A surprise cell of origin for Barrett’s esophagus

References

• Bhat S, Coleman HG, Yousef F, Johnston BT, McManus DT, Gavin AT, et al. Risk of malignant progression in Barrett’s esophagus patients: results from a large population-based study. J Natl Cancer Inst 2011; 103:1049 - 57; http://dx.doi.org/10.1093/jnci/djr203; PMID: 21680910
   PubMed Web of Science ®Google Scholar
• Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett’s esophagus. N Engl J Med 2011; 365:1375 - 83; http://dx.doi.org/10.1056/NEJMoa1103042; PMID: 21995385
   PubMed Web of Science ®Google Scholar
• Sharma P. Clinical practice. Barrett’s esophagus. N Engl J Med 2009; 361:2548 - 56; http://dx.doi.org/10.1056/NEJMcp0902173; PMID: 20032324
   PubMed Web of Science ®Google Scholar
• Reid BJ, Li X, Galipeau PC, Vaughan TL. Barrett’s oesophagus and oesophageal adenocarcinoma: time for a new synthesis. Nat Rev Cancer 2010; 10:87 - 101; http://dx.doi.org/10.1038/nrc2773; PMID: 20094044
   PubMed Web of Science ®Google Scholar
• Wang X, Ouyang H, Yamamoto Y, Kumar PA, Wei TS, Dagher R, et al. Residual embryonic cells as precursors of a Barrett’s-like metaplasia. Cell 2011; 145:1023 - 35; http://dx.doi.org/10.1016/j.cell.2011.05.026; PMID: 21703447
   PubMed Web of Science ®Google Scholar
• Stairs DB, Nakagawa H, Klein-Szanto A, Mitchell SD, Silberg DG, Tobias JW, et al. Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett’s esophagus. PLoS One 2008; 3:e3534; http://dx.doi.org/10.1371/journal.pone.0003534; PMID: 18953412
   PubMed Web of Science ®Google Scholar
• Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, et al. Differential gene expression in normal esophagus and Barrett’s esophagus. J Gastroenterol 2009; 44:897 - 911; http://dx.doi.org/10.1007/s00535-009-0082-2; PMID: 19468668
   PubMed Web of Science ®Google Scholar
• Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, et al. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol 2004; 287:C171 - 81; http://dx.doi.org/10.1152/ajpcell.00226.2003; PMID: 15189821
   PubMed Web of Science ®Google Scholar
• Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 2002; 70:537 - 46; http://dx.doi.org/10.1046/j.1432-0436.2002.700907.x
   PubMed Web of Science ®Google Scholar
• Chen H, Fang Y, Tevebaugh W, Orlando RC, Shaheen NJ, Chen X. Molecular mechanisms of Barrett’s esophagus. Dig Dis Sci 2011; 56:3405 - 20; http://dx.doi.org/10.1007/s10620-011-1885-6; PMID: 21984436
   PubMed Web of Science ®Google Scholar
• Dvorak K, Goldman A, Kong J, Lynch JP, Hutchinson L, Houghton JM, et al. Molecular mechanisms of Barrett’s esophagus and adenocarcinoma. Ann N Y Acad Sci 2011; 1232:381 - 91; http://dx.doi.org/10.1111/j.1749-6632.2011.06062.x; PMID: 21950830
   PubMed Web of Science ®Google Scholar
• Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 1999; 398:714 - 8; http://dx.doi.org/10.1038/19539; PMID: 10227294
   PubMed Web of Science ®Google Scholar
• Crum CP, McKeon FD. p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol 2010; 5:349 - 71; http://dx.doi.org/10.1146/annurev-pathol-121808-102117; PMID: 20078223
   PubMed Web of Science ®Google Scholar
• Senoo M, Pinto F, Crum CP, McKeon F. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell 2007; 129:523 - 36; http://dx.doi.org/10.1016/j.cell.2007.02.045; PMID: 17482546
   PubMed Web of Science ®Google Scholar
• Lefort K, Dotto GP. p63 and epithelial metaplasia: a gutsy choice. Cell 2011; 145:1003 - 5; http://dx.doi.org/10.1016/j.cell.2011.06.008; PMID: 21703442
   PubMed Web of Science ®Google Scholar
• Roman S, Pétré A, Thépot A, Hautefeuille A, Scoazec JY, Mion F, et al. Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture. Am J Physiol Gastrointest Liver Physiol 2007; 293:G45 - 53; http://dx.doi.org/10.1152/ajpgi.00583.2006; PMID: 17615180
   PubMedGoogle Scholar
• Burgess DJ. Disease mechanisms: Out with the old, in with the new. Nat Rev Cancer 2011; 11:536; http://dx.doi.org/10.1038/nrc3116; PMID: 21779007
   PubMed Web of Science ®Google Scholar
• Beck F, Chawengsaksophak K, Waring P, Playford RJ, Furness JB. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci U S A 1999; 96:7318 - 23; http://dx.doi.org/10.1073/pnas.96.13.7318; PMID: 10377412
   PubMed Web of Science ®Google Scholar
• Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002; 122:689 - 96; http://dx.doi.org/10.1053/gast.2002.31902; PMID: 11875002
   PubMed Web of Science ®Google Scholar
• Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119:961 - 71; http://dx.doi.org/10.1053/gast.2000.18142; PMID: 11040183
   PubMed Web of Science ®Google Scholar
• Souza RF, Krishnan K, Spechler SJ. Acid, bile, and CDX: the ABCs of making Barrett’s metaplasia. Am J Physiol Gastrointest Liver Physiol 2008; 295:G211 - 8; http://dx.doi.org/10.1152/ajpgi.90250.2008; PMID: 18556417
   PubMed Web of Science ®Google Scholar
• Vallböhmer D, DeMeester SR, Peters JH, Oh DS, Kuramochi H, Shimizu D, et al. Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus. Dis Esophagus 2006; 19:260 - 6; http://dx.doi.org/10.1111/j.1442-2050.2006.00586.x; PMID: 16866857
   PubMed Web of Science ®Google Scholar
• Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 2009; 16:588 - 99; http://dx.doi.org/10.1016/j.devcel.2009.02.010; PMID: 19386267
   PubMed Web of Science ®Google Scholar
• Kong J, Nakagawa H, Isariyawongse BK, Funakoshi S, Silberg DG, Rustgi AK, et al. Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis 2009; 30:122 - 30; http://dx.doi.org/10.1093/carcin/bgn227; PMID: 18845559
   PubMed Web of Science ®Google Scholar