Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

Reference

• Skrott Z, Cvek B. Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells. Mini Rev Med Chem 2012; 12:1184 - 92; http://dx.doi.org/10.2174/138955712802762068; PMID: 22931589
   PubMed Web of Science ®Google Scholar
• Loganathan R, Ramakrishnan S, Suresh E, Riyasdeen A, Akbarsha MA, Palaniandavar M. Mixed ligand copper(II) complexes of N,N-bis(benzimidazol-2-ylmethyl)amine (BBA) with diimine co-ligands: efficient chemical nuclease and protease activities and cytotoxicity. Inorg Chem 2012; 51:5512 - 32; http://dx.doi.org/10.1021/ic2017177; PMID: 22559171
   PubMed Web of Science ®Google Scholar
• Gandin V, Pellei M, Tisato F, Porchia M, Santini C, Marzano C. A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling. J Cell Mol Med 2012; 16:142 - 51; http://dx.doi.org/10.1111/j.1582-4934.2011.01292.x; PMID: 21388518
   PubMed Web of Science ®Google Scholar
• Duff B, Thangella VR, Creaven BS, Walsh M, Egan DA. Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells. Eur J Pharmacol 2012; 689:45 - 55; http://dx.doi.org/10.1016/j.ejphar.2012.06.004; PMID: 22705894
   PubMed Web of Science ®Google Scholar
• Frezza M, Hindo S, Chen D, Davenport A, Schmitt S, Tomco D, Dou QP. Novel metals and metal complexes as platforms for cancer therapy. Curr Pharm Des 2010; 16:1813 - 25; http://dx.doi.org/10.2174/138161210791209009; PMID: 20337575
   PubMed Web of Science ®Google Scholar
• Chen D, Dou QP. New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer. Expert Opin Ther Targets 2008; 12:739 - 48; http://dx.doi.org/10.1517/14728222.12.6.739; PMID: 18479220
   PubMed Web of Science ®Google Scholar
• Chen D, Milacic V, Frezza M, Dou QP. Metal complexes, their cellular targets and potential for cancer therapy. Curr Pharm Des 2009; 15:777 - 91; http://dx.doi.org/10.2174/138161209787582183; PMID: 19275642
   PubMed Web of Science ®Google Scholar
• Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 2007; 7:573 - 84; http://dx.doi.org/10.1038/nrc2167; PMID: 17625587
   PubMed Web of Science ®Google Scholar
• Tardito S, Marchiò L. Copper compounds in anticancer strategies. Curr Med Chem 2009; 16:1325 - 48; http://dx.doi.org/10.2174/092986709787846532; PMID: 19355889
   PubMed Web of Science ®Google Scholar
• Jungwirth U, Kowol CR, Keppler BK, Hartinger CG, Berger W, Heffeter P. Anticancer activity of metal complexes: involvement of redox processes. Antioxid Redox Signal 2011; 15:1085 - 127; http://dx.doi.org/10.1089/ars.2010.3663; PMID: 21275772
   PubMed Web of Science ®Google Scholar
• Duncan C, White AR. Copper complexes as therapeutic agents. Metallomics 2012; 4:127 - 38; http://dx.doi.org/10.1039/c2mt00174h; PMID: 22187112
   PubMed Web of Science ®Google Scholar
• Chen D, Cui QC, Yang H, Dou QP. Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res 2006; 66:10425 - 33; http://dx.doi.org/10.1158/0008-5472.CAN-06-2126; PMID: 17079463
   PubMed Web of Science ®Google Scholar
• Lovejoy DB, Jansson PJ, Brunk UT, Wong J, Ponka P, Richardson DR. Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res 2011; 71:5871 - 80; http://dx.doi.org/10.1158/0008-5472.CAN-11-1218; PMID: 21750178
   PubMed Web of Science ®Google Scholar
• Tardito S, Bassanetti I, Bignardi C, Elviri L, Tegoni M, Mucchino C, Bussolati O, Franchi-Gazzola R, Marchiò L. Copper binding agents acting as copper ionophores lead to caspase inhibition and paraptotic cell death in human cancer cells. J Am Chem Soc 2011; 133:6235 - 42; http://dx.doi.org/10.1021/ja109413c; PMID: 21452832
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445 - 544; http://dx.doi.org/10.4161/auto.19496; PMID: 22966490
   PubMed Web of Science ®Google Scholar
• Sun Y, Zou M, Hu C, Qin Y, Song X, Lu N, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2013; 51:53-60.
   Google Scholar
• Zhou Z, Zhang D, Yang L, Ma P, Si Y, Kortz U, Niu J, Wang J. Nona-copper(II)-containing 18-tungsto-8-arsenate(III) exhibits antitumor activity. Chem Commun (Camb) 2013; 49:5189 - 91; http://dx.doi.org/10.1039/c3cc41628c; PMID: 23628910
   PubMed Web of Science ®Google Scholar
• Trejo-Solís C, Jimenez-Farfan D, Rodriguez-Enriquez S, Fernandez-Valverde F, Cruz-Salgado A, Ruiz-Azuara L, Sotelo J. Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and JNK activation. BMC Cancer 2012; 12:156; http://dx.doi.org/10.1186/1471-2407-12-156; PMID: 22540380
   PubMed Web of Science ®Google Scholar
• Sun T, Yan Y, Zhao Y, Guo F, Jiang C. Copper oxide nanoparticles induce autophagic cell death in A549 cells. PLoS One 2012; 7:e43442; http://dx.doi.org/10.1371/journal.pone.0043442; PMID: 22916263
   PubMed Web of Science ®Google Scholar
• Hancock CN, Stockwin LH, Han B, Divelbiss RD, Jun JH, Malhotra SV, Hollingshead MG, Newton DL. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med 2011; 50:110 - 21; http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.696; PMID: 20971185
   PubMed Web of Science ®Google Scholar
• Guo WJ, Ye SS, Cao N, Huang J, Gao J, Chen QY. ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) complex. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie 2010; 62:577-82.
   Google Scholar
• Paris I, Perez-Pastene C, Couve E, Caviedes P, Ledoux S, Segura-Aguilar J. Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death. J Biol Chem 2009; 284:13306 - 15; http://dx.doi.org/10.1074/jbc.M900323200; PMID: 19265190
   PubMed Web of Science ®Google Scholar
• Myhre O, Andersen JM, Aarnes H, Fonnum F. Evaluation of the probes 2′,7′-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation. Biochem Pharmacol 2003; 65:1575 - 82; http://dx.doi.org/10.1016/S0006-2952(03)00083-2; PMID: 12754093
   PubMed Web of Science ®Google Scholar
• Meister A, Anderson ME. Glutathione. Annu Rev Biochem 1983; 52:711 - 60; http://dx.doi.org/10.1146/annurev.bi.52.070183.003431; PMID: 6137189
   PubMed Web of Science ®Google Scholar
• Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 2009; 10:57 - 63; http://dx.doi.org/10.1038/nrg2484; PMID: 19015660
   PubMed Web of Science ®Google Scholar
• Ozsolak F, Milos PM. RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 2011; 12:87 - 98; http://dx.doi.org/10.1038/nrg2934; PMID: 21191423
   PubMed Web of Science ®Google Scholar
• Wacker SA, Houghtaling BR, Elemento O, Kapoor TM. Using transcriptome sequencing to identify mechanisms of drug action and resistance. Nat Chem Biol 2012; 8:235 - 7; http://dx.doi.org/10.1038/nchembio.779; PMID: 22327403
   PubMed Web of Science ®Google Scholar
• Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2010; 120:127 - 41; http://dx.doi.org/10.1172/JCI40027; PMID: 20038797
   PubMed Web of Science ®Google Scholar
• Zhang XY, Wu XQ, Deng R, Sun T, Feng GK, Zhu XF. Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cell Signal 2013; 25:150 - 8; http://dx.doi.org/10.1016/j.cellsig.2012.09.004; PMID: 22982090
   PubMed Web of Science ®Google Scholar
• Carra S, Seguin SJ, Landry J. HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy 2008; 4:237 - 9; PMID: 18094623
   PubMed Web of Science ®Google Scholar
• Behl C. BAG3 and friends: co-chaperones in selective autophagy during aging and disease. Autophagy 2011; 7:795 - 8; http://dx.doi.org/10.4161/auto.7.7.15844; PMID: 21681022
   PubMed Web of Science ®Google Scholar
• Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A 2013; 110:6841 - 6; http://dx.doi.org/10.1073/pnas.1217692110; PMID: 23569248
   PubMed Web of Science ®Google Scholar
• Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, Zhao F, Ren X, Xiao J, Wang N, et al. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy 2009; 5:314 - 20; http://dx.doi.org/10.4161/auto.5.3.7888; PMID: 19242113
   PubMed Web of Science ®Google Scholar
• Malik SA, Shen S, Mariño G, BenYounès A, Maiuri MC, Kroemer G. BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades. Autophagy 2011; 7:914 - 6; http://dx.doi.org/10.4161/auto.7.8.15785; PMID: 21508685
   PubMed Web of Science ®Google Scholar
• Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 2011; 278:403 - 13; http://dx.doi.org/10.1111/j.1742-4658.2010.07965.x; PMID: 21182587
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4:151 - 75; PMID: 18188003
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646 - 74; http://dx.doi.org/10.1016/j.cell.2011.02.013; PMID: 21376230
   PubMed Web of Science ®Google Scholar
• Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726 - 34; http://dx.doi.org/10.1038/nrc1692; PMID: 16148885
   PubMed Web of Science ®Google Scholar
• Tian S, Lin J, Jun Zhou J, Wang X, Li Y, Ren X, Yu W, Zhong W, Xiao J, Sheng F, et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 2010; 6:1032 - 41; http://dx.doi.org/10.4161/auto.6.8.13336; PMID: 20818185
   PubMed Web of Science ®Google Scholar
• Whitmarsh AJ. A central role for p38 MAPK in the early transcriptional response to stress. BMC Biol 2010; 8:47; http://dx.doi.org/10.1186/1741-7007-8-47; PMID: 20515460
   PubMed Web of Science ®Google Scholar
• Bazuine M, Carlotti F, Rabelink MJ, Vellinga J, Hoeben RC, Maassen JA. The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state. Endocrinology 2005; 146:1818 - 24; http://dx.doi.org/10.1210/en.2004-1347; PMID: 15665038
   PubMed Web of Science ®Google Scholar
• Bennett BL, Sasaki DT, Murray BW, O’Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A 2001; 98:13681 - 6; http://dx.doi.org/10.1073/pnas.251194298; PMID: 11717429
   PubMed Web of Science ®Google Scholar
• Hancock CN, Stockwin LH, Han B, Divelbiss RD, Jun JH, Malhotra SV, Hollingshead MG, Newton DL. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med 2011; 50:110 - 21; http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.696; PMID: 20971185
   PubMed Web of Science ®Google Scholar
• White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12:401 - 10; http://dx.doi.org/10.1038/nrc3262; PMID: 22534666
   PubMed Web of Science ®Google Scholar
• He H, Zang LH, Feng YS, Chen LX, Kang N, Tashiro S, Onodera S, Qiu F, Ikejima T. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells. J Ethnopharmacol 2013; 148:544 - 55; http://dx.doi.org/10.1016/j.jep.2013.04.051; PMID: 23684722
   PubMed Web of Science ®Google Scholar
• McClung JM, Judge AR, Powers SK, Yan Z. p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting. Am J Physiol Cell Physiol 2010; 298:C542 - 9; http://dx.doi.org/10.1152/ajpcell.00192.2009; PMID: 19955483
   PubMed Web of Science ®Google Scholar