EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner

References

• Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008; 133:38 - 52; http://dx.doi.org/10.1016/j.cell.2008.03.011; PMID: 18394988
   PubMed Web of Science ®Google Scholar
• Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol 2007; 17:230 - 8; http://dx.doi.org/10.1016/j.tcb.2007.03.004; PMID: 17420126
   PubMed Web of Science ®Google Scholar
• Himanen JP, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol 2007; 19:534 - 42; http://dx.doi.org/10.1016/j.ceb.2007.08.004; PMID: 17928214
   PubMed Web of Science ®Google Scholar
• Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 1999; 4:403 - 14; http://dx.doi.org/10.1016/S1097-2765(00)80342-1; PMID: 10518221
   PubMed Web of Science ®Google Scholar
• Füller T, Korff T, Kilian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci 2003; 116:2461 - 70; http://dx.doi.org/10.1242/jcs.00426; PMID: 12734395
   PubMed Web of Science ®Google Scholar
• Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010; 10:165 - 80; http://dx.doi.org/10.1038/nrc2806; PMID: 20179713
   PubMed Web of Science ®Google Scholar
• Noren NK, Foos G, Hauser CA, Pasquale EB. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 2006; 8:815 - 25; http://dx.doi.org/10.1038/ncb1438; PMID: 16862147
   PubMed Web of Science ®Google Scholar
• Kuang SQ, Bai H, Fang ZH, Lopez G, Yang H, Tong W, et al. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood 2010; 115:2412 - 9; http://dx.doi.org/10.1182/blood-2009-05-222208; PMID: 20061560
   PubMed Web of Science ®Google Scholar
• Clevers H, Batlle E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res 2006; 66:2 - 5; http://dx.doi.org/10.1158/0008-5472.CAN-05-3849; PMID: 16397205
   PubMed Web of Science ®Google Scholar
• Cortina C, Palomo-Ponce S, Iglesias M, Fernández-Masip JL, Vivancos A, Whissell G, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet 2007; 39:1376 - 83; http://dx.doi.org/10.1038/ng.2007.11; PMID: 17906625
   PubMed Web of Science ®Google Scholar
• Davalos V, Dopeso H, Castaño J, Wilson AJ, Vilardell F, Romero-Gimenez J, et al. EPHB4 and survival of colorectal cancer patients. Cancer Res 2006; 66:8943 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-05-4640; PMID: 16982731
   PubMed Web of Science ®Google Scholar
• Batlle E, Bacani J, Begthel H, Jonkheer S, Gregorieff A, van de Born M, et al. EphB receptor activity suppresses colorectal cancer progression. Nature 2005; 435:1126 - 30; http://dx.doi.org/10.1038/nature03626; PMID: 15973414
   PubMed Web of Science ®Google Scholar
• Kumar SR, Masood R, Spannuth WA, Singh J, Scehnet J, Kleiber G, et al. The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. Br J Cancer 2007; 96:1083 - 91; http://dx.doi.org/10.1038/sj.bjc.6603642; PMID: 17353927
   PubMed Web of Science ®Google Scholar
• Kumar SR, Scehnet JS, Ley EJ, Singh J, Krasnoperov V, Liu R, et al. Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. Cancer Res 2009; 69:3736 - 45; http://dx.doi.org/10.1158/0008-5472.CAN-08-3232; PMID: 19366806
   PubMed Web of Science ®Google Scholar
• Xia G, Kumar SR, Masood R, Zhu S, Reddy R, Krasnoperov V, et al. EphB4 expression and biological significance in prostate cancer. Cancer Res 2005; 65:4623 - 32; http://dx.doi.org/10.1158/0008-5472.CAN-04-2667; PMID: 15930280
   PubMed Web of Science ®Google Scholar
• Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marmé D, et al. Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia 2004; 6:248 - 57; http://dx.doi.org/10.1593/neo.03457; PMID: 15153337
   PubMed Web of Science ®Google Scholar
• Kertesz N, Krasnoperov V, Reddy R, Leshanski L, Kumar SR, Zozulya S, et al. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood 2006; 107:2330 - 8; http://dx.doi.org/10.1182/blood-2005-04-1655; PMID: 16322467
   PubMed Web of Science ®Google Scholar
• Kim I, Ryu YS, Kwak HJ, Ahn SY, Oh JL, Yancopoulos GD, et al. EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J 2002; 16:1126 - 8; http://dx.doi.org/10.1096/fj.01-0805fje; PMID: 12039842
   PubMed Web of Science ®Google Scholar
• Elowe S, Holland SJ, Kulkarni S, Pawson T. Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. Mol Cell Biol 2001; 21:7429 - 41; http://dx.doi.org/10.1128/MCB.21.21.7429-7441.2001; PMID: 11585923
   PubMed Web of Science ®Google Scholar
• Parri M, Buricchi F, Taddei ML, Giannoni E, Raugei G, Ramponi G, et al. EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. J Biol Chem 2005; 280:34008 - 18; http://dx.doi.org/10.1074/jbc.M502879200; PMID: 16051609
   PubMed Web of Science ®Google Scholar
• Miao H, Burnett E, Kinch M, Simon E, Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2000; 2:62 - 9; http://dx.doi.org/10.1038/35000008; PMID: 10655584
   PubMed Web of Science ®Google Scholar
• Noren NK, Pasquale EB. Paradoxes of the EphB4 receptor in cancer. Cancer Res 2007; 67:3994 - 7; http://dx.doi.org/10.1158/0008-5472.CAN-07-0525; PMID: 17483308
   PubMed Web of Science ®Google Scholar
• Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001; 353:417 - 39; http://dx.doi.org/10.1042/0264-6021:3530417; PMID: 11171037
   PubMed Web of Science ®Google Scholar
• Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 2005; 280:36029 - 36; http://dx.doi.org/10.1074/jbc.M506986200; PMID: 16129692
   PubMed Web of Science ®Google Scholar
• Hu X, Wu X, Xu J, Zhou J, Han X, Guo J. Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia. BMC Neurosci 2009; 10:74; http://dx.doi.org/10.1186/1471-2202-10-74; PMID: 19602257
   PubMed Web of Science ®Google Scholar
• Adams DG, Coffee RL Jr., Zhang H, Pelech S, Strack S, Wadzinski BE. Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. J Biol Chem 2005; 280:42644 - 54; http://dx.doi.org/10.1074/jbc.M502464200; PMID: 16239230
   PubMed Web of Science ®Google Scholar
• Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr Biol 2003; 13:1356 - 64; http://dx.doi.org/10.1016/S0960-9822(03)00535-9; PMID: 12932319
   PubMed Web of Science ®Google Scholar
• Kumar SR, Singh J, Xia G, Krasnoperov V, Hassanieh L, Ley EJ, et al. Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol 2006; 169:279 - 93; http://dx.doi.org/10.2353/ajpath.2006.050889; PMID: 16816380
   PubMed Web of Science ®Google Scholar