ATG13

References

• Klionsky DJ. Autophagy revisited: a conversation with Christian de Duve. Autophagy 2008; 4:740 - 3; PMID: 18567941
   PubMed Web of Science ®Google Scholar
• Tsukada M, Ohsumi Y. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 1993; 333:169 - 74; http://dx.doi.org/10.1016/0014-5793(93)80398-E; PMID: 8224160
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Cregg JM, Dunn WA Jr., Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539 - 45; http://dx.doi.org/10.1016/S1534-5807(03)00296-X; PMID: 14536056
   PubMed Web of Science ®Google Scholar
• Araki Y, Ku WC, Akioka M, May AI, Hayashi Y, Arisaka F, Ishihama Y, Ohsumi Y. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol 2013; 203:299 - 313; http://dx.doi.org/10.1083/jcb.201304123; PMID: 24165940
   PubMed Web of Science ®Google Scholar
• Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 2001; 20:5971 - 81; http://dx.doi.org/10.1093/emboj/20.21.5971; PMID: 11689437
   PubMed Web of Science ®Google Scholar
• Funakoshi T, Matsuura A, Noda T, Ohsumi Y. Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae. Gene 1997; 192:207 - 13; http://dx.doi.org/10.1016/S0378-1119(97)00031-0; PMID: 9224892
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Kawamata T, Suzuki K, Ohsumi Y. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2007; 356:405 - 10; http://dx.doi.org/10.1016/j.bbrc.2007.02.150; PMID: 17362880
   PubMed Web of Science ®Google Scholar
• Kamada Y, Funakoshi T, Shintani T, Nagano K, Ohsumi M, Ohsumi Y. Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 2000; 150:1507 - 13; http://dx.doi.org/10.1083/jcb.150.6.1507; PMID: 10995454
   PubMed Web of Science ®Google Scholar
• Kawamata T, Kamada Y, Suzuki K, Kuboshima N, Akimatsu H, Ota S, Ohsumi M, Ohsumi Y. Characterization of a novel autophagy-specific gene, ATG29. Biochem Biophys Res Commun 2005; 338:1884 - 9; http://dx.doi.org/10.1016/j.bbrc.2005.10.163; PMID: 16289106
   PubMed Web of Science ®Google Scholar
• Kim J, Kamada Y, Stromhaug PE, Guan J, Hefner-Gravink A, Baba M, Scott SV, Ohsumi Y, Dunn WA Jr., Klionsky DJ. Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol 2001; 153:381 - 96; http://dx.doi.org/10.1083/jcb.153.2.381; PMID: 11309418
   PubMed Web of Science ®Google Scholar
• Nice DC, Sato TK, Stromhaug PE, Emr SD, Klionsky DJ. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem 2002; 277:30198 - 207; http://dx.doi.org/10.1074/jbc.M204736200; PMID: 12048214
   PubMed Web of Science ®Google Scholar
• Scott SV, Nice DC 3rd, Nau JJ, Weisman LS, Kamada Y, Keizer-Gunnink I, Funakoshi T, Veenhuis M, Ohsumi Y, Klionsky DJ. Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem 2000; 275:25840 - 9; http://dx.doi.org/10.1074/jbc.M002813200; PMID: 10837477
   PubMed Web of Science ®Google Scholar
• Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132 - 9; http://dx.doi.org/10.1016/j.ceb.2009.12.004; PMID: 20056399
   PubMed Web of Science ®Google Scholar
• Reggiori F, Klionsky DJ. Autophagic processes in yeast: mechanism, machinery and regulation. Genetics 2013; 194:341 - 61; http://dx.doi.org/10.1534/genetics.112.149013; PMID: 23733851
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Noda NN, Fujioka Y, Suzuki K, Inagaki F, Ohsumi Y. Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Biochem Biophys Res Commun 2009; 389:612 - 5; http://dx.doi.org/10.1016/j.bbrc.2009.09.034; PMID: 19755117
   PubMed Web of Science ®Google Scholar
• Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y. Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol Biol Cell 2008; 19:2039 - 50; http://dx.doi.org/10.1091/mbc.E07-10-1048; PMID: 18287526
   PubMed Web of Science ®Google Scholar
• Suzuki K, Kubota Y, Sekito T, Ohsumi Y. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 2007; 12:209 - 18; http://dx.doi.org/10.1111/j.1365-2443.2007.01050.x; PMID: 17295840
   PubMed Web of Science ®Google Scholar
• Cheong H, Yorimitsu T, Reggiori F, Legakis JE, Wang CW, Klionsky DJ. Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell 2005; 16:3438 - 53; http://dx.doi.org/10.1091/mbc.E04-10-0894; PMID: 15901835
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y. Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 2005; 16:2544 - 53; http://dx.doi.org/10.1091/mbc.E04-08-0669; PMID: 15743910
   PubMed Web of Science ®Google Scholar
• Cheong H, Nair U, Geng J, Klionsky DJ. The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell 2008; 19:668 - 81; http://dx.doi.org/10.1091/mbc.E07-08-0826; PMID: 18077553
   PubMed Web of Science ®Google Scholar
• Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y. Atg17 recruits Atg9 to organize the pre-autophagosomal structure. Genes Cells 2009; 14:525 - 38; http://dx.doi.org/10.1111/j.1365-2443.2009.01299.x; PMID: 19371383
   PubMed Web of Science ®Google Scholar
• Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H, Ohsumi Y. Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J Cell Sci 2013; 126:2534 - 44; http://dx.doi.org/10.1242/jcs.122960; PMID: 23549786
   PubMed Web of Science ®Google Scholar
• Yeh YY, Shah KH, Herman PK. An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy. J Biol Chem 2011; 286:28931 - 9; http://dx.doi.org/10.1074/jbc.M111.250324; PMID: 21712380
   PubMed Web of Science ®Google Scholar
• Ragusa MJ, Stanley RE, Hurley JH. Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. Cell 2012; 151:1501 - 12; http://dx.doi.org/10.1016/j.cell.2012.11.028; PMID: 23219485
   PubMed Web of Science ®Google Scholar
• Jao CC, Ragusa MJ, Stanley RE, Hurley JH. What the N-terminal domain of Atg13 looks like and what it does: a HORMA fold required for PtdIns 3-kinase recruitment. Autophagy 2013; 9:1112 - 4; http://dx.doi.org/10.4161/auto.24896; PMID: 23670046
   PubMed Web of Science ®Google Scholar
• Jao CC, Ragusa MJ, Stanley RE, Hurley JH. A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proc Natl Acad Sci U S A 2013; 110:5486 - 91; http://dx.doi.org/10.1073/pnas.1220306110; PMID: 23509291
   PubMed Web of Science ®Google Scholar
• Kraft C, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, Stoffel I, Brezovich A, Verma M, Hansmann I, et al. Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. EMBO J 2012; 31:3691 - 703; http://dx.doi.org/10.1038/emboj.2012.225; PMID: 22885598
   PubMed Web of Science ®Google Scholar
• Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y. Tor directly controls the Atg1 kinase complex to regulate autophagy. Mol Cell Biol 2010; 30:1049 - 58; http://dx.doi.org/10.1128/MCB.01344-09; PMID: 19995911
   PubMed Web of Science ®Google Scholar
• Stephan JS, Yeh YY, Ramachandran V, Deminoff SJ, Herman PK. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy. Proc Natl Acad Sci U S A 2009; 106:17049 - 54; http://dx.doi.org/10.1073/pnas.0903316106; PMID: 19805182
   PubMed Web of Science ®Google Scholar
• Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992 - 2003; http://dx.doi.org/10.1091/mbc.E08-12-1249; PMID: 19225151
   PubMed Web of Science ®Google Scholar
• Alers S, Löffler AS, Paasch F, Dieterle AM, Keppeler H, Lauber K, Campbell DG, Fehrenbacher B, Schaller M, Wesselborg S, et al. Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction. Autophagy 2011; 7:1423 - 33; http://dx.doi.org/10.4161/auto.7.12.18027; PMID: 22024743
   PubMed Web of Science ®Google Scholar
• Alemu EA, Lamark T, Torgersen KM, Birgisdottir AB, Larsen KB, Jain A, Olsvik H, Øvervatn A, Kirkin V, Johansen T. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. J Biol Chem 2012; 287:39275 - 90; http://dx.doi.org/10.1074/jbc.M112.378109; PMID: 23043107
   PubMed Web of Science ®Google Scholar
• Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649 - 62; http://dx.doi.org/10.4161/auto.5.5.8249; PMID: 19287211
   PubMed Web of Science ®Google Scholar
• Karanasios E, Stapleton E, Manifava M, Kaizuka T, Mizushima N, Walker SA, Ktistakis NT. Dynamic association of the ULK1 complex with omegasomes during autophagy induction. J Cell Sci 2013; 126:5224 - 38; http://dx.doi.org/10.1242/jcs.132415; PMID: 24013547
   PubMed Web of Science ®Google Scholar
• Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2011; 43:572 - 85; http://dx.doi.org/10.1016/j.molcel.2011.06.018; PMID: 21855797
   PubMed Web of Science ®Google Scholar
• Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A 2011; 108:4788 - 93; http://dx.doi.org/10.1073/pnas.1100844108; PMID: 21383122
   PubMed Web of Science ®Google Scholar
• Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011; 332:1317 - 22; http://dx.doi.org/10.1126/science.1199498; PMID: 21659604
   PubMed Web of Science ®Google Scholar
• Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 2010; 143:1174 - 89; http://dx.doi.org/10.1016/j.cell.2010.12.001; PMID: 21183079
   PubMed Web of Science ®Google Scholar
• Schreiber TB, Mäusbacher N, Kéri G, Cox J, Daub H. An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 2010; 9:1047 - 62; http://dx.doi.org/10.1074/mcp.M900486-MCP200; PMID: 20071362
   PubMed Web of Science ®Google Scholar
• Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL. Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 2012; 11:215 - 29; http://dx.doi.org/10.1074/mcp.O112.018366; PMID: 22645316
   PubMed Web of Science ®Google Scholar
• Villén J, Beausoleil SA, Gerber SA, Gygi SP. Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 2007; 104:1488 - 93; http://dx.doi.org/10.1073/pnas.0609836104; PMID: 17242355
   PubMed Web of Science ®Google Scholar
• Wiśniewski JR, Nagaraj N, Zougman A, Gnad F, Mann M. Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 2010; 9:3280 - 9; http://dx.doi.org/10.1021/pr1002214; PMID: 20415495
   PubMed Web of Science ®Google Scholar
• Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011; 332:1322 - 6; http://dx.doi.org/10.1126/science.1199484; PMID: 21659605
   PubMed Web of Science ®Google Scholar
• Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M. Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 2008; 7:5314 - 26; http://dx.doi.org/10.1021/pr800599n; PMID: 19367708
   PubMed Web of Science ®Google Scholar
• Aravind L, Koonin EV. The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends Biochem Sci 1998; 23:284 - 6; http://dx.doi.org/10.1016/S0968-0004(98)01257-2; PMID: 9757827
   PubMed Web of Science ®Google Scholar
• Sironi L, Mapelli M, Knapp S, De Antoni A, Jeang KT, Musacchio A. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint. EMBO J 2002; 21:2496 - 506; http://dx.doi.org/10.1093/emboj/21.10.2496; PMID: 12006501
   PubMed Web of Science ®Google Scholar
• Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 2001; 152:519 - 30; http://dx.doi.org/10.1083/jcb.152.3.519; PMID: 11157979
   PubMed Web of Science ®Google Scholar
• Simonsen A, Tooze SA. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol 2009; 186:773 - 82; http://dx.doi.org/10.1083/jcb.200907014; PMID: 19797076
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 2009; 5:973 - 9; http://dx.doi.org/10.4161/auto.5.7.9296; PMID: 19597335
   PubMed Web of Science ®Google Scholar
• Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685 - 701; http://dx.doi.org/10.1083/jcb.200803137; PMID: 18725538
   PubMed Web of Science ®Google Scholar
• Itakura E, Mizushima N. Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy 2010; 6:764 - 76; http://dx.doi.org/10.4161/auto.6.6.12709; PMID: 20639694
   PubMed Web of Science ®Google Scholar
• Miller-Fleming L, Cheong H, Antas P, Klionsky DJ. Detection of Saccharomyces cerevisiae Atg13 by western blot. Autophagy 2014; 10:514 - 7; http://dx.doi.org/10.4161/auto.27707; PMID: 24430166
   PubMed Web of Science ®Google Scholar
• Meijer WH, van der Klei IJ, Veenhuis M, Kiel JA. ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Autophagy 2007; 3:106 - 16; PMID: 17204848
   PubMed Web of Science ®Google Scholar
• Ogura K, Wicky C, Magnenat L, Tobler H, Mori I, Müller F, Ohshima Y. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Genes Dev 1994; 8:2389 - 400; http://dx.doi.org/10.1101/gad.8.20.2389; PMID: 7958904
   PubMed Web of Science ®Google Scholar
• Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T. Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment. Genomics 1998; 51:76 - 85; http://dx.doi.org/10.1006/geno.1998.5340; PMID: 9693035
   PubMed Web of Science ®Google Scholar
• Yan J, Kuroyanagi H, Kuroiwa A, Matsuda Y, Tokumitsu H, Tomoda T, Shirasawa T, Muramatsu M. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Biochem Biophys Res Commun 1998; 246:222 - 7; http://dx.doi.org/10.1006/bbrc.1998.8546; PMID: 9600096
   PubMed Web of Science ®Google Scholar
• Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, et al. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene 1999; 18:5850 - 9; http://dx.doi.org/10.1038/sj.onc.1202988; PMID: 10557072
   PubMed Web of Science ®Google Scholar
• Chan EY, Longatti A, McKnight NC, Tooze SA. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Mol Cell Biol 2009; 29:157 - 71; http://dx.doi.org/10.1128/MCB.01082-08; PMID: 18936157
   PubMed Web of Science ®Google Scholar
• Hara T, Mizushima N. Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?. Autophagy 2009; 5:85 - 7; http://dx.doi.org/10.4161/auto.5.1.7180; PMID: 18981720
   PubMed Web of Science ®Google Scholar
• Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol 2008; 181:497 - 510; http://dx.doi.org/10.1083/jcb.200712064; PMID: 18443221
   PubMed Web of Science ®Google Scholar
• Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010; 466:68 - 76; http://dx.doi.org/10.1038/nature09204; PMID: 20562859
   PubMed Web of Science ®Google Scholar
• Ganley IG, Lam H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284:12297 - 305; http://dx.doi.org/10.1074/jbc.M900573200; PMID: 19258318
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981 - 91; http://dx.doi.org/10.1091/mbc.E08-12-1248; PMID: 19211835
   PubMed Web of Science ®Google Scholar
• Chang YY, Neufeld TP. An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. Mol Biol Cell 2009; 20:2004 - 14; http://dx.doi.org/10.1091/mbc.E08-12-1250; PMID: 19225150
   PubMed Web of Science ®Google Scholar
• Tian E, Wang F, Han J, Zhang H. epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans. Autophagy 2009; 5:608 - 15; http://dx.doi.org/10.4161/auto.5.5.8624; PMID: 19377305
   PubMed Web of Science ®Google Scholar
• Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974; 77:71 - 94; PMID: 4366476
   PubMed Web of Science ®Google Scholar
• Lai T, Garriga G. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Development 2004; 131:5991 - 6000; http://dx.doi.org/10.1242/dev.01457; PMID: 15539493
   PubMed Web of Science ®Google Scholar
• Ogura K, Shirakawa M, Barnes TM, Hekimi S, Ohshima Y. The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51. Genes Dev 1997; 11:1801 - 11; http://dx.doi.org/10.1101/gad.11.14.1801; PMID: 9242488
   PubMed Web of Science ®Google Scholar
• Toda H, Mochizuki H, Flores R 3rd, Josowitz R, Krasieva TB, Lamorte VJ, Suzuki E, Gindhart JG, Furukubo-Tokunaga K, Tomoda T. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Genes Dev 2008; 22:3292 - 307; http://dx.doi.org/10.1101/gad.1734608; PMID: 19056884
   PubMed Web of Science ®Google Scholar
• Lee EJ, Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689 - 95; http://dx.doi.org/10.4161/auto.7.7.15450; PMID: 21460635
   PubMed Web of Science ®Google Scholar
• Tomoda T, Bhatt RS, Kuroyanagi H, Shirasawa T, Hatten ME. A mouse serine/threonine kinase homologous to C. elegans UNC51 functions in parallel fiber formation of cerebellar granule neurons. Neuron 1999; 24:833 - 46; http://dx.doi.org/10.1016/S0896-6273(00)81031-4; PMID: 10624947
   PubMed Web of Science ®Google Scholar
• Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T, Tomoda T, Tani T, Wooten MW, Wang F. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc Natl Acad Sci U S A 2007; 104:5842 - 7; http://dx.doi.org/10.1073/pnas.0701402104; PMID: 17389358
   PubMed Web of Science ®Google Scholar
• Rajesh S, Bago R, Odintsova E, Muratov G, Baldwin G, Sridhar P, Rajesh S, Overduin M, Berditchevski F. Binding to syntenin-1 protein defines a new mode of ubiquitin-based interactions regulated by phosphorylation. J Biol Chem 2011; 286:39606 - 14; http://dx.doi.org/10.1074/jbc.M111.262402; PMID: 21949238
   PubMed Web of Science ®Google Scholar
• Tomoda T, Kim JH, Zhan C, Hatten ME. Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev 2004; 18:541 - 58; http://dx.doi.org/10.1101/gad.1151204; PMID: 15014045
   PubMed Web of Science ®Google Scholar
• Wong PM, Puente C, Ganley IG, Jiang X. The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 2013; 9:124 - 37; http://dx.doi.org/10.4161/auto.23323; PMID: 23295650
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149:274 - 93; http://dx.doi.org/10.1016/j.cell.2012.03.017; PMID: 22500797
   PubMed Web of Science ®Google Scholar
• McEwan DG, Dikic I. Not all autophagy membranes are created equal. Cell 2010; 141:564 - 6; http://dx.doi.org/10.1016/j.cell.2010.04.030; PMID: 20478247
   PubMed Web of Science ®Google Scholar
• Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol 2009; 11:1433 - 7; http://dx.doi.org/10.1038/ncb1991; PMID: 19898463
   PubMed Web of Science ®Google Scholar
• Matsunaga K, Morita E, Saitoh T, Akira S, Ktistakis NT, Izumi T, Noda T, Yoshimori T. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol 2010; 190:511 - 21; http://dx.doi.org/10.1083/jcb.200911141; PMID: 20713597
   PubMed Web of Science ®Google Scholar
• Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen EL. 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 2009; 5:1180 - 5; http://dx.doi.org/10.4161/auto.5.8.10274; PMID: 19855179
   PubMed Web of Science ®Google Scholar
• Suzuki H, Tabata K, Morita E, Kawasaki M, Kato R, Dobson RC, Yoshimori T, Wakatsuki S. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. Structure 2014; 22:47 - 58; http://dx.doi.org/10.1016/j.str.2013.09.023; PMID: 24290141
   PubMed Web of Science ®Google Scholar
• Takaesu G, Kobayashi T, Yoshimura A. TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. J Biochem 2012; 151:157 - 66; http://dx.doi.org/10.1093/jb/mvr123; PMID: 21976705
   PubMed Web of Science ®Google Scholar
• Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M, Pagliarini V, Matteoni S, Fuoco C, Giunta L, et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol 2010; 191:155 - 68; http://dx.doi.org/10.1083/jcb.201002100; PMID: 20921139
   PubMed Web of Science ®Google Scholar
• Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 2013; 15:741 - 50; http://dx.doi.org/10.1038/ncb2757; PMID: 23685627
   PubMed Web of Science ®Google Scholar
• Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V, Elazar Z. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J 2010; 29:1792 - 802; http://dx.doi.org/10.1038/emboj.2010.74; PMID: 20418806
   PubMed Web of Science ®Google Scholar
• Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res 2000; 85:1 - 12; http://dx.doi.org/10.1016/S0169-328X(00)00218-7; PMID: 11146101
   PubMedGoogle Scholar
• Suttangkakul A, Li F, Chung T, Vierstra RD. The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell 2011; 23:3761 - 79; http://dx.doi.org/10.1105/tpc.111.090993; PMID: 21984698
   PubMed Web of Science ®Google Scholar