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Journal Club

Loss of OATP1B3 function causes Rotor syndrome

Implications for potential use of inhibitors in cancer

, &
Pages 1374-1375 | Received 22 Aug 2012, Accepted 29 Aug 2012, Published online: 06 Sep 2012

References

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  • Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, et al. Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res 2008; 14:3312 - 8; http://dx.doi.org/10.1158/1078-0432.CCR-07-4118; PMID: 18519758
  • Sharifi N, Hamada A, Sissung T, Danesi R, Venzon D, Baum C, et al. A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer. BJU Int 2008; 102:617 - 21; http://dx.doi.org/10.1111/j.1464-410X.2008.07629.x; PMID: 18537956
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  • van de Steeg E, Stránecký V, Hartmannová H, Nosková L, Hřebíček M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012; 122:519 - 28; http://dx.doi.org/10.1172/JCI59526; PMID: 22232210
  • Pressler H, Sissung TM, Venzon D, Price DK, Figg WD. Expression of OATP family members in hormone-related cancers: potential markers of progression. PLoS One 2011; 6:e20372; http://dx.doi.org/10.1371/journal.pone.0020372; PMID: 21625523
  • Sharma P, Butters CJ, Smith V, Elsby R, Surry D. Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins. Eur J Pharm Sci 2012; 47:244 - 55; http://dx.doi.org/10.1016/j.ejps.2012.04.003; PMID: 22538052

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