Biol 2012; 44:311 - 9; http://dx.doi.org/10.1016/j.biocel.2011.11.001; PMID: 22085531
   PubMed Web of Science ®Google Scholar
• Yang S, Wang S, Peng N, Xie Z, Wang P, Zhao C, Wei L, Yang H, Zhao B, Miao J, et al. Butyrolactone derivative 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one protects against amyloid-β peptides-induced cytotoxicity in PC12 cells. J Alzheimers Dis 2012; 28:345 - 56; PMID: 21988929
   PubMed Web of Science ®Google Scholar
• Wei L, Yang H, Xie Z, Yang S, Yang H, Zhao C, Wang P, Xu S, Miao J, Zhao B, et al. A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model. J Alzheimers Dis 2012; 30:531 - 43; PMID: 22451314
   PubMed Web of Science ®Google Scholar
• Spring DR. Chemical genetics to chemical genomics: small molecules offer big insights. Chem Soc Rev 2005; 34:472 - 82; http://dx.doi.org/10.1039/b312875j; PMID: 16137160
   PubMed Web of Science ®Google Scholar
• Bossé Y, Postma DS, Sin DD, Lamontagne M, Couture C, Gaudreault N, Joubert P, Wong V, Elliott M, van den Berge M, et al. Molecular signature of smoking in human lung tissues. Cancer Res 2012; 72:3753 - 63; http://dx.doi.org/10.1158/0008-5472.CAN-12-1160; PMID: 22659451
   PubMed Web of Science ®Google Scholar
• Busch W, Kühnel D, Schirmer K, Scholz S. Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes. BMC Genomics 2010; 11:65; http://dx.doi.org/10.1186/1471-2164-11-65; PMID: 20105288
   PubMed Web of Science ®Google Scholar
• Terragni J, Graham JR, Adams KW, Schaffer ME, Tullai JW, Cooper GM. Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors. BMC Cell Biol 2008; 9:6; http://dx.doi.org/10.1186/1471-2121-9-6; PMID: 18226221
   PubMed Web of Science ®Google Scholar
• Pluvinet R, Olivar R, Krupinski J, Herrero-Fresneda I, Luque A, Torras J, Cruzado JM, Grinyó JM, Sumoy L, Aran JM. CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood 2008; 112:3624 - 37; http://dx.doi.org/10.1182/blood-2008-03-143305; PMID: 18669876
   PubMed Web of Science ®Google Scholar
• van der Heul-Nieuwenhuijsen L, Hendriksen PJ, van der Kwast TH, Jenster G. Gene expression profiling of the human prostate zones. BJU Int 2006; 98:886 - 97; http://dx.doi.org/10.1111/j.1464-410X.2006.06427.x; PMID: 16978289
   PubMed Web of Science ®Google Scholar
• Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC, Erle DJ. IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production. Am J Respir Cell Mol Biol 2007; 36:244 - 53; http://dx.doi.org/10.1165/rcmb.2006-0180OC; PMID: 16980555
   PubMed Web of Science ®Google Scholar
• Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D. A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. Exp Mol Med 2012; 44:281 - 92; http://dx.doi.org/10.3858/emm.2012.44.4.024; PMID: 22228119
   PubMed Web of Science ®Google Scholar
• Ganti R, Hunt RC, Parapuram SK, Hunt DM. Vitreous modulation of gene expression in low-passage human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2007; 48:1853 - 63; http://dx.doi.org/10.1167/iovs.06-0198; PMID: 17389521
   PubMed Web of Science ®Google Scholar
• Kim YC, Wu Q, Chen J, Xuan Z, Jung YC, Zhang MQ, Rowley JD, Wang SM. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc Natl Acad Sci U S A 2009; 106:8278 - 83; http://dx.doi.org/10.1073/pnas.0903390106; PMID: 19416867
   PubMed Web of Science ®Google Scholar
• Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Res 2007; 67:1502 - 12; http://dx.doi.org/10.1158/0008-5472.CAN-06-3311; PMID: 17308088
   PubMed Web of Science ®Google Scholar
• Huang S, Bjornsti MA, Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2003; 2:222 - 32; http://dx.doi.org/10.4161/cbt.2.3.360; PMID: 12878853
   PubMed Web of Science ®Google Scholar
• Huang S, Houghton PJ. Mechanisms of resistance to rapamycins. Drug Resist Updat 2001; 4:378 - 91; http://dx.doi.org/10.1054/drup.2002.0227; PMID: 12030785
   PubMed Web of Science ®Google Scholar
• Copp J, Manning G, Hunter T. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res 2009; 69:1821 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-08-3014; PMID: 19244117
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445 - 544; http://dx.doi.org/10.4161/auto.19496; PMID: 22966490
   PubMed Web of Science ®Google Scholar
• Damgaard CK, Lykke-Andersen J. Translational coregulation of 5’TOP mRNAs by TIA-1 and TIAR. Genes Dev 2011; 25:2057 - 68; http://dx.doi.org/10.1101/gad.17355911; PMID: 21979918
   PubMed Web of Science ®Google Scholar
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet 2004; 36:40 - 5; http://dx.doi.org/10.1038/ng1285; PMID: 14702039
   PubMed Web of Science ®Google Scholar
• Alers S, Löffler AS, Wesselborg S, Stork B. The incredible ULKs. Cell Commun Signal 2012; 10:7; http://dx.doi.org/10.1186/1478-811X-10-7; PMID: 22413737
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 1998; 23:33 - 42; http://dx.doi.org/10.1247/csf.23.33; PMID: 9639028
   PubMed Web of Science ®Google Scholar
• Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649 - 62; http://dx.doi.org/10.4161/auto.5.5.8249; PMID: 19287211
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981 - 91; http://dx.doi.org/10.1091/mbc.E08-12-1248; PMID: 19211835
   PubMed Web of Science ®Google Scholar
• Aroca A, Díaz-Quintana A, Díaz-Moreno I. A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein. FEBS Lett 2011; 585:2958 - 64; http://dx.doi.org/10.1016/j.febslet.2011.07.037; PMID: 21846467
   PubMed Web of Science ®Google Scholar
• Förch P, Puig O, Kedersha N, Martínez C, Granneman S, Séraphin B, Anderson P, Valcárcel J. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Mol Cell 2000; 6:1089 - 98; http://dx.doi.org/10.1016/S1097-2765(00)00107-6; PMID: 11106748
   PubMed Web of Science ®Google Scholar
• Förch P, Valcárcel J. Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1. Apoptosis 2001; 6:463 - 8; http://dx.doi.org/10.1023/A:1012441824719; PMID: 11595836
   PubMed Web of Science ®Google Scholar
• Dixon DA, Balch GC, Kedersha N, Anderson P, Zimmerman GA, Beauchamp RD, Prescott SM. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med 2003; 198:475 - 81; http://dx.doi.org/10.1084/jem.20030616; PMID: 12885872
   PubMed Web of Science ®Google Scholar
• Piecyk M, Wax S, Beck AR, Kedersha N, Gupta M, Maritim B, Chen S, Gueydan C, Kruys V, Streuli M, et al. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J 2000; 19:4154 - 63; http://dx.doi.org/10.1093/emboj/19.15.4154; PMID: 10921895
   PubMed Web of Science ®Google Scholar
• López de Silanes I, Galbán S, Martindale JL, Yang X, Mazan-Mamczarz K, Indig FE, Falco G, Zhan M, Gorospe M. Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol 2005; 25:9520 - 31; http://dx.doi.org/10.1128/MCB.25.21.9520-9531.2005; PMID: 16227602
   PubMed Web of Science ®Google Scholar
• Izquierdo JM, Alcalde J, Carrascoso I, Reyes R, Ludeña MD. Knockdown of T-cell intracellular antigens triggers cell proliferation, invasion and tumour growth. Biochem J 2011; 435:337 - 44; http://dx.doi.org/10.1042/BJ20101030; PMID: 21284605
   PubMed Web of Science ®Google Scholar
• Mercer TR, Wilhelm D, Dinger ME, Soldà G, Korbie DJ, Glazov EA, Truong V, Schwenke M, Simons C, Matthaei KI, et al. Expression of distinct RNAs from 3′ untranslated regions. Nucleic Acids Res 2011; 39:2393 - 403; http://dx.doi.org/10.1093/nar/gkq1158; PMID: 21075793
   PubMed Web of Science ®Google Scholar
• Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell 2011; 146:353 - 8; http://dx.doi.org/10.1016/j.cell.2011.07.014; PMID: 21802130
   PubMed Web of Science ®Google Scholar
• Fang L, Du WW, Yang X, Chen K, Ghanekar A, Levy G, Yang W, Yee AJ, Lu WY, Xuan JW, et al. Versican 3′-untranslated region (3′-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity. FASEB J 2013; 27:907 - 19; http://dx.doi.org/10.1096/fj.12-220905; PMID: 23180826
   PubMed Web of Science ®Google Scholar
• Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A, Bozzoni I. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 2011; 147:358 - 69; http://dx.doi.org/10.1016/j.cell.2011.09.028; PMID: 22000014
   PubMed Web of Science ®Google Scholar
• Rutnam ZJ, Yang BB. The non-coding 3′ UTR of CD44 induces metastasis by regulating extracellular matrix functions. J Cell Sci 2012; 125:2075 - 85; http://dx.doi.org/10.1242/jcs.100818; PMID: 22637644
   PubMed Web of Science ®Google Scholar
• Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973; 52:2745 - 56; http://dx.doi.org/10.1172/JCI107470; PMID: 4355998
   PubMed Web of Science ®Google Scholar
• Patterson TA, Lobenhofer EK, Fulmer-Smentek SB, Collins PJ, Chu TM, Bao W, Fang H, Kawasaki ES, Hager J, Tikhonova IR, et al. Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nat Biotechnol 2006; 24:1140 - 50; http://dx.doi.org/10.1038/nbt1242; PMID: 16964228
   PubMed Web of Science ®Google Scholar
• Wang N, Sun C, Huo S, Zhang Y, Zhao J, Zhang S, Miao J. Cooperation of phosphatidylcholine-specific phospholipase C and basic fibroblast growth factor in the neural differentiation of mesenchymal stem cells in vitro. Int J Biochem Cell Biol 2008; 40:294 - 306; http://dx.doi.org/10.1016/j.biocel.2007.08.003; PMID: 17890138
   PubMed Web of Science ®Google Scholar