Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo

References

• Warburg O, Posener K, Negelein E. Über den Stoffwechsel der Carcinomzelle. Biochem Z 1924; 152:309 - 44
   Google Scholar
• Warburg O, Wind F, Negelein E. The Metabolism of Tumors in the Body. J Gen Physiol 1927; 8:519 - 30; http://dx.doi.org/10.1085/jgp.8.6.519; PMID: 19872213
   PubMedGoogle Scholar
• Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 2004; 4:891 - 9; http://dx.doi.org/10.1038/nrc1478; PMID: 15516961
   PubMed Web of Science ®Google Scholar
• Czernin J, Phelps ME. Positron emission tomography scanning: current and future applications. Annu Rev Med 2002; 53:89 - 112; http://dx.doi.org/10.1146/annurev.med.53.082901.104028; PMID: 11818465
   PubMed Web of Science ®Google Scholar
• Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 2009; 1790:1149 - 60; http://dx.doi.org/10.1016/j.bbagen.2009.07.026; PMID: 19664690
   PubMed Web of Science ®Google Scholar
• Handelman GJ, Han D, Tritschler H, Packer L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol 1994; 47:1725 - 30; http://dx.doi.org/10.1016/0006-2952(94)90298-4; PMID: 8204089
   PubMed Web of Science ®Google Scholar
• Packer L, Witt EH, Tritschler HJ. alpha-Lipoic acid as a biological antioxidant. Free Radic Biol Med 1995; 19:227 - 50; http://dx.doi.org/10.1016/0891-5849(95)00017-R; PMID: 7649494
   PubMed Web of Science ®Google Scholar
• Packer L, Roy S, Sen CK. Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription. Adv Pharmacol 1997; 38:79 - 101; http://dx.doi.org/10.1016/S1054-3589(08)60980-1; PMID: 8895805
   PubMedGoogle Scholar
• Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schütte K, et al. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995; 38:1425 - 33; http://dx.doi.org/10.1007/BF00400603; PMID: 8786016
   PubMed Web of Science ®Google Scholar
• Mijnhout GS, Alkhalaf A, Kleefstra N, Bilo HJ. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?. Neth J Med 2010; 68:158 - 62; PMID: 20421656
   PubMed Web of Science ®Google Scholar
• Zhang WJ, Bird KE, McMillen TS, LeBoeuf RC, Hagen TM, Frei B. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 2008; 117:421 - 8; http://dx.doi.org/10.1161/CIRCULATIONAHA.107.725275; PMID: 18158360
   PubMed Web of Science ®Google Scholar
• de Oliveira AM, Rondó PH, Luzia LA, D’Abronzo FH, Illison VK. The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Diabetes Res Clin Pract 2011; 92:253 - 60; http://dx.doi.org/10.1016/j.diabres.2011.02.010; PMID: 21371770
   PubMed Web of Science ®Google Scholar
• Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 1997; 29:315 - 31; http://dx.doi.org/10.1016/S0306-3623(96)00474-0; PMID: 9378235
   PubMedGoogle Scholar
• Novotny L, Rauko P, Cojocel C. alpha-Lipoic acid: the potential for use in cancer therapy. Neoplasma 2008; 55:81 - 6; PMID: 18237244
   PubMed Web of Science ®Google Scholar
• Korotchkina LG, Sidhu S, Patel MS. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase. Free Radic Res 2004; 38:1083 - 92; http://dx.doi.org/10.1080/10715760400004168; PMID: 15512796
   PubMed Web of Science ®Google Scholar
• Michelakis ED, Webster L, Mackey JR. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 2008; 99:989 - 94; http://dx.doi.org/10.1038/sj.bjc.6604554; PMID: 18766181
   PubMed Web of Science ®Google Scholar
• Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11:37 - 51; http://dx.doi.org/10.1016/j.ccr.2006.10.020; PMID: 17222789
   PubMed Web of Science ®Google Scholar
• Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol 2008; 109:394 - 402; http://dx.doi.org/10.1016/j.ygyno.2008.01.038; PMID: 18423823
   PubMed Web of Science ®Google Scholar
• Cao W, Yacoub S, Shiverick KT, Namiki K, Sakai Y, Porvasnik S, et al. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 2008; 68:1223 - 31; http://dx.doi.org/10.1002/pros.20788; PMID: 18465755
   PubMed Web of Science ®Google Scholar
• Na MH, Seo EY, Kim WK. Effects of alpha-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells. Nutr Res Pract 2009; 3:265 - 71; http://dx.doi.org/10.4162/nrp.2009.3.4.265; PMID: 20098578
   PubMed Web of Science ®Google Scholar
• Pack RA, Hardy K, Madigan MC, Hunt NH. Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells. Mol Immunol 2002; 38:733 - 45; http://dx.doi.org/10.1016/S0161-5890(01)00110-9; PMID: 11841833
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029 - 33; http://dx.doi.org/10.1126/science.1160809; PMID: 19460998
   PubMed Web of Science ®Google Scholar
• Berkson BM, Rubin DM, Berkson AJ. Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009; 8:416 - 22; http://dx.doi.org/10.1177/1534735409352082; PMID: 20042414
   PubMed Web of Science ®Google Scholar
• Wenzel U, Nickel A, Daniel H. alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. Apoptosis 2005; 10:359 - 68; http://dx.doi.org/10.1007/s10495-005-0810-x; PMID: 15843897
   PubMed Web of Science ®Google Scholar
• Deubzer B, Mayer F, Kuçi Z, Niewisch M, Merkel G, Handgretinger R, et al. H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin. Cell Physiol Biochem 2010; 25:767 - 74; http://dx.doi.org/10.1159/000315098; PMID: 20511723
   PubMed Web of Science ®Google Scholar
• van de Mark K, Chen JS, Steliou K, Perrine SP, Faller DV. Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines. J Cell Physiol 2003; 194:325 - 40; http://dx.doi.org/10.1002/jcp.10205; PMID: 12548552
   PubMed Web of Science ®Google Scholar
• Selvakumar E, Hsieh TC. Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy. J Hematol Oncol 2008; 1:4; http://dx.doi.org/10.1186/1756-8722-1-4; PMID: 18577252
   PubMed Web of Science ®Google Scholar
• Sen CK, Sashwati R, Packer L. Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid. Cell Death Differ 1999; 6:481 - 91; http://dx.doi.org/10.1038/sj.cdd.4400514; PMID: 10381641
   PubMed Web of Science ®Google Scholar
• Choi SY, Yu JH, Kim H. Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells. Ann N Y Acad Sci 2009; 1171:149 - 55; http://dx.doi.org/10.1111/j.1749-6632.2009.04708.x; PMID: 19723049
   PubMed Web of Science ®Google Scholar
• Kim JI, Cho SR, Lee CM, Park ES, Kim KN, Kim HC, et al. Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines. Korean J Thorac Cardiovasc Surg 2012; 45:1 - 10; http://dx.doi.org/10.5090/kjtcs.2012.45.1.1; PMID: 22363901
   PubMedGoogle Scholar
• Dozio E, Ruscica M, Passafaro L, Dogliotti G, Steffani L, Marthyn P, et al. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. Eur J Pharmacol 2010; 641:29 - 34; http://dx.doi.org/10.1016/j.ejphar.2010.05.009; PMID: 20580704
   PubMed Web of Science ®Google Scholar
• Xu X, Zur Hausen A, Coy JF, Löchelt M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer 2009; 124:1330 - 7; http://dx.doi.org/10.1002/ijc.24078; PMID: 19065656
   PubMed Web of Science ®Google Scholar
• Ramos-Montoya A, Lee WN, Bassilian S, Lim S, Trebukhina RV, Kazhyna MV, et al. Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. Int J Cancer 2006; 119:2733 - 41; http://dx.doi.org/10.1002/ijc.22227; PMID: 17019714
   PubMed Web of Science ®Google Scholar
• Langbein S, Zerilli M, Zur Hausen A, Staiger W, Rensch-Boschert K, Lukan N, et al. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer 2006; 94:578 - 85; http://dx.doi.org/10.1038/sj.bjc.6602962; PMID: 16465194
   PubMed Web of Science ®Google Scholar
• Sugden MC, Holness MJ. Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 2003; 284:E855 - 62; PMID: 12676647
   PubMed Web of Science ®Google Scholar
• Chen LB. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 1988; 4:155 - 81; http://dx.doi.org/10.1146/annurev.cb.04.110188.001103; PMID: 3058159
   PubMedGoogle Scholar
• Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ. In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A 2008; 105:12051 - 6; http://dx.doi.org/10.1073/pnas.0805953105; PMID: 18689683
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248 - 54; http://dx.doi.org/10.1016/0003-2697(76)90527-3; PMID: 942051
   PubMed Web of Science ®Google Scholar
• Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407:770 - 6; http://dx.doi.org/10.1038/35037710; PMID: 11048727
   PubMed Web of Science ®Google Scholar
• Bullwinkel J, Baron-Lühr B, Lüdemann A, Wohlenberg C, Gerdes J, Scholzen T. Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J Cell Physiol 2006; 206:624 - 35; http://dx.doi.org/10.1002/jcp.20494; PMID: 16206250
   PubMed Web of Science ®Google Scholar