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Addendum

Engineering ribosomal leaky scanning and upstream open reading frames for precise control of protein translation

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Pages 186-192 | Received 09 Dec 2013, Accepted 20 Dec 2013, Published online: 14 Jan 2014

References

  • Peacock RW, Sullivan KA, Wang CL. Tetracycline-regulated expression implemented through transcriptional activation combined with proximal and distal repression. ACS Synth Biol 2012; 1:156 - 62; http://dx.doi.org/10.1021/sb200029a; PMID: 23651153
  • Ferreira JP, Peacock RW, Lawhorn IE, Wang CL. Modulating ectopic gene expression levels by using retroviral vectors equipped with synthetic promoters. Syst Synth Biol 2011; 5:131 - 8; http://dx.doi.org/10.1007/s11693-011-9089-0; PMID: 23205156
  • Ferreira JP, Lawhorn IE, Peacock RW, Wang CL. Quantitative assessment of Ras over-expression via shotgun deployment of vectors utilizing synthetic promoters. Integr Biol (Camb) 2012; 4:108 - 14; http://dx.doi.org/10.1039/c1ib00082a; PMID: 22108821
  • Myasnikov AG, Simonetti A, Marzi S, Klaholz BP. Structure-function insights into prokaryotic and eukaryotic translation initiation. Curr Opin Struct Biol 2009; 19:300 - 9; http://dx.doi.org/10.1016/j.sbi.2009.04.010; PMID: 19493673
  • Hinnebusch AG. Molecular mechanism of scanning and start codon selection in eukaryotes. Microbiol Mol Biol Rev 2011; 75:434 - 67; http://dx.doi.org/10.1128/MMBR.00008-11; PMID: 21885680
  • Ferreira JP, Overton KW, Wang CL. Tuning gene expression with synthetic upstream open reading frames. Proc Natl Acad Sci U S A 2013; 110:11284 - 9; http://dx.doi.org/10.1073/pnas.1305590110; PMID: 23798422
  • Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 1986; 44:283 - 92; http://dx.doi.org/10.1016/0092-8674(86)90762-2; PMID: 3943125
  • Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987; 196:947 - 50; http://dx.doi.org/10.1016/0022-2836(87)90418-9; PMID: 3681984
  • Kozak M. Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6. EMBO J 1997; 16:2482 - 92; http://dx.doi.org/10.1093/emboj/16.9.2482; PMID: 9171361
  • Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 1987; 15:8125 - 48; http://dx.doi.org/10.1093/nar/15.20.8125; PMID: 3313277
  • Kozak M. Emerging links between initiation of translation and human diseases. Mamm Genome 2002; 13:401 - 10; http://dx.doi.org/10.1007/s00335-002-4002-5; PMID: 12226704
  • Nagalakshmi U, Wang Z, Waern K, Shou C, Raha D, Gerstein M, Snyder M. The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 2008; 320:1344 - 9; http://dx.doi.org/10.1126/science.1158441; PMID: 18451266
  • Lawless C, Pearson RD, Selley JN, Smirnova JB, Grant CM, Ashe MP, Pavitt GD, Hubbard SJ. Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast. BMC Genomics 2009; 10:7; http://dx.doi.org/10.1186/1471-2164-10-7; PMID: 19128476
  • Kochetov AV, Syrnik OA, Rogozin IB, Glazko GV, Komarova ML, Shumnyĭ VK. [Context organization of mRNA 5′-untranslated regions of higher plants]. Mol Biol (Mosk) 2002; 36:649 - 56; PMID: 12173469
  • Calvo SE, Pagliarini DJ, Mootha VK. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A 2009; 106:7507 - 12; http://dx.doi.org/10.1073/pnas.0810916106; PMID: 19372376
  • Kozak M. Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol Cell Biol 1987; 7:3438 - 45; PMID: 3683388
  • Merrick WC. Eukaryotic protein synthesis: still a mystery. J Biol Chem 2010; 285:21197 - 201; http://dx.doi.org/10.1074/jbc.R110.111476; PMID: 20444697
  • Jackson RJ, Hellen CU, Pestova TV. Termination and post-termination events in eukaryotic translation. Adv Protein Chem Struct Biol 2012; 86:45 - 93; http://dx.doi.org/10.1016/B978-0-12-386497-0.00002-5; PMID: 22243581
  • Skabkin MA, Skabkina OV, Hellen CU, Pestova TV. Reinitiation and other unconventional posttermination events during eukaryotic translation. Mol Cell 2013; 51:249 - 64; http://dx.doi.org/10.1016/j.molcel.2013.05.026; PMID: 23810859
  • Ferreira JP, Wang CL. Optimization of oncogene expression through intra-population competition. Biotechnol J 2013; 8:1476 - 84; http://dx.doi.org/10.1002/biot.201300037; PMID: 23843261
  • Kozak M. Determinants of translational fidelity and efficiency in vertebrate mRNAs. Biochimie 1994; 76:815 - 21; http://dx.doi.org/10.1016/0300-9084(94)90182-1; PMID: 7880897
  • Yamasaki S, Anderson P. Reprogramming mRNA translation during stress. Curr Opin Cell Biol 2008; 20:222 - 6; http://dx.doi.org/10.1016/j.ceb.2008.01.013; PMID: 18356035
  • Sheikh MS, Fornace AJ Jr.. Regulation of translation initiation following stress. Oncogene 1999; 18:6121 - 8; http://dx.doi.org/10.1038/sj.onc.1203131; PMID: 10557103
  • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012; 13:89 - 102; PMID: 22251901
  • Hinnebusch AG. Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 2005; 59:407 - 50; http://dx.doi.org/10.1146/annurev.micro.59.031805.133833; PMID: 16153175
  • Hinnebusch AG, Jackson BM, Mueller PP. Evidence for regulation of reinitiation in translational control of GCN4 mRNA. Proc Natl Acad Sci U S A 1988; 85:7279 - 83; http://dx.doi.org/10.1073/pnas.85.19.7279; PMID: 3050993
  • Mueller PP, Hinnebusch AG. Multiple upstream AUG codons mediate translational control of GCN4. Cell 1986; 45:201 - 7; http://dx.doi.org/10.1016/0092-8674(86)90384-3; PMID: 3516411
  • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000; 6:1099 - 108; http://dx.doi.org/10.1016/S1097-2765(00)00108-8; PMID: 11106749
  • Lu PD, Harding HP, Ron D. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol 2004; 167:27 - 33; http://dx.doi.org/10.1083/jcb.200408003; PMID: 15479734
  • Vattem KM, Wek RC. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A 2004; 101:11269 - 74; http://dx.doi.org/10.1073/pnas.0400541101; PMID: 15277680
  • Hann SR, Sloan-Brown K, Spotts GD. Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation. Genes Dev 1992; 6:1229 - 40; http://dx.doi.org/10.1101/gad.6.7.1229; PMID: 1628829
  • Grant CM, Hinnebusch AG. Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control. Mol Cell Biol 1994; 14:606 - 18; PMID: 8264629
  • Grant CM, Miller PF, Hinnebusch AG. Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron. Mol Cell Biol 1994; 14:2616 - 28; http://dx.doi.org/10.1128/MCB.14.4.2616; PMID: 8139562
  • Kozak M. Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. Proc Natl Acad Sci U S A 1990; 87:8301 - 5; http://dx.doi.org/10.1073/pnas.87.21.8301; PMID: 2236042

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