2,680
Views
54
CrossRef citations to date
0
Altmetric
Basic Research Paper

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

, , , , , & show all
Pages 1212-1228 | Received 17 Apr 2013, Accepted 03 Apr 2014, Published online: 30 Apr 2014

References

  • Verheij M. Clinical biomarkers and imaging for radiotherapy-induced cell death. Cancer Metastasis Rev 2008; 27:471 - 80; http://dx.doi.org/10.1007/s10555-008-9131-1; PMID: 18470482
  • Ren JL, Pan JS, Lu YP, Sun P, Han J. Inflammatory signaling and cellular senescence. Cell Signal 2009; 21:378 - 83; http://dx.doi.org/10.1016/j.cellsig.2008.10.011; PMID: 18992324
  • Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev 2011; 25:814 - 30; http://dx.doi.org/10.1101/gad.2000211; PMID: 21498571
  • Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547 - 56; http://dx.doi.org/10.1083/jcb.201009094; PMID: 21321098
  • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5:99 - 118; http://dx.doi.org/10.1146/annurev-pathol-121808-102144; PMID: 20078217
  • Morgan WF, Sowa MB. Non-targeted bystander effects induced by ionizing radiation. Mutat Res 2007; 616:159 - 64; http://dx.doi.org/10.1016/j.mrfmmm.2006.11.009; PMID: 17134726
  • Choi KS. Autophagy and cancer. Exp Mol Med 2012; 44:109 - 20; http://dx.doi.org/10.3858/emm.2012.44.2.033; PMID: 22257886
  • Brech A, Ahlquist T, Lothe RA, Stenmark H. Autophagy in tumour suppression and promotion. Mol Oncol 2009; 3:366 - 75; http://dx.doi.org/10.1016/j.molonc.2009.05.007; PMID: 19559660
  • Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev 2007; 28:165 - 86; http://dx.doi.org/10.1210/er.2006-0042; PMID: 17325339
  • Chiu SJ, Chao JI, Lee YJ, Hsu TS. Regulation of gamma-H2AX and securin contribute to apoptosis by oxaliplatin via a p38 mitogen-activated protein kinase-dependent pathway in human colorectal cancer cells. Toxicol Lett 2008; 179:63 - 70; http://dx.doi.org/10.1016/j.toxlet.2008.04.004; PMID: 18499365
  • Panguluri SK, Yeakel C, Kakar SS. PTTG: an important target gene for ovarian cancer therapy. J Ovarian Res 2008; 1:6; http://dx.doi.org/10.1186/1757-2215-1-6; PMID: 19014669
  • Chen WS, Yu YC, Lee YJ, Chen JH, Hsu HY, Chiu SJ. Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression. Int J Radiat Oncol Biol Phys 2010; 77:566 - 74; http://dx.doi.org/10.1016/j.ijrobp.2009.12.013; PMID: 20457353
  • Yu YC, Yang PM, Chuah QY, Huang YH, Peng CW, Lee YJ, Chiu SJ. Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways. Sci Rep 2013; 3:1675; http://dx.doi.org/10.1038/srep01675; PMID: 23591770
  • Young AR, Narita M. Connecting autophagy to senescence in pathophysiology. Curr Opin Cell Biol 2010; 22:234 - 40; http://dx.doi.org/10.1016/j.ceb.2009.12.005; PMID: 20045302
  • Narita M, Young AR, Narita M. Autophagy facilitates oncogene-induced senescence. Autophagy 2009; 5:1046 - 7; http://dx.doi.org/10.4161/auto.5.7.9444; PMID: 19652542
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. Lab Invest 2010; 90:835 - 43; http://dx.doi.org/10.1038/labinvest.2010.56; PMID: 20212459
  • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542 - 5; PMID: 17611390
  • Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445 - 544; http://dx.doi.org/10.4161/auto.19496; PMID: 22966490
  • Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603 - 14; http://dx.doi.org/10.1083/jcb.200507002; PMID: 16286508
  • Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657 - 68; http://dx.doi.org/10.1083/jcb.152.4.657; PMID: 11266458
  • Kang HT, Lee KB, Kim SY, Choi HR, Park SC. Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 2011; 6:e23367; http://dx.doi.org/10.1371/journal.pone.0023367; PMID: 21858089
  • Essmann F, Engels IH, Totzke G, Schulze-Osthoff K, Jänicke RU. Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res 2004; 64:7065 - 72; http://dx.doi.org/10.1158/0008-5472.CAN-04-1082; PMID: 15466201
  • Williams ME, Quesenberry PJ. Hematopoietic growth factors. Hematol Pathol 1992; 6:105 - 24; PMID: 1429340
  • Mueller MM, Herold-Mende CC, Riede D, Lange M, Steiner HH, Fusenig NE. Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression. Am J Pathol 1999; 155:1557 - 67; http://dx.doi.org/10.1016/S0002-9440(10)65472-7; PMID: 10550313
  • Obermueller E, Vosseler S, Fusenig NE, Mueller MM. Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells. Cancer Res 2004; 64:7801 - 12; http://dx.doi.org/10.1158/0008-5472.CAN-03-3301; PMID: 15520186
  • Pei XH, Nakanishi Y, Takayama K, Bai F, Hara N. Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells. Br J Cancer 1999; 79:40 - 6; http://dx.doi.org/10.1038/sj.bjc.6690009; PMID: 10408691
  • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5:99 - 118; http://dx.doi.org/10.1146/annurev-pathol-121808-102144; PMID: 20078217
  • Brizzi MF, Aronica MG, Rosso A, Bagnara GP, Yarden Y, Pegoraro L. Granulocyte-macrophage colony-stimulating factor stimulates JAK2 signaling pathway and rapidly activates p93fes, STAT1 p91, and STAT3 p92 in polymorphonuclear leukocytes. J Biol Chem 1996; 271:3562 - 7; http://dx.doi.org/10.1074/jbc.271.7.3562; PMID: 8631962
  • Zhu W, Fu A, Hu J, Wang T, Luo Y, Peng M, Ma Y, Wei Y, Chen L. 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway. Exp Mol Med 2011; 43:146 - 52; http://dx.doi.org/10.3858/emm.2011.43.3.017; PMID: 21297378
  • Chen Z, Htay A, Dos Santos W, Gillies GT, Fillmore HL, Sholley MM, Broaddus WC. In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. J Neurooncol 2009; 92:121 - 8; http://dx.doi.org/10.1007/s11060-008-9742-y; PMID: 19039523
  • Matsui J, Wakabayashi T, Asada M, Yoshimatsu K, Okada M. Stem cell factor/c-kit signaling promotes the survival, migration, and capillary tube formation of human umbilical vein endothelial cells. J Biol Chem 2004; 279:18600 - 7; http://dx.doi.org/10.1074/jbc.M311643200; PMID: 14985355
  • Zois CE, Koukourakis MI. Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies?. Autophagy 2009; 5:442 - 50; http://dx.doi.org/10.4161/auto.5.4.7667; PMID: 19164950
  • Gewirtz DA. Autophagy, senescence and tumor dormancy in cancer therapy. Autophagy 2009; 5:1232 - 4; http://dx.doi.org/10.4161/auto.5.8.9896; PMID: 19770583
  • Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654 - 66; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634; PMID: 21325294
  • Young AR, Narita M. Connecting autophagy to senescence in pathophysiology. Curr Opin Cell Biol 2010; 22:234 - 40; http://dx.doi.org/10.1016/j.ceb.2009.12.005; PMID: 20045302
  • Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?. J Pharmacol Exp Ther 2012; 343:763 - 78; http://dx.doi.org/10.1124/jpet.112.197590; PMID: 22927544
  • Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, et al. Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23:798 - 803; http://dx.doi.org/10.1101/gad.519709; PMID: 19279323
  • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741 - 52; http://dx.doi.org/10.1038/nrm2239; PMID: 17717517
  • Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA. p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells. Int J Radiat Biol 2005; 81:445 - 58; http://dx.doi.org/10.1080/09553000500168549; PMID: 16308915
  • Rzeszowska-Wolny J, Przybyszewski WM, Widel M. Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy. Eur J Pharmacol 2009; 625:156 - 64; http://dx.doi.org/10.1016/j.ejphar.2009.07.028; PMID: 19835860
  • Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547 - 56; http://dx.doi.org/10.1083/jcb.201009094; PMID: 21321098
  • Huang WL, Yeh HH, Lin CC, Lai WW, Chang JY, Chang WT, Su WC. Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Mol Cancer 2010; 9:309; http://dx.doi.org/10.1186/1476-4598-9-309; PMID: 21122157
  • Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001; 11:S27 - 31; http://dx.doi.org/10.1016/S0962-8924(01)02151-1; PMID: 11684439
  • Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 2009; 9:81 - 94; http://dx.doi.org/10.1038/nrc2560; PMID: 19132009
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. Lab Invest 2010; 90:835 - 43; http://dx.doi.org/10.1038/labinvest.2010.56; PMID: 20212459
  • Lorusso G, Rüegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 2008; 130:1091 - 103; http://dx.doi.org/10.1007/s00418-008-0530-8; PMID: 18987874
  • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3:401 - 10; http://dx.doi.org/10.1038/nrc1093; PMID: 12778130
  • Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy 2011; 7:829 - 39; http://dx.doi.org/10.4161/auto.7.8.15598; PMID: 21685724
  • Sun Y, Liu JH, Sui YX, Jin L, Yang Y, Lin SM, Shi H. Beclin1 overexpression inhibitis proliferation, invasion and migration of CaSki cervical cancer cells. Asian Pac J Cancer Prev 2011; 12:1269 - 73; PMID: 21875280
  • Yang Z, Klionsky DJ. An overview of the molecular mechanism of autophagy. Curr Top Microbiol Immunol 2009; 335:1 - 32; http://dx.doi.org/10.1007/978-3-642-00302-8_1; PMID: 19802558
  • Lv Q, Wang W, Xue J, Hua F, Mu R, Lin H, Yan J, Lv X, Chen X, Hu ZW. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res 2012; 72:3238 - 50; http://dx.doi.org/10.1158/0008-5472.CAN-11-3832; PMID: 22719072
  • Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 2009; 4:1798 - 806; http://dx.doi.org/10.1038/nprot.2009.191; PMID: 20010931
  • Artym VV, Yamada KM, Mueller SC. ECM degradation assays for analyzing local cell invasion. Methods Mol Biol 2009; 522:211 - 9; http://dx.doi.org/10.1007/978-1-59745-413-1_15; PMID: 19247615

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.