Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

References

• Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69 - 90; http://dx.doi.org/10.3322/caac.20107; PMID: 21296855
   PubMed Web of Science ®Google Scholar
• Weir HK, Thun MJ, Hankey BF, Ries LA, Howe HL, Wingo PA, Jemal A, Ward E, Anderson RN, Edwards BK. Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control. J Natl Cancer Inst 2003; 95:1276 - 99; http://dx.doi.org/10.1093/jnci/djg040; PMID: 12953083
   PubMed Web of Science ®Google Scholar
• Fearon ER. Molecular genetics of colorectal cancer. Annu Rev Pathol 2011; 6:479 - 507; http://dx.doi.org/10.1146/annurev-pathol-011110-130235; PMID: 21090969
   PubMed Web of Science ®Google Scholar
• Pancione M, Remo A, Colantuoni V. Genetic and epigenetic events generate multiple pathways in colorectal cancer progression. Patholog Res Int 2012; 2012:509348; http://dx.doi.org/10.1155/2012/509348; PMID: 22888469
   PubMedGoogle Scholar
• Grivennikov SI. Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol 2013; 35:229 - 44; http://dx.doi.org/10.1007/s00281-012-0352-6; PMID: 23161445
   PubMed Web of Science ®Google Scholar
• Rogler G. Inflammatory bowel disease cancer risk, detection and surveillance. Dig Dis 2012; 30:Suppl 2 48 - 54; http://dx.doi.org/10.1159/000341893; PMID: 23207932
   PubMedGoogle Scholar
• Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009; 30:1073 - 81; http://dx.doi.org/10.1093/carcin/bgp127; PMID: 19468060
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646 - 74; http://dx.doi.org/10.1016/j.cell.2011.02.013; PMID: 21376230
   PubMed Web of Science ®Google Scholar
• Terzić J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology 2010; 138:2101 - 14, e5; http://dx.doi.org/10.1053/j.gastro.2010.01.058; PMID: 20420949
   PubMed Web of Science ®Google Scholar
• Fantini MC, Pallone F. Cytokines: from gut inflammation to colorectal cancer. Curr Drug Targets 2008; 9:375 - 80; http://dx.doi.org/10.2174/138945008784221206; PMID: 18473765
   PubMed Web of Science ®Google Scholar
• Bernstein CN, Blanchard JF, Kliewer E, Wajda A. Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 2001; 91:854 - 62; http://dx.doi.org/10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z; PMID: 11241255
   PubMed Web of Science ®Google Scholar
• Triantafillidis JK, Nasioulas G, Kosmidis PA. Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res 2009; 29:2727 - 37; PMID: 19596953
   PubMed Web of Science ®Google Scholar
• Farrell RJ, Peppercorn MA. Ulcerative colitis. Lancet 2002; 359:331 - 40; http://dx.doi.org/10.1016/S0140-6736(02)07499-8; PMID: 11830216
   PubMed Web of Science ®Google Scholar
• Gross O, Thomas CJ, Guarda G, Tschopp J. The inflammasome: an integrated view. Immunol Rev 2011; 243:136 - 51; http://dx.doi.org/10.1111/j.1600-065X.2011.01046.x; PMID: 21884173
   PubMed Web of Science ®Google Scholar
• Nunes T, de Souza HS. Inflammasome in intestinal inflammation and cancer. Mediators Inflamm 2013; 2013:654963; http://dx.doi.org/10.1155/2013/654963; PMID: 23606794
   PubMed Web of Science ®Google Scholar
• Ding WX, Yin XM. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem 2012; 393:547 - 64; http://dx.doi.org/10.1515/hsz-2012-0119; PMID: 22944659
   PubMed Web of Science ®Google Scholar
• Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013; 14:480 - 8; http://dx.doi.org/10.1038/ni.2563; PMID: 23525089
   PubMed Web of Science ®Google Scholar
• Wiart C, Kumar K, Yusof MY, Hamimah H, Fauzi ZM, Sulaiman M. Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Phytother Res 2005; 19:1069 - 70; http://dx.doi.org/10.1002/ptr.1765; PMID: 16372376
   PubMed Web of Science ®Google Scholar
• Abu-Ghefreh AA, Canatan H, Ezeamuzie CI. In vitro and in vivo anti-inflammatory effects of andrographolide. Int Immunopharmacol 2009; 9:313 - 8; http://dx.doi.org/10.1016/j.intimp.2008.12.002; PMID: 19110075
   PubMed Web of Science ®Google Scholar
• Chan SJ, Wong WS, Wong PT, Bian JS. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia. Br J Pharmacol 2010; 161:668 - 79; http://dx.doi.org/10.1111/j.1476-5381.2010.00906.x; PMID: 20880404
   PubMed Web of Science ®Google Scholar
• Rajagopal S, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J Exp Ther Oncol 2003; 3:147 - 58; http://dx.doi.org/10.1046/j.1359-4117.2003.01090.x; PMID: 14641821
   PubMedGoogle Scholar
• Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 2011; 31:986 - 1000; http://dx.doi.org/10.1161/ATVBAHA.110.207449; PMID: 21508345
   PubMed Web of Science ®Google Scholar
• Jobin C, Sartor RB. NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases. Inflamm Bowel Dis 2000; 6:206 - 13; http://dx.doi.org/10.1097/00054725-200008000-00007; PMID: 10961593
   PubMed Web of Science ®Google Scholar
• Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012; 36:401 - 14; http://dx.doi.org/10.1016/j.immuni.2012.01.009; PMID: 22342844
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469:221 - 5; http://dx.doi.org/10.1038/nature09663; PMID: 21124315
   PubMed Web of Science ®Google Scholar
• Nathan C, Ding A. Nonresolving inflammation. Cell 2010; 140:871 - 82; http://dx.doi.org/10.1016/j.cell.2010.02.029; PMID: 20303877
   PubMed Web of Science ®Google Scholar
• Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D. Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease. Gut 1990; 31:686 - 9; http://dx.doi.org/10.1136/gut.31.6.686; PMID: 2379873
   PubMed Web of Science ®Google Scholar
• Gionchetti P, Campieri M, Belluzzi A, Boni P, Brignola C, Ferretti H, Iannone P, Miglioli M, Barbara L. Interleukin 1 in ulcerative colitis. Gut 1991; 32:338; http://dx.doi.org/10.1136/gut.32.3.338-a; PMID: 2013435
   PubMed Web of Science ®Google Scholar
• Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP, Raedler A. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease. Clin Exp Immunol 1993; 94:174 - 81; http://dx.doi.org/10.1111/j.1365-2249.1993.tb05997.x; PMID: 8403503
   PubMed Web of Science ®Google Scholar
• McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 β and interleukin 1 β converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut 1998; 42:214 - 9; http://dx.doi.org/10.1136/gut.42.2.214; PMID: 9536946
   PubMed Web of Science ®Google Scholar
• Coccia M, Harrison OJ, Schiering C, Asquith MJ, Becher B, Powrie F, Maloy KJ. IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells. J Exp Med 2012; 209:1595 - 609; http://dx.doi.org/10.1084/jem.20111453; PMID: 22891275
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996; 87:2095 - 147; PMID: 8630372
   PubMed Web of Science ®Google Scholar
• Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A 2009; 106:7119 - 24; http://dx.doi.org/10.1073/pnas.0902745106; PMID: 19359475
   PubMed Web of Science ®Google Scholar
• Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006; 203:1685 - 91; http://dx.doi.org/10.1084/jem.20060285; PMID: 16818675
   PubMed Web of Science ®Google Scholar
• Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002; 10:417 - 26; http://dx.doi.org/10.1016/S1097-2765(02)00599-3; PMID: 12191486
   PubMed Web of Science ®Google Scholar
• Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010; 32:379 - 91; http://dx.doi.org/10.1016/j.immuni.2010.03.003; PMID: 20303296
   PubMed Web of Science ®Google Scholar
• Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C, Ting JP. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med 2010; 207:1045 - 56; http://dx.doi.org/10.1084/jem.20100050; PMID: 20385749
   PubMed Web of Science ®Google Scholar
• Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 2010; 59:1192 - 9; http://dx.doi.org/10.1136/gut.2009.197822; PMID: 20442201
   PubMed Web of Science ®Google Scholar
• Arai Y, Takanashi H, Kitagawa H, Okayasu I. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine 1998; 10:890 - 6; http://dx.doi.org/10.1006/cyto.1998.0355; PMID: 9878126
   PubMed Web of Science ®Google Scholar
• Siegmund B, Lehr H-A, Fantuzzi G, Dinarello CA. IL-1 β -converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci U S A 2001; 98:13249 - 54; http://dx.doi.org/10.1073/pnas.231473998; PMID: 11606779
   PubMed Web of Science ®Google Scholar
• Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M. Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors. Dig Dis 2012; 30:Suppl 1 82 - 90; http://dx.doi.org/10.1159/000341681; PMID: 23075874
   PubMed Web of Science ®Google Scholar
• Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, Dinarello CA, Endres S, Eigler A. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 2001; 281:R1264 - 73; PMID: 11557635
   PubMed Web of Science ®Google Scholar
• Sivakumar PV, Westrich GM, Kanaly S, Garka K, Born TL, Derry JM, Viney JL. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 2002; 50:812 - 20; http://dx.doi.org/10.1136/gut.50.6.812; PMID: 12010883
   PubMed Web of Science ®Google Scholar
• Bauer C, Loher F, Dauer M, Mayer C, Lehr HA, Schönharting M, Hallwachs R, Endres S, Eigler A. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression. Dig Dis Sci 2007; 52:1642 - 52; http://dx.doi.org/10.1007/s10620-007-9802-8; PMID: 17393315
   PubMed Web of Science ®Google Scholar
• Loher F, Bauer C, Landauer N, Schmall K, Siegmund B, Lehr HA, Dauer M, Schoenharting M, Endres S, Eigler A. The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation. J Pharmacol Exp Ther 2004; 308:583 - 90; http://dx.doi.org/10.1124/jpet.103.057059; PMID: 14610233
   PubMed Web of Science ®Google Scholar
• Thomas TK, Will PC, Srivastava A, Wilson CL, Harbison M, Little J, Chesonis RS, Pignatello M, Schmolze D, Symington J, et al. Evaluation of an interleukin-1 receptor antagonist in the rat acetic acid-induced colitis model. Agents Actions 1991; 34:187 - 90; http://dx.doi.org/10.1007/BF01993274; PMID: 1838896
   PubMedGoogle Scholar
• Coll RC, O’Neill LA. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS One 2011; 6:e29539; http://dx.doi.org/10.1371/journal.pone.0029539; PMID: 22216309
   PubMedGoogle Scholar
• Lee KC, Chang HH, Chung YH, Lee TY. Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. J Ethnopharmacol 2011; 135:678 - 84; http://dx.doi.org/10.1016/j.jep.2011.03.068; PMID: 21497192
   PubMed Web of Science ®Google Scholar
• Hsieh CY, Hsu MJ, Hsiao G, Wang YH, Huang CW, Chen SW, Jayakumar T, Chiu PT, Chiu YH, Sheu JR. Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells. J Biol Chem 2011; 286:5942 - 55; http://dx.doi.org/10.1074/jbc.M110.123968; PMID: 21169355
   PubMed Web of Science ®Google Scholar
• Martinon F. Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome. Immunity 2012; 36:313 - 5; http://dx.doi.org/10.1016/j.immuni.2012.03.005; PMID: 22444626
   PubMed Web of Science ®Google Scholar
• Kepp O, Galluzzi L, Kroemer G. Mitochondrial control of the NLRP3 inflammasome. Nat Immunol 2011; 12:199 - 200; http://dx.doi.org/10.1038/ni0311-199; PMID: 21321591
   PubMed Web of Science ®Google Scholar
• Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140:821 - 32; http://dx.doi.org/10.1016/j.cell.2010.01.040; PMID: 20303873
   PubMed Web of Science ®Google Scholar
• Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12:222 - 30; http://dx.doi.org/10.1038/ni.1980; PMID: 21151103
   PubMed Web of Science ®Google Scholar
• Chen W, Feng L, Nie H, Zheng X. Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore. Carcinogenesis 2012; 33:2190 - 8; http://dx.doi.org/10.1093/carcin/bgs264; PMID: 22869602
   PubMed Web of Science ®Google Scholar
• Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia D, Zhu X, Yang XF, Ong CN, Shen HM. Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells. Autophagy 2012; 8:338 - 49; http://dx.doi.org/10.4161/auto.18721; PMID: 22302005
   PubMed Web of Science ®Google Scholar
• Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A 2012; 109:6130 - 5; http://dx.doi.org/10.1073/pnas.1201351109; PMID: 22474389
   PubMed Web of Science ®Google Scholar
• Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2007; 2:541 - 6; http://dx.doi.org/10.1038/nprot.2007.41; PMID: 17406617
   PubMed Web of Science ®Google Scholar
• Guo WJ, Zhang YM, Zhang L, Huang B, Tao FF, Chen W, Guo ZJ, Xu Q, Sun Y. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin. Autophagy 2013; 9:996 - 1008; http://dx.doi.org/10.4161/auto.24407; PMID: 23580233
   PubMed Web of Science ®Google Scholar