824
Views
11
CrossRef citations to date
0
Altmetric
Commentary

Signaling network from GPCR to the actin cytoskeleton during chemotaxis

&
Pages 15-18 | Published online: 01 Mar 2012

References

  • Jin T, Xu X, Hereld D. Chemotaxis, chemokine receptors and human disease. Cytokine 2008; 44:1 - 8; http://dx.doi.org/10.1016/j.cyto.2008.06.017; PMID: 18722135
  • Jin T. GPCR-controlled chemotaxis in Dictyostelium discoideum. Wiley interdisciplinary reviews Systems biology and medicine 2011; 3:717-27.
  • Wang Y, Chen CL, Iijima M. Signaling mechanisms for chemotaxis. Dev Growth Differ 2011; 53:495 - 502; http://dx.doi.org/10.1111/j.1440-169X.2011.01265.x; PMID: 21585354
  • Jin T, Xu X, Fang J, Isik N, Yan J, Brzostowski JA, et al. How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum. Immunol Res 2009; 43:118 - 27; http://dx.doi.org/10.1007/s12026-008-8056-7; PMID: 18827980
  • Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T. Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal 2010; 3:ra71; http://dx.doi.org/10.1126/scisignal.2000980; PMID: 20876874
  • Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN. G protein signaling events are activated at the leading edge of chemotactic cells. Cell 1998; 95:81 - 91; http://dx.doi.org/10.1016/S0092-8674(00)81784-5; PMID: 9778249
  • Meili R, Ellsworth C, Lee S, Reddy TB, Ma H, Firtel RA. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J 1999; 18:2092 - 105; http://dx.doi.org/10.1093/emboj/18.8.2092; PMID: 10205164
  • Iijima M, Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 2002; 109:599 - 610; http://dx.doi.org/10.1016/S0092-8674(02)00745-6; PMID: 12062103
  • Funamoto S, Meili R, Lee S, Parry L, Firtel RA. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 2002; 109:611 - 23; http://dx.doi.org/10.1016/S0092-8674(02)00755-9; PMID: 12062104
  • Hoeller O, Kay RR. Chemotaxis in the absence of PIP3 gradients. Curr Biol 2007; 17:813 - 7; http://dx.doi.org/10.1016/j.cub.2007.04.004; PMID: 17462897
  • Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, et al. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 2007; 12:603 - 14; http://dx.doi.org/10.1016/j.devcel.2007.03.005; PMID: 17419997
  • Veltman DM, Keizer-Gunnik I, Van Haastert PJ. Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J Cell Biol 2008; 180:747 - 53; http://dx.doi.org/10.1083/jcb.200709180; PMID: 18299345
  • Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10:457 - 68; http://dx.doi.org/10.1016/S1097-2765(02)00636-6; PMID: 12408816
  • Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, et al. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 2005; 16:4572 - 83; http://dx.doi.org/10.1091/mbc.E05-04-0342; PMID: 16079174
  • Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN. PIP3-independent activation of TorC2 and PKB at the cell’s leading edge mediates chemotaxis. Curr Biol 2008; 18:1034 - 43; http://dx.doi.org/10.1016/j.cub.2008.06.068; PMID: 18635356
  • Kamimura Y, Devreotes PN. Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 2010; 285:7938 - 46; http://dx.doi.org/10.1074/jbc.M109.089235; PMID: 20075071
  • Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol 2010; 190:233 - 45; http://dx.doi.org/10.1083/jcb.201001129; PMID: 20660630
  • Yan J, Hereld D, Jin T. Chemotaxis: new role for Ras revealed. Protein Cell 2010; 1:879 - 80; http://dx.doi.org/10.1007/s13238-010-0119-6; PMID: 21204012
  • Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel RA. A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev Cell 2010; 18:737 - 49; http://dx.doi.org/10.1016/j.devcel.2010.03.017; PMID: 20493808
  • Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, et al. A Gβγ Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis. Dev Cell 2012; 22:92 - 103; http://dx.doi.org/10.1016/j.devcel.2011.11.007; PMID: 22264729
  • Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, et al. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 2002; 4:574 - 82; PMID: 12134158
  • Côté JF, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 2007; 17:383 - 93; http://dx.doi.org/10.1016/j.tcb.2007.05.001; PMID: 17765544
  • Reddien PW, Horvitz HR. The engulfment process of programmed cell death in caenorhabditis elegans. Annu Rev Cell Dev Biol 2004; 20:193 - 221; http://dx.doi.org/10.1146/annurev.cellbio.20.022003.114619; PMID: 15473839