A curated census of autophagy-modulating proteins and small molecules

References

• De Duve C, Wattiaux R. Functions of lysosomes. Annu Rev Physiol 1966; 28:435 - 92; http://dx.doi.org/10.1146/annurev.ph.28.030166.002251; PMID: 5322983
   PubMed Web of Science ®Google Scholar
• Mijaljica D, Prescott M, Devenish RJ. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 2011; 7:673 - 82; http://dx.doi.org/10.4161/auto.7.7.14733; PMID: 21646866
   PubMed Web of Science ®Google Scholar
• Kaushik S, Bandyopadhyay U, Sridhar S, Kiffin R, Martinez-Vicente M, Kon M, Orenstein SJ, Wong E, Cuervo AM. Chaperone-mediated autophagy at a glance. J Cell Sci 2011; 124:495 - 9; http://dx.doi.org/10.1242/jcs.073874; PMID: 21282471
   PubMed Web of Science ®Google Scholar
• White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12:401 - 10; http://dx.doi.org/10.1038/nrc3262; PMID: 22534666
   PubMed Web of Science ®Google Scholar
• Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010; 466:68 - 76; http://dx.doi.org/10.1038/nature09204; PMID: 20562859
   PubMed Web of Science ®Google Scholar
• Dengjel J, Høyer-Hansen M, Nielsen MO, Eisenberg T, Harder LM, Schandorff S, Farkas T, Kirkegaard T, Becker AC, Schroeder S, et al. Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Mol Cell Proteomics 2012; 11:014035; http://dx.doi.org/10.1074/mcp.M111.014035; PMID: 22311637
   PubMedGoogle Scholar
• Homma K, Suzuki K, Sugawara H. The Autophagy Database: an all-inclusive information resource on autophagy that provides nourishment for research. Nucleic Acids Res 2011; 39:D986 - 90; http://dx.doi.org/10.1093/nar/gkq995; PMID: 20972215
   PubMed Web of Science ®Google Scholar
• Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem 2007; 282:25464 - 74; http://dx.doi.org/10.1074/jbc.M703663200; PMID: 17595159
   PubMed Web of Science ®Google Scholar
• Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, et al. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 2010; 18:1041 - 52; http://dx.doi.org/10.1016/j.devcel.2010.05.005; PMID: 20627085
   PubMed Web of Science ®Google Scholar
• Szyniarowski P, Corcelle-Termeau E, Farkas T, Høyer-Hansen M, Nylandsted J, Kallunki T, Jäättelä M. A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions. Autophagy 2011; 7:892 - 903; http://dx.doi.org/10.4161/auto.7.8.15770; PMID: 21508686
   PubMed Web of Science ®Google Scholar
• McKnight NC, Jefferies HB, Alemu EA, Saunders RE, Howell M, Johansen T, Tooze SA. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J 2012; 31:1931 - 46; http://dx.doi.org/10.1038/emboj.2012.36; PMID: 22354037
   PubMed Web of Science ®Google Scholar
• Kestler HA, Müller A, Gress TM, Buchholz M. Generalized Venn diagrams: a new method of visualizing complex genetic set relations. Bioinformatics 2005; 21:1592 - 5; http://dx.doi.org/10.1093/bioinformatics/bti169; PMID: 15572472
   PubMed Web of Science ®Google Scholar
• Kestler HA, Müller A, Kraus JM, Buchholz M, Gress TM, Liu H, Kane DW, Zeeberg BR, Weinstein JN. VennMaster: area-proportional Euler diagrams for functional GO analysis of microarrays. BMC Bioinformatics 2008; 9:67; http://dx.doi.org/10.1186/1471-2105-9-67; PMID: 18230172
   PubMed Web of Science ®Google Scholar
• Cardoso CM, Groth-Pedersen L, Høyer-Hansen M, Kirkegaard T, Corcelle E, Andersen JS, Jäättelä M, Nylandsted J. Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells. PLoS One 2009; 4:e4424; http://dx.doi.org/10.1371/journal.pone.0004424; PMID: 19242560
   PubMed Web of Science ®Google Scholar
• Jane EP, Premkumar DR, Pollack IF. Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-kappaB signaling pathway. Mol Cancer Ther 2011; 10:198 - 208; http://dx.doi.org/10.1158/1535-7163.MCT-10-0725; PMID: 21220502
   PubMed Web of Science ®Google Scholar
• Seldon MP, Silva G, Pejanovic N, Larsen R, Gregoire IP, Filipe J, Anrather J, Soares MP. Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. J Immunol 2007; 179:7840 - 51; http://dx.doi.org/10.4049/jimmunol.179.11.7840; PMID: 18025230
   PubMed Web of Science ®Google Scholar
• Lim CB, Fu PY, Ky N, Zhu HS, Feng X, Li J, Srinivasan KG, Hamza MS, Zhao Y. NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC Complement Altern Med 2012; 12:93; http://dx.doi.org/10.1186/1472-6882-12-93; PMID: 22784363
   PubMed Web of Science ®Google Scholar
• Perkins ND. The diverse and complex roles of NF-κB subunits in cancer. Nat Rev Cancer 2012; 12:121 - 32; PMID: 22257950
   PubMed Web of Science ®Google Scholar
• Sarfstein R, Werner H. The WT1 Wilms’ tumor suppressor gene is a downstream target for insulin-like growth factor-I (IGF-I) action in PC12 cells. J Neurochem 2006; 99:818 - 26; http://dx.doi.org/10.1111/j.1471-4159.2006.04119.x; PMID: 16911581
   PubMed Web of Science ®Google Scholar
• Bratton MR, Frigo DE, Vigh-Conrad KA, Fan D, Wadsworth S, McLachlan JA, Burow ME. Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase. Carcinogenesis 2009; 30:106 - 13; http://dx.doi.org/10.1093/carcin/bgn213; PMID: 18791200
   PubMed Web of Science ®Google Scholar
• Pulgar V, Tapia C, Vignolo P, Santos J, Sunkel CE, Allende CC, Allende JE. The recombinant alpha isoform of protein kinase CK1 from Xenopus laevis can phosphorylate tyrosine in synthetic substrates. Eur J Biochem 1996; 242:519 - 28; http://dx.doi.org/10.1111/j.1432-1033.1996.0519r.x; PMID: 9022677
   PubMedGoogle Scholar
• Matsushita Y, Hanazawa K, Yoshioka K, Oguchi T, Kawakami S, Watanabe Y, Nishiguchi M, Nyunoya H. In vitro phosphorylation of the movement protein of tomato mosaic tobamovirus by a cellular kinase. J Gen Virol 2000; 81:2095 - 102; PMID: 10900049
   PubMed Web of Science ®Google Scholar
• Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K. Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol 2006; 26:6024 - 36; http://dx.doi.org/10.1128/MCB.02354-05; PMID: 16880514
   PubMed Web of Science ®Google Scholar
• Mitev V, Pauloin A, Houdebine LM. Purification and characterization of casein kinase II from lactating rabbit mammary gland. Int J Biochem 1994; 26:667 - 77; http://dx.doi.org/10.1016/0020-711X(94)90167-8; PMID: 8005352
   PubMedGoogle Scholar
• Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 2007; 14:500 - 10; http://dx.doi.org/10.1038/sj.cdd.4402039; PMID: 16990848
   PubMed Web of Science ®Google Scholar
• Rikka S, Quinsay MN, Thomas RL, Kubli DA, Zhang X, Murphy AN, Gustafsson AB. Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover. Cell Death Differ 2011; 18:721 - 31; http://dx.doi.org/10.1038/cdd.2010.146; PMID: 21278801
   PubMed Web of Science ®Google Scholar
• Sinha S, Levine B. The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 2008; 27:Suppl 1 S137 - 48; http://dx.doi.org/10.1038/onc.2009.51; PMID: 19641499
   PubMed Web of Science ®Google Scholar
• Höcker R, Walker A, Schmitz I. Inhibition of autophagy through MAPK14-mediated phosphorylation of ATG5. Autophagy 2013; 9:426 - 8; http://dx.doi.org/10.4161/auto.22924; PMID: 23235332
   PubMed Web of Science ®Google Scholar
• Sakaki K, Wu J, Kaufman RJ. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem 2008; 283:15370 - 80; http://dx.doi.org/10.1074/jbc.M710209200; PMID: 18356160
   PubMed Web of Science ®Google Scholar
• Maiuri MC, Malik SA, Morselli E, Kepp O, Criollo A, Mouchel PL, Carnuccio R, Kroemer G. Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 2009; 8:1571 - 6; http://dx.doi.org/10.4161/cc.8.10.8498; PMID: 19377293
   PubMed Web of Science ®Google Scholar
• Tennant DA, Durán RV, Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 2010; 10:267 - 77; http://dx.doi.org/10.1038/nrc2817; PMID: 20300106
   PubMed Web of Science ®Google Scholar
• Kim KW, Mutter RW, Cao C, Albert JM, Freeman M, Hallahan DE, Lu B. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 2006; 281:36883 - 90; http://dx.doi.org/10.1074/jbc.M607094200; PMID: 17005556
   PubMed Web of Science ®Google Scholar
• Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N, Fueyo J. The RB-E2F1 pathway regulates autophagy. Cancer Res 2010; 70:7882 - 93; http://dx.doi.org/10.1158/0008-5472.CAN-10-1604; PMID: 20807803
   PubMed Web of Science ®Google Scholar
• Pattingre S, Petiot A, Codogno P. Analyses of Galpha-interacting protein and activator of G-protein-signaling-3 functions in macroautophagy. Methods Enzymol 2004; 390:17 - 31; http://dx.doi.org/10.1016/S0076-6879(04)90002-X; PMID: 15488168
   PubMed Web of Science ®Google Scholar
• Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol 2008; 10:935 - 45; http://dx.doi.org/10.1038/ncb1753; PMID: 18604198
   PubMed Web of Science ®Google Scholar
• Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D’Amelio M, Criollo A, Morselli E, Zhu C, Harper F, et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 2008; 10:676 - 87; http://dx.doi.org/10.1038/ncb1730; PMID: 18454141
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle 2010; 9:3515 - 33; http://dx.doi.org/10.4161/cc.9.17.12928; PMID: 20855962
   PubMed Web of Science ®Google Scholar
• Jiang M, Liu K, Luo J, Dong Z. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol 2010; 176:1181 - 92; http://dx.doi.org/10.2353/ajpath.2010.090594; PMID: 20075199
   PubMed Web of Science ®Google Scholar
• Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283:10892 - 903; http://dx.doi.org/10.1074/jbc.M800102200; PMID: 18281291
   PubMed Web of Science ®Google Scholar
• Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10:51 - 64; http://dx.doi.org/10.1016/j.ccr.2006.06.001; PMID: 16843265
   PubMed Web of Science ®Google Scholar
• Samari HR, Seglen PO. Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem 1998; 273:23758 - 63; http://dx.doi.org/10.1074/jbc.273.37.23758; PMID: 9726984
   PubMed Web of Science ®Google Scholar
• Meley D, Bauvy C, Houben-Weerts JH, Dubbelhuis PF, Helmond MT, Codogno P, Meijer AJ. AMP-activated protein kinase and the regulation of autophagic proteolysis. J Biol Chem 2006; 281:34870 - 9; http://dx.doi.org/10.1074/jbc.M605488200; PMID: 16990266
   PubMed Web of Science ®Google Scholar
• Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P. Role of AMP-activated protein kinase in autophagy and proteasome function. Biochem Biophys Res Commun 2008; 369:964 - 8; http://dx.doi.org/10.1016/j.bbrc.2008.02.126; PMID: 18328803
   PubMed Web of Science ®Google Scholar
• Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13:1016 - 23; http://dx.doi.org/10.1038/ncb2329; PMID: 21892142
   PubMed Web of Science ®Google Scholar
• Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, Atomi Y, Ueno T, Ochiai A, Esumi H. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 2007; 67:9677 - 84; http://dx.doi.org/10.1158/0008-5472.CAN-07-1462; PMID: 17942897
   PubMed Web of Science ®Google Scholar
• White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15:5308 - 16; http://dx.doi.org/10.1158/1078-0432.CCR-07-5023; PMID: 19706824
   PubMed Web of Science ®Google Scholar
• Adastra KL, Chi MM, Riley JK, Moley KH. A differential autophagic response to hyperglycemia in the developing murine embryo. Reproduction 2011; 141:607 - 15; http://dx.doi.org/10.1530/REP-10-0265; PMID: 21367963
   PubMed Web of Science ®Google Scholar
• Chiang HL, Schekman R, Hamamoto S. Selective uptake of cytosolic, peroxisomal, and plasma membrane proteins into the yeast lysosome for degradation. J Biol Chem 1996; 271:9934 - 41; http://dx.doi.org/10.1074/jbc.271.17.9934; PMID: 8626630
   PubMed Web of Science ®Google Scholar
• Han D, Yang B, Olson LK, Greenstein A, Baek SH, Claycombe KJ, Goudreau JL, Yu SW, Kim EK. Activation of autophagy through modulation of 5′-AMP-activated protein kinase protects pancreatic beta-cells from high glucose. Biochem J 2010; 425:541 - 51; http://dx.doi.org/10.1042/BJ20090429; PMID: 19903169
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 2003; 12:985 - 94; http://dx.doi.org/10.1093/hmg/ddg109; PMID: 12700167
   PubMed Web of Science ®Google Scholar
• Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem 2010; 285:11061 - 7; http://dx.doi.org/10.1074/jbc.R109.072181; PMID: 20147746
   PubMed Web of Science ®Google Scholar
• Lacraz G, Giroix MH, Kassis N, Coulaud J, Galinier A, Noll C, Cornut M, Schmidlin F, Paul JL, Janel N, et al. Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat. PLoS One 2009; 4:e6963; http://dx.doi.org/10.1371/journal.pone.0006963; PMID: 19742300
   PubMedGoogle Scholar
• Quan Y, Du J, Wang X. High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-kappaB pathways. J Neurosci Res 2007; 85:3150 - 9; http://dx.doi.org/10.1002/jnr.21421; PMID: 17639599
   PubMed Web of Science ®Google Scholar
• Szabó C, Biser A, Benko R, Böttinger E, Suszták K. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes 2006; 55:3004 - 12; http://dx.doi.org/10.2337/db06-0147; PMID: 17065336
   PubMed Web of Science ®Google Scholar
• Durán RV, Oppliger W, Robitaille AM, Heiserich L, Skendaj R, Gottlieb E, Hall MN. Glutaminolysis activates Rag-mTORC1 signaling. Mol Cell 2012; 47:349 - 58; http://dx.doi.org/10.1016/j.molcel.2012.05.043; PMID: 22749528
   PubMed Web of Science ®Google Scholar
• van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, et al. Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol 2012; 14:829 - 37; http://dx.doi.org/10.1038/ncb2536; PMID: 22820375
   PubMed Web of Science ®Google Scholar
• Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Sci Signal 2010; 3:ra31; http://dx.doi.org/10.1126/scisignal.2000911; PMID: 20424262
   PubMed Web of Science ®Google Scholar
• Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009; 136:521 - 34; http://dx.doi.org/10.1016/j.cell.2008.11.044; PMID: 19203585
   PubMed Web of Science ®Google Scholar
• Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2010; 120:127 - 41; http://dx.doi.org/10.1172/JCI40027; PMID: 20038797
   PubMed Web of Science ®Google Scholar
• Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010; 29:4424 - 35; http://dx.doi.org/10.1038/onc.2010.191; PMID: 20514020
   PubMed Web of Science ®Google Scholar
• Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr 2010; 140:2020 - 7; http://dx.doi.org/10.3945/jn.110.129197; PMID: 20861212
   PubMed Web of Science ®Google Scholar
• Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res 2010; 70:2465 - 75; http://dx.doi.org/10.1158/0008-5472.CAN-09-2782; PMID: 20215500
   PubMed Web of Science ®Google Scholar
• Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67:6745 - 52; http://dx.doi.org/10.1158/0008-5472.CAN-06-4447; PMID: 17638885
   PubMed Web of Science ®Google Scholar
• Claerhout S, Verschooten L, Van Kelst S, De Vos R, Proby C, Agostinis P, Garmyn M. Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. Int J Cancer 2010; 127:2790 - 803; http://dx.doi.org/10.1002/ijc.25300; PMID: 21351258
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654 - 66; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634; PMID: 21325294
   PubMed Web of Science ®Google Scholar
• Wander SA, Hennessy BT, Slingerland JM. Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest 2011; 121:1231 - 41; http://dx.doi.org/10.1172/JCI44145; PMID: 21490404
   PubMed Web of Science ®Google Scholar
• Kasof GM, Prosser JC, Liu D, Lorenzi MV, Gomes BC. The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. FEBS Lett 2000; 473:285 - 91; http://dx.doi.org/10.1016/S0014-5793(00)01473-3; PMID: 10818227
   PubMed Web of Science ®Google Scholar
• Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 2011; 34:340 - 51; http://dx.doi.org/10.1016/j.immuni.2010.12.018; PMID: 21419663
   PubMed Web of Science ®Google Scholar
• Kanki T, Klionsky DJ. The molecular mechanism of mitochondria autophagy in yeast. Mol Microbiol 2010; 75:795 - 800; http://dx.doi.org/10.1111/j.1365-2958.2009.07035.x; PMID: 20487284
   PubMed Web of Science ®Google Scholar
• Kissová I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004; 279:39068 - 74; http://dx.doi.org/10.1074/jbc.M406960200; PMID: 15247238
   PubMed Web of Science ®Google Scholar
• Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, et al. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One 2012; 7:e41831; http://dx.doi.org/10.1371/journal.pone.0041831; PMID: 22848625
   PubMed Web of Science ®Google Scholar
• Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB, Casimiro MC, Wang C, Pestell RG, et al. HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle 2010; 9:3534 - 51; http://dx.doi.org/10.4161/cc.9.17.12908; PMID: 20864819
   PubMed Web of Science ®Google Scholar
• Bourgeaux V, Hequet O, Campion Y, Delcambre G, Chevrier AM, Rigal D, Godfrin Y. Inositol hexaphosphate-loaded red blood cells prevent in vitro sickling. Transfusion 2010; 50:2176 - 84; http://dx.doi.org/10.1111/j.1537-2995.2010.02663.x; PMID: 20456710
   PubMed Web of Science ®Google Scholar
• Yu M, Henning R, Walker A, Kim G, Perroy A, Alessandro R, Virador V, Kohn EC. L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. J Cell Mol Med 2012; 16:2369 - 78; http://dx.doi.org/10.1111/j.1582-4934.2012.01547.x; PMID: 22333033
   PubMed Web of Science ®Google Scholar
• Avramis VI. Asparaginases: biochemical pharmacology and modes of drug resistance. Anticancer Res 2012; 32:2423 - 37; PMID: 22753699
   PubMed Web of Science ®Google Scholar
• Kumar K, Kaur J, Walia S, Pathak T, Aggarwal D. L-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia. Leuk Lymphoma 2014; 55:256 - 62; http://dx.doi.org/10.3109/10428194.2013.803224; PMID: 23662993
   PubMed Web of Science ®Google Scholar
• Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25:460 - 70; http://dx.doi.org/10.1101/gad.2016311; PMID: 21317241
   PubMed Web of Science ®Google Scholar
• Yang ZJ, Chee CE, Huang S, Sinicrope F. Autophagy modulation for cancer therapy. Cancer Biol Ther 2011; 11:169 - 76; http://dx.doi.org/10.4161/cbt.11.2.14663; PMID: 21263212
   PubMed Web of Science ®Google Scholar
• Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 2013; 27:1447 - 61; http://dx.doi.org/10.1101/gad.219642.113; PMID: 23824538
   PubMed Web of Science ®Google Scholar
• Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov 2013; 3:1272 - 85; http://dx.doi.org/10.1158/2159-8290.CD-13-0397; PMID: 23965987
   PubMed Web of Science ®Google Scholar
• Claerhout S, Dutta B, Bossuyt W, Zhang F, Nguyen-Charles C, Dennison JB, Yu Q, Yu S, Balázsi G, Lu Y, et al. Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells. PLoS One 2012; 7:e39400; http://dx.doi.org/10.1371/journal.pone.0039400; PMID: 22745748
   PubMedGoogle Scholar
• Zhang JH, Chung TD, Oldenburg KR. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 1999; 4:67 - 73; http://dx.doi.org/10.1177/108705719900400206; PMID: 10838414
   PubMed Web of Science ®Google Scholar