HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation

References

• Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8:967 - 75; http://dx.doi.org/10.1038/nrc2540; PMID: 18987634
   PubMed Web of Science ®Google Scholar
• Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegue E, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008; 13:206 - 20; http://dx.doi.org/10.1016/j.ccr.2008.01.034; PMID: 18328425
   PubMed Web of Science ®Google Scholar
• Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004; 6:485 - 95; http://dx.doi.org/10.1016/j.ccr.2004.09.026; PMID: 15542432
   PubMed Web of Science ®Google Scholar
• Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17:3005 - 15; http://dx.doi.org/10.1093/emboj/17.11.3005; PMID: 9606183
   PubMed Web of Science ®Google Scholar
• Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, et al. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 2000; 60:4010 - 5; PMID: 10945599
   PubMed Web of Science ®Google Scholar
• Kaelin WG Jr., Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393 - 402; http://dx.doi.org/10.1016/j.molcel.2008.04.009; PMID: 18498744
   PubMed Web of Science ®Google Scholar
• Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003; 22:4082 - 90; http://dx.doi.org/10.1093/emboj/cdg392; PMID: 12912907
   PubMed Web of Science ®Google Scholar
• Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009; 15:527 - 38; http://dx.doi.org/10.1016/j.ccr.2009.04.010; PMID: 19477431
   PubMed Web of Science ®Google Scholar
• Ameln AK, Muschter A, Mamlouk S, Kalucka J, Prade I, Franke K, et al. Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ. Cancer Res 2011; 71:3306 - 16; http://dx.doi.org/10.1158/0008-5472.CAN-10-3838; PMID: 21436457
   PubMed Web of Science ®Google Scholar
• Wang M, Zhao D, Spinetti G, Zhang J, Jiang LQ, Pintus G, et al. Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol 2006; 26:1503 - 9; http://dx.doi.org/10.1161/01.ATV.0000225777.58488.f2; PMID: 16690877
   PubMed Web of Science ®Google Scholar
• Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000; 14:163 - 76; PMID: 10652271
   PubMed Web of Science ®Google Scholar
• Tatti O, Vehvilainen P, Lehti K, Keski-Oja J. MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. Exp Cell Res 2008; 314:2501 - 14; http://dx.doi.org/10.1016/j.yexcr.2008.05.018; PMID: 18602101
   PubMed Web of Science ®Google Scholar
• Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, et al. Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell 2004; 5:477 - 88; http://dx.doi.org/10.1016/S1535-6108(04)00116-3; PMID: 15144955
   PubMed Web of Science ®Google Scholar
• Wielockx B, Lannoy K, Shapiro SD, Itoh T, Itohara S, Vandekerckhove J, et al. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med 2001; 7:1202 - 8; http://dx.doi.org/10.1038/nm1101-1202; PMID: 11689884
   PubMed Web of Science ®Google Scholar
• Vecchi A, Garlanda C, Lampugnani MG, Resnati M, Matteucci C, Stoppacciaro A, et al. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur J Cell Biol 1994; 63:247 - 54; PMID: 8082649
   PubMed Web of Science ®Google Scholar
• Lein M, Jung K, Ortel B, Stephan C, Rothaug W, Juchem R, et al. The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene 2002; 21:2089 - 96; http://dx.doi.org/10.1038/sj.onc.1205267; PMID: 11960381
   PubMed Web of Science ®Google Scholar
• Overall CM, Kleifeld O. Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer 2006; 6:227 - 39; http://dx.doi.org/10.1038/nrc1821; PMID: 16498445
   PubMed Web of Science ®Google Scholar
• Fingleton B. MMPs as therapeutic targets–still a viable option?. Semin Cell Dev Biol 2008; 19:61 - 8; http://dx.doi.org/10.1016/j.semcdb.2007.06.006; PMID: 17693104
   PubMed Web of Science ®Google Scholar
• Ridgway PF, Ziprin P, Alkhamesi N, Paraskeva PA, Peck DH, Darzi AW. Hypoxia augments gelatinase activity in a variety of adenocarcinomas in vitro. J Surg Res 2005; 124:180 - 6; http://dx.doi.org/10.1016/j.jss.2004.10.020; PMID: 15820246
   PubMed Web of Science ®Google Scholar
• Muñoz-Ńjar UM, Neurath KM, Vumbaca F, Claffey KP. Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activation. Oncogene 2006; 25:2379 - 92; http://dx.doi.org/10.1038/sj.onc.1209273; PMID: 16369494
   PubMed Web of Science ®Google Scholar
• Barth S, Edlich F, Berchner-Pfannschmidt U, Gneuss S, Jahreis G, Hasgall PA, et al. Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem 2009; 284:23046 - 58; http://dx.doi.org/10.1074/jbc.M109.032631; PMID: 19546213
   PubMed Web of Science ®Google Scholar
• Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29:117 - 29; http://dx.doi.org/10.1038/ng1001-117; PMID: 11586292
   PubMed Web of Science ®Google Scholar
• Stawowy P, Margeta C, Kallisch H, Seidah NG, Chretien M, Fleck E, et al. Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovasc Res 2004; 63:87 - 97; http://dx.doi.org/10.1016/j.cardiores.2004.03.010; PMID: 15194465
   PubMed Web of Science ®Google Scholar
• Hagedorn HG, Bachmeier BE, Nerlich AG. Synthesis and degradation of basement membranes and extracellular matrix and their regulation by TGF-beta in invasive carcinomas. [Review] Int J Oncol 2001; 18:669 - 81; PMID: 11251160
   PubMed Web of Science ®Google Scholar