AMP-activated protein kinase (AMPK) beyond metabolism

References

• Kourtis N, Tavernarakis N. Cellular stress response pathways and ageing: intricate molecular relationships. EMBO J 2011; 30:2520 - 31; http://dx.doi.org/10.1038/emboj.2011.162; PMID: 21587205
   PubMed Web of Science ®Google Scholar
• Oakhill JS, Scott JW, Kemp BE. Structure and function of AMP-activated protein kinase. Acta Physiol (Oxf) 2009; 196:3 - 14; http://dx.doi.org/10.1111/j.1748-1716.2009.01977.x; PMID: 19245650
   PubMed Web of Science ®Google Scholar
• Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13:1016 - 23; http://dx.doi.org/10.1038/ncb2329; PMID: 21892142
   PubMed Web of Science ®Google Scholar
• Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 2009; 196:65 - 80; http://dx.doi.org/10.1111/j.1748-1716.2009.01972.x; PMID: 19245654
   PubMed Web of Science ®Google Scholar
• Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP?. Trends Biochem Sci 2011; 36:470 - 7; http://dx.doi.org/10.1016/j.tibs.2011.06.004; PMID: 21782450
   PubMed Web of Science ®Google Scholar
• Hardie DG, Hawley SA. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 2001; 23:1112 - 9; http://dx.doi.org/10.1002/bies.10009; PMID: 11746230
   PubMed Web of Science ®Google Scholar
• Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9:563 - 75; http://dx.doi.org/10.1038/nrc2676; PMID: 19629071
   PubMed Web of Science ®Google Scholar
• Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2005; 2:21 - 33; http://dx.doi.org/10.1016/j.cmet.2005.06.005; PMID: 16054096
   PubMed Web of Science ®Google Scholar
• Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2005; 2:9 - 19; http://dx.doi.org/10.1016/j.cmet.2005.05.009; PMID: 16054095
   PubMed Web of Science ®Google Scholar
• Dzamko N, van Denderen BJ, Hevener AL, Jørgensen SB, Honeyman J, Galic S, Chen ZP, Watt MJ, Campbell DJ, Steinberg GR, et al. AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem 2010; 285:115 - 22; http://dx.doi.org/10.1074/jbc.M109.056762; PMID: 19892703
   PubMed Web of Science ®Google Scholar
• O’Neill HM, Maarbjerg SJ, Crane JD, Jeppesen J, Jørgensen SB, Schertzer JD, Shyroka O, Kiens B, van Denderen BJ, Tarnopolsky MA, et al. AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A 2011; 108:16092 - 7; http://dx.doi.org/10.1073/pnas.1105062108; PMID: 21896769
   PubMed Web of Science ®Google Scholar
• Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A 2010; 107:19237 - 41; http://dx.doi.org/10.1073/pnas.1009705107; PMID: 20974912
   PubMed Web of Science ®Google Scholar
• Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, Iseli TJ, Koay A, Gooley PR, Stapleton D, et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol 2008; 15:1220 - 30; http://dx.doi.org/10.1016/j.chembiol.2008.10.005; PMID: 19022182
   PubMed Web of Science ®Google Scholar
• Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 2012; 336:918 - 22; http://dx.doi.org/10.1126/science.1215327; PMID: 22517326
   PubMed Web of Science ®Google Scholar
• Steinberg GR, O’Neill HM, Dzamko NL, Galic S, Naim T, Koopman R, Jørgensen SB, Honeyman J, Hewitt K, Chen ZP, et al. Whole body deletion of AMP-activated protein kinase beta2 reduces muscle AMPK activity and exercise capacity. J Biol Chem 2010; 285:37198 - 209; http://dx.doi.org/10.1074/jbc.M110.102434; PMID: 20855892
   PubMed Web of Science ®Google Scholar
• Bateman A. The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem Sci 1997; 22:12 - 3; http://dx.doi.org/10.1016/S0968-0004(96)30046-7; PMID: 9020585
   PubMed Web of Science ®Google Scholar
• Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13:251 - 62; http://dx.doi.org/10.1038/nrm3311; PMID: 22436748
   PubMed Web of Science ®Google Scholar
• Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, et al. Structure of mammalian AMPK and its regulation by ADP. Nature 2011; 472:230 - 3; http://dx.doi.org/10.1038/nature09932; PMID: 21399626
   PubMed Web of Science ®Google Scholar
• Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. Eur J Biochem 1995; 229:558 - 65; http://dx.doi.org/10.1111/j.1432-1033.1995.tb20498.x; PMID: 7744080
   PubMedGoogle Scholar
• Carlson CA, Kim KH. Regulation of hepatic acetyl coenzyme A carboxylase by phosphorylation and dephosphorylation. J Biol Chem 1973; 248:378 - 80; PMID: 4692841
   PubMed Web of Science ®Google Scholar
• Linher-Melville K, Zantinge S, Sanli T, Gerstein H, Tsakiridis T, Singh G. Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. BMC Cancer 2011; 11:56; http://dx.doi.org/10.1186/1471-2407-11-56; PMID: 21294903
   PubMed Web of Science ®Google Scholar
• Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21 - 35; http://dx.doi.org/10.1038/nrm3025; PMID: 21157483
   PubMed Web of Science ®Google Scholar
• van Veelen W, Korsse SE, van de Laar L, Peppelenbosch MP. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling. Oncogene 2011; 30:2289 - 303; http://dx.doi.org/10.1038/onc.2010.630; PMID: 21258412
   PubMed Web of Science ®Google Scholar
• Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 2008; 27:1919 - 31; http://dx.doi.org/10.1038/emboj.2008.119; PMID: 18566587
   PubMed Web of Science ®Google Scholar
• Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30:214 - 26; http://dx.doi.org/10.1016/j.molcel.2008.03.003; PMID: 18439900
   PubMed Web of Science ®Google Scholar
• Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007; 282:30107 - 19; http://dx.doi.org/10.1074/jbc.M705325200; PMID: 17711846
   PubMed Web of Science ®Google Scholar
• Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011; 13:376 - 88; http://dx.doi.org/10.1016/j.cmet.2011.03.009; PMID: 21459323
   PubMed Web of Science ®Google Scholar
• Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 2007; 104:12017 - 22; http://dx.doi.org/10.1073/pnas.0705070104; PMID: 17609368
   PubMed Web of Science ®Google Scholar
• Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18:283 - 93; http://dx.doi.org/10.1016/j.molcel.2005.03.027; PMID: 15866171
   PubMed Web of Science ®Google Scholar
• Lee CW, Wong LL, Tse EY, Liu HF, Leong VY, Lee JM, Hardie DG, Ng IO, Ching YP. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res 2012; 72:4394 - 404; http://dx.doi.org/10.1158/0008-5472.CAN-12-0429; PMID: 22728651
   PubMed Web of Science ®Google Scholar
• Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218 - 24; http://dx.doi.org/10.1038/ncb1537; PMID: 17237771
   PubMed Web of Science ®Google Scholar
• Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D, Thompson CB, Jones RG, Berger SL. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010; 329:1201 - 5; http://dx.doi.org/10.1126/science.1191241; PMID: 20647423
   PubMed Web of Science ®Google Scholar
• Warburg O, Wind F, Negelein E. The Metabolism of Tumors in the Body. J Gen Physiol 1927; 8:519 - 30; http://dx.doi.org/10.1085/jgp.8.6.519; PMID: 19872213
   PubMedGoogle Scholar
• Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006; 9:425 - 34; http://dx.doi.org/10.1016/j.ccr.2006.04.023; PMID: 16766262
   PubMed Web of Science ®Google Scholar
• Moreno-Sánchez R, Rodríguez-Enríquez S, Marín-Hernández A, Saavedra E. Energy metabolism in tumor cells. FEBS J 2007; 274:1393 - 418; http://dx.doi.org/10.1111/j.1742-4658.2007.05686.x; PMID: 17302740
   PubMed Web of Science ®Google Scholar
• Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg’s effect. J Bioenerg Biomembr 2007; 39:223 - 9; http://dx.doi.org/10.1007/s10863-007-9080-3; PMID: 17661163
   PubMed Web of Science ®Google Scholar
• Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18:598 - 608; http://dx.doi.org/10.1016/j.ceb.2006.10.005; PMID: 17046224
   PubMed Web of Science ®Google Scholar
• Smolková K, Plecitá-Hlavatá L, Bellance N, Benard G, Rossignol R, Ježek P. Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells. Int J Biochem Cell Biol 2011; 43:950 - 68; http://dx.doi.org/10.1016/j.biocel.2010.05.003; PMID: 20460169
   PubMed Web of Science ®Google Scholar
• Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009; 23:537 - 48; http://dx.doi.org/10.1101/gad.1756509; PMID: 19270154
   PubMed Web of Science ®Google Scholar
• Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth BJ, Viollet B, et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab 2013; 17:113 - 24; http://dx.doi.org/10.1016/j.cmet.2012.12.001; PMID: 23274086
   PubMed Web of Science ®Google Scholar
• Lee YG, Lee SW, Sin HS, Kim EJ, Um SJ. Kinase activity-independent suppression of p73alpha by AMP-activated kinase alpha (AMPKalpha). Oncogene 2009; 28:1040 - 52; http://dx.doi.org/10.1038/onc.2008.452; PMID: 19079340
   PubMed Web of Science ®Google Scholar
• Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefström J. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A 2013; 110:E1839 - 48; http://dx.doi.org/10.1073/pnas.1208530110; PMID: 23589839
   PubMedGoogle Scholar
• Bensimon A, Aebersold R, Shiloh Y. Beyond ATM: the protein kinase landscape of the DNA damage response. FEBS Lett 2011; 585:1625 - 39; http://dx.doi.org/10.1016/j.febslet.2011.05.013; PMID: 21570395
   PubMed Web of Science ®Google Scholar
• Ditch S, Paull TT. The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends Biochem Sci 2012; 37:15 - 22; http://dx.doi.org/10.1016/j.tibs.2011.10.002; PMID: 22079189
   PubMed Web of Science ®Google Scholar
• Zakikhani M, Bazile M, Hashemi S, Javeshghani S, Avizonis D, St Pierre J, Pollak MN. Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin. PLoS One 2012; 7:e49513; http://dx.doi.org/10.1371/journal.pone.0049513; PMID: 23185347
   PubMedGoogle Scholar
• Armata HL, Golebiowski D, Jung DY, Ko HJ, Kim JK, Sluss HK. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol 2010; 30:5787 - 94; http://dx.doi.org/10.1128/MCB.00347-10; PMID: 20956556
   PubMed Web of Science ®Google Scholar
• Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 2000; 151:1381 - 90; http://dx.doi.org/10.1083/jcb.151.7.1381; PMID: 11134068
   PubMed Web of Science ®Google Scholar
• Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the genome. DNA Repair (Amst) 2004; 3:959 - 67; http://dx.doi.org/10.1016/j.dnarep.2004.03.024; PMID: 15279782
   PubMed Web of Science ®Google Scholar
• Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004; 59:928 - 42; http://dx.doi.org/10.1016/j.ijrobp.2004.03.005; PMID: 15234026
   PubMed Web of Science ®Google Scholar
• Stracker TH, Roig I, Knobel PA, Marjanović M. The ATM signaling network in development and disease. Front Genet 2013; 4:37; http://dx.doi.org/10.3389/fgene.2013.00037; PMID: 23532176
   PubMedGoogle Scholar
• Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160 - 6; http://dx.doi.org/10.1126/science.1140321; PMID: 17525332
   PubMed Web of Science ®Google Scholar
• Alexander A, Kim J, Walker CL. ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 2010; 6:672 - 3; http://dx.doi.org/10.4161/auto.6.5.12509; PMID: 20581436
   PubMed Web of Science ®Google Scholar
• Sun Y, Connors KE, Yang DQ. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol Cell Biochem 2007; 306:239 - 45; http://dx.doi.org/10.1007/s11010-007-9575-6; PMID: 17786544
   PubMed Web of Science ®Google Scholar
• Alexander A, Walker CL. The role of LKB1 and AMPK in cellular responses to stress and damage. FEBS Lett 2011; 585:952 - 7; http://dx.doi.org/10.1016/j.febslet.2011.03.010; PMID: 21396365
   PubMed Web of Science ®Google Scholar
• Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A 2010; 107:4153 - 8; http://dx.doi.org/10.1073/pnas.0913860107; PMID: 20160076
   PubMed Web of Science ®Google Scholar
• Amatya PN, Kim HB, Park SJ, Youn CK, Hyun JW, Chang IY, Lee JH, You HJ. A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation. Biochim Biophys Acta 2012; 1823:2099 - 108; http://dx.doi.org/10.1016/j.bbamcr.2012.08.022; PMID: 22982065
   PubMed Web of Science ®Google Scholar
• Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, Singh G, Wright J, Tsakiridis T. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys 2010; 78:221 - 9; http://dx.doi.org/10.1016/j.ijrobp.2010.03.005; PMID: 20615625
   PubMed Web of Science ®Google Scholar
• Storozhuk YH, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, Tsakiridis T. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 2013; 108:2021 - 32; http://dx.doi.org/10.1038/bjc.2013.187; PMID: 23632475
   PubMed Web of Science ®Google Scholar
• Woods A, Leiper JM, Carling D. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet 2012; 44:360 - 1; http://dx.doi.org/10.1038/ng.2235; PMID: 22456733
   PubMed Web of Science ®Google Scholar
• Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J 2002; 368:507 - 16; http://dx.doi.org/10.1042/BJ20021284; PMID: 12234250
   PubMed Web of Science ®Google Scholar
• Storozhuk Y, Sanli T, Hopmans SN, Schultz C, Farrell T, Cutz JC, Steinberg GR, Wright J, Singh G, Tsakiridis T. Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts. Radiat Oncol 2012; 7:71; http://dx.doi.org/10.1186/1748-717X-7-71; PMID: 22607554
   PubMed Web of Science ®Google Scholar
• Fu X, Wan S, Lyu YL, Liu LF, Qi H. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One 2008; 3:e2009; http://dx.doi.org/10.1371/journal.pone.0002009; PMID: 18431490
   PubMed Web of Science ®Google Scholar
• Sanli T, Storozhuk Y, Linher-Melville K, Bristow RG, Laderout K, Viollet B, Wright J, Singh G, Tsakiridis T. Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival. Radiother Oncol 2012; 102:459 - 65; http://dx.doi.org/10.1016/j.radonc.2011.11.014; PMID: 22225791
   PubMed Web of Science ®Google Scholar
• Viniegra JG, Martínez N, Modirassari P, Hernández Losa J, Parada Cobo C, Sánchez-Arévalo Lobo VJ, Aceves Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, et al. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 2005; 280:4029 - 36; http://dx.doi.org/10.1074/jbc.M410344200; PMID: 15546863
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098 - 101; http://dx.doi.org/10.1126/science.1106148; PMID: 15718470
   PubMed Web of Science ®Google Scholar
• Braunstein S, Badura ML, Xi Q, Formenti SC, Schneider RJ. Regulation of protein synthesis by ionizing radiation. Mol Cell Biol 2009; 29:5645 - 56; http://dx.doi.org/10.1128/MCB.00711-09; PMID: 19704005
   PubMed Web of Science ®Google Scholar
• Bristow RG, Hill R. Molecular and Cellular Basis of Radiotherapy. The Basic Science of Oncology. Toronto: McGraw-Hill, 1998:295-321.
   Google Scholar
• Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20:267 - 75; http://dx.doi.org/10.1101/gad.1363206; PMID: 16452501
   PubMed Web of Science ®Google Scholar
• Maclaine NJ, Hupp TR. The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging (Albany NY) 2009; 1:490 - 502; PMID: 20157532
   PubMedGoogle Scholar
• Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134:451 - 60; http://dx.doi.org/10.1016/j.cell.2008.06.028; PMID: 18692468
   PubMed Web of Science ®Google Scholar
• Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 2007; 67:3043 - 53; http://dx.doi.org/10.1158/0008-5472.CAN-06-4149; PMID: 17409411
   PubMed Web of Science ®Google Scholar
• Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 2002; 21:6017 - 31; http://dx.doi.org/10.1038/sj.onc.1205877; PMID: 12203114
   PubMed Web of Science ®Google Scholar
• Sanli T, Linher-Melville K, Tsakiridis T, Singh G. Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. PLoS One 2012; 7:e32035; http://dx.doi.org/10.1371/journal.pone.0032035; PMID: 22363791
   PubMed Web of Science ®Google Scholar
• Zannella VE, Cojocari D, Hilgendorf S, Vellanki RN, Chung S, Wouters BG, Koritzinsky M. AMPK regulates metabolism and survival in response to ionizing radiation. Radiother Oncol 2011; 99:293 - 9; http://dx.doi.org/10.1016/j.radonc.2011.05.049; PMID: 21715037
   PubMed Web of Science ®Google Scholar
• Sanli T, Liu C, Rashid A, Hopmans SN, Tsiani E, Schultz C, Farrell T, Singh G, Wright J, Tsakiridis T. Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. J Thorac Oncol 2011; 6:439 - 50; http://dx.doi.org/10.1097/JTO.0b013e3182049d8b; PMID: 21258249
   PubMed Web of Science ®Google Scholar
• Fritz G, Brachetti C, Kaina B. Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage. Int J Radiat Biol 2003; 79:601 - 10; http://dx.doi.org/10.1080/09553000310001609233; PMID: 14555343
   PubMed Web of Science ®Google Scholar
• Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways. Radiat Oncol 2011; 6:144; http://dx.doi.org/10.1186/1748-717X-6-144; PMID: 22029423
   PubMed Web of Science ®Google Scholar
• Zoberi I, Bradbury CM, Curry HA, Bisht KS, Goswami PC, Roti Roti JL, Gius D. Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines. Cancer Lett 2002; 175:165 - 73; http://dx.doi.org/10.1016/S0304-3835(01)00719-4; PMID: 11741744
   PubMed Web of Science ®Google Scholar
• Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 2012; 18:290 - 300; http://dx.doi.org/10.1158/1078-0432.CCR-11-2260; PMID: 22090360
   PubMed Web of Science ®Google Scholar
• Song CW, Lee H, Dings RP, Williams B, Powers J, Santos TD, Choi BH, Park HJ. Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells. Sci Rep 2012; 2:362; http://dx.doi.org/10.1038/srep00362; PMID: 22500211
   PubMed Web of Science ®Google Scholar
• Luo L, Huang W, Tao R, Hu N, Xiao ZX, Luo Z. ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis. Cancer Lett 2013; 328:114 - 9; http://dx.doi.org/10.1016/j.canlet.2012.08.034; PMID: 22960274
   PubMed Web of Science ®Google Scholar
• Basu A, Krishnamurthy S. Cellular responses to Cisplatin-induced DNA damage. J Nucleic Acids 2010; 2010:pii: 201367; http://dx.doi.org/10.4061/2010/201367; PMID: 20811617
   PubMedGoogle Scholar
• Shi Y, Felley-Bosco E, Marti TM, Orlowski K, Pruschy M, Stahel RA. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer 2012; 12:571; http://dx.doi.org/10.1186/1471-2407-12-571; PMID: 23211021
   PubMed Web of Science ®Google Scholar
• Wang L, Mosel AJ, Oakley GG, Peng A. Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer. Mol Cancer Ther 2012; 11:2401 - 9; http://dx.doi.org/10.1158/1535-7163.MCT-12-0448; PMID: 22973056
   PubMed Web of Science ®Google Scholar
• Ji C, Yang B, Yang YL, He SH, Miao DS, He L, Bi ZG. Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition. Oncogene 2010; 29:6557 - 68; http://dx.doi.org/10.1038/onc.2010.379; PMID: 20802518
   PubMed Web of Science ®Google Scholar
• Zajkowicz A, Rusin M. The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. Mech Ageing Dev 2011; 132:543 - 51; http://dx.doi.org/10.1016/j.mad.2011.09.002; PMID: 21945951
   PubMed Web of Science ®Google Scholar
• Bettencourt-Dias M, Giet R, Sinka R, Mazumdar A, Lock WG, Balloux F, Zafiropoulos PJ, Yamaguchi S, Winter S, Carthew RW, et al. Genome-wide survey of protein kinases required for cell cycle progression. Nature 2004; 432:980 - 7; http://dx.doi.org/10.1038/nature03160; PMID: 15616552
   PubMed Web of Science ®Google Scholar
• Mirouse V, Swick LL, Kazgan N, St Johnston D, Brenman JE. LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 2007; 177:387 - 92; http://dx.doi.org/10.1083/jcb.200702053; PMID: 17470638
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle 2009; 8:2385 - 98; http://dx.doi.org/10.4161/cc.8.15.9082; PMID: 19556893
   PubMed Web of Science ®Google Scholar
• Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong M, Kim JM, Kim J, et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 2007; 447:1017 - 20; http://dx.doi.org/10.1038/nature05828; PMID: 17486097
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Lopez-Bonet E, Menendez JA. AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor. Cell Cycle 2009; 8:3679 - 83; http://dx.doi.org/10.4161/cc.8.22.9905; PMID: 19844168
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, López-Bonet E, Oliveras-Ferraros C, Pérez-Martínez MC, Bernadó L, Menendez JA. Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells. Cell Cycle 2009; 8:788 - 91; http://dx.doi.org/10.4161/cc.8.5.7787; PMID: 19221486
   PubMed Web of Science ®Google Scholar
• Thaiparambil JT, Eggers CM, Marcus AI. AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain. Mol Cell Biol 2012; 32:3203 - 17; http://dx.doi.org/10.1128/MCB.00418-12; PMID: 22688514
   PubMed Web of Science ®Google Scholar
• Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell 2011; 44:878 - 92; http://dx.doi.org/10.1016/j.molcel.2011.11.005; PMID: 22137581
   PubMed Web of Science ®Google Scholar
• Pinter K, Jefferson A, Czibik G, Watkins H, Redwood C. Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification. Cell Cycle 2012; 11:917 - 21; http://dx.doi.org/10.4161/cc.11.5.19412; PMID: 22333580
   PubMed Web of Science ®Google Scholar
• Saitoh S, Takahashi K, Nabeshima K, Yamashita Y, Nakaseko Y, Hirata A, Yanagida M. Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. J Cell Biol 1996; 134:949 - 61; http://dx.doi.org/10.1083/jcb.134.4.949; PMID: 8769419
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Corominas-Faja B, Oliveras-Ferraros C, Cufí S, Dalla Venezia N, Menendez JA. Serine79-phosphorylated acetyl-CoA carboxylase, a downstream target of AMPK, localizes to the mitotic spindle poles and the cytokinesis furrow. Cell Cycle 2013; 12:1639 - 41; http://dx.doi.org/10.4161/cc.24700
   PubMed Web of Science ®Google Scholar
• Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M, Giri S, Andreelli F. AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol 2010; 45:276 - 95; http://dx.doi.org/10.3109/10409238.2010.488215; PMID: 20522000
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Thompson CB. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res 2007; 13:7271 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-07-1595; PMID: 18094407
   PubMed Web of Science ®Google Scholar
• Mathew R, White E. Autophagy, stress, and cancer metabolism: what doesn’t kill you makes you stronger. Cold Spring Harb Symp Quant Biol 2011; 76:389 - 96; http://dx.doi.org/10.1101/sqb.2012.76.011015; PMID: 22442109
   PubMedGoogle Scholar
• Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132 - 41; http://dx.doi.org/10.1038/ncb2152; PMID: 21258367
   PubMed Web of Science ®Google Scholar
• Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726 - 34; http://dx.doi.org/10.1038/nrc1692; PMID: 16148885
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672 - 6; http://dx.doi.org/10.1038/45257; PMID: 10604474
   PubMed Web of Science ®Google Scholar
• Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68:1485 - 94; http://dx.doi.org/10.1158/0008-5472.CAN-07-0562; PMID: 18316613
   PubMed Web of Science ®Google Scholar
• Xie BS, Zhao HC, Yao SK, Zhuo DX, Jin B, Lv DC, Wu CL, Ma DL, Gao C, Shu XM, et al. Autophagy inhibition enhances etoposide-induced cell death in human hepatoma G2 cells. Int J Mol Med 2011; 27:599 - 606; PMID: 21274505
   PubMed Web of Science ®Google Scholar
• Rocha GZ, Dias MM, Ropelle ER, Osório-Costa F, Rossato FA, Vercesi AE, Saad MJ, Carvalheira JB. Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. Clin Cancer Res 2011; 17:3993 - 4005; http://dx.doi.org/10.1158/1078-0432.CCR-10-2243; PMID: 21543517
   PubMed Web of Science ®Google Scholar
• Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67:6745 - 52; http://dx.doi.org/10.1158/0008-5472.CAN-06-4447; PMID: 17638885
   PubMed Web of Science ®Google Scholar