575
Views
9
CrossRef citations to date
0
Altmetric
Research Paper

C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis

, , , , , , , & show all
Pages 880-889 | Received 23 Dec 2011, Accepted 22 May 2012, Published online: 01 Aug 2012

References

  • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277 - 300; http://dx.doi.org/10.3322/caac.20073; PMID: 20610543
  • Fearon ER. Human cancer syndromes: clues to the origin and nature of cancer. Science 1997; 278:1043 - 50; http://dx.doi.org/10.1126/science.278.5340.1043; PMID: 9353177
  • Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 1984; 308:693 - 8; http://dx.doi.org/10.1038/308693a0; PMID: 6232463
  • Kikkawa U, Kishimoto A, Nishizuka Y. The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem 1989; 58:31 - 44; http://dx.doi.org/10.1146/annurev.bi.58.070189.000335; PMID: 2549852
  • Clemens MJ, Trayner I, Menaya J. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation. J Cell Sci 1992; 103:881 - 7; PMID: 1487501
  • Blumberg PM. Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture. Cancer Res 1988; 48:1 - 8; PMID: 3275491
  • Nguyen TA, Takemoto LJ, Takemoto DJ. Inhibition of gap junction activity through the release of the C1B domain of protein kinase Cgamma (PKCgamma) from 14-3-3: identification of PKCgamma-binding sites. J Biol Chem 2004; 279:52714 - 25; http://dx.doi.org/10.1074/jbc.M403040200; PMID: 15459208
  • Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 2007; 7:281 - 94; http://dx.doi.org/10.1038/nrc2110; PMID: 17384583
  • Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 1982; 257:7847 - 51; PMID: 7085651
  • Mackay HJ, Twelves CJ. Protein kinase C: a target for anticancer drugs?. Endocr Relat Cancer 2003; 10:389 - 96; http://dx.doi.org/10.1677/erc.0.0100389; PMID: 14503915
  • Craven PA, DeRubertis FR. Loss of protein kinase C delta isozyme immunoreactivity in human adenocarcinomas. Dig Dis Sci 1994; 39:481 - 9; http://dx.doi.org/10.1007/BF02088331; PMID: 8131683
  • Wali RK, Frawley BP Jr., Hartmann S, Roy HK, Khare S, Scaglione-Sewell BA, et al. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta. Cancer Res 1995; 55:5257 - 64; PMID: 7585585
  • Cerda SR, Bissonnette M, Scaglione-Sewell B, Lyons MR, Khare S, Mustafi R, et al. PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells. Gastroenterology 2001; 120:1700 - 12; http://dx.doi.org/10.1053/gast.2001.24843; PMID: 11375951
  • Gökmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 2001; 61:1375 - 81; PMID: 11245437
  • Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DGAPF, Fields AP. Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. J Cell Biol 1999; 145:699 - 711; http://dx.doi.org/10.1083/jcb.145.4.699; PMID: 10330400
  • Murray NR, Weems C, Chen L, Leon J, Yu W, Davidson LA, et al. Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. J Cell Biol 2002; 157:915 - 20; http://dx.doi.org/10.1083/jcb.200201127; PMID: 12058013
  • Wilkinson SE, Parker PJ, Nixon JS. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 1993; 294:335 - 7; PMID: 8373348
  • Birchall AM, Bishop J, Bradshaw D, Cline A, Coffey J, Elliott LH, et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J Pharmacol Exp Ther 1994; 268:922 - 9; PMID: 8114006
  • Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 2005; 65:7462 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-05-0071; PMID: 16103100
  • Mroz RM, Holownia A, Chyczewska E, Chyczewski L, Braszko JJ. p53 N-terminal Ser-15 approximately P and Ser-20 approximately P levels in squamous cell lung cancer after radio/chemotherapy. Am J Respir Cell Mol Biol 2004; 30:564 - 8; http://dx.doi.org/10.1165/rcmb.2003-0077OC; PMID: 14527925
  • Borner C, Ueffing M, Jaken S, Parker PJ, Weinstein IB. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. J Biol Chem 1995; 270:78 - 86; http://dx.doi.org/10.1074/jbc.270.1.78; PMID: 7814423
  • Choi PM, Tchou-Wong KM, Weinstein IB. Overexpression of protein kinase C in HT29 colon cancer cells causes growth inhibition and tumor suppression. Mol Cell Biol 1990; 10:4650 - 7; PMID: 2388620
  • Goldstein DR, Cacace AM, Weinstein IB. Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis 1995; 16:1121 - 6; http://dx.doi.org/10.1093/carcin/16.5.1121; PMID: 7767974
  • Fields AP, Calcagno SR, Krishna M, Rak S, Leitges M, Murray NR. Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. Cancer Res 2009; 69:1643 - 50; http://dx.doi.org/10.1158/0008-5472.CAN-08-3187; PMID: 19221092
  • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307 - 10; http://dx.doi.org/10.1038/35042675; PMID: 11099028
  • Leonard TA, Różycki B, Saidi LF, Hummer G, Hurley JH. Crystal structure and allosteric activation of protein kinase C βII. Cell 2011; 144:55 - 66; http://dx.doi.org/10.1016/j.cell.2010.12.013; PMID: 21215369
  • Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, et al. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res 2009; 315:1415 - 28; http://dx.doi.org/10.1016/j.yexcr.2009.02.002; PMID: 19232344
  • Saxon ML, Zhao X, Black JD. Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ. J Cell Biol 1994; 126:747 - 63; http://dx.doi.org/10.1083/jcb.126.3.747; PMID: 8045938
  • Verstovsek G, Byrd A, Frey MR, Petrelli NJ, Black JD. Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. Gastroenterology 1998; 115:75 - 85; http://dx.doi.org/10.1016/S0016-5085(98)70367-1; PMID: 9649461
  • Frey MR, Clark JA, Leontieva O, Uronis JM, Black AR, Black JD. Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium. J Cell Biol 2000; 151:763 - 78; http://dx.doi.org/10.1083/jcb.151.4.763; PMID: 11076962
  • Oster H, Leitges M. Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res 2006; 66:6955 - 63; http://dx.doi.org/10.1158/0008-5472.CAN-06-0268; PMID: 16849539

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.