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Research Paper

Gadd45a inhibits cell migration and invasion by altering the global RNA expression

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Pages 1112-1122 | Received 17 Feb 2012, Accepted 20 Jun 2012, Published online: 24 Jul 2012

References

  • Fornace AJ Jr., Alamo I Jr., Hollander MC. DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci U S A 1988; 85:8800 - 4; http://dx.doi.org/10.1073/pnas.85.23.8800; PMID: 3194391
  • Papathanasiou MA, Fornace AJ Jr.. DNA-damage inducible genes. Cancer Treat Res 1991; 57:13 - 36; http://dx.doi.org/10.1007/978-1-4615-3872-1_2; PMID: 1686714
  • Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr., Barrett SF, et al. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol 1991; 11:1009 - 16; PMID: 1990262
  • Yamasawa K, Nio Y, Dong M, Yamaguchi K, Itakura M. Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer. Clin Cancer Res 2002; 8:2563 - 9; PMID: 12171884
  • Wang W, Huper G, Guo Y, Murphy SK, Olson JA Jr., Marks JR. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene 2005; 24:2705 - 14; http://dx.doi.org/10.1038/sj.onc.1208464; PMID: 15735726
  • Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC, et al. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 1999; 18:2892 - 900; http://dx.doi.org/10.1038/sj.onc.1202667; PMID: 10362260
  • Jin S, Tong T, Fan W, Fan F, Antinore MJ, Zhu X, et al. GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity. Oncogene 2002; 21:8696 - 704; http://dx.doi.org/10.1038/sj.onc.1206034; PMID: 12483522
  • Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994; 266:1376 - 80; http://dx.doi.org/10.1126/science.7973727; PMID: 7973727
  • Tong T, Ji J, Jin S, Li X, Fan W, Song Y, et al. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol Cell Biol 2005; 25:4488 - 500; http://dx.doi.org/10.1128/MCB.25.11.4488-4500.2005; PMID: 15899854
  • Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007; 445:671 - 5; http://dx.doi.org/10.1038/nature05515; PMID: 17268471
  • Jin SG, Guo C, Pfeifer GP. GADD45A does not promote DNA demethylation. PLoS Genet 2008; 4:e1000013; http://dx.doi.org/10.1371/journal.pgen.1000013; PMID: 18369439
  • Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, et al. Genomic instability in Gadd45a-deficient mice. Nat Genet 1999; 23:176 - 84; http://dx.doi.org/10.1038/13802; PMID: 10508513
  • Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12:895 - 904; http://dx.doi.org/10.1038/nm1469; PMID: 16892035
  • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57 - 70; http://dx.doi.org/10.1016/S0092-8674(00)81683-9; PMID: 10647931
  • Chiang AC, Massagué J. Molecular basis of metastasis. N Engl J Med 2008; 359:2814 - 23; http://dx.doi.org/10.1056/NEJMra0805239; PMID: 19109576
  • Hildesheim J, Belova GI, Tyner SD, Zhou X, Vardanian L, Fornace AJ Jr.. Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Oncogene 2004; 23:1829 - 37; http://dx.doi.org/10.1038/sj.onc.1207301; PMID: 14647429
  • Ji J, Liu R, Tong T, Song Y, Jin S, Wu M, et al. Gadd45a regulates beta-catenin distribution and maintains cell-cell adhesion/contact. Oncogene 2007; 26:6396 - 405; http://dx.doi.org/10.1038/sj.onc.1210469; PMID: 17452974
  • Zhan Q. Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage. Mutat Res 2005; 569:133 - 43; http://dx.doi.org/10.1016/j.mrfmmm.2004.06.055; PMID: 15603758
  • Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996; 84:345 - 57; http://dx.doi.org/10.1016/S0092-8674(00)81279-9; PMID: 8608588
  • Zucker S, Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 2004; 23:101 - 17; http://dx.doi.org/10.1023/A:1025867130437; PMID: 15000152
  • Denys H, De Wever O, Nusgens B, Kong Y, Sciot R, Le AT, et al. Invasion and MMP expression profile in desmoid tumours. Br J Cancer 2004; 90:1443 - 9; http://dx.doi.org/10.1038/sj.bjc.6601661; PMID: 15054469
  • Huang X, Ji G, Wu Y, Wan B, Yu L. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. J Cancer Res Clin Oncol 2008; 134:705 - 14; http://dx.doi.org/10.1007/s00432-007-0342-6; PMID: 18084776
  • Nagato S, Nakagawa K, Harada H, Kohno S, Fujiwara H, Sekiguchi K, et al. Downregulation of laminin alpha4 chain expression inhibits glioma invasion in vitro and in vivo. Int J Cancer 2005; 117:41 - 50; http://dx.doi.org/10.1002/ijc.21102; PMID: 15915502
  • Tapper J, Kettunen E, El-Rifai W, Seppala M, Andersson LC, Knuutila S. Changes in gene expression during progression of ovarian carcinoma. Cancer Genet Cytogenet 2001; 128:1 - 6; http://dx.doi.org/10.1016/S0165-4608(01)00386-7; PMID: 11454421
  • Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, et al. Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis and carcinogenesis by serial analysis of gene expression. Cancer Res 2004; 64:2397 - 405; http://dx.doi.org/10.1158/0008-5472.CAN-03-3514; PMID: 15059891
  • Hassan NJ, Barclay AN, Brown MH. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol 2004; 34:930 - 40; http://dx.doi.org/10.1002/eji.200424856; PMID: 15048703
  • King JA, Ofori-Acquah SF, Stevens T, Al-Mehdi AB, Fodstad O, Jiang WG. Activated leukocyte cell adhesion molecule in breast cancer: prognostic indicator. Breast Cancer Res 2004; 6:R478 - 87; http://dx.doi.org/10.1186/bcr815; PMID: 15318930
  • Davies SR, Dent C, Watkins G, King JA, Mokbel K, Jiang WG. Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. Oncol Rep 2008; 19:555 - 61; PMID: 18202807
  • Mao X, Seidlitz E, Truant R, Hitt M, Ghosh HP. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene 2004; 23:5632 - 42; http://dx.doi.org/10.1038/sj.onc.1207756; PMID: 15184878
  • Koreth J, Bakkenist CJ, McGee JO. Allelic deletions at chromosome 11q22-q23.1 and 11q25-qterm are frequent in sporadic breast but not colorectal cancers. Oncogene 1997; 14:431 - 7; http://dx.doi.org/10.1038/sj.onc.1200847; PMID: 9053840
  • Murakami Y, Nobukuni T, Tamura K, Maruyama T, Sekiya T, Arai Y, et al. Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q. Proc Natl Acad Sci U S A 1998; 95:8153 - 8; http://dx.doi.org/10.1073/pnas.95.14.8153; PMID: 9653156
  • Yen CC, Chen YJ, Chen JT, Hsia JY, Chen PM, Liu JH, et al. Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer 2001; 92:2769 - 77; http://dx.doi.org/10.1002/1097-0142(20011201)92:11<2769::AID-CNCR10118>3.0.CO;2-M; PMID: 11753950
  • Ito T, Shimada Y, Hashimoto Y, Kaganoi J, Kan T, Watanabe G, et al. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res 2003; 63:6320 - 6; PMID: 14559819
  • Lindsey JC, Lusher ME, Anderton JA, Bailey S, Gilbertson RJ, Pearson AD, et al. Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis 2004; 25:661 - 8; http://dx.doi.org/10.1093/carcin/bgh055; PMID: 14688019
  • Manavi M, Hudelist G, Fink-Retter A, Gschwandtler-Kaulich D, Pischinger K, Czerwenka K. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Gynecol Oncol 2007; 105:418 - 26; http://dx.doi.org/10.1016/j.ygyno.2006.12.032; PMID: 17306351
  • Bühler H, Schaller G. Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo. Mol Cancer Res 2005; 3:365 - 71; http://dx.doi.org/10.1158/1541-7786.MCR-04-0117; PMID: 16046547
  • Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, et al. Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res 2008; 10:R105; http://dx.doi.org/10.1186/bcr2210; PMID: 19087274
  • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683 - 92; http://dx.doi.org/10.1016/j.cell.2007.01.029; PMID: 17320506
  • Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase and gadd45. Cell 2008; 135:1201 - 12; http://dx.doi.org/10.1016/j.cell.2008.11.042; PMID: 19109892
  • Yu J, Qian H, Li Y, Wang Y, Zhang X, Liang X, et al. Arsenic trioxide (As2O3) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo. Gynecol Oncol 2007; 106:400 - 6; http://dx.doi.org/10.1016/j.ygyno.2007.04.016; PMID: 17512576
  • Yu J, Zhang L, Chen A, Xiang G, Wang Y, Wu J, et al. Identification of the gene transcription and apoptosis mediated by TGF-beta-Smad2/3-Smad4 signaling. J Cell Physiol 2008; 215:422 - 33; http://dx.doi.org/10.1002/jcp.21325; PMID: 17960585

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