Chimeric p53 as an alternative therapy for hypoxic tumors

References

• Egleton RD, Davis TP. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides 1997; 18:1431 - 1439
   PubMed Web of Science ®Google Scholar
• van de Waterbeemd H, Camenisch G, Folkers G, Chretien JR, Raevsky OA. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J Drug Target 1998; 6:151 - 165
   PubMed Web of Science ®Google Scholar
• Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999; 285:1569 - 1572
   PubMed Web of Science ®Google Scholar
• Derossi D, Joliot AH, Chassaing G, Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem 1994; 269:10444 - 10450
   PubMed Web of Science ®Google Scholar
• Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88:223 - 233
   PubMed Web of Science ®Google Scholar
• Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell 1988; 55:1179 - 1188
   PubMed Web of Science ®Google Scholar
• Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988; 55:1189 - 1193
   PubMed Web of Science ®Google Scholar
• Becker-Hapak M, McAllister SS, Dowdy SF. TAT-mediated protein transduction into mammalian cells. Methods 2001; 24:247 - 256
   PubMed Web of Science ®Google Scholar
• Fawell S, Seery J, Daikh Y, Moore C, Chen LL, Pepinsky B, et al. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 1994; 91:664 - 668
   PubMed Web of Science ®Google Scholar
• Schwarze SR, Dowdy SF. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci 2000; 21:45 - 48
   PubMed Web of Science ®Google Scholar
• Frankel AD, Bredt DS, Pabo CO. Tat protein from human immunodeficiency virus forms a metal-linked dimer. Science 1988; 240:70 - 73
   PubMed Web of Science ®Google Scholar
• Vocero-Akbani AM, Heyden NV, Lissy NA, Ratner L, Dowdy SF. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med 1999; 5:29 - 33
   PubMed Web of Science ®Google Scholar
• Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, et al. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 1998; 4:1449 - 1452
   PubMed Web of Science ®Google Scholar
• Park J, Ryu J, Kim KA, Lee HJ, Bahn JH, Han K, et al. Mutational analysis of a human immunodeficiency virus type 1 Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells. J Gen Virol 2002; 83:1173 - 1181
   PubMed Web of Science ®Google Scholar
• Jin LH, Bahn JH, Eum WS, Kwon HY, Jang SH, Han KH, et al. Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells. Free Radic Biol Med 2001; 31:1509 - 1519
   PubMed Web of Science ®Google Scholar
• Kwon HY, Eum WS, Jang HW, Kang JH, Ryu J, Ryong Lee B, et al. Transduction of Cu, Zn-superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells. FEBS Lett 2000; 485:163 - 167
   PubMed Web of Science ®Google Scholar
• Sun W, Yang J. Functional mechanisms for human tumor suppressors. J Cancer 2010; 1:136 - 140
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307 - 310
   PubMed Web of Science ®Google Scholar
• Soussi T, Dehouche K, Beroud C. p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. Hum Mutat 2000; 15:105 - 113
   PubMed Web of Science ®Google Scholar
• Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991; 253:49 - 53
   PubMed Web of Science ®Google Scholar
• Ryu J, Lee HJ, Kim KA, Lee JY, Lee KS, Park J, et al. Intracellular delivery of p53 fused to the basic domain of HIV-1 Tat. Mol Cells 2004; 17:353 - 359
   PubMed Web of Science ®Google Scholar
• Jiang L, Ma Y, Wang J, Tao X, Wei D. The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis. Mol Biol Rep 2008; 35:1 - 8
   PubMed Web of Science ®Google Scholar
• Brown JM. The hypoxic cell: a target for selective cancer therapy—eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 1999; 59:5863 - 5870
   PubMed Web of Science ®Google Scholar
• Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun 2005; 331:718 - 725
   PubMed Web of Science ®Google Scholar
• Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993; 268:21513 - 21518
   PubMed Web of Science ®Google Scholar
• Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 1991; 88:5680 - 5684
   PubMed Web of Science ®Google Scholar
• Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998; 95:7987 - 7992
   PubMed Web of Science ®Google Scholar
• Harada H, Hiraoka M, Kizaka-Kondoh S. Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells. Cancer Res 2002; 62:2013 - 2018
   PubMed Web of Science ®Google Scholar
• Koshikawa N, Takenaga K. Hypoxia-regulated expression of attenuated diphtheria toxin A fused with hypoxia-inducible factor-1alpha oxygen-dependent degradation domain preferentially induces apoptosis of hypoxic cells in solid tumor. Cancer Res 2005; 65:11622 - 11630
   PubMed Web of Science ®Google Scholar
• Yu Z, Wu J, Wu S, Jia P, Tong Y, Wu X, et al. A recombinant cell-permeable p53 fusion protein is selectively stabilized under hypoxia and inhibits tumor cell growth. Cancer Lett 2009; 279:101 - 107
   PubMed Web of Science ®Google Scholar
• Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, Prochiantz A. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J Biol Chem 1996; 271:18188 - 18193
   PubMed Web of Science ®Google Scholar