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Cancer Biology & Therapy Volume 13, 2012 - Issue 5
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Dihydrotestosterone synthesis from adrenal precursors does not involve testosterone in castration-resistant prostate cancer

Tessa Campbell Molecular Pharmacology Section; Medical Oncology Branch; National Cancer Institute, Bethesda, MD USA;
,
Donald J. Tindall Departments of Urology, Biochemistry Molecular Biology; Mayo Clinic College of Medicine; Rochester, MN USA
&
William D Figg Molecular Pharmacology Section; Medical Oncology Branch; National Cancer Institute, Bethesda, MD USA; Clinical Pharmacology Section; Medical Oncology Branch; National Cancer Institute; Bethesda, MD USACorrespondence[email protected]
Pages 237-238 | Received 11 Jan 2012, Accepted 03 Feb 2012, Published online: 01 Mar 2012

References

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  • Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL. Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 2005; 11:4653 - 4657; PMID: 16000557; http://dx.doi.org/10.1158/1078-0432.CCR-05-0525
  • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008; 68:4447 - 4454; PMID: 18519708; http://dx.doi.org/10.1158/0008-5472.CAN-08-0249
  • Luu-The V, Bélanger A, Labrie F. Androgen biosynthetic pathways in the human prostate. Best Pract Res Clin Endocrinol Metab 2008; 22:207 - 221; PMID: 18471780; http://dx.doi.org/10.1016/j.beem.2008.01.008
  • Andersson S, Russell DW, Wilson JD. 17β-Hydroxysteroid dehydrogenase 3 deficiency. Trends Endocrinol Metab 1996; 7:121 - 126; PMID: 18406737; http://dx.doi.org/10.1016/1043-2760(96)00034-3
  • Chang KH, Li R, Papari-Zareei M, Watumull L, Zhao YD, Auchus RJ, et al. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci USA 2011; 108:13728 - 13733; PMID: 21795608; http://dx.doi.org/10.1073/pnas.1107898108
  • Titus MA, Gregory CW, Ford OH 3rd, Schell MJ, Maygarden SJ, Mohler JL. Steroid 5α-reductase isozymes I and II in recurrent prostate cancer. Clin Cancer Res 2005; 11:4365 - 4371; PMID: 15958619; http://dx.doi.org/10.1158/1078-0432.CCR-04-0738
  • Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 2006; 66:2815 - 2825; PMID: 16510604; http://dx.doi.org/10.1158/0008-5472.CAN-05-4000

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