Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

References

• Dupouy S, Viardot-Foucault V, Alifano M, Souazé F, Plu-Bureau G, Chaouat M, et al. The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. PLoS ONE 2009; 4:4223; PMID: 19156213; http://dx.doi.org/10.1371/journal.pone.0004223
   PubMed Web of Science ®Google Scholar
• Wang L, Friess H, Zhu Z, Graber H, Zimmermann A, Korc M, et al. Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. Clin Cancer Res 2000; 6:566 - 571; PMID: 10690540
   PubMed Web of Science ®Google Scholar
• Seethalakshmi L, Mitra SP, Dobner PR, Menon M, Carraway RE. Neurotensin receptor expression in prostate cancer cell line and growth effect of NT at physiological concentrations. Prostate 1997; 31:183 - 192; PMID: 9167771; http://dx.doi.org/10.1002/(SICI)1097-0045(19970515)31:3<183::AIDPROS7>3.0.CO;2-M
   PubMed Web of Science ®Google Scholar
• Gui X, Guzman G, Dobner PR, Kadkol SS. Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. Peptides 2008; 29:1609 - 1615; PMID: 18541341; http://dx.doi.org/10.1016/j.peptides.2008.04.014
   PubMed Web of Science ®Google Scholar
• Goedert M, Reeve JG, Emson PC, Bleehen NM. Neurotensin in human small cell lung carcinoma. Br J Cancer 1984; 50:179 - 183; PMID: 6087865; http://dx.doi.org/10.1038/bjc.1984.160
   PubMed Web of Science ®Google Scholar
• Resh MD. Palmitoylation of ligands, receptors and intracellular signaling molecules. Sci STKE 2006; 2006:14; PMID: 17077383; http://dx.doi.org/10.1126/stke.3592006re14
   PubMedGoogle Scholar
• Karnik SS, Ridge KD, Bhattacharya S, Khorana HG. Palmitoylation of bovine opsin and its cysteine mutants in COS cells. Proc Natl Acad Sci USA 1993; 90:40 - 44; PMID: 8419942; http://dx.doi.org/10.1073/pnas.90.1.40
   PubMed Web of Science ®Google Scholar
• Chini B, Parenti M. G-protein coupled receptors, cholesterol and palmitoylation: facts about fats. J Mol Endocrinol 2009; 42:371 - 379; PMID: 19131499; http://dx.doi.org/10.1677/JME-08-0114
   PubMed Web of Science ®Google Scholar
• Jin H, Zastawny R, George SR, O'Dowd BF. Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction. Eur J Pharmacol 1997; 324:109 - 116; PMID: 9137920; http://dx.doi.org/10.1016/S0014-2999(97)00059-9
   PubMed Web of Science ®Google Scholar
• Jin H, Xie Z, George SR, O'Dowd BF. Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D[1] receptor. Eur J Pharmacol 1999; 386:305 - 312; PMID: 10618483; http://dx.doi.org/10.1016/S0014-2999(99)00727-X
   PubMed Web of Science ®Google Scholar
• Ng GY, Mouillac B, George SR, et al. Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor. Eur J Pharmacol 1994; 267:7 - 19; PMID: 7515822; http://dx.doi.org/10.1016/0922-4106(94)90219-4
   PubMed Web of Science ®Google Scholar
• Loisel TP, Adam L, Hebert TE, Bouvier M. Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation. Biochemistry 1996; 35:15923 - 15932; PMID: 8961959; http://dx.doi.org/10.1021/bi9611321
   PubMed Web of Science ®Google Scholar
• Kennedy ME, Limbird LE. Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation. J Biol Chem 1994; 269:31915 - 31922; PMID: 7989367
   PubMed Web of Science ®Google Scholar
• Blanpain C, Wittamer V, Vanderwinden JM, Boom A, Renneboog B, Lee B, et al. Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. J Biol Chem 2001; 276:23795 - 23804; PMID: 11323418; http://dx.doi.org/10.1074/jbc.M100583200
   PubMed Web of Science ®Google Scholar
• Gao Z, Ni Y, Szabo G, Linden J. Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors. Biochem J 1999; 342:387 - 395; PMID: 10455026; http://dx.doi.org/10.1042/0264-6021:3420387
   PubMed Web of Science ®Google Scholar
• Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation is required for signaling functions and membrane attachment of Gqalpha and Gsalpha. J Biol Chem 1993; 268:25001 - 25008; PMID: 8227063
   PubMed Web of Science ®Google Scholar
• Ducker CE, Griffel LK, Smith RA, Keller SN, Zhuang Y, Xia Z, et al. Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther 2006; 5:1647 - 1659; PMID: 16891450; http://dx.doi.org/10.1158/1535-7163.MCT-06-0114
   PubMed Web of Science ®Google Scholar
• Draper JM, Smith CD. Palmitoyl acyltransferase assays and inhibitors [Review]. Mol Membr Biol 2009; 26:5 - 13; PMID: 19152182; http://dx.doi.org/10.1080/09687680802683839
   PubMed Web of Science ®Google Scholar
• Heakal Y, Kester M. Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells. Mol Cancer Res 2009; 7:724 - 734; PMID: 19435815; http://dx.doi.org/10.1158/1541-7786.MCR-08-0322
   PubMed Web of Science ®Google Scholar
• Jennings BC, Nadolski MJ, Ling Y, Baker MB, Harrison ML, Deschenes RJ, et al. 2-Bromopalmitate and 2-[2-hydroxy-5-nitro-benzylidene]-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro. J Lipid Res 2009; 50:233 - 242; PMID: 18827284; http://dx.doi.org/10.1194/jlr.M800270-JLR200
   PubMed Web of Science ®Google Scholar
• Mikic I, Planey S, Zhang J, Ceballos C, Seron T, von Massenbach B, et al. A live cell, image-based approach to understanding the enzymology and pharmacology of 2-bromopalmitate and palmitoylation. Methods Enzymol 2006; 414:150 - 187; PMID: 17110192; http://dx.doi.org/10.1016/S0076-6879(06)14010-0
   PubMed Web of Science ®Google Scholar
• Webb Y, Hermida-Matsumoto L, Resh MD. Inhibition of protein palmitoylation, raft localization and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids. J Biol Chem 2000; 275:261 - 270; PMID: 10617614; http://dx.doi.org/10.1074/jbc.275.1.261
   PubMed Web of Science ®Google Scholar
• Chini B, Parenti M. G-protein coupled receptors, cholesterol and palmitoylation: facts about fats. J Mol Endocrinol 2009; 42:371 - 379
   Web of Science ®Google Scholar
• Ochsenbauer-Jambor C, Miller DC, Roberts CR, Rhee SS, Hunter E. Palmitoylation of the Rous sarcoma virus transmembrane glycoprotein is required for protein stability and virus infectivity. J Virol 2001; 75:11544 - 11554; PMID: 11689636; http://dx.doi.org/10.1128/JVI.75.23.11544-54.2001
   PubMed Web of Science ®Google Scholar
• Percherancier Y, Planchenault T, Valenzuela-Fernandez A, Virelizier JL, Arenzana-Seisdedos F, Bachelerie F, et al. Palmitoylation-dependent control of degradation, life span and membrane expression of the CCR5 receptor. J Biol Chem 2001; 276:31936 - 31944; PMID: 11390405; http://dx.doi.org/10.1074/jbc.M104013200
   PubMed Web of Science ®Google Scholar
• Planey SL, Zacharias DA. Palmitoyl acyltransferases, their substrates and novel assays to connect them [Review]. Mol Membr Biol 2009; 26:14 - 31; PMID: 19191172; http://dx.doi.org/10.1080/09687680802646703
   PubMed Web of Science ®Google Scholar
• Roth AF, Wan J, Bailey AO, et al. Global analysis of protein palmitoylation in yeast. Cell 2006; 125:1003 - 1013; PMID: 16751107; http://dx.doi.org/10.1016/j.cell.2006.03.042
   PubMed Web of Science ®Google Scholar
• Singaraja RR, Kang MH, Vaid K, Sanders SS, Vilas GL, Arstikaitis P, et al. Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Circ Res 2009; 105:138 - 147; PMID: 19556522; http://dx.doi.org/10.1161/CIRCRESAHA.108.193011
   PubMed Web of Science ®Google Scholar
• Drisdel RC, Alexander JK, Sayeed A, Green WN. Assays of protein palmitoylation. Methods 2006; 40:127 - 134; PMID: 17012024; http://dx.doi.org/10.1016/j.ymeth.2006.04.015
   PubMed Web of Science ®Google Scholar
• Song KS, Li S, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP, et al. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem 1996; 271:9690 - 9697; PMID: 8621645; http://dx.doi.org/10.1074/jbc.271.16.9690
   PubMed Web of Science ®Google Scholar
• Fox TE, Houck KL, O'Neill SM, Nagarajan M, Stover TC, Pomianowski PT, et al. Ceramide recruits and activates protein kinase C zeta [PKCzeta] within structured membrane microdomains. J Biol Chem 2007; 282:12450 - 12457; PMID: 17308302; http://dx.doi.org/10.1074/jbc.M700082200
   PubMed Web of Science ®Google Scholar