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Commentary & View

BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization

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Pages 6-10 | Received 26 Jun 2010, Accepted 28 Jul 2010, Published online: 01 Jan 2011

References

  • Coultas L, Strasser A. The role of the Bcl-2 protein family in cancer. Semin Cancer Biol 2003; 13:1 - 3
  • Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335:440 - 442
  • Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990; 348:331 - 333
  • Murphy KL, Kittrell FS, Gay JP, Jager R, Medina D, Rosen JM. Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice. Oncogene 1999; 18:6597 - 6604
  • de la Coste A, Fabre M, McDonell N, Porteu A, Gilgenkrantz H, Perret C, et al. Differential protective effects of Bcl-xL and Bcl-2 on apoptotic liver injury in transgenic mice. Am J Physiol 1999; 277:702 - 708
  • Lu PJ, Lu QL, Rughetti A, Taylor-Papadimitriou J. bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells. J Cell Biol 1995; 129:1363 - 1378
  • Gil-Gomez G, Berns A, Brady HJ. A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis. EMBO J 1998; 17:7209 - 7218
  • Quinn L, Coombe M, Mills K, Daish T, Colussi P, Kumar S, et al. Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions. EMBO J 2003; 22:3568 - 3579
  • Trisciuoglio D, Desideri M, Ciuffreda L, Mottolese M, Ribatti D, Vacca A, et al. Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth. J Cell Physiol 2005; 205:414 - 421
  • Von Wangenheim KH, Peterson HP. A mechanism of intracellular timing and its cooperation with extracellular signals in controlling cell proliferation and differentiation, an amended hypothesis. J Theor Biol 2001; 211:239 - 251
  • Callagy GM, Webber MJ, Pharoah PD, Caldas C. Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer. BMC Cancer 2008; 8:153
  • Ke H, Parron VI, Reece J, Zhang JY, Akiyama SK, French JE. BCL2 inhibits cell adhesion, spreading and motility by enhancing actin polymerization. Cell Res 2010; 20:458 - 469
  • Merritt AJ, Potten CS, Watson AJ, Loh DY, Nakayama K, Hickman JA. Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia. J Cell Sci 1995; 108:2261 - 2271
  • Nakayama K, Negishi I, Kuida K, Sawa H, Loh DY. Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease and lymphocytopenia. Proc Natl Acad Sci USA 1994; 91:3700 - 3704
  • Mak SS, Moriyama M, Nishioka E, Osawa M, Nishikawa S. Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev Biol 2006; 291:144 - 153
  • Pollard TD, Cooper JA. Actin, a central player in cell shape and movement. Science 2009; 326:1208 - 1212
  • Reinhart-King CA, Dembo M, Hammer DA. The dynamics and mechanics of endothelial cell spreading. Biophys J 2005; 89:676 - 689
  • Koestler SA, Rottner K, Lai F, Block J, Vinzenz M, Small JV. F- and G-actin concentrations in lamellipodia of moving cells. PLoS One 2009; 4:e4810
  • Moissoglu K, Schwartz MA. Integrin signalling in directed cell migration. Biol Cell 2006; 98:547 - 555
  • Martin SS, Leder P. Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. Mol Cell Biol 2001; 21:6529 - 6536
  • Zhang W, Pantschenko AG, McCarthy MB, Gronowicz G. Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro. Calcif Tissue Int 2007; 80:111 - 122
  • Whittard JD, Akiyama SK. Activation of beta1 integrins induces cell-cell adhesion. Exp Cell Res 2001; 263:65 - 76
  • Lee BH, Ruoslahti E. alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase and Ca2+/calmodulin-dependent protein kinase IV. J Cell Biochem 2005; 95:1214 - 1223
  • Nobes CD, Hall A. Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 1995; 81:53 - 62
  • Yamazaki D, Oikawa T, Takenawa T. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. J Cell Sci 2007; 120:86 - 100
  • Hartwig JH, Chambers KA, Stossel TP. Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol 1989; 108:467 - 479
  • Sorenson CM. Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem 2004; 279:11368 - 11374
  • Li L, Backer J, Wong AS, Schwanke EL, Stewart BG, Pasdar M. Bcl-2 expression decreases cadherin-mediated cell-cell adhesion. J Cell Sci 2003; 116:3687 - 3700
  • Zhu T, Starling-Emerald B, Zhang X, Lee KO, Gluckman PD, Mertani HC, et al. Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res 2005; 65:317 - 324
  • Lin HM, Lee YJ, Li G, Pestell RG, Kim HR. Bcl-2 induces cyclin D1 promoter activity in human breast epithelial cells independent of cell anchorage. Cell Death Differ 2001; 8:44 - 50
  • Pinkas J, Martin SS, Leder P. Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. Mol Cancer Res 2004; 2:551 - 556
  • Miyake H, Hara I, Yamanaka K, Gohji K, Arakawa S, Kamidono S. Overexpression of Bcl-2 enhances metastatic potential of human bladder cancer cells. Br J Cancer 1999; 79:1651 - 1656
  • Kondo S, Tang Y, Scheef EA, Sheibani N, Sorenson CM. Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2. Am J Physiol Cell Physiol 2008; 294:1521 - 1530
  • Sheibani N, Scheef EA, Dimaio TA, Wang Y, Kondo S, Sorenson CM. Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells. J Cell Physiol 2007; 210:616 - 625