The tumor suppressor Lgl1 regulates front-rear polarity of migrating cells

References

• Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science 2003; 302:1704-9; PMID:14657486; http://dx.doi.org/10.1126/science.1092053
   PubMed Web of Science ®Google Scholar
• Etienne-Manneville S. Polarity proteins in migration and invasion. Oncogene 2008; 27:6970-80; PMID:19029938; http://dx.doi.org/10.1038/onc.2008.347
   PubMed Web of Science ®Google Scholar
• Dahan I, Yearim A, Touboul Y, Ravid S. The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration. Mol Biol Cell 2012; 23:591-601; PMID:22219375; http://dx.doi.org/10.1091/mbc.E11-01-0015
   PubMed Web of Science ®Google Scholar
• Dahan I, Petrov D, Cohen-Kfir E, Ravid S. The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation. J Cell Sci 2014; 127:295-304; PMID:24213535; http://dx.doi.org/10.1242/jcs.127357
   PubMedGoogle Scholar
• Conti MA, Adelstein RS. Nonmuscle myosin II moves in new directions. J Cell Sci 2008; 121:11-8; PMID:18096687; http://dx.doi.org/10.1242/jcs.007112
   PubMed Web of Science ®Google Scholar
• Vicente-Manzanares M, Ma X, Adelstein RS, Horwitz AR. Non-muscle myosin II takes centre stage in cell adhesion and migration. Nat Rev Mol Cell Biol 2009; 10:778-90; PMID:19851336; http://dx.doi.org/10.1038/nrm2786
   PubMed Web of Science ®Google Scholar
• Wylie SR, Chantler PD. Myosin IIA drives neurite retraction. Mol Biol Cell 2003; 14:4654-66; PMID:12960431; http://dx.doi.org/10.1091/mbc.E03-03-0187
   PubMedGoogle Scholar
• Martins GG, Kolega J. Endothelial cell protrusion and migration in three-dimensional collagen matrices. Cell Motil Cytoskeleton 2006; 63:101-15; PMID:16395720; http://dx.doi.org/10.1002/cm.20104
   PubMed Web of Science ®Google Scholar
• Sandquist JC, Swenson KI, Demali KA, Burridge K, Means AR. Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem 2006; 281:35873-83; PMID:17020881; http://dx.doi.org/10.1074/jbc.M605343200
   PubMed Web of Science ®Google Scholar
• Vicente-Manzanares M, Koach MA, Whitmore L, Lamers ML, Horwitz AF. Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol 2008; 183:543-54; PMID:18955554; http://dx.doi.org/10.1083/jcb.200806030
   PubMed Web of Science ®Google Scholar
• Vicente-Manzanares M, Newell-Litwa K, Bachir AI, Whitmore LA, Horwitz AR. Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol 2011; 193:381-96; PMID:21482721; http://dx.doi.org/10.1083/jcb.201012159
   PubMed Web of Science ®Google Scholar
• Assémat E, Bazellières E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:614-30; PMID:18005931; http://dx.doi.org/10.1016/j.bbamem.2007.08.029
   PubMed Web of Science ®Google Scholar
• Schimanski CC, Schmitz G, Kashyap A, Bosserhoff AK, Bataille F, Schäfer SC, Lehr HA, Berger MR, Galle PR, Strand S, et al. Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene 2005; 24:3100-9; PMID:15735678; http://dx.doi.org/10.1038/sj.onc.1208520
   PubMed Web of Science ®Google Scholar
• Plant PJ, Fawcett JP, Lin DC, Holdorf AD, Binns K, Kulkarni S, Pawson T. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol 2003; 5:301-8; PMID:12629547; http://dx.doi.org/10.1038/ncb948
   PubMed Web of Science ®Google Scholar
• Strand D, Jakobs R, Merdes G, Neumann B, Kalmes A, Heid HW, Husmann I, Mechler BM. The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain. J Cell Biol 1994; 127:1361-73; PMID:7962095; http://dx.doi.org/10.1083/jcb.127.5.1361
   PubMed Web of Science ®Google Scholar
• Peng CY, Manning L, Albertson R, Doe CQ. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 2000; 408:596-600; PMID:11117748; http://dx.doi.org/10.1038/35046094
   PubMed Web of Science ®Google Scholar
• Barros CS, Phelps CB, Brand AH. Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport. Dev Cell 2003; 5:829-40; PMID:14667406; http://dx.doi.org/10.1016/S1534-5807(03)00359-9
   PubMed Web of Science ®Google Scholar
• Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, Horwitz AR. Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol 2008; 10:1039-50; PMID:19160484; http://dx.doi.org/10.1038/ncb1763
   PubMed Web of Science ®Google Scholar
• Friedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 2004; 48:441-9; PMID:15349818; http://dx.doi.org/10.1387/ijdb.041821pf
   PubMed Web of Science ®Google Scholar
• Woodhouse E, Hersperger E, Shearn A. Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev Genes Evol 1998; 207:542-50; PMID:9510549; http://dx.doi.org/10.1007/s004270050145
   PubMed Web of Science ®Google Scholar
• Suzuki A, Ohno S. The PAR-aPKC system: lessons in polarity. J Cell Sci 2006; 119:979-87; PMID:16525119; http://dx.doi.org/10.1242/jcs.02898
   PubMed Web of Science ®Google Scholar
• Betschinger J, Mechtler K, Knoblich JA. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 2003; 422:326-30; PMID:12629552; http://dx.doi.org/10.1038/nature01486
   PubMed Web of Science ®Google Scholar
• Hutterer A, Betschinger J, Petronczki M, Knoblich JA. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell 2004; 6:845-54; PMID:15177032; http://dx.doi.org/10.1016/j.devcel.2004.05.003
   PubMed Web of Science ®Google Scholar
• Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A, Ohno S. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol 2003; 13:734-43; PMID:12725730; http://dx.doi.org/10.1016/S0960-9822(03)00244-6
   PubMed Web of Science ®Google Scholar
• Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ. Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol 2003; 163:1089-98; PMID:14657233; http://dx.doi.org/10.1083/jcb.200306079
   PubMed Web of Science ®Google Scholar
• Grifoni D, Garoia F, Bellosta P, Parisi F, De Biase D, Collina G, Strand D, Cavicchi S, Pession A. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. Oncogene 2007; 26:5960-5; PMID:17369850; http://dx.doi.org/10.1038/sj.onc.1210389
   PubMedGoogle Scholar
• Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, Lauwers GY. Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study. Mod Pathol 2009; 22:977-84; PMID:19407852; http://dx.doi.org/10.1038/modpathol.2009.68
   PubMedGoogle Scholar
• Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2000; 2:531-9; PMID:10934474; http://dx.doi.org/10.1038/35019573
   PubMed Web of Science ®Google Scholar
• Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2000; 2:540-7; PMID:10934475; http://dx.doi.org/10.1038/35019592
   PubMed Web of Science ®Google Scholar
• Even-Faitelson L, Ravid S. PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly. Mol Biol Cell 2006; 17:2869-81; PMID:16611744; http://dx.doi.org/10.1091/mbc.E05-11-1001
   PubMed Web of Science ®Google Scholar
• Dulyaninova NG, Bresnick AR. The heavy chain has its day: Regulation of myosin-II assembly. Bioarchitecture 2013; 3:77-85; PMID:24002531; http://dx.doi.org/10.4161/bioa.26133
   PubMedGoogle Scholar