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Research Paper

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading

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Pages 499-508 | Received 19 Mar 2014, Accepted 20 May 2014, Published online: 31 Oct 2014

References

  • Stewart JD, Marchan R, Lesjak MS, Lambert J, Hergenroeder R, Ellis JK, Lau CH, Keun HC, Schmitz G, Schiller J, et al. Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A 2012; 109:8155-60; PMID:22570503; http://dx.doi.org/10.1073/pnas.1117654109
  • Marchan R, Lesjak MS, Stewart JD, Winter R, Seeliger J, Hengstler JG. Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities. Cell Cycle 2012; 11:4499-506; PMID:23114620; http://dx.doi.org/10.4161/cc.22544
  • Tayebati SK, Amenta F. Choline-containing phospholipids: relevance to brain functional pathways. Clin Chem Lab Med 2013; 51:513-21; PMID:23314552; http://dx.doi.org/10.1515/cclm-2012-0559
  • Corbin KD, Zeisel SH. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol 2012; 28:159-65; PMID:22134222; http://dx.doi.org/10.1097/MOG.0b013e32834e7b4b
  • Lombardi B, Pani P, Schlunk FF. Choline-deficiency fatty liver: impaired release of hepatic triglycerides. J Lipid Res 1968; 9:437-46; PMID:5725875
  • Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res 1999; 59:80-4; PMID:9892190
  • Ackerstaff E, Glunde K, Bhujwalla ZM. Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem 2003; 90:525-33; PMID:14523987; http://dx.doi.org/10.1002/jcb.10659
  • Glunde K, Ackerstaff E, Mori N, Jacobs MA, Bhujwalla ZM. Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm 2006; 3:496-506; PMID:17009848; http://dx.doi.org/10.1021/mp060067e
  • Glunde K, Bhujwalla ZM, Ronen SM. Choline metabolism in malignant transformation. Nat Rev Cancer 2011; 11:835-48; PMID:22089420
  • Iorio E, Mezzanzanica D, Alberti P, Spadaro F, Ramoni C, D’Ascenzo S, Millimaggi D, Pavan A, Dolo V, Canevari S, et al. Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res 2005; 65:9369-76; PMID:16230400; http://dx.doi.org/10.1158/0008-5472.CAN-05-1146
  • Ackerstaff E, Pflug BR, Nelson JB, Bhujwalla ZM. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res 2001; 61:3599-603; PMID:11325827
  • Eliyahu G, Kreizman T, Degani H. Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies. Int J Cancer 2007; 120:1721-30; PMID:17236204; http://dx.doi.org/10.1002/ijc.22293
  • Hattingen E, Bähr O, Rieger J, Blasel S, Steinbach J, Pilatus U. Phospholipid metabolites in recurrent glioblastoma: in vivo markers detect different tumor phenotypes before and under antiangiogenic therapy. PLoS One 2013; 8:e56439; PMID:23520454; http://dx.doi.org/10.1371/journal.pone.0056439
  • Gallego-Ortega D, Gómez del Pulgar T, Valdés-Mora F, Cebrián A, Lacal JC. Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions. Adv Enzyme Regul 2011; 51:183-94; PMID:21035492; http://dx.doi.org/10.1016/j.advenzreg.2010.09.010
  • Iorio E, Ricci A, Bagnoli M, Pisanu ME, Castellano G, Di Vito M, Venturini E, Glunde K, Bhujwalla ZM, Mezzanzanica D, et al. Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res 2010; 70:2126-35; PMID:20179205; http://dx.doi.org/10.1158/0008-5472.CAN-09-3833
  • Ramírez de Molina A, Gutiérrez R, Ramos MA, Silva JM, Silva J, Bonilla F, Sánchez JJ, Lacal JC. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 2002; 21:4317-22; PMID:12082619; http://dx.doi.org/10.1038/sj.onc.1205556
  • Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, Martínez-Piñeiro L, Sánchez J, Bonilla F, Rosell R, Lacal J. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 2002; 296:580-3; PMID:12176020; http://dx.doi.org/10.1016/S0006-291X(02)00920-8
  • Okazaki Y, Ohshima N, Yoshizawa I, Kamei Y, Mariggiò S, Okamoto K, Maeda M, Nogusa Y, Fujioka Y, Izumi T, et al. A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem 2010; 285:27652-63; PMID:20576599; http://dx.doi.org/10.1074/jbc.M110.106708
  • Rosfjord EC, Maemura M, Johnson MD, Torri JA, Akiyama SK, Woods VL Jr, Dickson RB. Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells. Exp Cell Res 1999; 248:260-71; PMID:10094832; http://dx.doi.org/10.1006/excr.1998.4390
  • Ng T, Shima D, Squire A, Bastiaens PI, Gschmeissner S, Humphries MJ, Parker PJ. PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic. EMBO J 1999; 18:3909-23; PMID:10406796; http://dx.doi.org/10.1093/emboj/18.14.3909
  • Guo HB, Lee I, Bryan BT, Pierce M. Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathway. J Biol Chem 2005; 280:8332-42; PMID:15615721; http://dx.doi.org/10.1074/jbc.M413532200
  • Cao MD, Döpkens M, Krishnamachary B, Vesuna F, Gadiya MM, Lønning PE, Bhujwalla ZM, Gribbestad IS, Glunde K. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed 2012; 25:1033-42; PMID:22279038; http://dx.doi.org/10.1002/nbm.2766
  • Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res 2008; 49:1187-94; PMID:18204095; http://dx.doi.org/10.1194/jlr.R700019-JLR200
  • Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr 2006; 26:229-50; PMID:16848706; http://dx.doi.org/10.1146/annurev.nutr.26.061505.111156
  • Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH. Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell 2008; 19:3111-23; PMID:18480413; http://dx.doi.org/10.1091/mbc.E07-04-0337
  • Du G, Frohman MA. A lipid-signaled myosin phosphatase surge disperses cortical contractile force early in cell spreading. Mol Biol Cell 2009; 20:200-8; PMID:18946083; http://dx.doi.org/10.1091/mbc.E08-06-0555
  • Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol 2009; 75:437-46; PMID:19064628; http://dx.doi.org/10.1124/mol.108.053298
  • Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baquié M, Waldmann T, Ensenat-Waser R, et al. Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol 2013; 87:123-43; PMID:23179753; http://dx.doi.org/10.1007/s00204-012-0967-3
  • Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4:249-64; PMID:12925520; http://dx.doi.org/10.1093/biostatistics/4.2.249
  • Smyth GK, Michaud J, Scott HS. Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics 2005; 21:2067-75; PMID:15657102; http://dx.doi.org/10.1093/bioinformatics/bti270
  • Alexa A, Rahnenführer J, Lengauer T. Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics 2006; 22:1600-7; PMID:16606683; http://dx.doi.org/10.1093/bioinformatics/btl140