New thoughts regarding Atg8 and ubiquitination

References

• Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Øvervatn A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603 - 14; http://dx.doi.org/10.1083/jcb.200507002; PMID: 16286508
   PubMed Web of Science ®Google Scholar
• Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009; 34:259 - 69; http://dx.doi.org/10.1016/j.molcel.2009.04.026; PMID: 19450525
   PubMed Web of Science ®Google Scholar
• Menzies FM, Moreau K, Rubinsztein DC. Protein misfolding disorders and macroautophagy. Curr Opin Cell Biol 2011; 23:190 - 7; http://dx.doi.org/10.1016/j.ceb.2010.10.010; PMID: 21087849
   PubMed Web of Science ®Google Scholar
• Dupont N, Temime-Smaali N, Lafont F. How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection. Biol Cell 2010; 102:621 - 34; http://dx.doi.org/10.1042/BC20100101; PMID: 21077843
   PubMed Web of Science ®Google Scholar
• Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010; 6:1090 - 106; http://dx.doi.org/10.4161/auto.6.8.13426; PMID: 20890124
   PubMed Web of Science ®Google Scholar
• Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183:795 - 803; http://dx.doi.org/10.1083/jcb.200809125; PMID: 19029340
   PubMed Web of Science ®Google Scholar
• Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010; 19:4861 - 70; http://dx.doi.org/10.1093/hmg/ddq419; PMID: 20871098
   PubMed Web of Science ®Google Scholar
• Geisler S, Holmström KM, Treis A, Skujat D, Weber SS, Fiesel FC, et al. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 2010; 6:871 - 8; http://dx.doi.org/10.4161/auto.6.7.13286; PMID: 20798600
   PubMed Web of Science ®Google Scholar
• Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010; 189:671 - 9; http://dx.doi.org/10.1083/jcb.201001039; PMID: 20457763
   PubMed Web of Science ®Google Scholar
• Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 2010; 189:211 - 21; http://dx.doi.org/10.1083/jcb.200910140; PMID: 20404107
   PubMed Web of Science ®Google Scholar
• Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119 - 31; http://dx.doi.org/10.1038/ncb2012; PMID: 20098416
   PubMed Web of Science ®Google Scholar
• Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2010; 107:378 - 83; http://dx.doi.org/10.1073/pnas.0911187107; PMID: 19966284
   PubMed Web of Science ®Google Scholar
• Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 2010; 191:933 - 42; http://dx.doi.org/10.1083/jcb.201008084; PMID: 21115803
   PubMed Web of Science ®Google Scholar
• Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, et al. A protein conjugation system essential for autophagy. Nature 1998; 395:395 - 8; http://dx.doi.org/10.1038/26506; PMID: 9759731
   PubMed Web of Science ®Google Scholar
• Kirisako T, Baba M, Ishihara N, Miyazawa K, Ohsumi M, Yoshimori T, et al. Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J Cell Biol 1999; 147:435 - 46; http://dx.doi.org/10.1083/jcb.147.2.435; PMID: 10525546
   PubMed Web of Science ®Google Scholar
• Lang T, Schaeffeler E, Bernreuther D, Bredschneider M, Wolf DH, Thumm M. Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J 1998; 17:3597 - 607; http://dx.doi.org/10.1093/emboj/17.13.3597; PMID: 9649430
   PubMed Web of Science ®Google Scholar
• Huang W-P, Scott SV, Kim J, Klionsky DJ. The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J Biol Chem 2000; 275:5845 - 51; http://dx.doi.org/10.1074/jbc.275.8.5845; PMID: 10681575
   PubMed Web of Science ®Google Scholar
• Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 2010; 142:590 - 600; http://dx.doi.org/10.1016/j.cell.2010.07.018; PMID: 20723759
   PubMed Web of Science ®Google Scholar
• Kraft C, Deplazes A, Sohrmann M, Peter M. Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nat Cell Biol 2008; 10:602 - 10; http://dx.doi.org/10.1038/ncb1723; PMID: 18391941
   PubMed Web of Science ®Google Scholar
• Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, et al. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy 2010; 6:217 - 27; http://dx.doi.org/10.4161/auto.6.2.11014; PMID: 20104022
   PubMed Web of Science ®Google Scholar
• Ju JS, Fuentealba RA, Miller SE, Jackson E, Piwnica-Worms D, Baloh RH, et al. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol 2009; 187:875 - 88; http://dx.doi.org/10.1083/jcb.200908115; PMID: 20008565
   PubMed Web of Science ®Google Scholar
• Krick R, Bremer S, Welter E, Schlotterhose P, Muehe Y, Eskelinen E-L, et al. Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8. J Cell Biol 2010; 190:965 - 73; http://dx.doi.org/10.1083/jcb.201002075; PMID: 20855502
   PubMed Web of Science ®Google Scholar