Advanced search
Publication Cover
Cancer Biology & Therapy Volume 14, 2013 - Issue 10
Submit an article Journal homepage
1,262
Views
23
CrossRef citations to date
0
Altmetric
Research Paper

MK-2206, an Akt inhibitor, enhances carboplatinum/paclitaxel efficacy in gastric cancer cell lines

Khaldoun Almhanna H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USACorrespondence[email protected]
,
Christopher L Cubitt H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
,
Shumin Zhang H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
,
Sabiha Kazim H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
,
Kazim Husain H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
,
Dan Sullivan H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
,
Said Sebti H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
&
Mokenge Malafa H. Lee Moffitt Cancer Center & Research Institute; Tampa, FL USA
 show all
Pages 932-936 | Received 04 Apr 2013, Accepted 29 Jul 2013, Published online: 05 Aug 2013

References

  • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11 - 30; http://dx.doi.org/10.3322/caac.21166; PMID: 23335087
  • Van Cutsem E, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, Rodrigues A, Fodor M, Chao Y, Voznyi E, et al, V325 Study Group. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 2006; 24:4991 - 7; http://dx.doi.org/10.1200/JCO.2006.06.8429; PMID: 17075117
  • Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, et al, ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376:687 - 97; http://dx.doi.org/10.1016/S0140-6736(10)61121-X; PMID: 20728210
  • Almhanna K, Strosberg J, Malafa M. Targeting AKT protein kinase in gastric cancer. Anticancer Res 2011; 31:4387 - 92; PMID: 22199303
  • Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA. Physiological functions of protein kinase B/Akt. Biochem Soc Trans 2004; 32:350 - 4; http://dx.doi.org/10.1042/BST0320350; PMID: 15046607
  • Bellacosa A, Kumar CC, Di Cristofano A, Testa JR. Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 2005; 94:29 - 86; http://dx.doi.org/10.1016/S0065-230X(05)94002-5; PMID: 16095999
  • Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001; 15:2203 - 8; http://dx.doi.org/10.1101/gad.913901; PMID: 11544177
  • Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001; 292:1728 - 31; http://dx.doi.org/10.1126/science.292.5522.1728; PMID: 11387480
  • Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, et al. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 2005; 25:1869 - 78; http://dx.doi.org/10.1128/MCB.25.5.1869-1878.2005; PMID: 15713641
  • Nam SY, Lee HS, Jung GA, Choi J, Cho SJ, Kim MK, Kim WH, Lee BL. Akt/PKB activation in gastric carcinomas correlates with clinicopathologic variables and prognosis. APMIS 2003; 111:1105 - 13; http://dx.doi.org/10.1111/j.1600-0463.2003.apm1111205.x; PMID: 14678019
  • Cinti C, Vindigni C, Zamparelli A, La Sala D, Epistolato MC, Marrelli D, Cevenini G, Tosi P. Activated Akt as an indicator of prognosis in gastric cancer. Virchows Arch 2008; 453:449 - 55; http://dx.doi.org/10.1007/s00428-008-0676-8; PMID: 18841391
  • Yang S, Ngo VC, Lew GB, Chong LW, Lee SS, Ong WJ, Lam WL, Thng CH, Koong HN, Ong HS, et al. AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. Mol Cancer Ther 2009; 8:2537 - 45; http://dx.doi.org/10.1158/1535-7163.MCT-09-0213; PMID: 19723882
  • Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K, Ueno Y, Hatch H, Majumder PK, Pan BS, et al. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 2010; 9:1956 - 67; http://dx.doi.org/10.1158/1535-7163.MCT-09-1012; PMID: 20571069
  • She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS One 2008; 3:e3065; http://dx.doi.org/10.1371/journal.pone.0003065; PMID: 18725974
  • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010; 70:440 - 6; http://dx.doi.org/10.1158/0008-5472.CAN-09-1947; PMID: 20068163

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.