Carbonic anhydrase IX

References

• Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat Cell Biol 2002; 4:E97 - 100; http://dx.doi.org/10.1038/ncb0402-e97; PMID: 11944043
   PubMed Web of Science ®Google Scholar
• Stock C, Schwab A. Protons make tumor cells move like clockwork. Pflugers Arch 2009; 458:981 - 92; http://dx.doi.org/10.1007/s00424-009-0677-8; PMID: 19437033
   PubMed Web of Science ®Google Scholar
• Martin C, Pedersen SF, Schwab A, Stock C. Intracellular pH gradients in migrating cells. Am J Physiol Cell Physiol 2011; 300:C490 - 5; http://dx.doi.org/10.1152/ajpcell.00280.2010; PMID: 21148407
   PubMed Web of Science ®Google Scholar
• Yilmaz M, Christofori G. Mechanisms of motility in metastasizing cells. Mol Cancer Res 2010; 8:629 - 42; http://dx.doi.org/10.1158/1541-7786.MCR-10-0139; PMID: 20460404
   PubMed Web of Science ®Google Scholar
• Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441:437 - 43; http://dx.doi.org/10.1038/nature04871; PMID: 16724055
   PubMed Web of Science ®Google Scholar
• Gillies RJ, Gatenby RA. Hypoxia and adaptive landscapes in the evolution of carcinogenesis. Cancer Metastasis Rev 2007; 26:311 - 7; http://dx.doi.org/10.1007/s10555-007-9065-z; PMID: 17404691
   PubMed Web of Science ®Google Scholar
• Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008; 7:168 - 81; http://dx.doi.org/10.1038/nrd2467; PMID: 18167490
   PubMed Web of Science ®Google Scholar
• Pastorek J, Pastoreková S, Callebaut I, Mornon JP, Zelník V, Opavský R, et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. Oncogene 1994; 9:2877 - 88; PMID: 8084592
   PubMed Web of Science ®Google Scholar
• Pastorekova S, Ratcliffe PJ, Pastorek J. Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia. BJU Int 2008; 101:Suppl 4 8 - 15; http://dx.doi.org/10.1111/j.1464-410X.2008.07642.x; PMID: 18430116
   PubMed Web of Science ®Google Scholar
• Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000; 60:7075 - 83; PMID: 11156414
   PubMed Web of Science ®Google Scholar
• Kaluz S, Kaluzová M, Chrastina A, Olive PL, Pastoreková S, Pastorek J, et al. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 α stabilization: a role for phosphatidylinositol 3′-kinase. Cancer Res 2002; 62:4469 - 77; PMID: 12154057
   PubMed Web of Science ®Google Scholar
• Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, et al. Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int J Oncol 2006; 29:1025 - 33; PMID: 16964400
   PubMed Web of Science ®Google Scholar
• Kopacek J, Barathova M, Dequiedt F, Sepelakova J, Kettmann R, Pastorek J, et al. MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX. Biochim Biophys Acta 2005; 1729:41 - 9; http://dx.doi.org/10.1016/j.bbaexp.2005.03.003; PMID: 15833446
   PubMed Web of Science ®Google Scholar
• Barathova M, Takacova M, Holotnakova T, Gibadulinova A, Ohradanova A, Zatovicova M, et al. Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype. Br J Cancer 2008; 98:129 - 36; http://dx.doi.org/10.1038/sj.bjc.6604111; PMID: 18026188
   PubMed Web of Science ®Google Scholar
• Ditte P, Dequiedt F, Svastova E, Hulikova A, Ohradanova-Repic A, Zatovicova M, et al. Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors. Cancer Res 2011; 71:7558 - 67; http://dx.doi.org/10.1158/0008-5472.CAN-11-2520; PMID: 22037869
   PubMed Web of Science ®Google Scholar
• Rafajová M, Zatovicová M, Kettmann R, Pastorek J, Pastoreková S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int J Oncol 2004; 24:995 - 1004; PMID: 15010840
   PubMed Web of Science ®Google Scholar
• Zatovicova M, Sedlakova O, Svastova E, Ohradanova A, Ciampor F, Arribas J, et al. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. Br J Cancer 2005; 93:1267 - 76; http://dx.doi.org/10.1038/sj.bjc.6602861; PMID: 16278664
   PubMed Web of Science ®Google Scholar
• Rzymski T, Petry A, Kračun D, Rieß F, Pike L, Harris AL, et al. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene 2012; 31:3621 - 34; http://dx.doi.org/10.1038/onc.2011.522; PMID: 22105359
   PubMed Web of Science ®Google Scholar
• Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol 2008; 18:330 - 7; http://dx.doi.org/10.1016/j.semcancer.2008.03.011; PMID: 18455429
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029 - 33; http://dx.doi.org/10.1126/science.1160809; PMID: 19460998
   PubMed Web of Science ®Google Scholar
• Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 2002; 8:1284 - 91; PMID: 11948144
   PubMed Web of Science ®Google Scholar
• Parks SK, Chiche J, Pouyssegur J. pH control mechanisms of tumor survival and growth. J Cell Physiol 2011; 226:299 - 308; http://dx.doi.org/10.1002/jcp.22400; PMID: 20857482
   PubMed Web of Science ®Google Scholar
• Cardone RA, Casavola V, Reshkin SJ. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer 2005; 5:786 - 95; http://dx.doi.org/10.1038/nrc1713; PMID: 16175178
   PubMed Web of Science ®Google Scholar
• Hulikova A, Harris AL, Vaughan-Jones RD, Swietach P. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia. J Cell Physiol 2013; 228:743 - 52; http://dx.doi.org/10.1002/jcp.24221; PMID: 22949268
   PubMed Web of Science ®Google Scholar
• Romero MF, Fulton CM, Boron WF. The SLC4 family of HCO 3 - transporters. Pflugers Arch 2004; 447:495 - 509; http://dx.doi.org/10.1007/s00424-003-1180-2; PMID: 14722772
   PubMed Web of Science ®Google Scholar
• Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE. Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem 2007; 282:35125 - 32; http://dx.doi.org/10.1074/jbc.M707266200; PMID: 17890222
   PubMed Web of Science ®Google Scholar
• Hulikova A, Vaughan-Jones RD, Swietach P. Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths. J Biol Chem 2011; 286:13815 - 26; http://dx.doi.org/10.1074/jbc.M111.219899; PMID: 21345798
   PubMed Web of Science ®Google Scholar
• Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res 2009; 69:2260 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-07-5575; PMID: 19276390
   PubMed Web of Science ®Google Scholar
• Sterling D, Reithmeier RA, Casey JR. A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J Biol Chem 2001; 276:47886 - 94; PMID: 11606574
   PubMed Web of Science ®Google Scholar
• Sterling D, Alvarez BV, Casey JR. The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV. J Biol Chem 2002; 277:25239 - 46; http://dx.doi.org/10.1074/jbc.M202562200; PMID: 11994299
   PubMed Web of Science ®Google Scholar
• Becker HM, Deitmer JW. Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter. J Biol Chem 2007; 282:13508 - 21; http://dx.doi.org/10.1074/jbc.M700066200; PMID: 17353189
   PubMed Web of Science ®Google Scholar
• Morgan PE, Pastorekova S, Stuart-Tilley AK, Alper SL, Casey JR. Interactions of transmembrane carbonic anhydrase, CA IX, with bicarbonate transporters. Am J Physiol Cell Physiol 2007; 293:738 - 48; http://dx.doi.org/10.1152/ajpcell.00157.2007
   PubMed Web of Science ®Google Scholar
• Svastová E, Hulíková A, Rafajová M, Zat’ovicová M, Gibadulinová A, Casini A, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004; 577:439 - 45; http://dx.doi.org/10.1016/j.febslet.2004.10.043; PMID: 15556624
   PubMed Web of Science ®Google Scholar
• Orlowski A, De Giusti VC, Morgan PE, Aiello EA, Alvarez BV. Binding of carbonic anhydrase IX to extracellular loop 4 of the NBCe1 Na+/HCO3- cotransporter enhances NBCe1-mediated HCO3- influx in the rat heart. Am J Physiol Cell Physiol 2012; 303:C69 - 80; http://dx.doi.org/10.1152/ajpcell.00431.2011; PMID: 22538240
   PubMed Web of Science ®Google Scholar
• Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD. The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths. J Biol Chem 2009; 284:20299 - 310; http://dx.doi.org/10.1074/jbc.M109.006478; PMID: 19458084
   PubMed Web of Science ®Google Scholar
• Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009; 69:358 - 68; http://dx.doi.org/10.1158/0008-5472.CAN-08-2470; PMID: 19118021
   PubMed Web of Science ®Google Scholar
• Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 2006; 66:5216 - 23; http://dx.doi.org/10.1158/0008-5472.CAN-05-4193; PMID: 16707446
   PubMed Web of Science ®Google Scholar
• Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, et al. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis 2008; 25:411 - 25; http://dx.doi.org/10.1007/s10585-008-9145-7; PMID: 18301995
   PubMed Web of Science ®Google Scholar
• DeClerck K, Elble RC. The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy. Front Biosci 2010; 15:213 - 25; http://dx.doi.org/10.2741/3616; PMID: 20036816
   PubMed Web of Science ®Google Scholar
• Stock C, Mueller M, Kraehling H, Mally S, Noël J, Eder C, et al. pH nanoenvironment at the surface of single melanoma cells. Cell Physiol Biochem 2007; 20:679 - 86; http://dx.doi.org/10.1159/000107550; PMID: 17762194
   PubMed Web of Science ®Google Scholar
• Klein M, Seeger P, Schuricht B, Alper SL, Schwab A. Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells. J Gen Physiol 2000; 115:599 - 608; http://dx.doi.org/10.1085/jgp.115.5.599; PMID: 10779317
   PubMed Web of Science ®Google Scholar
• Schwab A. Function and spatial distribution of ion channels and transporters in cell migration. Am J Physiol Renal Physiol 2001; 280:F739 - 47; PMID: 11292615
   PubMed Web of Science ®Google Scholar
• Stüwe L, Müller M, Fabian A, Waning J, Mally S, Noël J, et al. pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol 2007; 585:351 - 60; http://dx.doi.org/10.1113/jphysiol.2007.145185; PMID: 17916606
   PubMed Web of Science ®Google Scholar
• Svastova E, Witarski W, Csaderova L, Kosik I, Skvarkova L, Hulikova A, et al. Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain. J Biol Chem 2012; 287:3392 - 402; http://dx.doi.org/10.1074/jbc.M111.286062; PMID: 22170054
   PubMed Web of Science ®Google Scholar
• Jia Z, Barbier L, Stuart H, Amraei M, Pelech S, Dennis JW, et al. Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation. J Biol Chem 2005; 280:30564 - 73; http://dx.doi.org/10.1074/jbc.M501754200; PMID: 15985431
   PubMed Web of Science ®Google Scholar
• Nguyen TN, Wang HJ, Zalzal S, Nanci A, Nabi IR. Purification and characterization of beta-actin-rich tumor cell pseudopodia: role of glycolysis. Exp Cell Res 2000; 258:171 - 83; http://dx.doi.org/10.1006/excr.2000.4929; PMID: 10912799
   PubMed Web of Science ®Google Scholar
• Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, et al. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell 2008; 19:4930 - 41; http://dx.doi.org/10.1091/mbc.E08-06-0564; PMID: 18784251
   PubMed Web of Science ®Google Scholar
• Paulucci-Holthauzen AA, Vergara LA, Bellot LJ, Canton D, Scott JD, O’Connor KL. Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem 2009; 284:5956 - 67; http://dx.doi.org/10.1074/jbc.M805606200; PMID: 19106088
   PubMed Web of Science ®Google Scholar
• Yamashita H, Ueda K, Kioka N. WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions. J Biol Chem 2011; 286:3907 - 14; http://dx.doi.org/10.1074/jbc.M110.145409; PMID: 21119216
   PubMed Web of Science ®Google Scholar
• McKenzie AJ, Campbell SL, Howe AK. Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PLoS One 2011; 6:e26552; http://dx.doi.org/10.1371/journal.pone.0026552; PMID: 22028904
   PubMedGoogle Scholar
• Svastová E, Zilka N, Zat’ovicová M, Gibadulinová A, Ciampor F, Pastorek J, et al. Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin. Exp Cell Res 2003; 290:332 - 45; http://dx.doi.org/10.1016/S0014-4827(03)00351-3; PMID: 14567991
   PubMed Web of Science ®Google Scholar
• Radvak P, Repic M, Svastova E, Takacova M, Csaderova L, Strnad H, et al. Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells. Oncol Rep 2013; 29:1147 - 53; http://dx.doi.org/10.3892/or.2013.2226; PMID: 23291973
   PubMed Web of Science ®Google Scholar
• Závada J, Závadová Z, Pastorek J, Biesová Z, Jezek J, Velek J. Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion. Br J Cancer 2000; 82:1808 - 13; http://dx.doi.org/10.1054/bjoc.2000.1111; PMID: 10839295
   PubMed Web of Science ®Google Scholar
• Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 2004; 3:164 - 7; http://dx.doi.org/10.4161/cc.3.2.618; PMID: 14712082
   PubMed Web of Science ®Google Scholar
• Sullivan R, Graham CH. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 2007; 26:319 - 31; http://dx.doi.org/10.1007/s10555-007-9062-2; PMID: 17458507
   PubMed Web of Science ®Google Scholar