Accumulation of p62 in degenerated spinal cord under chronic mechanical compression

References

• Kameyama T, Hashizume Y, Ando T, Takahashi A, Yanagi T, Mizuno J. Spinal cord morphology and pathology in ossification of the posterior longitudinal ligament. Brain 1995; 118:263 - 78; http://dx.doi.org/10.1093/brain/118.1.263; PMID: 7895010
   PubMed Web of Science ®Google Scholar
• Gooding MR, Wilson CB, Hoff JT. Experimental cervical myelopathy. Effects of ischemia and compression of the canine cervical spinal cord. J Neurosurg 1975; 43:9 - 17; http://dx.doi.org/10.3171/jns.1975.43.1.0009; PMID: 1141988
   PubMed Web of Science ®Google Scholar
• Hukuda S, Wilson CB. Experimental cervical myelopathy: effects of compression and ischemia on the canine cervical cord. J Neurosurg 1972; 37:631 - 52; http://dx.doi.org/10.3171/jns.1972.37.6.0631; PMID: 4654695
   PubMed Web of Science ®Google Scholar
• Rao RD, Currier BL, Albert TJ, Bono CM, Marawar SV, Poelstra KA, et al. Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. J Bone Joint Surg Am 2007; 89:1360 - 78; PMID: 17575617
   PubMed Web of Science ®Google Scholar
• Kuusisto E, Salminen A, Alafuzoff I. Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation. Neuropathol Appl Neurobiol 2002; 28:228 - 37; http://dx.doi.org/10.1046/j.1365-2990.2002.00394.x; PMID: 12060347
   PubMed Web of Science ®Google Scholar
• Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol 2002; 160:255 - 63; http://dx.doi.org/10.1016/S0002-9440(10)64369-6; PMID: 11786419
   PubMed Web of Science ®Google Scholar
• Nagaoka U, Kim K, Jana NR, Doi H, Maruyama M, Mitsui K, et al. Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions. J Neurochem 2004; 91:57 - 68; http://dx.doi.org/10.1111/j.1471-4159.2004.02692.x; PMID: 15379887
   PubMed Web of Science ®Google Scholar
• Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ 2005; 12:Suppl 2 1535 - 41; http://dx.doi.org/10.1038/sj.cdd.4401728; PMID: 16247501
   PubMed Web of Science ®Google Scholar
• Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ 2005; 12:Suppl 2 1542 - 52; http://dx.doi.org/10.1038/sj.cdd.4401765; PMID: 16247502
   PubMed Web of Science ®Google Scholar
• Hosoda Y, Yoshimura Y, Higaki S. A new breed of mouse showing multiple osteochondral lesions–twy mouse. Ryumachi 1981; 21:Suppl 157 - 64; PMID: 7344126
   PubMedGoogle Scholar
• Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol 2004; 24:8055 - 68; http://dx.doi.org/10.1128/MCB.24.18.8055-8068.2004; PMID: 15340068
   PubMed Web of Science ®Google Scholar
• Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603 - 14; http://dx.doi.org/10.1083/jcb.200507002; PMID: 16286508
   PubMed Web of Science ®Google Scholar
• Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol 2004; 36:2491 - 502; http://dx.doi.org/10.1016/j.biocel.2004.02.005; PMID: 15325587
   PubMed Web of Science ®Google Scholar
• Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, Rout MP, et al. Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006; 26:8057 - 68; http://dx.doi.org/10.1523/JNEUROSCI.2261-06.2006; PMID: 16885219
   PubMed Web of Science ®Google Scholar
• Fehlings MG, Skaf G. A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine 1998; 23:2730 - 7; http://dx.doi.org/10.1097/00007632-199812150-00012; PMID: 9879098
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140:313 - 26; http://dx.doi.org/10.1016/j.cell.2010.01.028; PMID: 20144757
   PubMed Web of Science ®Google Scholar
• Hosokawa N, Hara Y, Mizushima N. Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 2006; 580:2623 - 9; http://dx.doi.org/10.1016/j.febslet.2006.04.008; PMID: 16647067
   PubMed Web of Science ®Google Scholar
• Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119 - 31; http://dx.doi.org/10.1038/ncb2012; PMID: 20098416
   PubMed Web of Science ®Google Scholar
• Pohl C, Jentsch S. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat Cell Biol 2009; 11:65 - 70; http://dx.doi.org/10.1038/ncb1813; PMID: 19079246
   PubMed Web of Science ®Google Scholar
• Kim PK, Hailey DW, Mullen RT, Lippincott-Schwartz J. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci USA 2008; 105:20567 - 74; http://dx.doi.org/10.1073/pnas.0810611105; PMID: 19074260
   PubMed Web of Science ®Google Scholar
• Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, et al. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol 2009; 11:1233 - 40; http://dx.doi.org/10.1038/ncb1967; PMID: 19749745
   PubMed Web of Science ®Google Scholar
• Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 2010; 584:1374 - 8; http://dx.doi.org/10.1016/j.febslet.2010.02.017; PMID: 20153326
   PubMed Web of Science ®Google Scholar
• Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 2005; 170:1101 - 11; http://dx.doi.org/10.1083/jcb.200504035; PMID: 16186256
   PubMed Web of Science ®Google Scholar
• Yu YL, Leong JC, Fang D, Woo E, Huang CY, Lau HK. Cervical myelopathy due to ossification of the posterior longitudinal ligament. A clinical, radiological and evoked potentials study in six Chinese patients. Brain 1988; 111:769 - 83; http://dx.doi.org/10.1093/brain/111.4.769; PMID: 3135912
   PubMed Web of Science ®Google Scholar
• Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 1998; 89:699 - 706; http://dx.doi.org/10.3171/jns.1998.89.5.0699; PMID: 9817404
   PubMed Web of Science ®Google Scholar
• Ogino H, Tada K, Okada K, Yonenobu K, Yamamoto T, Ono K, et al. Canal diameter, anteroposterior compression ratio, and spondylotic myelopathy of the cervical spine. Spine 1983; 8:1 - 15; http://dx.doi.org/10.1097/00007632-198301000-00001; PMID: 6867846
   PubMed Web of Science ®Google Scholar
• Ito T, Oyanagi K, Takahashi H, Takahashi HE, Ikuta F. Cervical spondylotic myelopathy. Clinicopathologic study on the progression pattern and thin myelinated fibers of the lesions of seven patients examined during complete autopsy. Spine 1996; 21:827 - 33; http://dx.doi.org/10.1097/00007632-199604010-00010; PMID: 8779013
   PubMed Web of Science ®Google Scholar
• Kuusisto E, Salminen A, Alafuzoff I. Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. Neuroreport 2001; 12:2085 - 90; http://dx.doi.org/10.1097/00001756-200107200-00009; PMID: 11447312
   PubMed Web of Science ®Google Scholar
• Kuusisto E, Kauppinen T, Alafuzoff I. Use of p62/SQSTM1 antibodies for neuropathological diagnosis. Neuropathol Appl Neurobiol 2008; 34:169 - 80; http://dx.doi.org/10.1111/j.1365-2990.2007.00884.x; PMID: 17961133
   PubMed Web of Science ®Google Scholar
• Ishii T, Yanagawa T, Yuki K, Kawane T, Yoshida H, Bannai S. Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. Biochem Biophys Res Commun 1997; 232:33 - 7; http://dx.doi.org/10.1006/bbrc.1997.6221; PMID: 9125146
   PubMed Web of Science ®Google Scholar
• Nakaso K, Yoshimoto Y, Nakano T, Takeshima T, Fukuhara Y, Yasui K, et al. Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease. Brain Res 2004; 1012:42 - 51; http://dx.doi.org/10.1016/j.brainres.2004.03.029; PMID: 15158159
   PubMed Web of Science ®Google Scholar
• Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A, et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem 2010; 285:22576 - 91; http://dx.doi.org/10.1074/jbc.M110.118976; PMID: 20452972
   PubMed Web of Science ®Google Scholar
• Donaldson KM, Li W, Ching KA, Batalov S, Tsai CC, Joazeiro CA. Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates. Proc Natl Acad Sci USA 2003; 100:8892 - 7; http://dx.doi.org/10.1073/pnas.1530212100; PMID: 12857950
   PubMed Web of Science ®Google Scholar
• Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131 - 45; http://dx.doi.org/10.1074/jbc.M702824200; PMID: 17580304
   PubMed Web of Science ®Google Scholar
• Rogers N, Paine S, Bedford L, Layfield R. Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathol Appl Neurobiol 2010; 36:113 - 24; PMID: 20202119
   PubMed Web of Science ®Google Scholar
• Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 131:1149 - 63; http://dx.doi.org/10.1016/j.cell.2007.10.035; PMID: 18083104
   PubMed Web of Science ®Google Scholar
• Alirezaei M, Kiosses WB, Flynn CT, Brady NR, Fox HS. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS ONE 2008; 3:e2906; http://dx.doi.org/10.1371/journal.pone.0002906; PMID: 18682838
   PubMed Web of Science ®Google Scholar
• Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 2010; 285:3499 - 509; http://dx.doi.org/10.1074/jbc.M109.072389; PMID: 19940130
   PubMed Web of Science ®Google Scholar
• Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr., Iwata J, Kominami E, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA 2007; 104:14489 - 94; http://dx.doi.org/10.1073/pnas.0701311104; PMID: 17726112
   PubMed Web of Science ®Google Scholar
• Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 2008; 283:22847 - 57; http://dx.doi.org/10.1074/jbc.M802182200; PMID: 18524774
   PubMed Web of Science ®Google Scholar
• Kirkin V, Lamark T, Sou YS, Bjorkoy G, Nunn JL, Bruun JA, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009; 33:505 - 16; http://dx.doi.org/10.1016/j.molcel.2009.01.020; PMID: 19250911
   PubMed Web of Science ®Google Scholar
• Zhu C, Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, et al. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005; 12:162 - 76; http://dx.doi.org/10.1038/sj.cdd.4401545; PMID: 15592434
   PubMed Web of Science ®Google Scholar
• Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, et al. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 2008; 4:214 - 26; PMID: 18094625
   PubMed Web of Science ®Google Scholar
• Diskin T, Tal-Or P, Erlich S, Mizrachy L, Alexandrovich A, Shohami E, et al. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury. J Neurotrauma 2005; 22:750 - 62; http://dx.doi.org/10.1089/neu.2005.22.750; PMID: 16004578
   PubMed Web of Science ®Google Scholar
• Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis 2008; 29:132 - 41; http://dx.doi.org/10.1016/j.nbd.2007.08.005; PMID: 17936001
   PubMed Web of Science ®Google Scholar
• Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008; 32:329 - 39; http://dx.doi.org/10.1016/j.nbd.2008.07.022; PMID: 18760364
   PubMed Web of Science ®Google Scholar
• Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005; 12:Suppl 2 1509 - 18; http://dx.doi.org/10.1038/sj.cdd.4401751; PMID: 16247498
   PubMed Web of Science ®Google Scholar
• Erlich S, Shohami E, Pinkas-Kramarski R. Neurodegeneration induces upregulation of Beclin 1. Autophagy 2006; 2:49 - 51; PMID: 16874043
   PubMed Web of Science ®Google Scholar
• Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 2007; 3:331 - 8; http://dx.doi.org/10.1038/nchembio883; PMID: 17486044
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Rubinsztein DC. Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?. Neuroreport 2004; 15:2443 - 5; http://dx.doi.org/10.1097/00001756-200411150-00001; PMID: 15538170
   PubMed Web of Science ®Google Scholar
• Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 2007; 26:86 - 93; http://dx.doi.org/10.1016/j.nbd.2006.12.003; PMID: 17270455
   PubMed Web of Science ®Google Scholar
• Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004; 6:1221 - 8; http://dx.doi.org/10.1038/ncb1192; PMID: 15558033
   PubMed Web of Science ®Google Scholar
• Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007; 170:75 - 86; http://dx.doi.org/10.2353/ajpath.2007.060524; PMID: 17200184
   PubMed Web of Science ®Google Scholar
• Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 2007; 3:663 - 6; PMID: 17622797
   PubMed Web of Science ®Google Scholar
• He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67 - 93; http://dx.doi.org/10.1146/annurev-genet-102808-114910; PMID: 19653858
   PubMed Web of Science ®Google Scholar
• Tanaka M, Setoguchi T, Hirotsu M, Gao H, Sasaki H, Matsunoshita Y, et al. Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. Br J Cancer 2009; 100:1957 - 65; http://dx.doi.org/10.1038/sj.bjc.6605060; PMID: 19455146
   PubMed Web of Science ®Google Scholar
• Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, et al. Smoothened as a new therapeutic target for human osteosarcoma. Mol Cancer 2010; 9:5; http://dx.doi.org/10.1186/1476-4598-9-5; PMID: 20067614
   PubMed Web of Science ®Google Scholar
• Reynolds ES. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 1963; 17:208 - 12; http://dx.doi.org/10.1083/jcb.17.1.208; PMID: 13986422
   PubMed Web of Science ®Google Scholar
• Kawai K, Saito A, Sudo T, Osada H. Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1. J Biochem 2008; 143:765 - 72; http://dx.doi.org/10.1093/jb/mvn027; PMID: 18296712
   PubMed Web of Science ®Google Scholar
• Matsunoshita Y, Ijiri K, Ishidou Y, Nagano S, Yamamoto T, Nagao H, et al. Suppression of Osteosarcoma Cell Invasion by Chemotherapy Is Mediated by Urokinase Plasminogen Activator Activity via Up-Regulation of EGR1. PLoS ONE 2011; 6:e16234; http://dx.doi.org/10.1371/journal.pone.0016234; PMID: 21283769
   PubMedGoogle Scholar